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P25446

- TNR6_MOUSE

UniProt

P25446 - TNR6_MOUSE

Protein

Tumor necrosis factor receptor superfamily member 6

Gene

Fas

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 152 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. activation-induced cell death of T cells Source: MGI
    2. apoptotic process Source: MGI
    3. apoptotic signaling pathway Source: MGI
    4. B cell mediated immunity Source: MGI
    5. cellular response to hyperoxia Source: Ensembl
    6. cellular response to lithium ion Source: MGI
    7. cellular response to mechanical stimulus Source: Ensembl
    8. circadian rhythm Source: UniProtKB
    9. extrinsic apoptotic signaling pathway Source: MGI
    10. extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    11. extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
    12. gene expression Source: MGI
    13. hepatocyte apoptotic process Source: MGI
    14. immunoglobulin production Source: MGI
    15. inflammatory cell apoptotic process Source: MGI
    16. motor neuron apoptotic process Source: MGI
    17. necroptotic signaling pathway Source: MGI
    18. negative regulation of apoptotic process Source: MGI
    19. negative regulation of B cell activation Source: MGI
    20. negative thymic T cell selection Source: MGI
    21. neuron apoptotic process Source: MGI
    22. positive regulation of apoptotic process Source: Ensembl
    23. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    24. positive regulation of necrotic cell death Source: Ensembl
    25. positive regulation of protein homooligomerization Source: BHF-UCL
    26. positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL
    27. protein homooligomerization Source: MGI
    28. regulation of lymphocyte differentiation Source: MGI
    29. regulation of myeloid cell differentiation Source: MGI
    30. renal system process Source: MGI
    31. response to glucocorticoid Source: MGI
    32. response to toxic substance Source: MGI
    33. spleen development Source: MGI
    34. T cell homeostasis Source: MGI
    35. transformed cell apoptotic process Source: MGI

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_215122. Regulation by c-FLIP.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 6
    Alternative name(s):
    Apo-1 antigen
    Apoptosis-mediating surface antigen FAS
    FASLG receptor
    CD_antigen: CD95
    Gene namesi
    Name:Fas
    Synonyms:Apt1, Tnfrsf6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:95484. Fas.

    Subcellular locationi

    GO - Cellular componenti

    1. CD95 death-inducing signaling complex Source: UniProtKB
    2. cell surface Source: MGI
    3. cytoplasm Source: Ensembl
    4. external side of plasma membrane Source: MGI
    5. extracellular region Source: MGI
    6. integral component of membrane Source: UniProtKB-KW
    7. membrane raft Source: Ensembl
    8. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Fas are the cause of the lymphoproliferation phenotype (lpr). Lpr mice show lymphadenopathy and autoantibody production.

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 327306Tumor necrosis factor receptor superfamily member 6PRO_0000034567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi44 ↔ 55PROSITE-ProRule annotation
    Disulfide bondi56 ↔ 69PROSITE-ProRule annotation
    Disulfide bondi59 ↔ 78PROSITE-ProRule annotation
    Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
    Disulfide bondi100 ↔ 115PROSITE-ProRule annotation
    Disulfide bondi103 ↔ 123PROSITE-ProRule annotation
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi125 ↔ 139PROSITE-ProRule annotation
    Disulfide bondi142 ↔ 153PROSITE-ProRule annotation
    Disulfide bondi145 ↔ 161PROSITE-ProRule annotation
    Modified residuei220 – 2201Phosphoserine1 Publication
    Modified residuei314 – 3141Phosphothreonine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP25446.
    PRIDEiP25446.

    PTM databases

    PhosphoSiteiP25446.

    Expressioni

    Tissue specificityi

    Detected in various tissues including thymus, liver, lung, heart, and adult ovary.

    Inductioni

    Expression oscillates in a circadian manner in the liver with peak levels seen at CT12.1 Publication

    Gene expression databases

    ArrayExpressiP25446.
    BgeeiP25446.
    CleanExiMM_FAS.
    GenevestigatoriP25446.

    Interactioni

    Subunit structurei

    Binds DAXX and RIPK1. Interacts with BRE and FEM1B By similarity. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with FADD By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Casp8O891103EBI-296206,EBI-851690
    DAXXQ9UER74EBI-296206,EBI-77321From a different organism.
    DaxxO356132EBI-296206,EBI-77304
    FADDQ131585EBI-296206,EBI-494804From a different organism.
    FaddQ611603EBI-296206,EBI-524415
    Hipk3Q9ERH73EBI-296206,EBI-524356
    PmlQ609536EBI-296206,EBI-3895605

    Protein-protein interaction databases

    BioGridi199594. 6 interactions.
    DIPiDIP-31093N.
    IntActiP25446. 11 interactions.
    MINTiMINT-144559.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3OQ9X-ray6.80A/B/C/D/E223-308[»]
    ProteinModelPortaliP25446.
    SMRiP25446. Positions 48-159, 223-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP25446.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 169148ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini187 – 327141CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei170 – 18617HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati43 – 7937TNFR-Cys 1Add
    BLAST
    Repeati80 – 12344TNFR-Cys 2Add
    BLAST
    Repeati124 – 16239TNFR-Cys 3Add
    BLAST
    Domaini222 – 30685DeathPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni204 – 309106Interaction with HIPK3Add
    BLAST

    Domaini

    Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

    Sequence similaritiesi

    Contains 1 death domain.PROSITE-ProRule annotation
    Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45364.
    GeneTreeiENSGT00730000111280.
    HOGENOMiHOG000139681.
    HOVERGENiHBG004091.
    InParanoidiQ6GT31.
    KOiK04390.
    OMAiCEHCNPC.
    OrthoDBiEOG7DVDC8.
    TreeFamiTF333916.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR008063. Fas_rcpt.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view]
    PRINTSiPR01680. TNFACTORR6.
    SMARTiSM00005. DEATH. 1 hit.
    SM00208. TNFR. 3 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25446-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWIWAVLPL VLAGSQLRVH TQGTNSISES LKLRRRVRET DKNCSEGLYQ    50
    GGPFCCQPCQ PGKKKVEDCK MNGGTPTCAP CTEGKEYMDK NHYADKCRRC 100
    TLCDEEHGLE VETNCTLTQN TKCKCKPDFY CDSPGCEHCV RCASCEHGTL 150
    EPCTATSNTN CRKQSPRNRL WLLTILVLLI PLVFIYRKYR KRKCWKRRQD 200
    DPESRTSSRE TIPMNASNLS LSKYIPRIAE DMTIQEAKKF ARENNIKEGK 250
    IDEIMHDSIQ DTAEQKVQLL LCWYQSHGKS DAYQDLIKGL KKAECRRTLD 300
    KFQDMVQKDL GKSTPDTGNE NEGQCLE 327
    Length:327
    Mass (Da):37,437
    Last modified:July 27, 2011 - v2
    Checksum:iD8DA95CA525CED56
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381R → H in AAA37593. (PubMed:1371136)Curated
    Sequence conflicti38 – 381R → H in CAC00638. 1 PublicationCurated
    Sequence conflicti38 – 381R → H in AAB25700. (PubMed:7680478)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti246 – 2461I → N in lpr. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83649 mRNA. Translation: AAA37593.1.
    AK002590 mRNA. Translation: BAB22211.1.
    AJ295702, AJ295703, AJ295704 Genomic DNA. Translation: CAC00638.1.
    DQ846748 mRNA. Translation: ABI24112.1.
    CH466534 Genomic DNA. Translation: EDL41748.1.
    BC061160 mRNA. Translation: AAH61160.1.
    S56490, S56485, S56486 Genomic DNA. Translation: AAB25700.1.
    CCDSiCCDS29758.1.
    PIRiA46484.
    RefSeqiNP_032013.2. NM_007987.2.
    UniGeneiMm.1626.

    Genome annotation databases

    EnsembliENSMUST00000025691; ENSMUSP00000025691; ENSMUSG00000024778.
    GeneIDi14102.
    KEGGimmu:14102.
    UCSCiuc008hgi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83649 mRNA. Translation: AAA37593.1 .
    AK002590 mRNA. Translation: BAB22211.1 .
    AJ295702 , AJ295703 , AJ295704 Genomic DNA. Translation: CAC00638.1 .
    DQ846748 mRNA. Translation: ABI24112.1 .
    CH466534 Genomic DNA. Translation: EDL41748.1 .
    BC061160 mRNA. Translation: AAH61160.1 .
    S56490 , S56485 , S56486 Genomic DNA. Translation: AAB25700.1 .
    CCDSi CCDS29758.1.
    PIRi A46484.
    RefSeqi NP_032013.2. NM_007987.2.
    UniGenei Mm.1626.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3OQ9 X-ray 6.80 A/B/C/D/E 223-308 [» ]
    ProteinModelPortali P25446.
    SMRi P25446. Positions 48-159, 223-308.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199594. 6 interactions.
    DIPi DIP-31093N.
    IntActi P25446. 11 interactions.
    MINTi MINT-144559.

    PTM databases

    PhosphoSitei P25446.

    Proteomic databases

    PaxDbi P25446.
    PRIDEi P25446.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025691 ; ENSMUSP00000025691 ; ENSMUSG00000024778 .
    GeneIDi 14102.
    KEGGi mmu:14102.
    UCSCi uc008hgi.2. mouse.

    Organism-specific databases

    CTDi 355.
    MGIi MGI:95484. Fas.

    Phylogenomic databases

    eggNOGi NOG45364.
    GeneTreei ENSGT00730000111280.
    HOGENOMi HOG000139681.
    HOVERGENi HBG004091.
    InParanoidi Q6GT31.
    KOi K04390.
    OMAi CEHCNPC.
    OrthoDBi EOG7DVDC8.
    TreeFami TF333916.

    Enzyme and pathway databases

    Reactomei REACT_215122. Regulation by c-FLIP.

    Miscellaneous databases

    ChiTaRSi FAS. mouse.
    EvolutionaryTracei P25446.
    NextBioi 285130.
    PROi P25446.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P25446.
    Bgeei P25446.
    CleanExi MM_FAS.
    Genevestigatori P25446.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR008063. Fas_rcpt.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view ]
    PRINTSi PR01680. TNFACTORR6.
    SMARTi SM00005. DEATH. 1 hit.
    SM00208. TNFR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen."
      Watanabe-Fukunaga R., Brannan C.I., Itoh N., Yonehara S., Copeland N.G., Jenkins N.A., Nagata S.
      J. Immunol. 148:1274-1279(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Role of a mutant fas receptor in a transgenic mouse."
      Koczan D., Ibrahim S.M., Thiesen H.J.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Kidney.
    4. "A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas."
      Villa-Morales M., Santos J., Perez-Gomez E., Quintanilla M., Fernandez-Piqueras J.
      Cancer Res. 67:5107-5116(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    7. "Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice."
      Adachi M., Watanabe-Fukunaga R., Nagata S.
      Proc. Natl. Acad. Sci. U.S.A. 90:1756-1760(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-96.
    8. "Daxx, a novel Fas-binding protein that activates JNK and apoptosis."
      Yang X., Khosravi-Far R., Chang H.Y., Baltimore D.
      Cell 89:1067-1076(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DAXX.
    9. "FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits Fas-mediated Jun NH2-terminal kinase activation."
      Rochat-Steiner V., Becker K., Micheau O., Schneider P., Burns K., Tschopp J.
      J. Exp. Med. 192:1165-1174(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HIPK3.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    11. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-220 AND THR-314, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks."
      Baeza-Raja B., Eckel-Mahan K., Zhang L., Vagena E., Tsigelny I.F., Sassone-Corsi P., Ptacek L.J., Akassoglou K.
      J. Neurosci. 33:10221-10234(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
    13. "Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis."
      Watanabe-Fukunaga R., Brannan C.I., Copeland N.G., Jenkins N.A., Nagata S.
      Nature 356:314-317(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LPR ASN-246.

    Entry informationi

    Entry nameiTNR6_MOUSE
    AccessioniPrimary (citable) accession number: P25446
    Secondary accession number(s): Q6GT31, Q9DCQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 152 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3