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P25487 (VL2_HPV2A) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Minor capsid protein L2
Gene names
Name:L2
OrganismHuman papillomavirus type 2a [Complete proteome]
Taxonomic identifier10584 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA By similarity.

Subunit structure

Interacts with major capsid protein L1 By similarity. Interacts with host importins By similarity.

Subcellular location

Virion By similarity. Host nucleus By similarity.

Post-translational modification

Highly phosphorylated Potential.

Sequence similarities

Belongs to the papillomaviridae L2 protein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 468468Minor capsid protein L2
PRO_0000133567

Regions

Motif1 – 1111Nuclear localization signal By similarity
Motif449 – 4579Nuclear localization signal By similarity

Amino acid modifications

Disulfide bond20 ↔ 26 By similarity

Sequences

Sequence LengthMass (Da)Tools
P25487 [UniParc].

Last modified May 3, 2011. Version 2.
Checksum: CF30E61105EC45BC

FASTA46849,842
        10         20         30         40         50         60 
MSIRAKRRKR ASPTDLYRTC KQAGTCPPDI IPRVEQNTLA DKILKWGSLG VFFGGLGIGT 

        70         80         90        100        110        120 
GSGTGGRTGY IPVGSRPTTV VDIGPTPRPP VIIEPVGASE PSIVTLVEDS SIINAGASHP 

       130        140        150        160        170        180 
TFTGTGGFEV TTSTVTDPAV LDITPSGTSV QVSSSSFLNP LYTEPAIVEA PQTGEVSGHV 

       190        200        210        220        230        240 
LVSTATSGSH GYEEIPMQTF ATSGGSGTEP ISSTPLPGVR RVAGPRLYSR ANQQVQVRDP 

       250        260        270        280        290        300 
AFLARPADLV TFDNPVYDPE ETIIFQHPDL HEPPDPDFLD IVALHRPALT SRRGTVRFSR 

       310        320        330        340        350        360 
LGRRATLRTR SGKQIGARVH FYHDISPIGT EELEMEPLLP PASTDNTDML YDVYADSDVL 

       370        380        390        400        410        420 
QPLLDELPAA PRGSLSLADT AVSATSASTL RGSTTVPLSS GIDVPVYTGP DIEPPNVPGM 

       430        440        450        460 
GPLIPVAPSL PSSVYIFGGD YYLMPSYVLW PKRRKRVHYF FADGFVAA 

« Hide

References

[1]"A comparative sequence analysis of two human papillomavirus (HPV) types 2a and 57."
Hirsch-Behnam A., Delius H., de Villiers E.M.
Virus Res. 18:81-98(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55964 Genomic DNA. No translation available.
PIRS15619.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR000784. Late_L2.
[Graphical view]
PfamPF00513. Late_protein_L2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVL2_HPV2A
AccessionPrimary (citable) accession number: P25487
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 3, 2011
Last modified: February 19, 2014
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families