P25487 (VL2_HPV2A) Reviewed, UniProtKB/Swiss-Prot
Last modified February 19, 2014. Version 50. History...
Names and origin
|Protein names||Recommended name:|
Minor capsid protein L2
|Organism||Human papillomavirus type 2a [Complete proteome]|
|Taxonomic identifier||10584 [NCBI]|
|Taxonomic lineage||Viruses › dsDNA viruses, no RNA stage › Papillomaviridae › Alphapapillomavirus ›|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
|Sequence length||468 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
Minor protein of the capsid that localizes along the inner surface of the virion, within the central cavities beneath the L1 pentamers. Plays a role in capsid stabilization through interaction with the major capsid protein L1. Once the virion enters the host cell, escorts the genomic DNA into the nucleus, in particular by promoting virion endosomal escape. It is involved, through its interaction with host dynein, in the intracellular microtubule-dependent transport of viral capsid toward the nucleus. Mediates the viral genome import into the nucleus through binding to host importins. Mediates the viral genome import into the nucleus through binding to host importins. Once within the nucleus, L2 localizes viral genomes to PML bodies in order to activate early gene expression for establishment of infection. Later on, promotes late gene expression by interacting with the viral E2 protein and by inhibiting its transcriptional activation functions. During virion assembly, encapsidates the genome by direct interaction with the viral DNA By similarity.
Interacts with major capsid protein L1 By similarity. Interacts with host importins By similarity.
Highly phosphorylated Potential.
Belongs to the papillomaviridae L2 protein family.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 468||468||Minor capsid protein L2||PRO_0000133567|
|Motif||1 – 11||11||Nuclear localization signal By similarity|
|Motif||449 – 457||9||Nuclear localization signal By similarity|
Amino acid modifications
|Disulfide bond||20 ↔ 26||By similarity|
|X55964 Genomic DNA. No translation available.|
3D structure databases
Protocols and materials databases
Family and domain databases
|InterPro||IPR000784. Late_L2. |
|Pfam||PF00513. Late_protein_L2. 1 hit. |
|Accession||Primary (citable) accession number: P25487|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Viral Protein Annotation Program|
Index of protein domains and families