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Protein

40S ribosomal protein S2

Gene

Rps2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cellular response to interleukin-4 Source: MGI
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S2
Alternative name(s):
40S ribosomal protein S4
Protein LLRep3
Gene namesi
Name:Rps2
Synonyms:Llrep3, Rps4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:105110. Rps2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 29329240S ribosomal protein S2PRO_0000131674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei252 – 2521PhosphothreonineBy similarity
Modified residuei263 – 2631N6-acetyllysineBy similarity
Modified residuei264 – 2641PhosphoserineBy similarity
Modified residuei270 – 2701PhosphothreonineBy similarity
Modified residuei275 – 2751N6-acetyllysine; alternateBy similarity
Cross-linki275 – 275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki275 – 275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei281 – 2811PhosphoserineBy similarity

Post-translational modificationi

Citrullinated by PADI4 in the Arg/Gly-rich region.By similarity
Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP25444.
PaxDbiP25444.
PeptideAtlasiP25444.
PRIDEiP25444.
TopDownProteomicsiP25444.

PTM databases

iPTMnetiP25444.
PhosphoSiteiP25444.
SwissPalmiP25444.

Expressioni

Gene expression databases

BgeeiP25444.
CleanExiMM_RPS2.
ExpressionAtlasiP25444. baseline and differential.
GenevisibleiP25444. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201174. 3 interactions.
IntActiP25444. 4 interactions.
MINTiMINT-1865158.
STRINGi10090.ENSMUSP00000133092.

Structurei

3D structure databases

ProteinModelPortaliP25444.
SMRiP25444. Positions 59-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini102 – 16564S5 DRBMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 5332Arg/Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S5P family.Curated
Contains 1 S5 DRBM domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0877. Eukaryota.
COG0098. LUCA.
HOVERGENiHBG000437.
InParanoidiP25444.
KOiK02981.
OrthoDBiEOG7P5T1Q.
TreeFamiTF300806.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005711. Ribosomal_S5_euk/arc.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR01020. uS5_euk_arch. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDAGAAGG PGGPGGPGLG GRGGFRGGFG SGLRGRGRGR GRGRGRGRGA
60 70 80 90 100
RGGKAEDKEW IPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA
110 120 130 140 150
SLKDEVLKIM PVQKQTRAGQ RTRFKAFVAI GDYNGHVGLG VKCSKEVATA
160 170 180 190 200
IRGAIILAKL SIVPVRRGYW GNKIGKPHTV PCKVTGRCGS VLVRLIPAPR
210 220 230 240 250
GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT FDAISKTYSY
260 270 280 290
LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT
Length:293
Mass (Da):31,231
Last modified:April 13, 2004 - v3
Checksum:i9092DB564AA624C9
GO

Sequence cautioni

The sequence AAA40074.1 differs from that shown. Reason: Frameshift at position 24. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti270 – 2701T → S in AAA40074 (PubMed:3405219).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20632 mRNA. Translation: AAA40074.1. Frameshift.
AF283559 mRNA. Translation: AAG13953.1.
BC002186 mRNA. Translation: AAH02186.1.
CCDSiCCDS37493.1.
PIRiA31139.
RefSeqiNP_032529.2. NM_008503.5.
XP_006523791.1. XM_006523728.2.
UniGeneiMm.157452.
Mm.308628.
Mm.328846.
Mm.379793.
Mm.389704.
Mm.390980.
Mm.440520.

Genome annotation databases

EnsembliENSMUST00000054289; ENSMUSP00000092502; ENSMUSG00000044533.
ENSMUST00000170715; ENSMUSP00000131474; ENSMUSG00000044533.
GeneIDi16898.
KEGGimmu:16898.
UCSCiuc008axy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20632 mRNA. Translation: AAA40074.1. Frameshift.
AF283559 mRNA. Translation: AAG13953.1.
BC002186 mRNA. Translation: AAH02186.1.
CCDSiCCDS37493.1.
PIRiA31139.
RefSeqiNP_032529.2. NM_008503.5.
XP_006523791.1. XM_006523728.2.
UniGeneiMm.157452.
Mm.308628.
Mm.328846.
Mm.379793.
Mm.389704.
Mm.390980.
Mm.440520.

3D structure databases

ProteinModelPortaliP25444.
SMRiP25444. Positions 59-276.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201174. 3 interactions.
IntActiP25444. 4 interactions.
MINTiMINT-1865158.
STRINGi10090.ENSMUSP00000133092.

PTM databases

iPTMnetiP25444.
PhosphoSiteiP25444.
SwissPalmiP25444.

Proteomic databases

EPDiP25444.
PaxDbiP25444.
PeptideAtlasiP25444.
PRIDEiP25444.
TopDownProteomicsiP25444.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054289; ENSMUSP00000092502; ENSMUSG00000044533.
ENSMUST00000170715; ENSMUSP00000131474; ENSMUSG00000044533.
GeneIDi16898.
KEGGimmu:16898.
UCSCiuc008axy.2. mouse.

Organism-specific databases

CTDi6187.
MGIiMGI:105110. Rps2.

Phylogenomic databases

eggNOGiKOG0877. Eukaryota.
COG0098. LUCA.
HOVERGENiHBG000437.
InParanoidiP25444.
KOiK02981.
OrthoDBiEOG7P5T1Q.
TreeFamiTF300806.

Miscellaneous databases

PROiP25444.
SOURCEiSearch...

Gene expression databases

BgeeiP25444.
CleanExiMM_RPS2.
ExpressionAtlasiP25444. baseline and differential.
GenevisibleiP25444. MM.

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000851. Ribosomal_S5.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005711. Ribosomal_S5_euk/arc.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR01020. uS5_euk_arch. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A highly conserved mouse gene with a propensity to form pseudogenes in mammals."
    Heller D.L., Gianola K.M., Leinwand L.A.
    Mol. Cell. Biol. 8:2797-2803(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Smith J.B., Nguyen T.T.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart, Lung, Pancreas and Testis.

Entry informationi

Entry nameiRS2_MOUSE
AccessioniPrimary (citable) accession number: P25444
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: April 13, 2004
Last modified: July 6, 2016
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.