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P25391

- LAMA1_HUMAN

UniProt

P25391 - LAMA1_HUMAN

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Protein
Laminin subunit alpha-1
Gene
LAMA1, LAMA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: UniProtKB
  2. glycosphingolipid binding Source: Ensembl
  3. protein binding Source: IntAct

GO - Biological processi

  1. axon guidance Source: Reactome
  2. branching involved in salivary gland morphogenesis Source: Ensembl
  3. cell adhesion Source: UniProtKB-KW
  4. cell surface receptor signaling pathway Source: UniProtKB
  5. epithelial tube branching involved in lung morphogenesis Source: Ensembl
  6. establishment of epithelial cell apical/basal polarity Source: Ensembl
  7. extracellular matrix organization Source: Reactome
  8. morphogenesis of an epithelial sheet Source: Ensembl
  9. regulation of cell adhesion Source: InterPro
  10. regulation of cell migration Source: InterPro
  11. regulation of embryonic development Source: InterPro
  12. retinal blood vessel morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_163874. Non-integrin membrane-ECM interactions.
REACT_163906. ECM proteoglycans.
REACT_169262. Laminin interactions.
REACT_22205. L1CAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Laminin subunit alpha-1
Alternative name(s):
Laminin A chain
Laminin-1 subunit alpha
Laminin-3 subunit alpha
S-laminin subunit alpha
Short name:
S-LAM alpha
Gene namesi
Name:LAMA1
Synonyms:LAMA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:6481. LAMA1.

Subcellular locationi

GO - Cellular componenti

  1. basement membrane Source: UniProtKB
  2. cell-cell junction Source: Ensembl
  3. extracellular region Source: Reactome
  4. extracellular space Source: UniProtKB
  5. laminin-1 complex Source: UniProtKB
  6. laminin-3 complex Source: UniProtKB
  7. proteinaceous extracellular matrix Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30270.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 30753058Laminin subunit alpha-1
PRO_0000017054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi270 ↔ 279 By similarity
Disulfide bondi272 ↔ 290 By similarity
Disulfide bondi292 ↔ 301 By similarity
Disulfide bondi297 ↔ 305 Reviewed prediction
Disulfide bondi304 ↔ 324 By similarity
Disulfide bondi327 ↔ 336 By similarity
Disulfide bondi329 ↔ 361 By similarity
Disulfide bondi364 ↔ 373 By similarity
Disulfide bondi376 ↔ 394 By similarity
Disulfide bondi397 ↔ 409 By similarity
Disulfide bondi399 ↔ 427 By similarity
Disulfide bondi429 ↔ 438 By similarity
Disulfide bondi441 ↔ 451 By similarity
Disulfide bondi454 ↔ 467 By similarity
Disulfide bondi456 ↔ 471 By similarity
Disulfide bondi473 ↔ 482 By similarity
Disulfide bondi485 ↔ 500 By similarity
Glycosylationi555 – 5551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi665 – 6651N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi742 ↔ 751 By similarity
Disulfide bondi744 ↔ 757 By similarity
Disulfide bondi760 ↔ 769 By similarity
Glycosylationi763 – 7631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi772 ↔ 788 By similarity
Disulfide bondi791 ↔ 806 By similarity
Disulfide bondi793 ↔ 816 By similarity
Disulfide bondi819 ↔ 828 By similarity
Disulfide bondi831 ↔ 846 By similarity
Disulfide bondi849 ↔ 863 By similarity
Disulfide bondi851 ↔ 870 By similarity
Disulfide bondi873 ↔ 882 By similarity
Disulfide bondi885 ↔ 899 By similarity
Disulfide bondi902 ↔ 914 By similarity
Disulfide bondi904 ↔ 921 By similarity
Disulfide bondi923 ↔ 932 By similarity
Glycosylationi926 – 9261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi935 ↔ 948 By similarity
Disulfide bondi951 ↔ 963 By similarity
Glycosylationi952 – 9521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi953 ↔ 969 By similarity
Disulfide bondi971 ↔ 980 By similarity
Disulfide bondi983 ↔ 995 By similarity
Disulfide bondi998 ↔ 1007 By similarity
Disulfide bondi1000 ↔ 1014 By similarity
Disulfide bondi1016 ↔ 1025 By similarity
Disulfide bondi1028 ↔ 1041 By similarity
Disulfide bondi1044 ↔ 1056 By similarity
Glycosylationi1045 – 10451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1046 ↔ 1063 By similarity
Disulfide bondi1065 ↔ 1074 By similarity
Disulfide bondi1077 ↔ 1087 By similarity
Disulfide bondi1090 ↔ 1102 By similarity
Disulfide bondi1092 ↔ 1118 By similarity
Disulfide bondi1120 ↔ 1129 By similarity
Disulfide bondi1132 ↔ 1147 By similarity
Disulfide bondi1403 ↔ 1412 By similarity
Disulfide bondi1405 ↔ 1419 By similarity
Glycosylationi1407 – 14071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1422 ↔ 1431 By similarity
Disulfide bondi1434 ↔ 1449 By similarity
Disulfide bondi1452 ↔ 1466 By similarity
Disulfide bondi1454 ↔ 1476 By similarity
Disulfide bondi1479 ↔ 1488 By similarity
Disulfide bondi1491 ↔ 1506 By similarity
Disulfide bondi1509 ↔ 1521 By similarity
Disulfide bondi1511 ↔ 1528 By similarity
Disulfide bondi1530 ↔ 1539 By similarity
Disulfide bondi1542 ↔ 1553 By similarity
Disulfide bondi1556 – 1556Interchain Inferred
Disulfide bondi1560 – 1560Interchain Inferred
Glycosylationi1579 – 15791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1596 – 15961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1678 – 16781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1689 – 16891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1698 – 16981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1717 – 17171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1804 – 18041N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1894 – 18941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1898 – 18981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1957 – 19571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1974 – 19741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1991 – 19911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2038 – 20381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2047 – 20471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2094 – 20941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2098 – 20981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2243 – 22431N-linked (GlcNAc...)1 Publication
Glycosylationi2244 – 22441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2271 ↔ 2297 By similarity
Glycosylationi2384 – 23841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2408 – 24081N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2457 ↔ 2481 By similarity
Glycosylationi2518 – 25181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2619 – 26191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2646 ↔ 2673 By similarity
Glycosylationi2729 – 27291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2852 – 28521N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2860 ↔ 2885 By similarity
Glycosylationi2915 – 29151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2983 – 29831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3039 ↔ 3070 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP25391.
PaxDbiP25391.
PRIDEiP25391.

PTM databases

PhosphoSiteiP25391.

Expressioni

Gene expression databases

ArrayExpressiP25391.
BgeeiP25391.
CleanExiHS_LAMA1.
GenevestigatoriP25391.

Organism-specific databases

HPAiCAB010179.
HPA032109.
HPA032110.

Interactioni

Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121 or S-laminin).

Binary interactionsi

WithEntry#Exp.IntActNotes
p4cQ8BDF82EBI-2529668,EBI-7167339From a different organism.

Protein-protein interaction databases

BioGridi129792. 10 interactions.
DIPiDIP-29324N.
IntActiP25391. 2 interactions.
MINTiMINT-6740485.
STRINGi9606.ENSP00000374309.

Structurei

3D structure databases

ProteinModelPortaliP25391.
SMRiP25391. Positions 17-537, 708-1155, 1361-1544, 2128-2472, 2491-2674, 2701-3074.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 269252Laminin N-terminal
Add
BLAST
Domaini270 – 32657Laminin EGF-like 1
Add
BLAST
Domaini327 – 39670Laminin EGF-like 2
Add
BLAST
Domaini397 – 45357Laminin EGF-like 3
Add
BLAST
Domaini454 – 50249Laminin EGF-like 4
Add
BLAST
Domaini503 – 51210Laminin EGF-like 5; first part
Domaini516 – 708193Laminin IV type A 1
Add
BLAST
Domaini709 – 74133Laminin EGF-like 5; second part
Add
BLAST
Domaini742 – 79049Laminin EGF-like 6
Add
BLAST
Domaini791 – 84858Laminin EGF-like 7
Add
BLAST
Domaini849 – 90153Laminin EGF-like 8
Add
BLAST
Domaini902 – 95049Laminin EGF-like 9
Add
BLAST
Domaini951 – 99747Laminin EGF-like 10
Add
BLAST
Domaini998 – 104346Laminin EGF-like 11
Add
BLAST
Domaini1044 – 108946Laminin EGF-like 12
Add
BLAST
Domaini1090 – 114960Laminin EGF-like 13
Add
BLAST
Domaini1150 – 115910Laminin EGF-like 14; first part
Domaini1170 – 1361192Laminin IV type A 2
Add
BLAST
Domaini1362 – 140241Laminin EGF-like 14; second part
Add
BLAST
Domaini1403 – 145149Laminin EGF-like 15
Add
BLAST
Domaini1452 – 150857Laminin EGF-like 16
Add
BLAST
Domaini1509 – 155547Laminin EGF-like 17
Add
BLAST
Domaini2117 – 2297181Laminin G-like 1
Add
BLAST
Domaini2305 – 2481177Laminin G-like 2
Add
BLAST
Domaini2486 – 2673188Laminin G-like 3
Add
BLAST
Domaini2713 – 2885173Laminin G-like 4
Add
BLAST
Domaini2890 – 3070181Laminin G-like 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1556 – 2116561Domain II and I
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1706 – 179691 Reviewed prediction
Add
BLAST
Coiled coili1968 – 198922 Reviewed prediction
Add
BLAST
Coiled coili2088 – 212033 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2534 – 25363Cell attachment site

Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI, IV and G are globular.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG247347.
HOGENOMiHOG000293201.
HOVERGENiHBG052298.
InParanoidiP25391.
KOiK05637.
OMAiEPFYWRL.
OrthoDBiEOG7SR4KJ.
PhylomeDBiP25391.
TreeFamiTF335359.

Family and domain databases

Gene3Di2.60.120.200. 5 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR002049. EGF_laminin.
IPR018031. Laminin_B_subgr.
IPR000034. Laminin_B_type_IV.
IPR001791. Laminin_G.
IPR009254. Laminin_I.
IPR010307. Laminin_II.
IPR008211. Laminin_N.
[Graphical view]
PfamiPF00052. Laminin_B. 2 hits.
PF00053. Laminin_EGF. 17 hits.
PF00054. Laminin_G_1. 5 hits.
PF06008. Laminin_I. 1 hit.
PF06009. Laminin_II. 1 hit.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00180. EGF_Lam. 15 hits.
SM00281. LamB. 2 hits.
SM00282. LamG. 5 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 5 hits.
PROSITEiPS00022. EGF_1. 11 hits.
PS01186. EGF_2. 2 hits.
PS01248. EGF_LAM_1. 15 hits.
PS50027. EGF_LAM_2. 15 hits.
PS50025. LAM_G_DOMAIN. 5 hits.
PS51115. LAMININ_IVA. 2 hits.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25391-1 [UniParc]FASTAAdd to Basket

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MRGGVLLVLL LCVAAQCRQR GLFPAILNLA SNAHISTNAT CGEKGPEMFC     50
KLVEHVPGRP VRNPQCRICD GNSANPRERH PISHAIDGTN NWWQSPSIQN 100
GREYHWVTIT LDLRQVFQVA YVIIKAANAP RPGNWILERS LDGTTFSPWQ 150
YYAVSDSECL SRYNITPRRG PPTYRADDEV ICTSYYSRLV PLEHGEIHTS 200
LINGRPSADD LSPKLLEFTS ARYIRLRLQR IRTLNADLMT LSHREPKELD 250
PIVTRRYYYS IKDISVGGMC ICYGHASSCP WDETTKKLQC QCEHNTCGES 300
CNRCCPGYHQ QPWRPGTVSS GNTCEACNCH NKAKDCYYDE SVAKQKKSLN 350
TAGQFRGGGV CINCLQNTMG INCETCIDGY YRPHKVSPYE DEPCRPCNCD 400
PVGSLSSVCI KDDLHSDLHN GKQPGQCPCK EGYTGEKCDR CQLGYKDYPT 450
CVSCGCNPVG SASDEPCTGP CVCKENVEGK ACDRCKPGFY NLKEKNPRGC 500
SECFCFGVSD VCSSLSWPVG QVNSMSGWLV TDLISPRKIP SQQDALGGRH 550
QVSINNTAVM QRLAPKYYWA APEAYLGNKL TAFGGFLKYT VSYDIPVETV 600
DSNLMSHADV IIKGNGLTLS TQAEGLSLQP YEEYLNVVRL VPENFQDFHS 650
KRQIDRDQLM TVLANVTHLL IRANYNSAKM ALYRLESVSL DIASSNAIDL 700
VVAADVEHCE CPQGYTGTSC ESCLSGYYRV DGILFGGICQ PCECHGHAAE 750
CNVHGVCIAC AHNTTGVHCE QCLPGFYGEP SRGTPGDCQP CACPLTIASN 800
NFSPTCHLND GDEVVCDWCA PGYSGAWCER CADGYYGNPT VPGESCVPCD 850
CSGNVDPSEA GHCDSVTGEC LKCLGNTDGA HCERCADGFY GDAVTAKNCR 900
ACECHVKGSH SAVCHLETGL CDCKPNVTGQ QCDQCLHGYY GLDSGHGCRP 950
CNCSVAGSVS DGCTDEGQCH CVPGVAGKRC DRCAHGFYAY QDGSCTPCDC 1000
PHTQNTCDPE TGECVCPPHT QGVKCEECED GHWGYDAEVG CQACNCSLVG 1050
STHHRCDVVT GHCQCKSKFG GRACDQCSLG YRDFPDCVPC DCDLRGTSGD 1100
ACNLEQGLCG CVEETGACPC KENVFGPQCN ECREGTFALR ADNPLGCSPC 1150
FCSGLSHLCS ELEDYVRTPV TLGSDQPLLR VVSQSNLRGT TEGVYYQAPD 1200
FLLDAATVRQ HIRAEPFYWR LPQQFQGDQL MAYGGKLKYS VAFYSLDGVG 1250
TSNFEPQVLI KGGRIRKQVI YMDAPAPENG VRQEQEVAMR ENFWKYFNSV 1300
SEKPVTREDF MSVLSDIEYI LIKASYGQGL QQSRISDISM EVGRKAEKLH 1350
PEEEVASLLE NCVCPPGTVG FSCQDCAPGY HRGKLPAGSD RGPRPLVAPC 1400
VPCSCNNHSD TCDPNTGKCL NCGDNTAGDH CDVCTSGYYG KVTGSASDCA 1450
LCACPHSPPA SFSPTCVLEG DHDFRCDACL LGYEGKHCER CSSSYYGNPQ 1500
TPGGSCQKCD CNPHGSVHGD CDRTSGQCVC RLGASGLRCD ECEPRHILME 1550
TDCVSCDDEC VGVLLNDLDE IGDAVLSLNL TGIIPVPYGI LSNLENTTKY 1600
LQESLLKENM QKDLGKIKLE GVAEETDNLQ KKLTRMLAST QKVNRATERI 1650
FKESQDLAIA IERLQMSITE IMEKTTLNQT LDEDFLLPNS TLQNMQQNGT 1700
SLLEIMQIRD FTQLHQNATL ELKAAEDLLS QIQENYQKPL EELEVLKEAA 1750
SHVLSKHNNE LKAAEALVRE AEAKMQESNH LLLMVNANLR EFSDKKLHVQ 1800
EEQNLTSELI VQGRGLIDAA AAQTDAVQDA LEHLEDHQDK LLLWSAKIRH 1850
HIDDLVMHMS QRNAVDLVYR AEDHAAEFQR LADVLYSGLE NIRNVSLNAT 1900
SAAYVHYNIQ SLIEESEELA RDAHRTVTET SLLSESLVSN GKAAVQRSSR 1950
FLKEGNNLSR KLPGIALELS ELRNKTNRFQ ENAVEITRQT NESLLILRAI 2000
PKGIRDKGAK TKELATSASQ SAVSTLRDVA GLSQELLNTS ASLSRVNTTL 2050
RETHQLLQDS TMATLLAGRK VKDVEIQANL LFDRLKPLKM LEENLSRNLS 2100
EIKLLISQAR KQAASIKVAV SADRDCIRAY QPQISSTNYN TLTLNVKTQE 2150
PDNLLFYLGS STASDFLAVE MRRGRVAFLW DLGSGSTRLE FPDFPIDDNR 2200
WHSIHVARFG NIGSLSVKEM SSNQKSPTKT SKSPGTANVL DVNNSTLMFV 2250
GGLGGQIKKS PAVKVTHFKG CLGEAFLNGK SIGLWNYIER EGKCRGCFGS 2300
SQNEDPSFHF DGSGYSVVEK SLPATVTQII MLFNTFSPNG LLLYLGSYGT 2350
KDFLSIELFR GRVKVMTDLG SGPITLLTDR RYNNGTWYKI AFQRNRKQGV 2400
LAVIDAYNTS NKETKQGETP GASSDLNRLD KDPIYVGGLP RSRVVRRGVT 2450
TKSFVGCIKN LEISRSTFDL LRNSYGVRKG CLLEPIRSVS FLKGGYIELP 2500
PKSLSPESEW LVTFATTNSS GIILAALGGD VEKRGDREEA HVPFFSVMLI 2550
GGNIEVHVNP GDGTGLRKAL LHAPTGTCSD GQAHSISLVR NRRIITVQLD 2600
ENNPVEMKLG TLVESRTINV SNLYVGGIPE GEGTSLLTMR RSFHGCIKNL 2650
IFNLELLDFN SAVGHEQVDL DTCWLSERPK LAPDAEDSKL LPEPRAFPEQ 2700
CVVDAALEYV PGAHQFGLTQ NSHFILPFNQ SAVRKKLSVE LSIRTFASSG 2750
LIYYMAHQNQ ADYAVLQLHG GRLHFMFDLG KGRTKVSHPA LLSDGKWHTV 2800
KTDYVKRKGF ITVDGRESPM VTVVGDGTML DVEGLFYLGG LPSQYQARKI 2850
GNITHSIPAC IGDVTVNSKQ LDKDSPVSAF TVNRCYAVAQ EGTYFDGSGY 2900
AALVKEGYKV QSDVNITLEF RTSSQNGVLL GISTAKVDAI GLELVDGKVL 2950
FHVNNGAGRI TAAYEPKTAT VLCDGKWHTL QANKSKHRIT LIVDGNAVGA 3000
ESPHTQSTSV DTNNPIYVGG YPAGVKQKCL RSQTSFRGCL RKLALIKSPQ 3050
VQSFDFSRAF ELHGVFLHSC PGTES 3075
Length:3,075
Mass (Da):337,084
Last modified:December 15, 2009 - v2
Checksum:i941167F8FE534745
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti349 – 3491L → S.
Corresponds to variant rs9950267 [ dbSNP | Ensembl ].
VAR_056132
Natural varianti559 – 5591V → I.
Corresponds to variant rs16951079 [ dbSNP | Ensembl ].
VAR_056133
Natural varianti674 – 6741N → T.2 Publications
Corresponds to variant rs566655 [ dbSNP | Ensembl ].
VAR_060785
Natural varianti1340 – 13401M → V.1 Publication
Corresponds to variant rs662471 [ dbSNP | Ensembl ].
VAR_060786
Natural varianti1577 – 15771S → A.
Corresponds to variant rs12961939 [ dbSNP | Ensembl ].
VAR_056134
Natural varianti1591 – 15911L → V.
Corresponds to variant rs596315 [ dbSNP | Ensembl ].
VAR_056135
Natural varianti1632 – 16321K → E.
Corresponds to variant rs11872364 [ dbSNP | Ensembl ].
VAR_056136
Natural varianti1682 – 16821D → V.
Corresponds to variant rs16950981 [ dbSNP | Ensembl ].
VAR_056137
Natural varianti1876 – 18761A → T.2 Publications
Corresponds to variant rs11664063 [ dbSNP | Ensembl ].
VAR_060787
Natural varianti2002 – 20021K → E.2 Publications
Corresponds to variant rs607230 [ dbSNP | Ensembl ].
VAR_060788
Natural varianti2076 – 20761I → T.
Corresponds to variant rs671871 [ dbSNP | Ensembl ].
VAR_056138
Natural varianti2511 – 25111L → M.
Corresponds to variant rs60009920 [ dbSNP | Ensembl ].
VAR_061347
Natural varianti2611 – 26111T → A.
Corresponds to variant rs543355 [ dbSNP | Ensembl ].
VAR_056139

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti228 – 2292LQ → FE in CAA41418. 1 Publication
Sequence conflicti252 – 2543IVT → MLP in CAA41418. 1 Publication
Sequence conflicti419 – 4191H → E in CAA41418. 1 Publication
Sequence conflicti519 – 5191V → L in CAA41418. 1 Publication
Sequence conflicti1023 – 10231V → G1 Publication
Sequence conflicti1075 – 10751D → V in CAA41418. 1 Publication
Sequence conflicti1513 – 15131P → R1 Publication
Sequence conflicti1659 – 16591I → V1 Publication
Sequence conflicti1659 – 16591I → V in CAA41418. 1 Publication
Sequence conflicti2079 – 20802NL → KV in CAA41418. 1 Publication
Sequence conflicti2692 – 26921P → R1 Publication
Sequence conflicti2692 – 26921P → R1 Publication
Sequence conflicti2746 – 27461F → L1 Publication
Sequence conflicti2962 – 29621A → P1 Publication
Sequence conflicti2962 – 29621A → P1 Publication
Sequence conflicti3054 – 30541F → L1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP002409 Genomic DNA. No translation available.
AP005062 Genomic DNA. No translation available.
AP005210 Genomic DNA. No translation available.
X58531 mRNA. Translation: CAA41418.1.
CCDSiCCDS32787.1.
PIRiS14458.
RefSeqiNP_005550.2. NM_005559.3.
UniGeneiHs.270364.

Genome annotation databases

EnsembliENST00000389658; ENSP00000374309; ENSG00000101680.
GeneIDi284217.
KEGGihsa:284217.
UCSCiuc002knm.3. human.

Polymorphism databases

DMDMi281185471.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP002409 Genomic DNA. No translation available.
AP005062 Genomic DNA. No translation available.
AP005210 Genomic DNA. No translation available.
X58531 mRNA. Translation: CAA41418.1 .
CCDSi CCDS32787.1.
PIRi S14458.
RefSeqi NP_005550.2. NM_005559.3.
UniGenei Hs.270364.

3D structure databases

ProteinModelPortali P25391.
SMRi P25391. Positions 17-537, 708-1155, 1361-1544, 2128-2472, 2491-2674, 2701-3074.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129792. 10 interactions.
DIPi DIP-29324N.
IntActi P25391. 2 interactions.
MINTi MINT-6740485.
STRINGi 9606.ENSP00000374309.

Chemistry

ChEMBLi CHEMBL2364187.
DrugBanki DB00009. Alteplase.
DB00029. Anistreplase.
DB00015. Reteplase.
DB00031. Tenecteplase.

PTM databases

PhosphoSitei P25391.

Polymorphism databases

DMDMi 281185471.

Proteomic databases

MaxQBi P25391.
PaxDbi P25391.
PRIDEi P25391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000389658 ; ENSP00000374309 ; ENSG00000101680 .
GeneIDi 284217.
KEGGi hsa:284217.
UCSCi uc002knm.3. human.

Organism-specific databases

CTDi 284217.
GeneCardsi GC18M006941.
H-InvDB HIX0014316.
HGNCi HGNC:6481. LAMA1.
HPAi CAB010179.
HPA032109.
HPA032110.
MIMi 150320. gene.
neXtProti NX_P25391.
PharmGKBi PA30270.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG247347.
HOGENOMi HOG000293201.
HOVERGENi HBG052298.
InParanoidi P25391.
KOi K05637.
OMAi EPFYWRL.
OrthoDBi EOG7SR4KJ.
PhylomeDBi P25391.
TreeFami TF335359.

Enzyme and pathway databases

Reactomei REACT_163874. Non-integrin membrane-ECM interactions.
REACT_163906. ECM proteoglycans.
REACT_169262. Laminin interactions.
REACT_22205. L1CAM interactions.

Miscellaneous databases

ChiTaRSi LAMA1. human.
GeneWikii Laminin,_alpha_1.
GenomeRNAii 284217.
NextBioi 94628.
PROi P25391.
SOURCEi Search...

Gene expression databases

ArrayExpressi P25391.
Bgeei P25391.
CleanExi HS_LAMA1.
Genevestigatori P25391.

Family and domain databases

Gene3Di 2.60.120.200. 5 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR002049. EGF_laminin.
IPR018031. Laminin_B_subgr.
IPR000034. Laminin_B_type_IV.
IPR001791. Laminin_G.
IPR009254. Laminin_I.
IPR010307. Laminin_II.
IPR008211. Laminin_N.
[Graphical view ]
Pfami PF00052. Laminin_B. 2 hits.
PF00053. Laminin_EGF. 17 hits.
PF00054. Laminin_G_1. 5 hits.
PF06008. Laminin_I. 1 hit.
PF06009. Laminin_II. 1 hit.
PF00055. Laminin_N. 1 hit.
[Graphical view ]
SMARTi SM00180. EGF_Lam. 15 hits.
SM00281. LamB. 2 hits.
SM00282. LamG. 5 hits.
SM00136. LamNT. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 5 hits.
PROSITEi PS00022. EGF_1. 11 hits.
PS01186. EGF_2. 2 hits.
PS01248. EGF_LAM_1. 15 hits.
PS50027. EGF_LAM_2. 15 hits.
PS50025. LAM_G_DOMAIN. 5 hits.
PS51115. LAMININ_IVA. 2 hits.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the cDNA encoding human laminin A chain."
    Haaparanta T., Uitto J., Ruoslahti E., Engvall E.
    Matrix 11:151-160(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-674; VAL-1340; THR-1876 AND GLU-2002.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Primary structure of the human laminin A chain. Limited expression in human tissues."
    Nissinen M., Vuolteenaho R., Boot-Handford R., Kallunki P., Tryggvason K.
    Biochem. J. 276:369-379(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-2628, VARIANTS THR-674; THR-1876 AND GLU-2002.
  4. "Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells."
    Olsen D., Nagayoshi T., Fazio M., Peltonen J., Jaakkola S., Sanborn D., Sasaki T., Kuivaniemi H., Chu M.-L., Deutzmann R., Timpl R., Uitto J.
    Lab. Invest. 60:772-782(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2397-3072.
  5. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2243.
    Tissue: Liver.

Entry informationi

Entry nameiLAMA1_HUMAN
AccessioniPrimary (citable) accession number: P25391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: December 15, 2009
Last modified: September 3, 2014
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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