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Protein

40S ribosomal protein S12

Gene

RPS12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112306-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S12
Gene namesi
Name:RPS12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:10385. RPS12.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi6206.
OpenTargetsiENSG00000112306.
PharmGKBiPA34784.

Polymorphism and mutation databases

BioMutaiRPS12.
DMDMi224471878.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001223232 – 13240S ribosomal protein S12Add BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei129N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP25398.
MaxQBiP25398.
PaxDbiP25398.
PeptideAtlasiP25398.
PRIDEiP25398.
TopDownProteomicsiP25398.

2D gel databases

UCD-2DPAGEP25398.

PTM databases

iPTMnetiP25398.
PhosphoSitePlusiP25398.
SwissPalmiP25398.

Expressioni

Gene expression databases

BgeeiENSG00000112306.
CleanExiHS_RPS12.
GenevisibleiP25398. HS.

Organism-specific databases

HPAiHPA006124.

Interactioni

Protein-protein interaction databases

BioGridi112120. 120 interactors.
IntActiP25398. 24 interactors.
MINTiMINT-1160578.
STRINGi9606.ENSP00000230050.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00AM1-132[»]
5A2Qelectron microscopy3.90M1-132[»]
5AJ0electron microscopy3.50BM1-132[»]
5FLXelectron microscopy3.90M1-132[»]
ProteinModelPortaliP25398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S12e family.Curated

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00390000018318.
HOGENOMiHOG000210688.
HOVERGENiHBG001720.
InParanoidiP25398.
KOiK02951.
OMAiNCDEPTY.
OrthoDBiEOG091G0UB5.
PhylomeDBiP25398.
TreeFamiTF300196.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
[Graphical view]
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01189. RIBOSOMAL_S12E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEGIAAGG VMDVNTALQE VLKTALIHDG LARGIREAAK ALDKRQAHLC
60 70 80 90 100
VLASNCDEPM YVKLVEALCA EHQINLIKVD DNKKLGEWVG LCKIDREGKP
110 120 130
RKVVGCSCVV VKDYGKESQA KDVIEEYFKC KK
Length:132
Mass (Da):14,515
Last modified:March 3, 2009 - v3
Checksum:i45AD1274D55FFA25
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52L → Q in CAA37582 (PubMed:1861993).Curated1
Sequence conflicti69C → L in CAA37582 (PubMed:1861993).Curated1
Sequence conflicti99K → N in CAA37582 (PubMed:1861993).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53505 mRNA. Translation: CAA37582.1.
AB061840 Genomic DNA. Translation: BAB79478.1.
AK311826 mRNA. Translation: BAG34768.1.
AL137783 Genomic DNA. Translation: CAC12946.1.
CH471051 Genomic DNA. Translation: EAW48011.1.
BC017321 mRNA. Translation: AAH17321.1.
BC071930 mRNA. Translation: AAH71930.1.
BC095424 mRNA. Translation: AAH95424.1.
AB007153 Genomic DNA. Translation: BAA25819.1.
CCDSiCCDS5164.1.
PIRiS22989. R3HU12.
RefSeqiNP_001007.2. NM_001016.3.
UniGeneiHs.546289.

Genome annotation databases

EnsembliENST00000230050; ENSP00000230050; ENSG00000112306.
GeneIDi6206.
KEGGihsa:6206.
UCSCiuc003qdx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53505 mRNA. Translation: CAA37582.1.
AB061840 Genomic DNA. Translation: BAB79478.1.
AK311826 mRNA. Translation: BAG34768.1.
AL137783 Genomic DNA. Translation: CAC12946.1.
CH471051 Genomic DNA. Translation: EAW48011.1.
BC017321 mRNA. Translation: AAH17321.1.
BC071930 mRNA. Translation: AAH71930.1.
BC095424 mRNA. Translation: AAH95424.1.
AB007153 Genomic DNA. Translation: BAA25819.1.
CCDSiCCDS5164.1.
PIRiS22989. R3HU12.
RefSeqiNP_001007.2. NM_001016.3.
UniGeneiHs.546289.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Xelectron microscopy5.00AM1-132[»]
5A2Qelectron microscopy3.90M1-132[»]
5AJ0electron microscopy3.50BM1-132[»]
5FLXelectron microscopy3.90M1-132[»]
ProteinModelPortaliP25398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112120. 120 interactors.
IntActiP25398. 24 interactors.
MINTiMINT-1160578.
STRINGi9606.ENSP00000230050.

PTM databases

iPTMnetiP25398.
PhosphoSitePlusiP25398.
SwissPalmiP25398.

Polymorphism and mutation databases

BioMutaiRPS12.
DMDMi224471878.

2D gel databases

UCD-2DPAGEP25398.

Proteomic databases

EPDiP25398.
MaxQBiP25398.
PaxDbiP25398.
PeptideAtlasiP25398.
PRIDEiP25398.
TopDownProteomicsiP25398.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230050; ENSP00000230050; ENSG00000112306.
GeneIDi6206.
KEGGihsa:6206.
UCSCiuc003qdx.4. human.

Organism-specific databases

CTDi6206.
DisGeNETi6206.
GeneCardsiRPS12.
HGNCiHGNC:10385. RPS12.
HPAiHPA006124.
MIMi603660. gene.
neXtProtiNX_P25398.
OpenTargetsiENSG00000112306.
PharmGKBiPA34784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3406. Eukaryota.
COG1358. LUCA.
GeneTreeiENSGT00390000018318.
HOGENOMiHOG000210688.
HOVERGENiHBG001720.
InParanoidiP25398.
KOiK02951.
OMAiNCDEPTY.
OrthoDBiEOG091G0UB5.
PhylomeDBiP25398.
TreeFamiTF300196.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000112306-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRPS12. human.
GeneWikiiRPS12.
GenomeRNAii6206.
PROiP25398.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112306.
CleanExiHS_RPS12.
GenevisibleiP25398. HS.

Family and domain databases

Gene3Di3.30.1330.30. 1 hit.
InterProiIPR029064. L30e-like.
IPR004038. Ribosomal_L7Ae/L30e/S12e/Gad45.
IPR000530. Ribosomal_S12e.
[Graphical view]
PANTHERiPTHR11843. PTHR11843. 1 hit.
PfamiPF01248. Ribosomal_L7Ae. 1 hit.
[Graphical view]
PRINTSiPR00972. RIBSOMALS12E.
SUPFAMiSSF55315. SSF55315. 1 hit.
PROSITEiPS01189. RIBOSOMAL_S12E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS12_HUMAN
AccessioniPrimary (citable) accession number: P25398
Secondary accession number(s): Q76M58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 3, 2009
Last modified: November 2, 2016
This is version 159 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.