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Protein

Neurotrophin-3

Gene

NTF3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:NTF3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001966519 – 138Add BLAST120
ChainiPRO_0000019666139 – 257Neurotrophin-3Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 217By similarity
Disulfide bondi195 ↔ 246By similarity
Disulfide bondi205 ↔ 248By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25433

Expressioni

Tissue specificityi

In the embryo, the expression peak at E4.5 and decreases at later stages of development.

Gene expression databases

BgeeiENSGALG00000027299

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027867

Structurei

3D structure databases

ProteinModelPortaliP25433
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHMM Eukaryota
ENOG410XRRK LUCA
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP25433
KOiK04356
OrthoDBiEOG091G0GHL
PhylomeDBiP25433
TreeFamiTF106463

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR015578 Neurotrophin-3
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF4 PTHR11589:SF4, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01914 NEUROTROPHN3
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25433-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILFYVIFL AYLRGIQSTN MDQRSLPEDS MNSLIIKLIR ADILKNKLSK
60 70 80 90 100
QVMDVKENYQ NIVQKVEDHQ EMDGDENVKS DFQPVISMDT DLLRQQRRYN
110 120 130 140 150
SPRVLLSDNT PLEPPPLYLT EDYVGSSVVL NRTSRRKRYA EHKSHRGEYS
160 170 180 190 200
VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEAKP
210 220 230 240 250
VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL

SRKIGRT
Length:257
Mass (Da):29,701
Last modified:December 1, 1992 - v2
Checksum:iEE043BA2A005C1E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83378 Genomic DNA Translation: AAA68880.1
Z30092 Genomic DNA Translation: CAA82908.1
PIRiI50400
RefSeqiNP_001026659.1, NM_001031488.1
UniGeneiGga.41617
Gga.53128

Genome annotation databases

GeneIDi428099
KEGGigga:428099

Similar proteinsi

Entry informationi

Entry nameiNTF3_CHICK
AccessioniPrimary (citable) accession number: P25433
Secondary accession number(s): Q6LAC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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