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P25487

- VL2_HPV2A

UniProt

P25487 - VL2_HPV2A

Protein

Minor capsid protein L2

Gene

L2

Organism
Human papillomavirus type 2a
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 2 (03 May 2011)
      Previous versions | rss
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    Functioni

    Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. microtubule-dependent intracellular transport of viral material towards nucleus Source: UniProtKB-KW
    2. viral entry into host cell Source: UniProtKB-KW
    3. viral penetration into host nucleus Source: UniProtKB-KW

    Keywords - Biological processi

    Cytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Viral penetration into host nucleus, Virus entry into host cell

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Minor capsid protein L2
    Gene namesi
    Name:L2
    OrganismiHuman papillomavirus type 2a
    Taxonomic identifieri10584 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000007710: Genome

    Subcellular locationi

    Virion By similarity. Host nucleus By similarity

    GO - Cellular componenti

    1. host cell nucleus Source: UniProtKB-SubCell
    2. intracellular Source: GOC
    3. viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, Host nucleus, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 468468Minor capsid protein L2PRO_0000133567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi20 ↔ 26By similarity

    Post-translational modificationi

    Highly phosphorylated.Curated

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Expressioni

    Keywords - Developmental stagei

    Late protein

    Interactioni

    Subunit structurei

    Interacts with major capsid protein L1. Interacts with host importins.By similarity

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1 – 1111Nuclear localization signalBy similarityAdd
    BLAST
    Motifi449 – 4579Nuclear localization signalBy similarity

    Sequence similaritiesi

    Belongs to the papillomaviridae L2 protein family.Curated

    Family and domain databases

    InterProiIPR000784. Late_L2.
    [Graphical view]
    PfamiPF00513. Late_protein_L2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25487-1 [UniParc]FASTAAdd to Basket

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    MSIRAKRRKR ASPTDLYRTC KQAGTCPPDI IPRVEQNTLA DKILKWGSLG    50
    VFFGGLGIGT GSGTGGRTGY IPVGSRPTTV VDIGPTPRPP VIIEPVGASE 100
    PSIVTLVEDS SIINAGASHP TFTGTGGFEV TTSTVTDPAV LDITPSGTSV 150
    QVSSSSFLNP LYTEPAIVEA PQTGEVSGHV LVSTATSGSH GYEEIPMQTF 200
    ATSGGSGTEP ISSTPLPGVR RVAGPRLYSR ANQQVQVRDP AFLARPADLV 250
    TFDNPVYDPE ETIIFQHPDL HEPPDPDFLD IVALHRPALT SRRGTVRFSR 300
    LGRRATLRTR SGKQIGARVH FYHDISPIGT EELEMEPLLP PASTDNTDML 350
    YDVYADSDVL QPLLDELPAA PRGSLSLADT AVSATSASTL RGSTTVPLSS 400
    GIDVPVYTGP DIEPPNVPGM GPLIPVAPSL PSSVYIFGGD YYLMPSYVLW 450
    PKRRKRVHYF FADGFVAA 468
    Length:468
    Mass (Da):49,842
    Last modified:May 3, 2011 - v2
    Checksum:iCF30E61105EC45BC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55964 Genomic DNA. No translation available.
    PIRiS15619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55964 Genomic DNA. No translation available.
    PIRi S15619.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR000784. Late_L2.
    [Graphical view ]
    Pfami PF00513. Late_protein_L2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparative sequence analysis of two human papillomavirus (HPV) types 2a and 57."
      Hirsch-Behnam A., Delius H., de Villiers E.M.
      Virus Res. 18:81-98(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiVL2_HPV2A
    AccessioniPrimary (citable) accession number: P25487
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 3, 2011
    Last modified: October 1, 2014
    This is version 51 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3