Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P25433 (NTF3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotrophin-3

Short name=NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name=NGF-2
Neurotrophic factor
Gene names
Name:NTF3
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length257 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Seems to promote the survival of visceral and proprioceptive sensory neurons.

Subcellular location

Secreted.

Tissue specificity

In the embryo, the expression peak at E4.5 and decreases at later stages of development.

Sequence similarities

Belongs to the NGF-beta family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionGrowth factor
   PTMCleavage on pair of basic residues
Disulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

activation of Ras GTPase activity

Inferred from electronic annotation. Source: Ensembl

activation of protein kinase B activity

Inferred from electronic annotation. Source: Ensembl

axon guidance

Inferred from electronic annotation. Source: Ensembl

brain development

Inferred from electronic annotation. Source: Ensembl

enteric nervous system development

Inferred from electronic annotation. Source: Ensembl

epidermis development

Inferred from electronic annotation. Source: Ensembl

glial cell fate determination

Inferred from electronic annotation. Source: Ensembl

induction of positive chemotaxis

Inferred from electronic annotation. Source: Ensembl

mechanoreceptor differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

nerve development

Inferred from electronic annotation. Source: Ensembl

neuromuscular synaptic transmission

Inferred from electronic annotation. Source: Ensembl

peripheral nervous system development

Inferred from electronic annotation. Source: Ensembl

positive regulation of actin cytoskeleton reorganization

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of receptor internalization

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

transmembrane receptor protein tyrosine kinase signaling pathway

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasmic membrane-bounded vesicle

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionchemoattractant activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Propeptide19 – 138120
PRO_0000019665
Chain139 – 257119Neurotrophin-3
PRO_0000019666

Amino acid modifications

Glycosylation1311N-linked (GlcNAc...) Potential
Disulfide bond152 ↔ 217 By similarity
Disulfide bond195 ↔ 246 By similarity
Disulfide bond205 ↔ 248 By similarity

Sequences

Sequence LengthMass (Da)Tools
P25433 [UniParc].

Last modified December 1, 1992. Version 2.
Checksum: EE043BA2A005C1E7

FASTA25729,701
        10         20         30         40         50         60 
MSILFYVIFL AYLRGIQSTN MDQRSLPEDS MNSLIIKLIR ADILKNKLSK QVMDVKENYQ 

        70         80         90        100        110        120 
NIVQKVEDHQ EMDGDENVKS DFQPVISMDT DLLRQQRRYN SPRVLLSDNT PLEPPPLYLT 

       130        140        150        160        170        180 
EDYVGSSVVL NRTSRRKRYA EHKSHRGEYS VCDSESLWVT DKSSAIDIRG HQVTVLGEIK 

       190        200        210        220        230        240 
TGNSPVKQYF YETRCKEAKP VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI 

       250 
RIDTSCVCAL SRKIGRT 

« Hide

References

[1]"Gene sequences of chicken BDNF and NT-3."
Maisonpierre P., Belluscio L., Conover J.C., Yancopoulos G.D.
DNA Seq. 3:49-54(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cellular localization of brain-derived neurotrophic factor and neurotrophin-3 mRNA expression in the early chicken embryo."
Hallboeoek F., Ibanez C.F., Ebendal T., Persson H.
Eur. J. Neurosci. 5:1-14(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-257.
[3]"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
Hallboeoek F., Ibanez C.F., Persson H.
Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-236.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M83378 Genomic DNA. Translation: AAA68880.1.
Z30092 Genomic DNA. Translation: CAA82908.1.
PIRI50400.
RefSeqNP_001026659.1. NM_001031488.1.
UniGeneGga.41617.
Gga.53128.

3D structure databases

ProteinModelPortalP25433.
SMRP25433. Positions 143-253.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-127872.
STRING9031.ENSGALP00000027867.

Proteomic databases

PaxDbP25433.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID428099.
KEGGgga:428099.

Organism-specific databases

CTD4908.

Phylogenomic databases

eggNOGNOG39844.
HOGENOMHOG000231516.
HOVERGENHBG006494.
InParanoidP25433.
KOK04356.
OMAYAEHKSH.
PhylomeDBP25433.
TreeFamTF106463.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamPF00243. NGF. 1 hit.
[Graphical view]
PIRSFPIRSF001789. NGF. 1 hit.
PRINTSPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20829173.
PROP25433.

Entry information

Entry nameNTF3_CHICK
AccessionPrimary (citable) accession number: P25433
Secondary accession number(s): Q6LAC6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 1, 1992
Last modified: June 11, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families