Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Brain-derived neurotrophic factor

Gene

BDNF

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-derived neurotrophic factor
Short name:
BDNF
Gene namesi
Name:BDNF
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001964919 – 127Add BLAST109
ChainiPRO_0000019650128 – 246Brain-derived neurotrophic factorAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi140 ↔ 207By similarity
Disulfide bondi185 ↔ 236By similarity
Disulfide bondi195 ↔ 238By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57 – 58Cleavage; by S1PBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25429.

Expressioni

Gene expression databases

BgeeiENSGALG00000012163.
ExpressionAtlasiP25429. baseline and differential.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019837.

Structurei

3D structure databases

ProteinModelPortaliP25429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IH7X. Eukaryota.
ENOG410XRPH. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP25429.
KOiK04355.
OMAiRVGWRFI.
OrthoDBiEOG091G0GHL.
PhylomeDBiP25429.
TreeFamiTF106463.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01912. BDNFACTOR.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25429-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILFLTMVI SYFSCMKAAP MKEASVRGHG SLAYPGLRTH GTLESLTGPN
60 70 80 90 100
AGSRGLTSLA DTFEHVIEEL LDEDQDIQPS EENKDADLYT SRVMLSSQVP
110 120 130 140 150
LEPPLLFLLE EYKNYLDAAN MSMRVRRHSD PARRGELSVC DSTSEWVTAA
160 170 180 190 200
EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF YETKCNPKGY TKEGCRGIDK
210 220 230 240
RHWNSQCRTT QSYVRALTMD NKKRVGWRFI RIDTSCVCTL TIKRGR
Length:246
Mass (Da):27,715
Last modified:December 1, 1992 - v2
Checksum:iCE1D93E99FDD3BA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83377 Genomic DNA. Translation: AAC42220.1.
DQ124361 mRNA. Translation: AAZ31074.1.
X61476 mRNA. Translation: CAA43704.1.
PIRiI50606.
RefSeqiNP_001026787.1. NM_001031616.1.
XP_015141637.1. XM_015286151.1.
XP_015141638.1. XM_015286152.1.
XP_015141639.1. XM_015286153.1.
XP_015141640.1. XM_015286154.1.
UniGeneiGga.696.

Genome annotation databases

EnsembliENSGALT00000019864; ENSGALP00000019837; ENSGALG00000012163.
GeneIDi396186.
KEGGigga:396186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83377 Genomic DNA. Translation: AAC42220.1.
DQ124361 mRNA. Translation: AAZ31074.1.
X61476 mRNA. Translation: CAA43704.1.
PIRiI50606.
RefSeqiNP_001026787.1. NM_001031616.1.
XP_015141637.1. XM_015286151.1.
XP_015141638.1. XM_015286152.1.
XP_015141639.1. XM_015286153.1.
XP_015141640.1. XM_015286154.1.
UniGeneiGga.696.

3D structure databases

ProteinModelPortaliP25429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019837.

Proteomic databases

PaxDbiP25429.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000019864; ENSGALP00000019837; ENSGALG00000012163.
GeneIDi396186.
KEGGigga:396186.

Organism-specific databases

CTDi627.

Phylogenomic databases

eggNOGiENOG410IH7X. Eukaryota.
ENOG410XRPH. LUCA.
GeneTreeiENSGT00390000007725.
HOGENOMiHOG000231516.
HOVERGENiHBG006494.
InParanoidiP25429.
KOiK04355.
OMAiRVGWRFI.
OrthoDBiEOG091G0GHL.
PhylomeDBiP25429.
TreeFamiTF106463.

Miscellaneous databases

PROiP25429.

Gene expression databases

BgeeiENSGALG00000012163.
ExpressionAtlasiP25429. baseline and differential.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR020430. Brain-der_neurotrophic_factor.
IPR029034. Cystine-knot_cytokine.
IPR020408. Nerve_growth_factor-like.
IPR002072. Nerve_growth_factor-rel.
IPR019846. Nerve_growth_factor_CS.
[Graphical view]
PANTHERiPTHR11589. PTHR11589. 1 hit.
PfamiPF00243. NGF. 1 hit.
[Graphical view]
PIRSFiPIRSF001789. NGF. 1 hit.
PRINTSiPR01912. BDNFACTOR.
PR00268. NGF.
ProDomiPD002052. Nerve_growth_factor-rel. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00140. NGF. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00248. NGF_1. 1 hit.
PS50270. NGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBDNF_CHICK
AccessioniPrimary (citable) accession number: P25429
Secondary accession number(s): Q45N27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 1, 1992
Last modified: October 5, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.