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Protein

Brain-derived neurotrophic factor

Gene

BDNF

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-GGA-9026527 Activated NTRK2 signals through PLCG1
R-GGA-9028731 Activated NTRK2 signals through FRS2 and FRS3

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-derived neurotrophic factor
Short name:
BDNF
Gene namesi
Name:BDNF
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001964919 – 127Add BLAST109
ChainiPRO_0000019650128 – 246Brain-derived neurotrophic factorAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 207By similarity
Disulfide bondi185 ↔ 236By similarity
Disulfide bondi195 ↔ 238By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57 – 58Cleavage; by S1PBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25429
PRIDEiP25429

Expressioni

Gene expression databases

BgeeiENSGALG00000012163
ExpressionAtlasiP25429 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019837

Structurei

3D structure databases

ProteinModelPortaliP25429
SMRiP25429
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH7X Eukaryota
ENOG410XRPH LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP25429
KOiK04355
OMAiRVGWRFI
OrthoDBiEOG091G0GHL
PhylomeDBiP25429
TreeFamiTF106463

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR020430 Brain-der_neurotrophic_factor
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF3 PTHR11589:SF3, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01912 BDNFACTOR
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILFLTMVI SYFSCMKAAP MKEASVRGHG SLAYPGLRTH GTLESLTGPN
60 70 80 90 100
AGSRGLTSLA DTFEHVIEEL LDEDQDIQPS EENKDADLYT SRVMLSSQVP
110 120 130 140 150
LEPPLLFLLE EYKNYLDAAN MSMRVRRHSD PARRGELSVC DSTSEWVTAA
160 170 180 190 200
EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF YETKCNPKGY TKEGCRGIDK
210 220 230 240
RHWNSQCRTT QSYVRALTMD NKKRVGWRFI RIDTSCVCTL TIKRGR
Length:246
Mass (Da):27,715
Last modified:December 1, 1992 - v2
Checksum:iCE1D93E99FDD3BA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83377 Genomic DNA Translation: AAC42220.1
DQ124361 mRNA Translation: AAZ31074.1
X61476 mRNA Translation: CAA43704.1
PIRiI50606
RefSeqiNP_001026787.1, NM_001031616.1
XP_015141637.1, XM_015286151.1
XP_015141638.1, XM_015286152.1
XP_015141639.1, XM_015286153.1
XP_015141640.1, XM_015286154.1
UniGeneiGga.696

Genome annotation databases

EnsembliENSGALT00000019864; ENSGALP00000019837; ENSGALG00000012163
ENSGALT00000083974; ENSGALP00000063948; ENSGALG00000012163
ENSGALT00000089246; ENSGALP00000063414; ENSGALG00000012163
GeneIDi396186
KEGGigga:396186

Similar proteinsi

Entry informationi

Entry nameiBDNF_CHICK
AccessioniPrimary (citable) accession number: P25429
Secondary accession number(s): Q45N27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 1, 1992
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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