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P25465

- HN_PI2H

UniProt

P25465 - HN_PI2H

Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Human parainfluenza 2 virus (HPIV-2)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion By similarity.By similarity
    Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

    Catalytic activityi

    Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

    GO - Molecular functioni

    1. exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
    2. exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
    3. exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. viral entry into host cell Source: UniProtKB-KW
    2. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hemagglutinin, Hydrolase

    Keywords - Biological processi

    Host-virus interaction, Viral attachment to host cell, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemagglutinin-neuraminidase (EC:3.2.1.18)
    Gene namesi
    Name:HN
    OrganismiHuman parainfluenza 2 virus (HPIV-2)
    Taxonomic identifieri11212 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeParamyxovirinaeRubulavirus
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Subcellular locationi

    GO - Cellular componenti

    1. host cell plasma membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW
    3. viral envelope Source: UniProtKB-KW
    4. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 571571Hemagglutinin-neuraminidasePRO_0000142622Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi272 – 2721N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi284 – 2841N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi335 – 3351N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi386 – 3861N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi454 – 4541N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi498 – 4981N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi501 – 5011N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi517 – 5171N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi522 – 5221N-linked (GlcNAc...); by hostSequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP25465.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525IntravirionSequence AnalysisAdd
    BLAST
    Topological domaini47 – 571525Virion surfaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di2.120.10.10. 1 hit.
    InterProiIPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view]
    PfamiPF00423. HN. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMiSSF50939. SSF50939. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P25465-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDYSNLSLK SIPKRTCRII FRTATILGIC TLIVLCSSIL HEIIHLDVSS    50
    GLMDSDDSQQ GIIQPIIESL KSLIALANQI LYNVAIIIPL KIDSIETVIY 100
    SALKDMHTGS MSNTNCTPGN LLLHDAAYIN GLNKFLVLKS YNGTPKYGPL 150
    LNIPSFIPSA TSPNGCTRIP SFSLIKTHWC YTHNVILGDC LDFTTSNQYL 200
    AMGIIQQSAA AFPIFRTMKT IYLSDGINRK SCSVTAIPGG CVLYCYVATR 250
    SEKEDYATTD LAELRLAFYY YNDTFIERVI SLPNTTGQWA TINPAVGSGI 300
    YHLGFILFPV YGGLIKGTPS YNKQSSRYFI PKHPNITCAG KSSEQAAAAR 350
    SSYVIRYHSN RLLQSAVLIC PLSDMHTARC NLVMFNNSQV MMGAEGRLYV 400
    IDNNLYYYQR SSSWWSASLF YRINTDFSKG IPPIIEAQWV PSYQVPRPGV 450
    MPCNATSFCP ANCITGVYAD VWPLNDPEPT SQNALNPNYR FAGAFLRNES 500
    NRTNPTFYTA SASALLNTTG FNNTNHKAAY TSSTCFKNTG TQKIYCLIII 550
    EMGSSLLGEF QIIPFLRELI P 571
    Length:571
    Mass (Da):63,316
    Last modified:May 1, 1992 - v1
    Checksum:i56B4DCFA4337F392
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00865 mRNA. Translation: BAA00739.1.
    PIRiA34767. HNNZT2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D00865 mRNA. Translation: BAA00739.1 .
    PIRi A34767. HNNZT2.

    3D structure databases

    ProteinModelPortali P25465.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.120.10.10. 1 hit.
    InterProi IPR000665. Hemagglutn-neuramid.
    IPR016285. Hemagglutn-neuramid_paramyxo.
    IPR011040. Sialidases.
    [Graphical view ]
    Pfami PF00423. HN. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001072. Hemagglut-neuramid_paramyxoV. 1 hit.
    SUPFAMi SSF50939. SSF50939. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the HN gene of parainfluenza virus type 2."
      Precious B., Southern J.A., Randall R.E.
      J. Gen. Virol. 71:1163-1168(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHN_PI2H
    AccessioniPrimary (citable) accession number: P25465
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3