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Protein

Tumor necrosis factor receptor superfamily member 6

Gene

FAS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).2 Publications

GO - Molecular functioni

  • kinase binding Source: BHF-UCL
  • receptor activity Source: UniProtKB
  • signal transducer activity Source: ProtInc
  • tumor necrosis factor-activated receptor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000026103-MONOMER.
ReactomeiR-HSA-140534. Ligand-dependent caspase activation.
R-HSA-3371378. Regulation by c-FLIP.
R-HSA-5213460. RIPK1-mediated regulated necrosis.
R-HSA-5218900. CASP8 activity is inhibited.
R-HSA-6803211. TP53 Regulates Transcription of Death Receptors and Ligands.
R-HSA-69416. Dimerization of procaspase-8.
R-HSA-75157. FasL/ CD95L signaling.
SIGNORiP25445.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
Gene namesi
Name:FAS
Synonyms:APT1, FAS1, TNFRSF6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:11920. FAS.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 173ExtracellularSequence analysisAdd BLAST148
Transmembranei174 – 190HelicalSequence analysisAdd BLAST17
Topological domaini191 – 335CytoplasmicSequence analysisAdd BLAST145

GO - Cellular componenti

  • CD95 death-inducing signaling complex Source: UniProtKB
  • cell surface Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • death-inducing signaling complex Source: UniProtKB
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • membrane raft Source: UniProtKB
  • neuron projection Source: GO_Central
  • nucleus Source: HPA
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Autoimmune lymphoproliferative syndrome 1A (ALPS1A)12 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.
See also OMIM:601859
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01341728T → A in ALPS1A; associated with autoimmune hepatitis type 2. 1 Publication1
Natural variantiVAR_01341882C → R in ALPS1A. 1 Publication1
Natural variantiVAR_013419121R → W in ALPS1A. 1 PublicationCorresponds to variant rs121913078dbSNPEnsembl.1
Natural variantiVAR_013423232Y → C in ALPS1A; no effect on interaction with FADD. 2 PublicationsCorresponds to variant rs121913079dbSNPEnsembl.1
Natural variantiVAR_013424241T → K in ALPS1A. 1 PublicationCorresponds to variant rs201072885dbSNPEnsembl.1
Natural variantiVAR_013425241T → P in ALPS1A. 2 PublicationsCorresponds to variant rs121913076dbSNPEnsembl.1
Natural variantiVAR_065128249V → L in ALPS1A. 1 Publication1
Natural variantiVAR_013426250R → P in ALPS1A. 2 PublicationsCorresponds to variant rs121913080dbSNPEnsembl.1
Natural variantiVAR_013427250R → Q in ALPS1A; no effect on interaction with FADD. 2 Publications1
Natural variantiVAR_065129253G → D in ALPS1A. 1 Publication1
Natural variantiVAR_065130253G → S in ALPS1A. 1 Publication1
Natural variantiVAR_013428257A → D in ALPS1A; loss of interaction with FADD. 2 Publications1
Natural variantiVAR_065131259I → R in ALPS1A. 1 Publication1
Natural variantiVAR_013429260D → G in ALPS1A. 1 Publication1
Natural variantiVAR_013431260D → V in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 4 PublicationsCorresponds to variant rs28929498dbSNPEnsembl.1
Natural variantiVAR_013430260D → Y in ALPS1A; loss of interaction with FADD. 2 PublicationsCorresponds to variant rs121913086dbSNPEnsembl.1
Natural variantiVAR_058910262I → S in ALPS1A. 1 Publication1
Natural variantiVAR_013433270T → I in ALPS1A. 2 PublicationsCorresponds to variant rs121913081dbSNPEnsembl.1
Natural variantiVAR_065132270T → K in ALPS1A; loss of interaction with FADD. 2 Publications1
Natural variantiVAR_013434272E → G in ALPS1A. 2 Publications1
Natural variantiVAR_013435272E → K in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 3 Publications1
Natural variantiVAR_013438310I → S in ALPS1A. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi250R → E: Strongly decreased interaction with FADD. 1 Publication1
Mutagenesisi261E → K: Loss of interaction with FADD. 1 Publication1
Mutagenesisi283Q → K: Loss of interaction with FADD. 1 Publication1
Mutagenesisi287K → D: Strongly decreased interaction with FADD. 1 Publication1
Mutagenesisi291Y → D: Decreased interaction with FADD. 1 Publication1
Mutagenesisi313I → D: Constitutive activation. Promotes apoptosis, both in the presence and in the absence of stimulation by a ligand. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi355.
MalaCardsiFAS.
MIMi601859. phenotype.
OpenTargetsiENSG00000026103.
Orphaneti3261. Autoimmune lymphoproliferative syndrome.
85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBiPA36613.

Polymorphism and mutation databases

BioMutaiFAS.
DMDMi119833.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003456326 – 335Tumor necrosis factor receptor superfamily member 6Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28O-linked (GalNAc...)1 Publication1
Disulfide bondi59 ↔ 73PROSITE-ProRule annotation
Disulfide bondi63 ↔ 82PROSITE-ProRule annotation
Disulfide bondi85 ↔ 101PROSITE-ProRule annotation
Disulfide bondi104 ↔ 119PROSITE-ProRule annotation
Disulfide bondi107 ↔ 127PROSITE-ProRule annotation
Glycosylationi118N-linked (GlcNAc...)1 Publication1
Disulfide bondi129 ↔ 143PROSITE-ProRule annotation
Glycosylationi136N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi146 ↔ 157PROSITE-ProRule annotation
Disulfide bondi149 ↔ 165PROSITE-ProRule annotation
Modified residuei209PhosphoserineCombined sources1
Modified residuei214PhosphothreonineBy similarity1
Modified residuei225PhosphoserineCombined sources1

Post-translational modificationi

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP25445.
MaxQBiP25445.
PaxDbiP25445.
PeptideAtlasiP25445.
PRIDEiP25445.
TopDownProteomicsiP25445-7. [P25445-7]

PTM databases

iPTMnetiP25445.
PhosphoSitePlusiP25445.
SwissPalmiP25445.
UniCarbKBiP25445.

Miscellaneous databases

PMAP-CutDBP25445.

Expressioni

Tissue specificityi

Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6.1 Publication

Gene expression databases

BgeeiENSG00000026103.
CleanExiHS_FAS.
ExpressionAtlasiP25445. baseline and differential.
GenevisibleiP25445. HS.

Organism-specific databases

HPAiHPA027444.

Interactioni

Subunit structurei

Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity).By similarity6 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-494743,EBI-494743
CALM3P621584EBI-494743,EBI-397435
CASP8Q1479014EBI-494743,EBI-78060
CAV1Q031353EBI-494743,EBI-603614
DAXXQ9UER73EBI-494743,EBI-77321
FADDQ1315833EBI-494743,EBI-494804
FASLGP480234EBI-494743,EBI-495538
MAP3K5Q996832EBI-494743,EBI-476263
Pdcd6P128152EBI-494743,EBI-309164From a different organism.
PMLP295904EBI-494743,EBI-295890
PML-RARQ151566EBI-494743,EBI-867256
PTPN13Q129233EBI-494743,EBI-355227
SRCP129312EBI-494743,EBI-621482

GO - Molecular functioni

  • kinase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi106851. 101 interactors.
DIPiDIP-924N.
IntActiP25445. 48 interactors.
MINTiMINT-146256.
STRINGi9606.ENSP00000347979.

Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi67 – 71Combined sources5
Beta strandi75 – 77Combined sources3
Beta strandi82 – 84Combined sources3
Turni87 – 89Combined sources3
Helixi109 – 111Combined sources3
Beta strandi113 – 117Combined sources5
Beta strandi126 – 129Combined sources4
Beta strandi137 – 139Combined sources3
Helixi174 – 181Combined sources8
Helixi184 – 193Combined sources10
Helixi232 – 242Combined sources11
Turni251 – 253Combined sources3
Helixi256 – 265Combined sources10
Helixi270 – 282Combined sources13
Helixi287 – 319Combined sources33
Helixi327 – 334Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BZImodel-A1-335[»]
1DDFNMR-A218-335[»]
2NA7NMR-A/B/C171-198[»]
3EWTX-ray2.40E230-254[»]
3EZQX-ray2.73A/C/E/G/I/K/M/O223-335[»]
3THMX-ray2.10F17-172[»]
3TJEX-ray1.93F17-172[»]
ProteinModelPortaliP25445.
SMRiP25445.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25445.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 83TNFR-Cys 1Add BLAST37
Repeati84 – 127TNFR-Cys 2Add BLAST44
Repeati128 – 166TNFR-Cys 3Add BLAST39
Domaini230 – 314DeathPROSITE-ProRule annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni212 – 317Interaction with HIPK3By similarityAdd BLAST106

Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J23A. Eukaryota.
ENOG4112ADB. LUCA.
GeneTreeiENSGT00730000111280.
HOGENOMiHOG000139681.
HOVERGENiHBG004091.
InParanoidiP25445.
KOiK04390.
OMAiCTTCEHG.
OrthoDBiEOG091G0DU6.
PhylomeDBiP25445.
TreeFamiTF333916.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PANTHERiPTHR23097:SF114. PTHR23097:SF114. 1 hit.
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P25445-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGIWTLLPL VLTSVARLSS KSVNAQVTDI NSKGLELRKT VTTVETQNLE
60 70 80 90 100
GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK
110 120 130 140 150
CRRCRLCDEG HGLEVEINCT RTQNTKCRCK PNFFCNSTVC EHCDPCTKCE
160 170 180 190 200
HGIIKECTLT SNTKCKEEGS RSNLGWLCLL LLPIPLIVWV KRKEVQKTCR
210 220 230 240 250
KHRKENQGSH ESPTLNPETV AINLSDVDLS KYITTIAGVM TLSQVKGFVR
260 270 280 290 300
KNGVNEAKID EIKNDNVQDT AEQKVQLLRN WHQLHGKKEA YDTLIKDLKK
310 320 330
ANLCTLAEKI QTIILKDITS DSENSNFRNE IQSLV
Length:335
Mass (Da):37,732
Last modified:May 1, 1992 - v1
Checksum:i0139942535111410
GO
Isoform 2 (identifier: P25445-2) [UniParc]FASTAAdd to basket
Also known as: del2, D

The sequence of this isoform differs from the canonical sequence as follows:
     66-103: GERKARDCTV...KAHFSSKCRR → DVNMESSRNA...GFVFFFCQFH
     104-335: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:103
Mass (Da):11,435
Checksum:iF0DEA7F598AFBB00
GO
Isoform 3 (identifier: P25445-3) [UniParc]FASTAAdd to basket
Also known as: del3, E

The sequence of this isoform differs from the canonical sequence as follows:
     66-86: GERKARDCTVNGDEPDCVPCQ → DVNMESSRNAHSPATPSAKRK
     87-335: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:86
Mass (Da):9,390
Checksum:iD55B05CA4C2D1D49
GO
Isoform 4 (identifier: P25445-4) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     112-149: GLEVEINCTR...CEHCDPCTKC → DVNMESSRNA...GFVFFFCQFH
     150-335: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:149
Mass (Da):16,648
Checksum:i5061E69484678FC0
GO
Isoform 5 (identifier: P25445-5) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     112-132: GLEVEINCTRTQNTKCRCKPN → DVNMESSRNAHSPATPSAKRK
     133-335: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:132
Mass (Da):14,602
Checksum:iB10B6F86DE5E8690
GO
Isoform 6 (identifier: P25445-6) [UniParc]FASTAAdd to basket
Also known as: TMdel, A

The sequence of this isoform differs from the canonical sequence as follows:
     169-189: Missing.

Show »
Length:314
Mass (Da):35,386
Checksum:i83F8FAC62DB8B457
GO
Isoform 7 (identifier: P25445-7) [UniParc]FASTAAdd to basket
Also known as: FasExo8Del

The sequence of this isoform differs from the canonical sequence as follows:
     218-220: ETV → MLT
     221-335: Missing.

Note: Dominant negative isoform, resistant to Fas-mediated apoptosis.
Show »
Length:220
Mass (Da):24,781
Checksum:iF4CD01DBF0649B39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224L → F in AAR08906 (Ref. 11) Curated1
Sequence conflicti242L → P in CAR92543 (Ref. 9) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02000816A → T.1 PublicationCorresponds to variant rs3218619dbSNPEnsembl.1
Natural variantiVAR_01341625A → T in non-Hodgkin lymphoma; somatic mutation. 1 PublicationCorresponds to variant rs606231364dbSNPEnsembl.1
Natural variantiVAR_01341728T → A in ALPS1A; associated with autoimmune hepatitis type 2. 1 Publication1
Natural variantiVAR_01341882C → R in ALPS1A. 1 Publication1
Natural variantiVAR_018321118N → S in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant rs121913083dbSNPEnsembl.1
Natural variantiVAR_013419121R → W in ALPS1A. 1 PublicationCorresponds to variant rs121913078dbSNPEnsembl.1
Natural variantiVAR_020009122T → I.1 PublicationCorresponds to variant rs3218614dbSNPEnsembl.1
Natural variantiVAR_018322178C → R in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant rs121913084dbSNPEnsembl.1
Natural variantiVAR_013420180L → F in non-Hodgkin lymphoma; somatic mutation. 1 Publication1
Natural variantiVAR_013421183P → L in non-Hodgkin lymphoma; somatic mutation. 1 PublicationCorresponds to variant rs758835365dbSNPEnsembl.1
Natural variantiVAR_052347184I → V.Corresponds to variant rs28362322dbSNPEnsembl.1
Natural variantiVAR_013422198T → I in non-Hodgkin lymphoma; somatic mutation. 1 Publication1
Natural variantiVAR_013423232Y → C in ALPS1A; no effect on interaction with FADD. 2 PublicationsCorresponds to variant rs121913079dbSNPEnsembl.1
Natural variantiVAR_013424241T → K in ALPS1A. 1 PublicationCorresponds to variant rs201072885dbSNPEnsembl.1
Natural variantiVAR_013425241T → P in ALPS1A. 2 PublicationsCorresponds to variant rs121913076dbSNPEnsembl.1
Natural variantiVAR_065128249V → L in ALPS1A. 1 Publication1
Natural variantiVAR_013426250R → P in ALPS1A. 2 PublicationsCorresponds to variant rs121913080dbSNPEnsembl.1
Natural variantiVAR_013427250R → Q in ALPS1A; no effect on interaction with FADD. 2 Publications1
Natural variantiVAR_065129253G → D in ALPS1A. 1 Publication1
Natural variantiVAR_065130253G → S in ALPS1A. 1 Publication1
Natural variantiVAR_018323255N → D in squamous cell carcinoma; burn-scar related; somatic mutation. 1 PublicationCorresponds to variant rs121913082dbSNPEnsembl.1
Natural variantiVAR_013428257A → D in ALPS1A; loss of interaction with FADD. 2 Publications1
Natural variantiVAR_065131259I → R in ALPS1A. 1 Publication1
Natural variantiVAR_013429260D → G in ALPS1A. 1 Publication1
Natural variantiVAR_013431260D → V in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 4 PublicationsCorresponds to variant rs28929498dbSNPEnsembl.1
Natural variantiVAR_013430260D → Y in ALPS1A; loss of interaction with FADD. 2 PublicationsCorresponds to variant rs121913086dbSNPEnsembl.1
Natural variantiVAR_058910262I → S in ALPS1A. 1 Publication1
Natural variantiVAR_013432264N → K in non-Hodgkin lymphoma; somatic mutation. 1 Publication1
Natural variantiVAR_013433270T → I in ALPS1A. 2 PublicationsCorresponds to variant rs121913081dbSNPEnsembl.1
Natural variantiVAR_065132270T → K in ALPS1A; loss of interaction with FADD. 2 Publications1
Natural variantiVAR_013434272E → G in ALPS1A. 2 Publications1
Natural variantiVAR_013435272E → K in ALPS1A; also found in non-Hodgkin lymphoma; somatic mutation; loss of interaction with FADD. 3 Publications1
Natural variantiVAR_013436278L → F in non-Hodgkin lymphoma; somatic mutation. 1 Publication1
Natural variantiVAR_013437299K → N in non-Hodgkin lymphoma; somatic mutation. 1 Publication1
Natural variantiVAR_020942305T → I.1 PublicationCorresponds to variant rs3218611dbSNPEnsembl.1
Natural variantiVAR_013438310I → S in ALPS1A. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00648166 – 103GERKA…SKCRR → DVNMESSRNAHSPATPSAKR KDPDLTWGGFVFFFCQFH in isoform 2. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_00648366 – 86GERKA…CVPCQ → DVNMESSRNAHSPATPSAKR K in isoform 3. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_00648487 – 335Missing in isoform 3. 2 PublicationsAdd BLAST249
Alternative sequenceiVSP_006482104 – 335Missing in isoform 2. 2 PublicationsAdd BLAST232
Alternative sequenceiVSP_006485112 – 149GLEVE…PCTKC → DVNMESSRNAHSPATPSAKR KDPDLTWGGFVFFFCQFH in isoform 4. 2 PublicationsAdd BLAST38
Alternative sequenceiVSP_006487112 – 132GLEVE…RCKPN → DVNMESSRNAHSPATPSAKR K in isoform 5. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_006488133 – 335Missing in isoform 5. 2 PublicationsAdd BLAST203
Alternative sequenceiVSP_006486150 – 335Missing in isoform 4. 2 PublicationsAdd BLAST186
Alternative sequenceiVSP_006489169 – 189Missing in isoform 6. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_045235218 – 220ETV → MLT in isoform 7. 1 Publication3
Alternative sequenceiVSP_045236221 – 335Missing in isoform 7. 1 PublicationAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M67454 mRNA. Translation: AAA63174.1.
X63717 mRNA. Translation: CAA45250.1.
X83490 mRNA. No translation available.
X83491 mRNA. No translation available.
X83492 mRNA. No translation available.
X83493 mRNA. No translation available.
Z47993 mRNA. Translation: CAA88031.1.
Z47994 mRNA. Translation: CAA88032.1.
Z47995 mRNA. Translation: CAA88033.1.
Z66556 mRNA. No translation available.
Z70519 mRNA. Translation: CAA94430.1.
Z70520 mRNA. Translation: CAA94431.1.
AY495076 mRNA. Translation: AAS76663.1.
X89101 mRNA. Translation: CAA61473.1.
FM246458 mRNA. Translation: CAR92543.1.
AK290978 mRNA. Translation: BAF83667.1.
AY450925 Genomic DNA. Translation: AAR08906.1.
AL157394 Genomic DNA. Translation: CAI13870.1.
AL157394 Genomic DNA. Translation: CAI13871.1.
AL157394 Genomic DNA. Translation: CAI13872.1.
CH471066 Genomic DNA. Translation: EAW50151.1.
BC012479 mRNA. Translation: AAH12479.1.
CCDSiCCDS7393.1. [P25445-1]
CCDS7394.1. [P25445-6]
CCDS7395.1. [P25445-7]
PIRiA40036.
I37383.
I37384.
S58662.
RefSeqiNP_000034.1. NM_000043.5. [P25445-1]
NP_001307548.1. NM_001320619.1.
NP_690610.1. NM_152871.3. [P25445-6]
NP_690611.1. NM_152872.3. [P25445-7]
UniGeneiHs.244139.
Hs.667309.

Genome annotation databases

EnsembliENST00000355279; ENSP00000347426; ENSG00000026103. [P25445-7]
ENST00000355740; ENSP00000347979; ENSG00000026103. [P25445-1]
ENST00000357339; ENSP00000349896; ENSG00000026103. [P25445-6]
ENST00000479522; ENSP00000424113; ENSG00000026103. [P25445-3]
ENST00000484444; ENSP00000420975; ENSG00000026103. [P25445-2]
ENST00000488877; ENSP00000425159; ENSG00000026103. [P25445-4]
ENST00000492756; ENSP00000422453; ENSG00000026103. [P25445-5]
ENST00000494410; ENSP00000423755; ENSG00000026103. [P25445-4]
GeneIDi355.
KEGGihsa:355.
UCSCiuc001kfr.4. human. [P25445-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Autoimmune Lymphoproliferative Syndrome Database (ALPSbase)

Mutations in TNFRSF6 causing ALPS type Ia

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M67454 mRNA. Translation: AAA63174.1.
X63717 mRNA. Translation: CAA45250.1.
X83490 mRNA. No translation available.
X83491 mRNA. No translation available.
X83492 mRNA. No translation available.
X83493 mRNA. No translation available.
Z47993 mRNA. Translation: CAA88031.1.
Z47994 mRNA. Translation: CAA88032.1.
Z47995 mRNA. Translation: CAA88033.1.
Z66556 mRNA. No translation available.
Z70519 mRNA. Translation: CAA94430.1.
Z70520 mRNA. Translation: CAA94431.1.
AY495076 mRNA. Translation: AAS76663.1.
X89101 mRNA. Translation: CAA61473.1.
FM246458 mRNA. Translation: CAR92543.1.
AK290978 mRNA. Translation: BAF83667.1.
AY450925 Genomic DNA. Translation: AAR08906.1.
AL157394 Genomic DNA. Translation: CAI13870.1.
AL157394 Genomic DNA. Translation: CAI13871.1.
AL157394 Genomic DNA. Translation: CAI13872.1.
CH471066 Genomic DNA. Translation: EAW50151.1.
BC012479 mRNA. Translation: AAH12479.1.
CCDSiCCDS7393.1. [P25445-1]
CCDS7394.1. [P25445-6]
CCDS7395.1. [P25445-7]
PIRiA40036.
I37383.
I37384.
S58662.
RefSeqiNP_000034.1. NM_000043.5. [P25445-1]
NP_001307548.1. NM_001320619.1.
NP_690610.1. NM_152871.3. [P25445-6]
NP_690611.1. NM_152872.3. [P25445-7]
UniGeneiHs.244139.
Hs.667309.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BZImodel-A1-335[»]
1DDFNMR-A218-335[»]
2NA7NMR-A/B/C171-198[»]
3EWTX-ray2.40E230-254[»]
3EZQX-ray2.73A/C/E/G/I/K/M/O223-335[»]
3THMX-ray2.10F17-172[»]
3TJEX-ray1.93F17-172[»]
ProteinModelPortaliP25445.
SMRiP25445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106851. 101 interactors.
DIPiDIP-924N.
IntActiP25445. 48 interactors.
MINTiMINT-146256.
STRINGi9606.ENSP00000347979.

PTM databases

iPTMnetiP25445.
PhosphoSitePlusiP25445.
SwissPalmiP25445.
UniCarbKBiP25445.

Polymorphism and mutation databases

BioMutaiFAS.
DMDMi119833.

Proteomic databases

EPDiP25445.
MaxQBiP25445.
PaxDbiP25445.
PeptideAtlasiP25445.
PRIDEiP25445.
TopDownProteomicsiP25445-7. [P25445-7]

Protocols and materials databases

DNASUi355.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355279; ENSP00000347426; ENSG00000026103. [P25445-7]
ENST00000355740; ENSP00000347979; ENSG00000026103. [P25445-1]
ENST00000357339; ENSP00000349896; ENSG00000026103. [P25445-6]
ENST00000479522; ENSP00000424113; ENSG00000026103. [P25445-3]
ENST00000484444; ENSP00000420975; ENSG00000026103. [P25445-2]
ENST00000488877; ENSP00000425159; ENSG00000026103. [P25445-4]
ENST00000492756; ENSP00000422453; ENSG00000026103. [P25445-5]
ENST00000494410; ENSP00000423755; ENSG00000026103. [P25445-4]
GeneIDi355.
KEGGihsa:355.
UCSCiuc001kfr.4. human. [P25445-1]

Organism-specific databases

CTDi355.
DisGeNETi355.
GeneCardsiFAS.
GeneReviewsiFAS.
HGNCiHGNC:11920. FAS.
HPAiHPA027444.
MalaCardsiFAS.
MIMi134637. gene.
601859. phenotype.
neXtProtiNX_P25445.
OpenTargetsiENSG00000026103.
Orphaneti3261. Autoimmune lymphoproliferative syndrome.
85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBiPA36613.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J23A. Eukaryota.
ENOG4112ADB. LUCA.
GeneTreeiENSGT00730000111280.
HOGENOMiHOG000139681.
HOVERGENiHBG004091.
InParanoidiP25445.
KOiK04390.
OMAiCTTCEHG.
OrthoDBiEOG091G0DU6.
PhylomeDBiP25445.
TreeFamiTF333916.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000026103-MONOMER.
ReactomeiR-HSA-140534. Ligand-dependent caspase activation.
R-HSA-3371378. Regulation by c-FLIP.
R-HSA-5213460. RIPK1-mediated regulated necrosis.
R-HSA-5218900. CASP8 activity is inhibited.
R-HSA-6803211. TP53 Regulates Transcription of Death Receptors and Ligands.
R-HSA-69416. Dimerization of procaspase-8.
R-HSA-75157. FasL/ CD95L signaling.
SIGNORiP25445.

Miscellaneous databases

EvolutionaryTraceiP25445.
GeneWikiiFas_receptor.
GenomeRNAii355.
PMAP-CutDBP25445.
PROiP25445.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000026103.
CleanExiHS_FAS.
ExpressionAtlasiP25445. baseline and differential.
GenevisibleiP25445. HS.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PANTHERiPTHR23097:SF114. PTHR23097:SF114. 1 hit.
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR6_HUMAN
AccessioniPrimary (citable) accession number: P25445
Secondary accession number(s): A9UJX4
, B6VNV4, Q14292, Q14293, Q14294, Q14295, Q16652, Q5T9P1, Q5T9P2, Q5T9P3, Q6SSE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 30, 2016
This is version 213 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.