ID NTF3_CHICK Reviewed; 257 AA. AC P25433; Q6LAC6; DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot. DT 01-DEC-1992, sequence version 2. DT 27-MAR-2024, entry version 143. DE RecName: Full=Neurotrophin-3; DE Short=NT-3; DE AltName: Full=HDNF; DE AltName: Full=Nerve growth factor 2; DE Short=NGF-2; DE AltName: Full=Neurotrophic factor; DE Flags: Precursor; GN Name=NTF3; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; OC Phasianinae; Gallus. OX NCBI_TaxID=9031; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=1457809; DOI=10.3109/10425179209039695; RA Maisonpierre P., Belluscio L., Conover J.C., Yancopoulos G.D.; RT "Gene sequences of chicken BDNF and NT-3."; RL DNA Seq. 3:49-54(1992). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-257. RX PubMed=8074744; DOI=10.1111/j.1460-9568.1993.tb00199.x; RA Hallboeoek F., Ibanez C.F., Ebendal T., Persson H.; RT "Cellular localization of brain-derived neurotrophic factor and RT neurotrophin-3 mRNA expression in the early chicken embryo."; RL Eur. J. Neurosci. 5:1-14(1993). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-236. RX PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8; RA Hallboeoek F., Ibanez C.F., Persson H.; RT "Evolutionary studies of the nerve growth factor family reveal a novel RT member abundantly expressed in Xenopus ovary."; RL Neuron 6:845-858(1991). CC -!- FUNCTION: Seems to promote the survival of visceral and proprioceptive CC sensory neurons. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- TISSUE SPECIFICITY: In the embryo, the expression peak at E4.5 and CC decreases at later stages of development. CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M83378; AAA68880.1; -; Genomic_DNA. DR EMBL; Z30092; CAA82908.1; -; Genomic_DNA. DR PIR; I50400; I50400. DR RefSeq; NP_001026659.1; NM_001031488.1. DR AlphaFoldDB; P25433; -. DR SMR; P25433; -. DR STRING; 9031.ENSGALP00000070337; -. DR GlyCosmos; P25433; 1 site, No reported glycans. DR PaxDb; 9031-ENSGALP00000043385; -. DR Ensembl; ENSGALT00010059737.1; ENSGALP00010036497.1; ENSGALG00010024492.1. DR Ensembl; ENSGALT00010059739.1; ENSGALP00010036499.1; ENSGALG00010024492.1. DR Ensembl; ENSGALT00010059745.1; ENSGALP00010036505.1; ENSGALG00010024492.1. DR Ensembl; ENSGALT00010059749.1; ENSGALP00010036509.1; ENSGALG00010024492.1. DR Ensembl; ENSGALT00010059755.1; ENSGALP00010036515.1; ENSGALG00010024492.1. DR Ensembl; ENSGALT00010059756.1; ENSGALP00010036516.1; ENSGALG00010024492.1. DR Ensembl; ENSGALT00010059757.1; ENSGALP00010036517.1; ENSGALG00010024492.1. DR Ensembl; ENSGALT00010059758.1; ENSGALP00010036518.1; ENSGALG00010024492.1. DR Ensembl; ENSGALT00015021370; ENSGALP00015011967; ENSGALG00015008872. DR Ensembl; ENSGALT00015021373; ENSGALP00015011970; ENSGALG00015008872. DR Ensembl; ENSGALT00015021380; ENSGALP00015011975; ENSGALG00015008872. DR Ensembl; ENSGALT00015021382; ENSGALP00015011977; ENSGALG00015008872. DR Ensembl; ENSGALT00015021384; ENSGALP00015011978; ENSGALG00015008872. DR Ensembl; ENSGALT00015021386; ENSGALP00015011979; ENSGALG00015008872. DR Ensembl; ENSGALT00015021388; ENSGALP00015011981; ENSGALG00015008872. DR Ensembl; ENSGALT00015021390; ENSGALP00015011983; ENSGALG00015008872. DR Ensembl; ENSGALT00015021394; ENSGALP00015011986; ENSGALG00015008872. DR GeneID; 428099; -. DR KEGG; gga:428099; -. DR CTD; 4908; -. DR VEuPathDB; HostDB:geneid_428099; -. DR eggNOG; ENOG502R4FK; Eukaryota. DR GeneTree; ENSGT00390000007725; -. DR HOGENOM; CLU_059942_1_1_1; -. DR InParanoid; P25433; -. DR OMA; ILLYVMF; -. DR PhylomeDB; P25433; -. DR TreeFam; TF106463; -. DR PRO; PR:P25433; -. DR Proteomes; UP000000539; Chromosome 1. DR GO; GO:0030424; C:axon; IBA:GO_Central. DR GO; GO:0030425; C:dendrite; IBA:GO_Central. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central. DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central. DR GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central. DR GO; GO:0007613; P:memory; IBA:GO_Central. DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central. DR GO; GO:0021675; P:nerve development; IBA:GO_Central. DR GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central. DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central. DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central. DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central. DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central. DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central. DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1. DR InterPro; IPR029034; Cystine-knot_cytokine. DR InterPro; IPR020408; Nerve_growth_factor-like. DR InterPro; IPR002072; Nerve_growth_factor-rel. DR InterPro; IPR019846; Nerve_growth_factor_CS. DR InterPro; IPR015578; Neurotrophin-3. DR InterPro; IPR045815; NTF3_N. DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1. DR PANTHER; PTHR11589:SF4; NEUROTROPHIN-3; 1. DR Pfam; PF00243; NGF; 1. DR Pfam; PF19338; NTF3_N; 1. DR PIRSF; PIRSF001789; NGF; 1. DR PRINTS; PR01914; NEUROTROPHN3. DR PRINTS; PR00268; NGF. DR SMART; SM00140; NGF; 1. DR SUPFAM; SSF57501; Cystine-knot cytokines; 1. DR PROSITE; PS00248; NGF_1; 1. DR PROSITE; PS50270; NGF_2; 1. PE 2: Evidence at transcript level; KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein; KW Growth factor; Reference proteome; Secreted; Signal. FT SIGNAL 1..18 FT /evidence="ECO:0000255" FT PROPEP 19..138 FT /id="PRO_0000019665" FT CHAIN 139..257 FT /note="Neurotrophin-3" FT /id="PRO_0000019666" FT CARBOHYD 131 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 152..217 FT /evidence="ECO:0000250" FT DISULFID 195..246 FT /evidence="ECO:0000250" FT DISULFID 205..248 FT /evidence="ECO:0000250" SQ SEQUENCE 257 AA; 29701 MW; EE043BA2A005C1E7 CRC64; MSILFYVIFL AYLRGIQSTN MDQRSLPEDS MNSLIIKLIR ADILKNKLSK QVMDVKENYQ NIVQKVEDHQ EMDGDENVKS DFQPVISMDT DLLRQQRRYN SPRVLLSDNT PLEPPPLYLT EDYVGSSVVL NRTSRRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEAKP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL SRKIGRT //