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Protein

Tellurite resistance protein TehA

Gene

tehA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for potassium tellurite resistance when present in high copy number. Ion channel involved in potassium tellurite resistance (By similarity). Otherwise, phenotypically silent.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei262Important for gating; obstructs channel and prevents ion flux in the closed conformationBy similarity1

GO - Molecular functioni

  • cation efflux transmembrane transporter activity Source: EcoCyc

GO - Biological processi

  • cation transport Source: EcoCyc
  • response to antibiotic Source: UniProtKB-KW
  • response to tellurium ion Source: EcoCyc
  • transmembrane transport Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Antibiotic resistance, Ion transport, Tellurium resistance, Transport

Enzyme and pathway databases

BioCyciEcoCyc:TEHA-MONOMER.
ECOL316407:JW1425-MONOMER.
MetaCyc:TEHA-MONOMER.

Protein family/group databases

TCDBi2.A.16.1.1. the telurite-resistance/dicarboxylate transporter (tdt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tellurite resistance protein TehA
Gene namesi
Name:tehA
Ordered Locus Names:b1429, JW1425
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11883. tehA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicBy similarity7
Transmembranei8 – 28HelicalBy similarityAdd BLAST21
Topological domaini29 – 35PeriplasmicBy similarity7
Transmembranei36 – 59HelicalBy similarityAdd BLAST24
Topological domaini60 – 79CytoplasmicBy similarityAdd BLAST20
Transmembranei80 – 98HelicalBy similarityAdd BLAST19
Topological domaini99 – 101PeriplasmicBy similarity3
Transmembranei102 – 127HelicalBy similarityAdd BLAST26
Topological domaini128 – 138CytoplasmicBy similarityAdd BLAST11
Transmembranei139 – 159HelicalBy similarityAdd BLAST21
Topological domaini160 – 161PeriplasmicBy similarity2
Transmembranei162 – 189HelicalBy similarityAdd BLAST28
Topological domaini190 – 194CytoplasmicBy similarity5
Transmembranei195 – 218HelicalBy similarityAdd BLAST24
Topological domaini219 – 224PeriplasmicBy similarity6
Transmembranei225 – 248HelicalBy similarityAdd BLAST24
Topological domaini249 – 254CytoplasmicBy similarity6
Transmembranei255 – 275HelicalBy similarityAdd BLAST21
Topological domaini276 – 283PeriplasmicBy similarity8
Transmembranei284 – 310HelicalBy similarityAdd BLAST27
Topological domaini311 – 330CytoplasmicBy similarityAdd BLAST20

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000724791 – 330Tellurite resistance protein TehAAdd BLAST330

Proteomic databases

PaxDbiP25396.
PRIDEiP25396.

Interactioni

Subunit structurei

Homotrimer. Each subunit forms a channel (By similarity).By similarity

Protein-protein interaction databases

BioGridi4261847. 4 interactors.
DIPiDIP-10977N.
STRINGi511145.b1429.

Structurei

3D structure databases

ProteinModelPortaliP25396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108NKP. Bacteria.
COG1275. LUCA.
HOGENOMiHOG000120585.
InParanoidiP25396.
KOiK03304.
OMAiWIALFTI.
PhylomeDBiP25396.

Family and domain databases

InterProiIPR011552. TehA/Mae1.
IPR004695. Voltage-dep_anion_channel.
[Graphical view]
PfamiPF03595. SLAC1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00816. tdt. 1 hit.

Sequencei

Sequence statusi: Complete.

P25396-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSDKVLNLP AGYFGIVLGT IGMGFAWRYA SQVWQVSHWL GDGLVILAMI
60 70 80 90 100
IWGLLTSAFI ARLIRFPHSV LAEVRHPVLS SFVSLFPATT MLVAIGFVPW
110 120 130 140 150
FRPLAVCLFS FGVVVQLAYA AWQTAGLWRG SHPEEATTPG LYLPTVANNF
160 170 180 190 200
ISAMACGALG YTDAGLVFLG AGVFSWLSLE PVILQRLRSS GELPTALRTS
210 220 230 240 250
LGIQLAPALV ACSAWLSVNG GEGDTLAKML FGYGLLQLLF MLRLMPWYLS
260 270 280 290 300
QPFNASFWSF SFGVSALATT GLHLGSGSDN GFFHTLAVPL FIFTNFIIAI
310 320 330
LLIRTFALLM QGKLLVRTER AVLMKAEDKE
Length:330
Mass (Da):35,932
Last modified:May 1, 1992 - v1
Checksum:iBC592152A2D2FFF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74072 Unassigned DNA. Translation: AAA19563.1.
U00096 Genomic DNA. Translation: AAC74511.1.
AP009048 Genomic DNA. Translation: BAA15058.1.
PIRiH64894.
RefSeqiNP_415946.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAC74511; AAC74511; b1429.
BAA15058; BAA15058; BAA15058.
GeneIDi945852.
KEGGiecj:JW1425.
eco:b1429.
PATRICi32118142. VBIEscCol129921_1491.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74072 Unassigned DNA. Translation: AAA19563.1.
U00096 Genomic DNA. Translation: AAC74511.1.
AP009048 Genomic DNA. Translation: BAA15058.1.
PIRiH64894.
RefSeqiNP_415946.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP25396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261847. 4 interactors.
DIPiDIP-10977N.
STRINGi511145.b1429.

Protein family/group databases

TCDBi2.A.16.1.1. the telurite-resistance/dicarboxylate transporter (tdt) family.

Proteomic databases

PaxDbiP25396.
PRIDEiP25396.

Protocols and materials databases

DNASUi945852.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74511; AAC74511; b1429.
BAA15058; BAA15058; BAA15058.
GeneIDi945852.
KEGGiecj:JW1425.
eco:b1429.
PATRICi32118142. VBIEscCol129921_1491.

Organism-specific databases

EchoBASEiEB1829.
EcoGeneiEG11883. tehA.

Phylogenomic databases

eggNOGiENOG4108NKP. Bacteria.
COG1275. LUCA.
HOGENOMiHOG000120585.
InParanoidiP25396.
KOiK03304.
OMAiWIALFTI.
PhylomeDBiP25396.

Enzyme and pathway databases

BioCyciEcoCyc:TEHA-MONOMER.
ECOL316407:JW1425-MONOMER.
MetaCyc:TEHA-MONOMER.

Miscellaneous databases

PROiP25396.

Family and domain databases

InterProiIPR011552. TehA/Mae1.
IPR004695. Voltage-dep_anion_channel.
[Graphical view]
PfamiPF03595. SLAC1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00816. tdt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTEHA_ECOLI
AccessioniPrimary (citable) accession number: P25396
Secondary accession number(s): P76864
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be plasmid encoded.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.