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Protein

Beta-nerve growth factor

Gene

Ngf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.By similarity

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: RGD
  • aging Source: RGD
  • cell-cell signaling Source: GO_Central
  • inflammatory response Source: RGD
  • memory Source: RGD
  • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: ParkinsonsUK-UCL
  • negative regulation of neuron apoptotic process Source: UniProtKB
  • negative regulation of type B pancreatic cell apoptotic process Source: RGD
  • neuron projection development Source: RGD
  • neuron projection morphogenesis Source: GO_Central
  • positive regulation of cell growth Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of DNA binding transcription factor activity Source: MGI
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of neurotrophin TRK receptor signaling pathway Source: MGI
  • positive regulation of protein autophosphorylation Source: MGI
  • positive regulation of protein binding Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of stem cell proliferation Source: RGD
  • response to drug Source: RGD
  • response to electrical stimulus Source: RGD
  • response to glucocorticoid Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to nicotine Source: RGD
  • response to organic cyclic compound Source: RGD
  • response to organic substance Source: RGD
  • response to ozone Source: RGD
  • response to peptide hormone Source: RGD
  • response to radiation Source: RGD
  • sensory perception of pain Source: RGD

Keywordsi

Molecular functionGrowth factor, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor

Enzyme and pathway databases

ReactomeiR-RNO-167060 NGF processing
R-RNO-170968 Frs2-mediated activation
R-RNO-170984 ARMS-mediated activation
R-RNO-177504 Retrograde neurotrophin signalling
R-RNO-187042 TRKA activation by NGF
R-RNO-198203 PI3K/AKT activation
R-RNO-205017 NFG and proNGF binds to p75NTR
R-RNO-205025 NADE modulates death signalling
R-RNO-205043 NRIF signals cell death from the nucleus
R-RNO-209543 p75NTR recruits signalling complexes
R-RNO-209560 NF-kB is activated and signals survival
R-RNO-209563 Axonal growth stimulation

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-nerve growth factor
Short name:
Beta-NGF
Gene namesi
Name:Ngf
Synonyms:Ngfb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1598328 Ngf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi221R → W: The mutant protein is unable to activate the NTRK1 receptor. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000001960919 – 121Sequence analysisAdd BLAST103
ChainiPRO_0000019610122 – 241Beta-nerve growth factorAdd BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 201By similarity
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi179 ↔ 229By similarity
Disulfide bondi189 ↔ 231By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP25427
PRIDEiP25427

Expressioni

Gene expression databases

BgeeiENSRNOG00000016571
ExpressionAtlasiP25427 baseline and differential
GenevisibleiP25427 RN

Interactioni

Subunit structurei

Homodimer. Interacts with ADAM10 in a divalent cation-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022200

Chemistry databases

BindingDBiP25427

Structurei

3D structure databases

ProteinModelPortaliP25427
SMRiP25427
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIPQ Eukaryota
ENOG4111F87 LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP25427
KOiK02582
PhylomeDBiP25427

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR020425 Nerve_growth_factor_bsu
IPR020437 Nerve_growth_factor_bsu_mml
IPR019846 Nerve_growth_factor_CS
PANTHERiPTHR11589 PTHR11589, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01925 MAMLNGFBETA
PR00268 NGF
PR01913 NGFBETA
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25427-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMLFYTLIT AFLIGVQAEP YTDSNVPEGD SVPEAHWTKL QHSLDTALRR
60 70 80 90 100
ARSAPAEPIA ARVTGQTRNI TVDPKLFKKR RLRSPRVLFS TQPPPTSSDT
110 120 130 140 150
LDLDFQAHGT ISFNRTHRSK RSSTHPVFHM GEFSVCDSVS VWVGDKTTAT
160 170 180 190 200
DIKGKEVTVL GEVNINNSVF KQYFFETKCR APNPVESGCR GIDSKHWNSY
210 220 230 240
CTTTHTFVKA LTTDDKQAAW RFIRIDTACV CVLSRKAARR G
Length:241
Mass (Da):27,010
Last modified:February 1, 1996 - v2
Checksum:i665F42371563213D
GO

Sequence cautioni

The sequence AAA41697 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36589 Genomic DNA Translation: AAA41697.1 Different initiation.
PIRiI56570
RefSeqiNP_001263984.1, NM_001277055.1
XP_006233114.1, XM_006233052.3
XP_006233115.1, XM_006233053.2
UniGeneiRn.22168

Genome annotation databases

EnsembliENSRNOT00000022200; ENSRNOP00000022200; ENSRNOG00000016571
GeneIDi310738
KEGGirno:310738

Similar proteinsi

Entry informationi

Entry nameiNGF_RAT
AccessioniPrimary (citable) accession number: P25427
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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