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P25433

- NTF3_CHICK

UniProt

P25433 - NTF3_CHICK

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Protein
Neurotrophin-3
Gene
NTF3
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Seems to promote the survival of visceral and proprioceptive sensory neurons.

GO - Molecular functioni

  1. chemoattractant activity Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. activation of Ras GTPase activity Source: Ensembl
  3. activation of protein kinase B activity Source: Ensembl
  4. axon guidance Source: Ensembl
  5. brain development Source: Ensembl
  6. enteric nervous system development Source: Ensembl
  7. epidermis development Source: Ensembl
  8. glial cell fate determination Source: Ensembl
  9. induction of positive chemotaxis Source: Ensembl
  10. mechanoreceptor differentiation Source: Ensembl
  11. negative regulation of neuron apoptotic process Source: Ensembl
  12. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  13. nerve development Source: Ensembl
  14. neuromuscular synaptic transmission Source: Ensembl
  15. peripheral nervous system development Source: Ensembl
  16. positive regulation of actin cytoskeleton reorganization Source: Ensembl
  17. positive regulation of cell migration Source: Ensembl
  18. positive regulation of cell proliferation Source: Ensembl
  19. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  20. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  21. positive regulation of receptor internalization Source: Ensembl
  22. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  23. smooth muscle cell differentiation Source: Ensembl
  24. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-3
Short name:
NT-3
Alternative name(s):
HDNF
Nerve growth factor 2
Short name:
NGF-2
Neurotrophic factor
Gene namesi
Name:NTF3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: Ensembl
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Propeptidei19 – 138120
PRO_0000019665Add
BLAST
Chaini139 – 257119Neurotrophin-3
PRO_0000019666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi152 ↔ 217 By similarity
Disulfide bondi195 ↔ 246 By similarity
Disulfide bondi205 ↔ 248 By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25433.

Expressioni

Tissue specificityi

In the embryo, the expression peak at E4.5 and decreases at later stages of development.

Interactioni

Protein-protein interaction databases

MINTiMINT-127872.
STRINGi9031.ENSGALP00000027867.

Structurei

3D structure databases

ProteinModelPortaliP25433.
SMRiP25433. Positions 143-253.

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39844.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP25433.
KOiK04356.
OMAiYAEHKSH.
PhylomeDBiP25433.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25433-1 [UniParc]FASTAAdd to Basket

« Hide

MSILFYVIFL AYLRGIQSTN MDQRSLPEDS MNSLIIKLIR ADILKNKLSK    50
QVMDVKENYQ NIVQKVEDHQ EMDGDENVKS DFQPVISMDT DLLRQQRRYN 100
SPRVLLSDNT PLEPPPLYLT EDYVGSSVVL NRTSRRKRYA EHKSHRGEYS 150
VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEAKP 200
VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL 250
SRKIGRT 257
Length:257
Mass (Da):29,701
Last modified:December 1, 1992 - v2
Checksum:iEE043BA2A005C1E7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83378 Genomic DNA. Translation: AAA68880.1.
Z30092 Genomic DNA. Translation: CAA82908.1.
PIRiI50400.
RefSeqiNP_001026659.1. NM_001031488.1.
UniGeneiGga.41617.
Gga.53128.

Genome annotation databases

GeneIDi428099.
KEGGigga:428099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M83378 Genomic DNA. Translation: AAA68880.1 .
Z30092 Genomic DNA. Translation: CAA82908.1 .
PIRi I50400.
RefSeqi NP_001026659.1. NM_001031488.1.
UniGenei Gga.41617.
Gga.53128.

3D structure databases

ProteinModelPortali P25433.
SMRi P25433. Positions 143-253.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-127872.
STRINGi 9031.ENSGALP00000027867.

Proteomic databases

PaxDbi P25433.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 428099.
KEGGi gga:428099.

Organism-specific databases

CTDi 4908.

Phylogenomic databases

eggNOGi NOG39844.
HOGENOMi HOG000231516.
HOVERGENi HBG006494.
InParanoidi P25433.
KOi K04356.
OMAi YAEHKSH.
PhylomeDBi P25433.
TreeFami TF106463.

Miscellaneous databases

NextBioi 20829173.
PROi P25433.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
IPR015578. Neurotrophin-3.
[Graphical view ]
PANTHERi PTHR11589. PTHR11589. 1 hit.
PTHR11589:SF4. PTHR11589:SF4. 1 hit.
Pfami PF00243. NGF. 1 hit.
[Graphical view ]
PIRSFi PIRSF001789. NGF. 1 hit.
PRINTSi PR01914. NEUROTROPHN3.
PR00268. NGF.
ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00140. NGF. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene sequences of chicken BDNF and NT-3."
    Maisonpierre P., Belluscio L., Conover J.C., Yancopoulos G.D.
    DNA Seq. 3:49-54(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cellular localization of brain-derived neurotrophic factor and neurotrophin-3 mRNA expression in the early chicken embryo."
    Hallboeoek F., Ibanez C.F., Ebendal T., Persson H.
    Eur. J. Neurosci. 5:1-14(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-257.
  3. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
    Hallboeoek F., Ibanez C.F., Persson H.
    Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-236.

Entry informationi

Entry nameiNTF3_CHICK
AccessioniPrimary (citable) accession number: P25433
Secondary accession number(s): Q6LAC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 1, 1992
Last modified: June 11, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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