Reviewed, UniProtKB/Swiss-Prot P25415 (DHQA_EMENI)

Names and origin

Protein names

Recommended name:
    Quinate dehydrogenase
    EC=1.1.1.24

Gene names

Name:	qutB
ORF Names:	AN1137

Organism

Emericella nidulans (Aspergillus nidulans)

Taxonomic identifier

162425 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › Emericella

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Quinate + NAD+ = 3-dehydroquinate + NADH.
Pathway	Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3-dehydroquinate from quinate (NAD route): step 1/1.

Ontologies

Keywords
Biological process	Quinate metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW quinate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	binding Inferred from electronic annotation. Source: InterPro quinate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Quinate dehydrogenase		PRO_0000079892
Experimental info
	Sequence conflict	22	1	R → P in EAA66255. Ref.1
	Sequence conflict	242	1	V → L in EAA66255. Ref.1
	Sequence conflict	297	1	L → V in EAA66255. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P25415-1 [UniParc]. Last modified May 26, 2009. Version 3. Checksum: 468ABB6CBA7E5B57	FASTA	329	36,090
	10 20 30 40 50 60 MEPITIPTDR DGVAYLYGHP LRNSLSPPLH QTVYNALGLN WTQIPLSTAT GTSFTRSPEI 70 80 90 100 110 120 STFLSSVRSN PKFVGSSVTM PWKVAIMPHL DDLTEDARQA GACNTIYLRK EDDGKTQYVG 130 140 150 160 170 180 TNTDCIGIRE ALLQGSPNGA EHFKGKPALI VGGGGTARTA IYVLRKWLGV SKIYIVNRDA 190 200 210 220 230 240 KEVEAILAED KQRNPSPQVA LVPVSDPSAA ATLEAPVAVV SGIPNYPPQT EEEIRARETL 250 260 270 280 290 300 RVFLNRQTHE KDQGVILEMC YHPLPWTDIA QIAQDARWKV ILGSEALIWQ GLEQARLWTG 310 320 KDVVSEPGLV EKVQAFVAQT IAERSKSNL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular organisation of the quinic acid utilization (QUT) gene cluster in Aspergillus nidulans." Hawkins A.R., Lamb H.K., Smith M., Keyte J.W., Roberts C.F. Mol. Gen. Genet. 214:224-231(1988) [PubMed: 2976880] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae." Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W. Nature 438:1105-1115(2005) [PubMed: 16372000] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FGSC 4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X13525 Genomic DNA. Translation: CAA31880.1. AACD01000016 Genomic DNA. Translation: EAA66255.1.
PIR	S08499.
3D structure databases
HSSP	HSSP built from PDB template 1NVT based on UniProtKB Q58484.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.24. 3859.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

DHQA_EMENI

Accession

Primary (citable) accession number: P25415
Secondary accession number(s): Q5BE93

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	May 26, 2009
Last modified:	June 16, 2009
This is version 47 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)