P25429 (BDNF_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-derived neurotrophic factor
Short name=BDNF

Gene names

Name:

BDNF

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.
Subcellular location	Secreted.
Sequence similarities	Belongs to the NGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from electronic annotation. Source: Compara axon target recognition Inferred from electronic annotation. Source: Compara dendrite development Inferred from electronic annotation. Source: Compara fear response Inferred from electronic annotation. Source: Compara feeding behavior Inferred from electronic annotation. Source: Compara glutamate secretion Inferred from electronic annotation. Source: Compara inner ear development Inferred from electronic annotation. Source: Compara learning or memory Inferred from electronic annotation. Source: Compara mechanoreceptor differentiation Inferred from electronic annotation. Source: Compara negative regulation of neuroblast proliferation Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from electronic annotation. Source: Compara nerve development Inferred from electronic annotation. Source: Compara neuron recognition Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of synapse assembly Inferred from electronic annotation. Source: Compara regulation of metabolic process Inferred from electronic annotation. Source: Compara regulation of retinal cell programmed cell death Inferred from electronic annotation. Source: Compara regulation of synaptic plasticity Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara ureteric bud development Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasmic membrane-bounded vesicle Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 127	109			PRO_0000019649
	Chain	128 – 246	119	Brain-derived neurotrophic factor		PRO_0000019650
Sites
	Site	57 – 58	2	Cleavage; by S1P By similarity
Amino acid modifications
	Glycosylation	120	1	N-linked (GlcNAc...) Potential
	Disulfide bond	140 ↔ 207		By similarity
	Disulfide bond	185 ↔ 236		By similarity
	Disulfide bond	195 ↔ 238		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P25429 [UniParc]. Last modified December 1, 1992. Version 2. Checksum: CE1D93E99FDD3BA0	FASTA	246	27,715
	10 20 30 40 50 60 MTILFLTMVI SYFSCMKAAP MKEASVRGHG SLAYPGLRTH GTLESLTGPN AGSRGLTSLA 70 80 90 100 110 120 DTFEHVIEEL LDEDQDIQPS EENKDADLYT SRVMLSSQVP LEPPLLFLLE EYKNYLDAAN 130 140 150 160 170 180 MSMRVRRHSD PARRGELSVC DSTSEWVTAA EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF 190 200 210 220 230 240 YETKCNPKGY TKEGCRGIDK RHWNSQCRTT QSYVRALTMD NKKRVGWRFI RIDTSCVCTL TIKRGR

References

[1]	"Gene sequences of chicken BDNF and NT-3." Maisonpierre P., Belluscio L., Conover J.C., Yancopoulos G.D. DNA Seq. 3:49-54(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Leghorn. Tissue: Liver.
[2]	"Brain-derived neurotrophic factor is critically involved in thermal-experience-dependent developmental plasticity." Katz A., Meiri N. J. Neurosci. 26:3899-3907(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Comparison of mammalian, chicken and Xenopus brain-derived neurotrophic factor coding sequences." Isackson P.J., Towner M.D., Huntsman M.M. FEBS Lett. 285:260-264(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 127-240.
[4]	"Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary." Hallboeoek F., Ibanez C.F., Persson H. Neuron 6:845-858(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 184-226.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M83377 Genomic DNA. Translation: AAC42220.1. DQ124361 mRNA. Translation: AAZ31074.1. X61476 mRNA. Translation: CAA43704.1.
IPI	IPI00600588.
PIR	I50606.
RefSeq	NP_001026787.1. NM_001031616.1.
UniGene	Gga.696.
3D structure databases
ProteinModelPortal	P25429.
SMR	P25429. Positions 135-243.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000019837.
Proteomic databases
PaxDb	P25429.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000019864; ENSGALP00000019837; ENSGALG00000012163.
GeneID	396186.
KEGG	gga:396186.
Organism-specific databases
CTD	627.
Phylogenomic databases
eggNOG	NOG45248.
GeneTree	ENSGT00390000007725.
HOGENOM	HOG000231516.
HOVERGEN	HBG006494.
InParanoid	P25429.
KO	K04355.
OMA	GQGSLAY.
OrthoDB	EOG4R503P.
Gene expression databases
ArrayExpress	P25429.
Family and domain databases
InterPro	IPR020430. Brain-der_neurotrophic_factor. IPR020408. Nerve_growth_factor-like. IPR002072. Nerve_growth_factor-rel. IPR019846. Nerve_growth_factor_CS. [Graphical view]
PANTHER	PTHR11589. PTHR11589. 1 hit.
Pfam	PF00243. NGF. 1 hit. [Graphical view]
PIRSF	PIRSF001789. NGF. 1 hit.
PRINTS	PR01912. BDNFACTOR. PR00268. NGF.
ProDom	PD002052. Nerve_growth_factor-rel. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00140. NGF. 1 hit. [Graphical view]
PROSITE	PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816238.

Entry information

Entry name

BDNF_CHICK

Accession

Primary (citable) accession number: P25429
Secondary accession number(s): Q45N27

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program