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P25487

- VL2_HPV2A

UniProt

P25487 - VL2_HPV2A

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Protein

Minor capsid protein L2

Gene

L2

Organism
Human papillomavirus type 2a
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA (By similarity).By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. microtubule-dependent intracellular transport of viral material towards nucleus Source: UniProtKB-KW
  2. viral entry into host cell Source: UniProtKB-KW
  3. viral penetration into host nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Viral penetration into host nucleus, Virus entry into host cell

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Minor capsid protein L2
Gene namesi
Name:L2
OrganismiHuman papillomavirus type 2a
Taxonomic identifieri10584 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePapillomaviridaeAlphapapillomavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
ProteomesiUP000007710: Genome

Subcellular locationi

Virion By similarity. Host nucleus By similarity

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Minor capsid protein L2PRO_0000133567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi20 ↔ 26By similarity

Post-translational modificationi

Highly phosphorylated.Curated

Keywords - PTMi

Disulfide bond, Phosphoprotein

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with major capsid protein L1. Interacts with host importins.By similarity

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1 – 1111Nuclear localization signalBy similarityAdd
BLAST
Motifi449 – 4579Nuclear localization signalBy similarity

Sequence similaritiesi

Belongs to the papillomaviridae L2 protein family.Curated

Family and domain databases

InterProiIPR000784. Late_L2.
[Graphical view]
PfamiPF00513. Late_protein_L2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25487-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSIRAKRRKR ASPTDLYRTC KQAGTCPPDI IPRVEQNTLA DKILKWGSLG
60 70 80 90 100
VFFGGLGIGT GSGTGGRTGY IPVGSRPTTV VDIGPTPRPP VIIEPVGASE
110 120 130 140 150
PSIVTLVEDS SIINAGASHP TFTGTGGFEV TTSTVTDPAV LDITPSGTSV
160 170 180 190 200
QVSSSSFLNP LYTEPAIVEA PQTGEVSGHV LVSTATSGSH GYEEIPMQTF
210 220 230 240 250
ATSGGSGTEP ISSTPLPGVR RVAGPRLYSR ANQQVQVRDP AFLARPADLV
260 270 280 290 300
TFDNPVYDPE ETIIFQHPDL HEPPDPDFLD IVALHRPALT SRRGTVRFSR
310 320 330 340 350
LGRRATLRTR SGKQIGARVH FYHDISPIGT EELEMEPLLP PASTDNTDML
360 370 380 390 400
YDVYADSDVL QPLLDELPAA PRGSLSLADT AVSATSASTL RGSTTVPLSS
410 420 430 440 450
GIDVPVYTGP DIEPPNVPGM GPLIPVAPSL PSSVYIFGGD YYLMPSYVLW
460
PKRRKRVHYF FADGFVAA
Length:468
Mass (Da):49,842
Last modified:May 3, 2011 - v2
Checksum:iCF30E61105EC45BC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55964 Genomic DNA. No translation available.
PIRiS15619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55964 Genomic DNA. No translation available.
PIRi S15619.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR000784. Late_L2.
[Graphical view ]
Pfami PF00513. Late_protein_L2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A comparative sequence analysis of two human papillomavirus (HPV) types 2a and 57."
    Hirsch-Behnam A., Delius H., de Villiers E.M.
    Virus Res. 18:81-98(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiVL2_HPV2A
AccessioniPrimary (citable) accession number: P25487
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 3, 2011
Last modified: October 29, 2014
This is version 52 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3