ID   NGF_RAT                 Reviewed;         241 AA.
AC   P25427;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   24-NOV-2009, entry version 71.
DE   RecName: Full=Beta-nerve growth factor;
DE            Short=Beta-NGF;
DE   Flags: Precursor;
GN   Name=Ngf; Synonyms=Ngfb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   MEDLINE=89037223; PubMed=3184206; DOI=10.1002/jnr.490200402;
RA   Whittemore S.R., Friedman P.L., Larhammar D.G., Persson H.,
RA   Gonzalez-Carvajal M., Holets V.R.;
RT   "Rat beta-nerve growth factor sequence and site of synthesis in the
RT   adult hippocampus.";
RL   J. Neurosci. Res. 20:403-410(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 178-219.
RC   STRAIN=Sprague-Dawley; TISSUE=Liver;
RX   MEDLINE=91222573; PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA   Hallboeoek F., Ibanez C.F., Persson H.;
RT   "Evolutionary studies of the nerve growth factor family reveal a novel
RT   member abundantly expressed in Xenopus ovary.";
RL   Neuron 6:845-858(1991).
CC   -!- FUNCTION: Nerve growth factor is important for the development and
CC       maintenance of the sympathetic and sensory nervous systems. It
CC       stimulates division and differentiation of sympathetic and
CC       embryonic sensory neurons.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
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DR   EMBL; M36589; AAA41697.1; ALT_INIT; Genomic_DNA.
DR   IPI; IPI00368881; -.
DR   PIR; I56570; I56570.
DR   UniGene; Rn.22168; -.
DR   SMR; P25427; 129-239.
DR   STRING; P25427; -.
DR   Ensembl; ENSRNOT00000022200; ENSRNOP00000022200; ENSRNOG00000016571; Rattus norvegicus.
DR   NMPDR; fig|10116.3.peg.16731; -.
DR   RGD; 1598328; Ngf.
DR   HOVERGEN; P25427; -.
DR   ArrayExpress; P25427; -.
DR   Genevestigator; P25427; -.
DR   GermOnline; ENSRNOG00000016571; Rattus norvegicus.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; EXP:Reactome.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0005796; C:Golgi lumen; EXP:Reactome.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008344; P:adult locomotory behavior; IMP:RGD.
DR   GO; GO:0006954; P:inflammatory response; IEP:RGD.
DR   GO; GO:0007613; P:memory; IMP:RGD.
DR   GO; GO:0031175; P:neuron projection development; IDA:RGD.
DR   GO; GO:0030307; P:positive regulation of cell growth; IDA:RGD.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IDA:RGD.
DR   GO; GO:0042493; P:response to drug; IEP:RGD.
DR   GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
DR   GO; GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0009612; P:response to mechanical stimulus; IEP:RGD.
DR   GO; GO:0014070; P:response to organic cyclic substance; IEP:RGD.
DR   GO; GO:0043434; P:response to peptide hormone stimulus; IEP:RGD.
DR   GO; GO:0009314; P:response to radiation; IEP:RGD.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR020425; Nerve_growth_factor_bsu.
DR   InterPro; IPR020437; Nerve_growth_factor_bsu_mml.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; NGF; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01925; MAMLNGFBETA.
DR   PRINTS; PR00268; NGF.
DR   PRINTS; PR01913; NGFBETA.
DR   ProDom; PD002052; Nerve_growth_factor-rel; 1.
DR   SMART; SM00140; NGF; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Phosphoprotein; Secreted; Signal.
FT   SIGNAL        1     18       Potential.
FT   PROPEP       19    121       Potential.
FT                                /FTId=PRO_0000019609.
FT   CHAIN       122    241       Beta-nerve growth factor.
FT                                /FTId=PRO_0000019610.
FT   MOD_RES      84     84       Phosphoserine (By similarity).
FT   CARBOHYD     69     69       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    114    114       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    166    166       N-linked (GlcNAc...) (Potential).
FT   DISULFID    136    201       By similarity.
FT   DISULFID    179    229       By similarity.
FT   DISULFID    189    231       By similarity.
SQ   SEQUENCE   241 AA;  27010 MW;  665F42371563213D CRC64;
     MSMLFYTLIT AFLIGVQAEP YTDSNVPEGD SVPEAHWTKL QHSLDTALRR ARSAPAEPIA
     ARVTGQTRNI TVDPKLFKKR RLRSPRVLFS TQPPPTSSDT LDLDFQAHGT ISFNRTHRSK
     RSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL GEVNINNSVF KQYFFETKCR
     APNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDDKQAAW RFIRIDTACV CVLSRKAARR
     G
//