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Protein

Tellurite resistance protein TehA

Gene

tehA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance (By similarity). Otherwise, phenotypically silent.By similarity

Caution

Was originally thought to be plasmid encoded.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei262Important for gating; obstructs channel and prevents ion flux in the closed conformationBy similarity1

GO - Molecular functioni

  • cation efflux transmembrane transporter activity Source: EcoCyc
  • identical protein binding Source: IntAct

GO - Biological processi

  • cation transport Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW
  • response to tellurium ion Source: EcoCyc
  • transmembrane transport Source: EcoCyc

Keywordsi

Molecular functionIon channel
Biological processAntibiotic resistance, Ion transport, Tellurium resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:TEHA-MONOMER
MetaCyc:TEHA-MONOMER

Protein family/group databases

TCDBi2.A.16.1.1 the telurite-resistance/dicarboxylate transporter (tdt) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tellurite resistance protein TehA
Gene namesi
Name:tehA
Ordered Locus Names:b1429, JW1425
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11883 tehA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicBy similarity7
Transmembranei8 – 28HelicalBy similarityAdd BLAST21
Topological domaini29 – 35PeriplasmicBy similarity7
Transmembranei36 – 59HelicalBy similarityAdd BLAST24
Topological domaini60 – 79CytoplasmicBy similarityAdd BLAST20
Transmembranei80 – 98HelicalBy similarityAdd BLAST19
Topological domaini99 – 101PeriplasmicBy similarity3
Transmembranei102 – 127HelicalBy similarityAdd BLAST26
Topological domaini128 – 138CytoplasmicBy similarityAdd BLAST11
Transmembranei139 – 159HelicalBy similarityAdd BLAST21
Topological domaini160 – 161PeriplasmicBy similarity2
Transmembranei162 – 189HelicalBy similarityAdd BLAST28
Topological domaini190 – 194CytoplasmicBy similarity5
Transmembranei195 – 218HelicalBy similarityAdd BLAST24
Topological domaini219 – 224PeriplasmicBy similarity6
Transmembranei225 – 248HelicalBy similarityAdd BLAST24
Topological domaini249 – 254CytoplasmicBy similarity6
Transmembranei255 – 275HelicalBy similarityAdd BLAST21
Topological domaini276 – 283PeriplasmicBy similarity8
Transmembranei284 – 310HelicalBy similarityAdd BLAST27
Topological domaini311 – 330CytoplasmicBy similarityAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724791 – 330Tellurite resistance protein TehAAdd BLAST330

Proteomic databases

PaxDbiP25396
PRIDEiP25396

Interactioni

Subunit structurei

Homotrimer. Each subunit forms a channel (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15888098,EBI-15888098

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi4261847, 4 interactors
DIPiDIP-10977N
STRINGi316385.ECDH10B_1556

Structurei

3D structure databases

ProteinModelPortaliP25396
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108NKP Bacteria
COG1275 LUCA
HOGENOMiHOG000120585
InParanoidiP25396
KOiK03304
OMAiWIGTIGQ
PhylomeDBiP25396

Family and domain databases

Gene3Di1.50.10.150, 1 hit
InterProiView protein in InterPro
IPR011552 TehA/Mae1
IPR004695 Voltage-dep_anion_channel
IPR038665 Voltage-dep_anion_channel_sf
PfamiView protein in Pfam
PF03595 SLAC1, 1 hit
TIGRFAMsiTIGR00816 tdt, 1 hit

Sequencei

Sequence statusi: Complete.

P25396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSDKVLNLP AGYFGIVLGT IGMGFAWRYA SQVWQVSHWL GDGLVILAMI
60 70 80 90 100
IWGLLTSAFI ARLIRFPHSV LAEVRHPVLS SFVSLFPATT MLVAIGFVPW
110 120 130 140 150
FRPLAVCLFS FGVVVQLAYA AWQTAGLWRG SHPEEATTPG LYLPTVANNF
160 170 180 190 200
ISAMACGALG YTDAGLVFLG AGVFSWLSLE PVILQRLRSS GELPTALRTS
210 220 230 240 250
LGIQLAPALV ACSAWLSVNG GEGDTLAKML FGYGLLQLLF MLRLMPWYLS
260 270 280 290 300
QPFNASFWSF SFGVSALATT GLHLGSGSDN GFFHTLAVPL FIFTNFIIAI
310 320 330
LLIRTFALLM QGKLLVRTER AVLMKAEDKE
Length:330
Mass (Da):35,932
Last modified:May 1, 1992 - v1
Checksum:iBC592152A2D2FFF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74072 Unassigned DNA Translation: AAA19563.1
U00096 Genomic DNA Translation: AAC74511.1
AP009048 Genomic DNA Translation: BAA15058.1
PIRiH64894
RefSeqiNP_415946.1, NC_000913.3
WP_001301046.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC74511; AAC74511; b1429
BAA15058; BAA15058; BAA15058
GeneIDi945852
KEGGiecj:JW1425
eco:b1429
PATRICifig|1411691.4.peg.842

Similar proteinsi

Entry informationi

Entry nameiTEHA_ECOLI
AccessioniPrimary (citable) accession number: P25396
Secondary accession number(s): P76864
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: April 25, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health