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P25433

- NTF3_CHICK

UniProt

P25433 - NTF3_CHICK

Protein

Neurotrophin-3

Gene

NTF3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (01 Dec 1992)
      Previous versions | rss
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    Functioni

    Seems to promote the survival of visceral and proprioceptive sensory neurons.

    GO - Molecular functioni

    1. chemoattractant activity Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. activation of protein kinase B activity Source: Ensembl
    3. activation of Ras GTPase activity Source: Ensembl
    4. axon guidance Source: Ensembl
    5. brain development Source: Ensembl
    6. enteric nervous system development Source: Ensembl
    7. epidermis development Source: Ensembl
    8. glial cell fate determination Source: Ensembl
    9. induction of positive chemotaxis Source: Ensembl
    10. mechanoreceptor differentiation Source: Ensembl
    11. negative regulation of neuron apoptotic process Source: Ensembl
    12. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    13. nerve development Source: Ensembl
    14. neuromuscular synaptic transmission Source: Ensembl
    15. peripheral nervous system development Source: Ensembl
    16. positive regulation of actin cytoskeleton reorganization Source: Ensembl
    17. positive regulation of cell migration Source: Ensembl
    18. positive regulation of cell proliferation Source: Ensembl
    19. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    20. positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    21. positive regulation of receptor internalization Source: Ensembl
    22. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    23. smooth muscle cell differentiation Source: Ensembl
    24. transmembrane receptor protein tyrosine kinase signaling pathway Source: Ensembl

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotrophin-3
    Short name:
    NT-3
    Alternative name(s):
    HDNF
    Nerve growth factor 2
    Short name:
    NGF-2
    Neurotrophic factor
    Gene namesi
    Name:NTF3
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Propeptidei19 – 138120PRO_0000019665Add
    BLAST
    Chaini139 – 257119Neurotrophin-3PRO_0000019666Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 217By similarity
    Disulfide bondi195 ↔ 246By similarity
    Disulfide bondi205 ↔ 248By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP25433.

    Expressioni

    Tissue specificityi

    In the embryo, the expression peak at E4.5 and decreases at later stages of development.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-127872.
    STRINGi9031.ENSGALP00000027867.

    Structurei

    3D structure databases

    ProteinModelPortaliP25433.
    SMRiP25433. Positions 143-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NGF-beta family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39844.
    HOGENOMiHOG000231516.
    HOVERGENiHBG006494.
    InParanoidiP25433.
    KOiK04356.
    OMAiYAEHKSH.
    PhylomeDBiP25433.
    TreeFamiTF106463.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR015578. Neurotrophin-3.
    [Graphical view]
    PANTHERiPTHR11589. PTHR11589. 1 hit.
    PTHR11589:SF4. PTHR11589:SF4. 1 hit.
    PfamiPF00243. NGF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001789. NGF. 1 hit.
    PRINTSiPR01914. NEUROTROPHN3.
    PR00268. NGF.
    ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00140. NGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25433-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSILFYVIFL AYLRGIQSTN MDQRSLPEDS MNSLIIKLIR ADILKNKLSK    50
    QVMDVKENYQ NIVQKVEDHQ EMDGDENVKS DFQPVISMDT DLLRQQRRYN 100
    SPRVLLSDNT PLEPPPLYLT EDYVGSSVVL NRTSRRKRYA EHKSHRGEYS 150
    VCDSESLWVT DKSSAIDIRG HQVTVLGEIK TGNSPVKQYF YETRCKEAKP 200
    VKNGCRGIDD KHWNSQCKTS QTYVRALTSE NNKLVGWRWI RIDTSCVCAL 250
    SRKIGRT 257
    Length:257
    Mass (Da):29,701
    Last modified:December 1, 1992 - v2
    Checksum:iEE043BA2A005C1E7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83378 Genomic DNA. Translation: AAA68880.1.
    Z30092 Genomic DNA. Translation: CAA82908.1.
    PIRiI50400.
    RefSeqiNP_001026659.1. NM_001031488.1.
    UniGeneiGga.41617.
    Gga.53128.

    Genome annotation databases

    GeneIDi428099.
    KEGGigga:428099.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M83378 Genomic DNA. Translation: AAA68880.1 .
    Z30092 Genomic DNA. Translation: CAA82908.1 .
    PIRi I50400.
    RefSeqi NP_001026659.1. NM_001031488.1.
    UniGenei Gga.41617.
    Gga.53128.

    3D structure databases

    ProteinModelPortali P25433.
    SMRi P25433. Positions 143-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-127872.
    STRINGi 9031.ENSGALP00000027867.

    Proteomic databases

    PaxDbi P25433.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 428099.
    KEGGi gga:428099.

    Organism-specific databases

    CTDi 4908.

    Phylogenomic databases

    eggNOGi NOG39844.
    HOGENOMi HOG000231516.
    HOVERGENi HBG006494.
    InParanoidi P25433.
    KOi K04356.
    OMAi YAEHKSH.
    PhylomeDBi P25433.
    TreeFami TF106463.

    Miscellaneous databases

    NextBioi 20829173.
    PROi P25433.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020408. Nerve_growth_factor-like.
    IPR002072. Nerve_growth_factor-rel.
    IPR019846. Nerve_growth_factor_CS.
    IPR015578. Neurotrophin-3.
    [Graphical view ]
    PANTHERi PTHR11589. PTHR11589. 1 hit.
    PTHR11589:SF4. PTHR11589:SF4. 1 hit.
    Pfami PF00243. NGF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001789. NGF. 1 hit.
    PRINTSi PR01914. NEUROTROPHN3.
    PR00268. NGF.
    ProDomi PD002052. Nerve_growth_factor-rel. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00140. NGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00248. NGF_1. 1 hit.
    PS50270. NGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene sequences of chicken BDNF and NT-3."
      Maisonpierre P., Belluscio L., Conover J.C., Yancopoulos G.D.
      DNA Seq. 3:49-54(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cellular localization of brain-derived neurotrophic factor and neurotrophin-3 mRNA expression in the early chicken embryo."
      Hallboeoek F., Ibanez C.F., Ebendal T., Persson H.
      Eur. J. Neurosci. 5:1-14(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 32-257.
    3. "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary."
      Hallboeoek F., Ibanez C.F., Persson H.
      Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-236.

    Entry informationi

    Entry nameiNTF3_CHICK
    AccessioniPrimary (citable) accession number: P25433
    Secondary accession number(s): Q6LAC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: December 1, 1992
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3