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Protein

Chaperone protein FaeE

Gene

faeE

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Mediates assembly of pili by forming soluble multimeric complexes with pili subunits as an intermediate step in the assembly process. This protein is involved in K88 pili assembly. Protects pilin protein from proteolytic degradation by DegP and from premature polymerization.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Fimbrium biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein FaeE
Gene namesi
Name:faeE
Encoded oniPlasmid pFM2050 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000000927035 – 258Chaperone protein FaeEAdd BLAST224

Structurei

Secondary structure

1258
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 39Combined sources4
Beta strandi41 – 46Combined sources6
Beta strandi52 – 58Combined sources7
Beta strandi61 – 63Combined sources3
Beta strandi65 – 75Combined sources11
Beta strandi82 – 92Combined sources11
Beta strandi97 – 104Combined sources8
Beta strandi111 – 113Combined sources3
Beta strandi115 – 124Combined sources10
Beta strandi129 – 132Combined sources4
Beta strandi135 – 146Combined sources12
Helixi148 – 150Combined sources3
Helixi157 – 160Combined sources4
Beta strandi162 – 165Combined sources4
Beta strandi171 – 174Combined sources4
Beta strandi177 – 179Combined sources3
Beta strandi183 – 188Combined sources6
Beta strandi191 – 193Combined sources3
Helixi198 – 204Combined sources7
Beta strandi212 – 214Combined sources3
Beta strandi219 – 225Combined sources7
Beta strandi231 – 237Combined sources7
Turni243 – 245Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F65X-ray2.29A/B/C/D/E/F/G/H35-258[»]
3F6IX-ray2.79A/B35-258[»]
3F6LX-ray2.80A/B35-258[»]
3GEWX-ray2.00B/C35-258[»]
3GFUX-ray1.99A/C35-258[»]
ProteinModelPortaliP25401.
SMRiP25401.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25401.

Family & Domainsi

Sequence similaritiesi

Belongs to the periplasmic pilus chaperone family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR001829. Pili_assmbl_chaperone_bac.
IPR016148. Pili_assmbl_chaperone_C.
IPR018046. Pili_assmbl_chaperone_CS.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF00345. PapD_N. 1 hit.
[Graphical view]
PRINTSiPR00969. CHAPERONPILI.
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
PROSITEiPS00635. PILI_CHAPERONE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRNAVTTF FTNRVTKALG MTLALMMTCQ SAMASLAVDQ TRYIFRGDKD
60 70 80 90 100
ALTITVTNND KERTFGGQAW VDNIVEKDTR PTFVVTPSFF KVKPNGQQTL
110 120 130 140 150
RIIMASDHLP KDKESVYWLN LQDIPPALEG SGIAVALRTK LKLFYRPKAL
160 170 180 190 200
LEGRKGAEEG ISLQSRPDGR TMLVNTTPYI FAIGSLLDGN GKKIATDNGT
210 220 230 240 250
TQKLLMFMPG DEVQVKGNVV KVDSLNDYGE LQTWTINKKK PAAPEAAKAE

KADTAEQK
Length:258
Mass (Da):28,478
Last modified:May 1, 1992 - v1
Checksum:iFF80904B3DE5420B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56003 Genomic DNA. Translation: CAA39478.1.
Z11699 Genomic DNA. Translation: CAA77756.1.
PIRiS15227.
RefSeqiWP_000044493.1. NZ_LVOL01000086.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56003 Genomic DNA. Translation: CAA39478.1.
Z11699 Genomic DNA. Translation: CAA77756.1.
PIRiS15227.
RefSeqiWP_000044493.1. NZ_LVOL01000086.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F65X-ray2.29A/B/C/D/E/F/G/H35-258[»]
3F6IX-ray2.79A/B35-258[»]
3F6LX-ray2.80A/B35-258[»]
3GEWX-ray2.00B/C35-258[»]
3GFUX-ray1.99A/C35-258[»]
ProteinModelPortaliP25401.
SMRiP25401.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP25401.

Family and domain databases

Gene3Di2.60.40.1070. 1 hit.
2.60.40.360. 1 hit.
InterProiIPR008962. PapD-like.
IPR001829. Pili_assmbl_chaperone_bac.
IPR016148. Pili_assmbl_chaperone_C.
IPR018046. Pili_assmbl_chaperone_CS.
IPR016147. Pili_assmbl_chaperone_N.
[Graphical view]
PfamiPF00345. PapD_N. 1 hit.
[Graphical view]
PRINTSiPR00969. CHAPERONPILI.
SUPFAMiSSF49354. SSF49354. 1 hit.
SSF49584. SSF49584. 1 hit.
PROSITEiPS00635. PILI_CHAPERONE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFAEE_ECOLX
AccessioniPrimary (citable) accession number: P25401
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 30, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.