P25455 (PIP1_DROME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II
EC=3.1.4.11

Alternative name(s):
Phosphoinositide phospholipase C

Gene names

Name:	Plc21C
Synonyms:	plc-21
ORF Names:	CG4574

Organism

Drosophila melanogaster (Fruit fly) [Reference proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	1318 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Tissue specificity	Expressed in neuronal cell bodies of the optic lobe, central brain, and thoracic ganglia in adults, and the brain of larvae. Ref.1
Sequence similarities	Contains 1 C2 domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain.

Ontologies

Keywords
Biological process	Lipid degradation Lipid metabolism
Coding sequence diversity	Alternative splicing
Molecular function	Hydrolase Transducer
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	flight behavior Inferred from genetic interaction PubMed 16899722. Source: FlyBase intracellular signal transduction Inferred from electronic annotation. Source: InterPro lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro phosphatidylinositol phospholipase C activity Inferred from electronic annotation. Source: EC signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform D (identifier: P25455-3)

Also known as: F;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 1 (identifier: P25455-2)

Also known as: Class-I;

The sequence of this isoform differs from the canonical sequence as follows:
     907-913: FVFVQVG → C
     1063-1069: Missing.

Isoform A (identifier: P25455-1)

Also known as: B; Class-II;

The sequence of this isoform differs from the canonical sequence as follows:
     907-913: FVFVQVG → C

Isoform C (identifier: P25455-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1063-1069: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1318	1318	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II		PRO_0000088511
Regions
	Domain	318 – 466	149	PI-PLC X-box
	Domain	599 – 715	117	PI-PLC Y-box
	Domain	722 – 820	99	C2
	Compositional bias	469 – 478	10	His-rich
Sites
	Active site	333	1	By similarity
	Active site	378	1	By similarity
	Binding site	464	1	Substrate By similarity
	Binding site	466	1	Substrate By similarity
	Binding site	628	1	Substrate By similarity
	Binding site	655	1	Substrate By similarity
Natural variations
	Alternative sequence	907 – 913	7	FVFVQVG → C in isoform 1 and isoform A.		VSP_021970
	Alternative sequence	1063 – 1069	7	Missing in isoform 1 and isoform C.		VSP_004727
Experimental info
	Sequence conflict	508	1	G → A in AAA28819. Ref.1
	Sequence conflict	508	1	G → A in AAA28820. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform D (F) [UniParc]. Last modified December 12, 2006. Version 3. Checksum: 95C14A73843A325E	FASTA	1,318	146,391
	10 20 30 40 50 60 MMSAGGTYIS TASVEVPQAL QDGEKFIRWD DDSGTGTPVT MRVDAKGFFL YWVDQNNELD 70 80 90 100 110 120 ILDIATIRDV RTGQYAKRPK DNKLRQIVTL GPQDTLEEKT VTVCHGSDFV NMTFVNFCCT 130 140 150 160 170 180 RRDIAQLWTD GLIKLAYSLA QLNGSAIMFL QKAHTKLCLQ VDKSGRIPVK NIIKLFAQNK 190 200 210 220 230 240 EDRKRVEKAL DVTGLPSGKV DSISVSKFQF EDFYNLYKYL TQRSEVERLF DSIVGNSKRK 250 260 270 280 290 300 CMSIAQLVEF LNKTQRDPRL NEILYPYANP ARAKELIQQY EPNKFNAQKG QLSLDGFLRY 310 320 330 340 350 360 LMGDDNPIMA PSKLDLCDDM DQPMSHYFIN SSHNTYLTGH QLTGKSSVEI YRQCLLAGCR 370 380 390 400 410 420 CVELDFWNGR TEEPVIVHGY TFVPEIFAKD VLEAIAESAF KTSEYPVILS FENHCNPRQQ 430 440 450 460 470 480 AKIANYCREI FGDMLLDKPL DSHPLEPNMD LPPPAMLRRK IIIKNKKKHH HHHHHHHHKK 490 500 510 520 530 540 PAQVGTPAAN NKLTTANSVD AKAAQQVGLS ASHEDGGVTR STANGDVATG TGTGSAAGTA 550 560 570 580 590 600 GHAPPLQQIR QSSKDSTGSS DSDSSSEDES LPNTTPNLPS GNEPPPEKAQ KETEAGAEIS 610 620 630 640 650 660 ALVNYVQPIH FSSFENAEKK NRCYEMSSFD EKQATTLLKE RPIEFVNYNK HQLSRVYPAG 670 680 690 700 710 720 TRFDSSNFMP QLFWNAGCQL VALNFQTLDL AMQLNLGIFE YNARSGYLLK PEFMRRSDRR 730 740 750 760 770 780 LDPFAESTVD GIIAGTVSIT VLSGQFLTDK RANTFVEVDM YGLPADTVRK KFRTKTVRDN 790 800 810 820 830 840 GMNPLYDEEP FVFKKVVLPE LASIRIAAYE EGGKLIGHRV LPVIGLCPGY RHVNLRSEVG 850 860 870 880 890 900 QPIALASLFL CVVVKDYVPD DLSNFAEALA NPIKYQSELE KRDIQLSVLT DEAEALGSAD 910 920 930 940 950 960 EDLSKSFVFV QVGGQKKELR PVESLATSPK HRPSISAAAA MSVDVTVDRT DGGRGEDSIS 970 980 990 1000 1010 1020 IVAPSIQHQH SLDQSVSTSI RQVESSQFDV DLVLAEPLEK ILDHKSVKEK RLEMEKKLES 1030 1040 1050 1060 1070 1080 LRKKHDKEKI KIAGQKSSPL EGKKPKFAIT NKLVKRLSNK SLNCLSPHSE PGVEIPACPL 1090 1100 1110 1120 1130 1140 DLGDSSEESA AADAGEDLAG GSSSLDGRTQ ESRLRSACRE YTSQYRELQE KYHEAIYSAA 1150 1160 1170 1180 1190 1200 EKVLKTSQTG QTKQLKASLD KVTGEVMHQL QEARRNEVKN LATVHRDRDE LIRMKREVAS 1210 1220 1230 1240 1250 1260 SVVERGVAER VRLKQTFDRR TDELQKQHDS VRNALAEHRS KARQILDKEA ESRSCVSSNG 1270 1280 1290 1300 1310 FLVLFHGPHH HGCTGSGSSA LSGNNLTLNL DAGAAGSHSA ISPAKSHNSI AAAAEMKT
	Isoform 1 (Class-I) [UniParc]. Checksum: CB5B3ED60B5C1ACC	FASTA	1,305	144,979
	10 20 30 40 50 60 MMSAGGTYIS TASVEVPQAL QDGEKFIRWD DDSGTGTPVT MRVDAKGFFL YWVDQNNELD 70 80 90 100 110 120 ILDIATIRDV RTGQYAKRPK DNKLRQIVTL GPQDTLEEKT VTVCHGSDFV NMTFVNFCCT 130 140 150 160 170 180 RRDIAQLWTD GLIKLAYSLA QLNGSAIMFL QKAHTKLCLQ VDKSGRIPVK NIIKLFAQNK 190 200 210 220 230 240 EDRKRVEKAL DVTGLPSGKV DSISVSKFQF EDFYNLYKYL TQRSEVERLF DSIVGNSKRK 250 260 270 280 290 300 CMSIAQLVEF LNKTQRDPRL NEILYPYANP ARAKELIQQY EPNKFNAQKG QLSLDGFLRY 310 320 330 340 350 360 LMGDDNPIMA PSKLDLCDDM DQPMSHYFIN SSHNTYLTGH QLTGKSSVEI YRQCLLAGCR 370 380 390 400 410 420 CVELDFWNGR TEEPVIVHGY TFVPEIFAKD VLEAIAESAF KTSEYPVILS FENHCNPRQQ 430 440 450 460 470 480 AKIANYCREI FGDMLLDKPL DSHPLEPNMD LPPPAMLRRK IIIKNKKKHH HHHHHHHHKK 490 500 510 520 530 540 PAQVGTPAAN NKLTTANSVD AKAAQQVGLS ASHEDGGVTR STANGDVATG TGTGSAAGTA 550 560 570 580 590 600 GHAPPLQQIR QSSKDSTGSS DSDSSSEDES LPNTTPNLPS GNEPPPEKAQ KETEAGAEIS 610 620 630 640 650 660 ALVNYVQPIH FSSFENAEKK NRCYEMSSFD EKQATTLLKE RPIEFVNYNK HQLSRVYPAG 670 680 690 700 710 720 TRFDSSNFMP QLFWNAGCQL VALNFQTLDL AMQLNLGIFE YNARSGYLLK PEFMRRSDRR 730 740 750 760 770 780 LDPFAESTVD GIIAGTVSIT VLSGQFLTDK RANTFVEVDM YGLPADTVRK KFRTKTVRDN 790 800 810 820 830 840 GMNPLYDEEP FVFKKVVLPE LASIRIAAYE EGGKLIGHRV LPVIGLCPGY RHVNLRSEVG 850 860 870 880 890 900 QPIALASLFL CVVVKDYVPD DLSNFAEALA NPIKYQSELE KRDIQLSVLT DEAEALGSAD 910 920 930 940 950 960 EDLSKSCGQK KELRPVESLA TSPKHRPSIS AAAAMSVDVT VDRTDGGRGE DSISIVAPSI 970 980 990 1000 1010 1020 QHQHSLDQSV STSIRQVESS QFDVDLVLAE PLEKILDHKS VKEKRLEMEK KLESLRKKHD 1030 1040 1050 1060 1070 1080 KEKIKIAGQK SSPLEGKKPK FAITNKLVKR LSNKSLEPGV EIPACPLDLG DSSEESAAAD 1090 1100 1110 1120 1130 1140 AGEDLAGGSS SLDGRTQESR LRSACREYTS QYRELQEKYH EAIYSAAEKV LKTSQTGQTK 1150 1160 1170 1180 1190 1200 QLKASLDKVT GEVMHQLQEA RRNEVKNLAT VHRDRDELIR MKREVASSVV ERGVAERVRL 1210 1220 1230 1240 1250 1260 KQTFDRRTDE LQKQHDSVRN ALAEHRSKAR QILDKEAESR SCVSSNGFLV LFHGPHHHGC 1270 1280 1290 1300 TGSGSSALSG NNLTLNLDAG AAGSHSAISP AKSHNSIAAA AEMKT
	Isoform A (B) (Class-II) [UniParc]. Checksum: B8DD0EF5A48C2665	FASTA	1,312	145,718
	10 20 30 40 50 60 MMSAGGTYIS TASVEVPQAL QDGEKFIRWD DDSGTGTPVT MRVDAKGFFL YWVDQNNELD 70 80 90 100 110 120 ILDIATIRDV RTGQYAKRPK DNKLRQIVTL GPQDTLEEKT VTVCHGSDFV NMTFVNFCCT 130 140 150 160 170 180 RRDIAQLWTD GLIKLAYSLA QLNGSAIMFL QKAHTKLCLQ VDKSGRIPVK NIIKLFAQNK 190 200 210 220 230 240 EDRKRVEKAL DVTGLPSGKV DSISVSKFQF EDFYNLYKYL TQRSEVERLF DSIVGNSKRK 250 260 270 280 290 300 CMSIAQLVEF LNKTQRDPRL NEILYPYANP ARAKELIQQY EPNKFNAQKG QLSLDGFLRY 310 320 330 340 350 360 LMGDDNPIMA PSKLDLCDDM DQPMSHYFIN SSHNTYLTGH QLTGKSSVEI YRQCLLAGCR 370 380 390 400 410 420 CVELDFWNGR TEEPVIVHGY TFVPEIFAKD VLEAIAESAF KTSEYPVILS FENHCNPRQQ 430 440 450 460 470 480 AKIANYCREI FGDMLLDKPL DSHPLEPNMD LPPPAMLRRK IIIKNKKKHH HHHHHHHHKK 490 500 510 520 530 540 PAQVGTPAAN NKLTTANSVD AKAAQQVGLS ASHEDGGVTR STANGDVATG TGTGSAAGTA 550 560 570 580 590 600 GHAPPLQQIR QSSKDSTGSS DSDSSSEDES LPNTTPNLPS GNEPPPEKAQ KETEAGAEIS 610 620 630 640 650 660 ALVNYVQPIH FSSFENAEKK NRCYEMSSFD EKQATTLLKE RPIEFVNYNK HQLSRVYPAG 670 680 690 700 710 720 TRFDSSNFMP QLFWNAGCQL VALNFQTLDL AMQLNLGIFE YNARSGYLLK PEFMRRSDRR 730 740 750 760 770 780 LDPFAESTVD GIIAGTVSIT VLSGQFLTDK RANTFVEVDM YGLPADTVRK KFRTKTVRDN 790 800 810 820 830 840 GMNPLYDEEP FVFKKVVLPE LASIRIAAYE EGGKLIGHRV LPVIGLCPGY RHVNLRSEVG 850 860 870 880 890 900 QPIALASLFL CVVVKDYVPD DLSNFAEALA NPIKYQSELE KRDIQLSVLT DEAEALGSAD 910 920 930 940 950 960 EDLSKSCGQK KELRPVESLA TSPKHRPSIS AAAAMSVDVT VDRTDGGRGE DSISIVAPSI 970 980 990 1000 1010 1020 QHQHSLDQSV STSIRQVESS QFDVDLVLAE PLEKILDHKS VKEKRLEMEK KLESLRKKHD 1030 1040 1050 1060 1070 1080 KEKIKIAGQK SSPLEGKKPK FAITNKLVKR LSNKSLNCLS PHSEPGVEIP ACPLDLGDSS 1090 1100 1110 1120 1130 1140 EESAAADAGE DLAGGSSSLD GRTQESRLRS ACREYTSQYR ELQEKYHEAI YSAAEKVLKT 1150 1160 1170 1180 1190 1200 SQTGQTKQLK ASLDKVTGEV MHQLQEARRN EVKNLATVHR DRDELIRMKR EVASSVVERG 1210 1220 1230 1240 1250 1260 VAERVRLKQT FDRRTDELQK QHDSVRNALA EHRSKARQIL DKEAESRSCV SSNGFLVLFH 1270 1280 1290 1300 1310 GPHHHGCTGS GSSALSGNNL TLNLDAGAAG SHSAISPAKS HNSIAAAAEM KT
	Isoform C [UniParc]. Checksum: 906B2BF56240A89E	FASTA	1,311	145,653
	10 20 30 40 50 60 MMSAGGTYIS TASVEVPQAL QDGEKFIRWD DDSGTGTPVT MRVDAKGFFL YWVDQNNELD 70 80 90 100 110 120 ILDIATIRDV RTGQYAKRPK DNKLRQIVTL GPQDTLEEKT VTVCHGSDFV NMTFVNFCCT 130 140 150 160 170 180 RRDIAQLWTD GLIKLAYSLA QLNGSAIMFL QKAHTKLCLQ VDKSGRIPVK NIIKLFAQNK 190 200 210 220 230 240 EDRKRVEKAL DVTGLPSGKV DSISVSKFQF EDFYNLYKYL TQRSEVERLF DSIVGNSKRK 250 260 270 280 290 300 CMSIAQLVEF LNKTQRDPRL NEILYPYANP ARAKELIQQY EPNKFNAQKG QLSLDGFLRY 310 320 330 340 350 360 LMGDDNPIMA PSKLDLCDDM DQPMSHYFIN SSHNTYLTGH QLTGKSSVEI YRQCLLAGCR 370 380 390 400 410 420 CVELDFWNGR TEEPVIVHGY TFVPEIFAKD VLEAIAESAF KTSEYPVILS FENHCNPRQQ 430 440 450 460 470 480 AKIANYCREI FGDMLLDKPL DSHPLEPNMD LPPPAMLRRK IIIKNKKKHH HHHHHHHHKK 490 500 510 520 530 540 PAQVGTPAAN NKLTTANSVD AKAAQQVGLS ASHEDGGVTR STANGDVATG TGTGSAAGTA 550 560 570 580 590 600 GHAPPLQQIR QSSKDSTGSS DSDSSSEDES LPNTTPNLPS GNEPPPEKAQ KETEAGAEIS 610 620 630 640 650 660 ALVNYVQPIH FSSFENAEKK NRCYEMSSFD EKQATTLLKE RPIEFVNYNK HQLSRVYPAG 670 680 690 700 710 720 TRFDSSNFMP QLFWNAGCQL VALNFQTLDL AMQLNLGIFE YNARSGYLLK PEFMRRSDRR 730 740 750 760 770 780 LDPFAESTVD GIIAGTVSIT VLSGQFLTDK RANTFVEVDM YGLPADTVRK KFRTKTVRDN 790 800 810 820 830 840 GMNPLYDEEP FVFKKVVLPE LASIRIAAYE EGGKLIGHRV LPVIGLCPGY RHVNLRSEVG 850 860 870 880 890 900 QPIALASLFL CVVVKDYVPD DLSNFAEALA NPIKYQSELE KRDIQLSVLT DEAEALGSAD 910 920 930 940 950 960 EDLSKSFVFV QVGGQKKELR PVESLATSPK HRPSISAAAA MSVDVTVDRT DGGRGEDSIS 970 980 990 1000 1010 1020 IVAPSIQHQH SLDQSVSTSI RQVESSQFDV DLVLAEPLEK ILDHKSVKEK RLEMEKKLES 1030 1040 1050 1060 1070 1080 LRKKHDKEKI KIAGQKSSPL EGKKPKFAIT NKLVKRLSNK SLEPGVEIPA CPLDLGDSSE 1090 1100 1110 1120 1130 1140 ESAAADAGED LAGGSSSLDG RTQESRLRSA CREYTSQYRE LQEKYHEAIY SAAEKVLKTS 1150 1160 1170 1180 1190 1200 QTGQTKQLKA SLDKVTGEVM HQLQEARRNE VKNLATVHRD RDELIRMKRE VASSVVERGV 1210 1220 1230 1240 1250 1260 AERVRLKQTF DRRTDELQKQ HDSVRNALAE HRSKARQILD KEAESRSCVS SNGFLVLFHG 1270 1280 1290 1300 1310 PHHHGCTGSG SSALSGNNLT LNLDAGAAGS HSAISPAKSH NSIAAAAEMK T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A Drosophila phospholipase C gene that is expressed in the central nervous system." Shortridge R.D., Yoon J., Lending C.R., Bloomquist B.T., Perdew M.H., Pak W.L. J. Biol. Chem. 266:12474-12480(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND A), TISSUE SPECIFICITY. Tissue: Head.
[2]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING. Strain: Berkeley.
[4]	"A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C). Strain: Berkeley. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M60452 mRNA. Translation: AAA28819.1. M60453 mRNA. Translation: AAA28820.1. AE014134 Genomic DNA. Translation: AAN10493.1. AE014134 Genomic DNA. Translation: AAS64631.1. AE014134 Genomic DNA. Translation: AAS64632.1. AE014134 Genomic DNA. Translation: AAS64633.1. AY051657 mRNA. Translation: AAK93081.1.
PIR	A40879. B40879.
RefSeq	NP_476851.2. NM_057503.5. NP_476852.1. NM_057504.5. NP_995604.2. NM_205882.2. NP_995605.1. NM_205883.2. NP_995606.1. NM_205884.2.
UniGene	Dm.4674.
3D structure databases
ProteinModelPortal	P25455.
SMR	P25455. Positions 16-469, 568-892.
ModBase	Search...
Proteomic databases
PaxDb	P25455.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0078050; FBpp0089226; FBgn0004611.
GeneID	33204.
KEGG	dme:Dmel_CG4574.
Organism-specific databases
CTD	33204.
FlyBase	FBgn0004611. Plc21C.
Phylogenomic databases
eggNOG	NOG149692.
GeneTree	ENSGT00700000104415.
InParanoid	P25455.
KO	K05858.
OMA	GSDFVNM.
OrthoDB	EOG47D7WX.
PhylomeDB	P25455.
Gene expression databases
Bgee	P25455.
GermOnline	CG4574. Drosophila melanogaster.
Family and domain databases
Gene3D	1.10.238.10. 1 hit. 2.30.29.30. 1 hit. 3.20.20.190. 2 hits.
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011992. EF-hand-like_dom. IPR011993. PH_like_dom. IPR001192. Pinositol_PLipase_C. IPR014815. PLC-beta_C. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR015359. PLipase_C_EF-hand-like. IPR000909. PLipase_C_PInositol-sp_X_dom. IPR001711. PLipase_C_Pinositol-sp_Y. [Graphical view]
PANTHER	PTHR10336. PTHR10336. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. PF08703. PLC-beta_C. 1 hit. [Graphical view]
PRINTS	PR00390. PHPHLIPASEC.
SMART	SM00239. C2. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF51695. PLC-like_Pdiesterase_TIM-brl. 1 hit.
PROSITE	PS50004. C2. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	Plc21C. drosophila.
GenomeRNAi	33204.
NextBio	782409.

Entry information

Entry name

PIP1_DROME

Accession

Primary (citable) accession number: P25455
Secondary accession number(s): A4UZX5 , Q0E8V1, Q7KTZ7, Q961D5, Q9VPN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	December 12, 2006
Last modified:	May 1, 2013
This is version 126 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project