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P25466

- HN_PI2HT

UniProt

P25466 - HN_PI2HT

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Human parainfluenza 2 virus (strain Toshiba) (HPIV-2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Protein family/group databases

    CAZyiGH83. Glycoside Hydrolase Family 83.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Gene namesi
    Name:HN
    OrganismiHuman parainfluenza 2 virus (strain Toshiba) (HPIV-2)
    Taxonomic identifieri11214 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000000472: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 571571Hemagglutinin-neuraminidasePRO_0000142623Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi272 – 2721N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi335 – 3351N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi341 – 3411N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi386 – 3861N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi454 – 4541N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi501 – 5011N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi517 – 5171N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi522 – 5221N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP25466.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini47 – 571525Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni228 – 2336Important for neuraminidase activityBy similarity
    Regioni393 – 3986Sialic receptor-binding siteCurated

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P25466-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDYSNLSLK SIPKRTCRII FRTATILGIC TLIVLCSSIL HEIIHLDVSS    50
    GLMDSDDSQQ GIIQPIIESL KSLIALANQI LYNVAIIIPL KIDSIETVIF 100
    SALKDMHTGS MSNTNCTPGN LLLHDAAYIN GINKFLVLKS YNGTPKYGPL 150
    LNIPSFIPSA TSPNGCTRIP SFSLIKTHWC YTHNVMLGDC LDFTTSNQYL 200
    AMGIIQQSAA AFPIFRTMKT IYLSDGINRK SCSVTAIPGG CVLYCYVATR 250
    SEKEDYATTD LAELRLAFYY YNDTFIERVI SLPNTTGQWA TINPAVGSGI 300
    YHLGFILFPV YGGLISGTPS YNKQSSRYFI PKHPNITCAG NSSEQAAAAR 350
    SSYVIRYHSN RLIQSAVLIC PLSDMHTARC NLVMFNNSQV MMGAEGRLYV 400
    IDNNLYYYQR SSSWWSASLF YRINTDFSKG IPPIIEAQWV PSYQVPRPGV 450
    MPCNATSFCP ANCITGVYAD VWPLNDPEPT SQNALNPNYR FAGAFLRNES 500
    NRTNPTFYTA SASALLNTTG FNNTNHKAAY TSSTCFKNTG TQKIYCLIII 550
    EMGSSLLGEF QIIPFLRELI P 571
    Length:571
    Mass (Da):63,263
    Last modified:May 1, 1992 - v1
    Checksum:iD7130A3BE6491406
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57559 mRNA. Translation: CAA40787.1.
    PIRiA33777. HNNZP2.
    RefSeqiNP_598405.1. NC_003443.1.

    Genome annotation databases

    GeneIDi935188.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57559 mRNA. Translation: CAA40787.1 .
    PIRi A33777. HNNZP2.
    RefSeqi NP_598405.1. NC_003443.1.

    3D structure databases

    ProteinModelPortali P25466.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH83. Glycoside Hydrolase Family 83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 935188.

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence determination of the hemagglutinin-neuraminidase (HN) gene of human parainfluenza type 2 virus and the construction of a phylogenetic tree for HN proteins of all the paramyxoviruses that are infectious to humans."
      Kawano M., Bando H., Yuasa T., Kondo K., Tsurudome M., Komada H., Nishio M., Ito Y.
      Virology 174:308-313(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHN_PI2HT
    AccessioniPrimary (citable) accession number: P25466
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3