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Protein

40S ribosomal protein S2

Gene

Rps2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S2
Alternative name(s):
40S ribosomal protein S4
Protein LLRep3
Gene namesi
Name:Rps2
Synonyms:Llrep3, Rps4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:105110 Rps2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001316742 – 29340S ribosomal protein S2Add BLAST292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki58Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei252PhosphothreonineBy similarity1
Modified residuei263N6-acetyllysineBy similarity1
Modified residuei264PhosphoserineBy similarity1
Modified residuei270PhosphothreonineBy similarity1
Modified residuei275N6-acetyllysine; alternateBy similarity1
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki275Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternateBy similarity
Modified residuei281PhosphoserineBy similarity1

Post-translational modificationi

Citrullinated by PADI4 in the Arg/Gly-rich region.By similarity
Asymmetric arginine dimethylation by PRMT3 occurs at multiple sites in the Arg/Gly-rich region.By similarity

Keywords - PTMi

Acetylation, Citrullination, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP25444
PaxDbiP25444
PeptideAtlasiP25444
PRIDEiP25444
TopDownProteomicsiP25444

PTM databases

iPTMnetiP25444
PhosphoSitePlusiP25444
SwissPalmiP25444

Expressioni

Gene expression databases

BgeeiENSMUSG00000044533
CleanExiMM_RPS2
ExpressionAtlasiP25444 baseline and differential
GenevisibleiP25444 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201174, 3 interactors
IntActiP25444, 4 interactors
MINTiP25444
STRINGi10090.ENSMUSP00000133092

Structurei

3D structure databases

ProteinModelPortaliP25444
SMRiP25444
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini102 – 165S5 DRBMPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 53Arg/Gly-richAdd BLAST32

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0877 Eukaryota
COG0098 LUCA
GeneTreeiENSGT00390000001433
HOVERGENiHBG000437
InParanoidiP25444
KOiK02981
TreeFamiTF300806

Family and domain databases

Gene3Di3.30.230.10, 1 hit
InterProiView protein in InterPro
IPR000851 Ribosomal_S5
IPR005324 Ribosomal_S5_C
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
IPR005711 Ribosomal_S5_euk/arc
IPR013810 Ribosomal_S5_N
IPR018192 Ribosomal_S5_N_CS
PANTHERiPTHR13718 PTHR13718, 1 hit
PfamiView protein in Pfam
PF00333 Ribosomal_S5, 1 hit
PF03719 Ribosomal_S5_C, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
TIGRFAMsiTIGR01020 uS5_euk_arch, 1 hit
PROSITEiView protein in PROSITE
PS00585 RIBOSOMAL_S5, 1 hit
PS50881 S5_DSRBD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25444-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDAGAAGG PGGPGGPGLG GRGGFRGGFG SGLRGRGRGR GRGRGRGRGA
60 70 80 90 100
RGGKAEDKEW IPVTKLGRLV KDMKIKSLEE IYLFSLPIKE SEIIDFFLGA
110 120 130 140 150
SLKDEVLKIM PVQKQTRAGQ RTRFKAFVAI GDYNGHVGLG VKCSKEVATA
160 170 180 190 200
IRGAIILAKL SIVPVRRGYW GNKIGKPHTV PCKVTGRCGS VLVRLIPAPR
210 220 230 240 250
GTGIVSAPVP KKLLMMAGID DCYTSARGCT ATLGNFAKAT FDAISKTYSY
260 270 280 290
LTPDLWKETV FTKSPYQEFT DHLVKTHTRV SVQRTQAPAV ATT
Length:293
Mass (Da):31,231
Last modified:April 13, 2004 - v3
Checksum:i9092DB564AA624C9
GO

Sequence cautioni

The sequence AAA40074 differs from that shown. Reason: Frameshift at position 24.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270T → S in AAA40074 (PubMed:3405219).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20632 mRNA Translation: AAA40074.1 Frameshift.
AF283559 mRNA Translation: AAG13953.1
BC002186 mRNA Translation: AAH02186.1
CCDSiCCDS37493.1
PIRiA31139
RefSeqiNP_032529.2, NM_008503.5
UniGeneiMm.157452
Mm.308628
Mm.328846
Mm.379793
Mm.389704
Mm.390980
Mm.440520

Genome annotation databases

EnsembliENSMUST00000054289; ENSMUSP00000092502; ENSMUSG00000044533
ENSMUST00000170715; ENSMUSP00000131474; ENSMUSG00000044533
GeneIDi16898
KEGGimmu:16898
UCSCiuc008axy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiRS2_MOUSE
AccessioniPrimary (citable) accession number: P25444
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: April 13, 2004
Last modified: May 23, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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