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Protein

63 kDa chaperonin, mitochondrial

Gene
N/A
Organism
Heliothis virescens (Tobacco budworm moth)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity).By similarity

Miscellaneous

Shows ATPase activity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
63 kDa chaperonin, mitochondrial
Alternative name(s):
p63
OrganismiHeliothis virescens (Tobacco budworm moth)
Taxonomic identifieri7102 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaLepidopteraGlossataDitrysiaNoctuoideaNoctuidaeHeliothinaeHeliothis

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29Mitochondrion1 PublicationAdd BLAST29
ChainiPRO_000000503430 – 56963 kDa chaperonin, mitochondrialAdd BLAST540

Expressioni

Tissue specificityi

Testis.

Developmental stagei

From the latter half of the larval final-instar, through the first two days of pupal development.

Interactioni

Subunit structurei

Forms a single seven-member ring complex, in tight association with the p60 protein.

Structurei

3D structure databases

ProteinModelPortaliP25420.
SMRiP25420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25420-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKMYRSPHI TRNSFKYLKA TNINSCRFYA KEVRFGPDVR SLMLQGVDIL
60 70 80 90 100
ADADDVTMGP KGVNVILAKN LGPPKITKDG VTVAKGIDLK DKFQNIGARL
110 120 130 140 150
VQNVANKTNE EAGDGTTTAT VLARPIAKEG FENISRGANP IEIRKGVMLA
160 170 180 190 200
VESVKRQLKE MSKPVNTSEE IEQVATISAN GDESIGKLIA AAMNRVGKNG
210 220 230 240 250
VITVKDGKTL EDELEIIEGM KFDRGYVSPY FINSNKGPKV EYNDALVLYS
260 270 280 290 300
EKKIYYASQV VPALELANSQ KKPLVIIAED YDGEPLSVLV VNKLKIGLPV
310 320 330 340 350
VAVKAPGFGE YRTNALLDMA AATGGVFEDD TNLVRLEDCQ AESFGQVGEV
360 370 380 390 400
IITKDSTLLL KGKGDPNEIK QRIDQIKEEL ETATSNYDRE RLIDRLGRLQ
410 420 430 440 450
SGVAVLLIGG CSEVEVNEKK DRVNDALNAT RAAVEEGIVP GGGAALLRCI
460 470 480 490 500
PALDLLKPAN KDQEIGVSII KKALRTPCIT IASNAGFDGA VVVSKVEDMG
510 520 530 540 550
PEYGYDALNN EYVNMIEKGI IDPTKVVRRA LTDASGVASL LTTAEAVICD
560
MPKQKDPPPE YAPIGGGDY
Length:569
Mass (Da):61,508
Last modified:May 1, 1992 - v1
Checksum:i1089DB9E87BA3CCA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56034 Genomic DNA. Translation: CAA39509.1.
PIRiS11035.

Similar proteinsi

Entry informationi

Entry nameiCH63_HELVI
AccessioniPrimary (citable) accession number: P25420
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 22, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families