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Protein

Neurotrophin-3

Gene

NTF3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:NTF3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Propeptidei19 – 138120PRO_0000019665Add
BLAST
Chaini139 – 257119Neurotrophin-3PRO_0000019666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi152 ↔ 217By similarity
Disulfide bondi195 ↔ 246By similarity
Disulfide bondi205 ↔ 248By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25433.

Expressioni

Tissue specificityi

In the embryo, the expression peak at E4.5 and decreases at later stages of development.

Interactioni

Protein-protein interaction databases

MINTiMINT-127872.
STRINGi9031.ENSGALP00000027867.

Structurei

3D structure databases

ProteinModelPortaliP25433.
SMRiP25433. Positions 143-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39844.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP25433.
KOiK04356.
PhylomeDBiP25433.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILFYVIFL AYLRGIQSTN MDQRSLPEDS MNSLIIKLIR ADILKNKLSK
60 70 80 90 100
QVMDVKENYQ NIVQKVEDHQ EMDGDENVKS DFQPVISMDT DLLRQQRRYN
110 120 130 140 150
SPRVLLSDNT PLEPPPLYLT EDYVGSSVVL NRTSRRKRYA EHKSHRGEYS
160 170 180 190 200
VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEAKP
210 220 230 240 250
VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL

SRKIGRT
Length:257
Mass (Da):29,701
Last modified:December 1, 1992 - v2
Checksum:iEE043BA2A005C1E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83378 Genomic DNA. Translation: AAA68880.1.
Z30092 Genomic DNA. Translation: CAA82908.1.
PIRiI50400.
RefSeqiNP_001026659.1. NM_001031488.1.
UniGeneiGga.41617.
Gga.53128.

Genome annotation databases

GeneIDi428099.
KEGGigga:428099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83378 Genomic DNA. Translation: AAA68880.1.
Z30092 Genomic DNA. Translation: CAA82908.1.
PIRiI50400.
RefSeqiNP_001026659.1. NM_001031488.1.
UniGeneiGga.41617.
Gga.53128.

3D structure databases

ProteinModelPortaliP25433.
SMRiP25433. Positions 143-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-127872.
STRINGi9031.ENSGALP00000027867.

Proteomic databases

PaxDbiP25433.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi428099.
KEGGigga:428099.

Organism-specific databases

CTDi4908.

Phylogenomic databases

eggNOGiNOG39844.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP25433.
KOiK04356.
PhylomeDBiP25433.
TreeFamiTF106463.

Miscellaneous databases

NextBioi20829173.
PROiP25433.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Gene sequences of chicken BDNF and NT-3."
    Maisonpierre P., Belluscio L., Conover J.C., Yancopoulos G.D.
    DNA Seq. 3:49-54(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cellular localization of brain-derived neurotrophic factor and neurotrophin-3 mRNA expression in the early chicken embryo."
    Hallboeoek F., Ibanez C.F., Ebendal T., Persson H.
    Eur. J. Neurosci. 5:1-14(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-257.
  3. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
    Hallboeoek F., Ibanez C.F., Persson H.
    Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-236.

Entry informationi

Entry nameiNTF3_CHICK
AccessioniPrimary (citable) accession number: P25433
Secondary accession number(s): Q6LAC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 1, 1992
Last modified: June 24, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.