Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase SSK22

Gene

SSK22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1063ATPPROSITE-ProRule annotation1
Active sitei1158Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1040 – 1048ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • MAPK cascade involved in osmosensory signaling pathway Source: SGD
  • stress-activated MAPK cascade Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSK22 (EC:2.7.11.1)
Alternative name(s):
MAP kinase kinase kinase SSK22
Suppressor of sensor kinase 22
Gene namesi
Name:SSK22
Ordered Locus Names:YCR073C
ORF Names:YCR73C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR073C.
SGDiS000000669. SSK22.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000866811 – 1331Serine/threonine-protein kinase SSK22Add BLAST1331

Proteomic databases

PRIDEiP25390.

PTM databases

iPTMnetiP25390.

Interactioni

Subunit structurei

Interacts with by SSK1.

Binary interactionsi

WithEntry#Exp.IntActNotes
SSK1Q070844EBI-18129,EBI-18184

Protein-protein interaction databases

BioGridi31048. 57 interactors.
DIPiDIP-5989N.
IntActiP25390. 11 interactors.
MINTiMINT-592715.

Structurei

3D structure databases

ProteinModelPortaliP25390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1034 – 1310Protein kinasePROSITE-ProRule annotationAdd BLAST277

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00590000083157.
HOGENOMiHOG000207441.
InParanoidiP25390.
KOiK11230.
OMAiWNEIATE.
OrthoDBiEOG092C05H5.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR017240. MAPKKK_Ssk2/Ssk22.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037579. MAPKKK_SSK22. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMDILNTQQ QKAAEGGRVL APHTISSKLV KRLSSHSSHK LSRSDLKALG
60 70 80 90 100
GSETISDGPS QLTFKDRYVF NESLYLKKLK KTALDDYYTR GIKLTNRYEE
110 120 130 140 150
DDGDDEIIRL SNGDRIDEDL HSGVKFFSTT PYCRKMRSDS DELAWNEIAT
160 170 180 190 200
ERFKWQSMLA RVLKGDIVKG EKTRIANQVK KPGLNKELSD EIWLELKAWL
210 220 230 240 250
NGRTMQEMEQ SLTYLRDSSD SVFEEIMKFQ IPQGKILSLD ALEAILQDLM
260 270 280 290 300
NRYHSVVSYW PNLKKMYKDK PITNTAEFTA RIDVMNSWLN FKTNLTLRRQ
310 320 330 340 350
ELDDWINRFS PISSSDNCQE DFDGVPQWNC KMKILAEQLM KEKNIESIFQ
360 370 380 390 400
KKIFYPLSPW MFKLKLHFIV YRETLTKMNI KYPYERLRSL LAFPVYLIKE
410 420 430 440 450
VILTRLSYAR KLKNPTMMMI DQMIDDFNAF IRLSVQLKYT LTKYCSNLPF
460 470 480 490 500
DVDFDPTFEN TVIEAIRYLF FLLNLKLIDS SKQNFKAPDL LLKYWDHLKN
510 520 530 540 550
TGHYINGAET VIPNEFLKLT LRLVHKLQFY LLKQQNFPPT FANASEAEKW
560 570 580 590 600
LSSIFENLGA MKRKLNRFSN ILVKAFQNSA VYQINHNAQL VKKLKDAHYF
610 620 630 640 650
LVYSGNTFES SGVYMFAAPE LLGCDNDTIL RILRNKSIGC DLVPKLDIGN
660 670 680 690 700
NLNVYDITTK ETDLNILVSK GEDSKGIPYY RVVANSSSDL DRHAHQSKKK
710 720 730 740 750
NFSTDPFDQH LDEKNNEVFE LEVALSSLGA LVVLYPGEPV VWDGPVYKLP
760 770 780 790 800
GNNLFASNEM DLGKIGNPNT LILLNQGSNY ALTYQIDKFN QTVGDSVSFI
810 820 830 840 850
EKRCSLNSIE SSLQKINKAY YKLTYTVLNN YKGILGSFMK QCPGNELLNS
860 870 880 890 900
IFMFGRDFGR SFLKYNAFSS KRKYVIIFLM VKLGMNWLKF LVEECDPTDQ
910 920 930 940 950
RTFRWCVLAM DFAMQMTSGY NILALNVKQF QELKERVSVC MSLLISHFDV
960 970 980 990 1000
MGARATEAEN GMQQARLNID TEENIDEEAT LEINSRLRLE AIKTLEKTMK
1010 1020 1030 1040 1050
RNPRQMGKVL DATDQGNKYL LSLASSLSNV SMRWQKRSFI GGGTFGQVYS
1060 1070 1080 1090 1100
AINLENGEIL AVKEIKIHDT TTMKKIFPLI KEEMTVLEML NHPNIVQYYG
1110 1120 1130 1140 1150
VEVHRDKVNI FMEYCEGGSL ASLLDHGRIE DEMVTQVYTF ELLEGLAYLH
1160 1170 1180 1190 1200
QSGVVHRDIK PENILLDFNG IIKYVDFGTA RTVVGSRTRT VRNAAVQDFG
1210 1220 1230 1240 1250
VETKSLNEMM GTPMYMAPET ISGSAVKGKL GADDVWALGC VVLEMATGRR
1260 1270 1280 1290 1300
PWSNLDNEWA IMYHVAAGRI PQLPNRDEMT AAGRAFLERC LVQDPTMRAT
1310 1320 1330
AVELLIDPWM IQIREIAFGN SEKDQVPILS S
Length:1,331
Mass (Da):152,718
Last modified:March 15, 2004 - v2
Checksum:i2C3CE7C4FF4463B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42271.2.
BK006937 Genomic DNA. Translation: DAA07544.1.
PIRiS19488.
RefSeqiNP_009998.2. NM_001178783.1.

Genome annotation databases

EnsemblFungiiCAA42271; CAA42271; CAA42271.
YCR073C; YCR073C; YCR073C.
GeneIDi850436.
KEGGisce:YCR073C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42271.2.
BK006937 Genomic DNA. Translation: DAA07544.1.
PIRiS19488.
RefSeqiNP_009998.2. NM_001178783.1.

3D structure databases

ProteinModelPortaliP25390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31048. 57 interactors.
DIPiDIP-5989N.
IntActiP25390. 11 interactors.
MINTiMINT-592715.

PTM databases

iPTMnetiP25390.

Proteomic databases

PRIDEiP25390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42271; CAA42271; CAA42271.
YCR073C; YCR073C; YCR073C.
GeneIDi850436.
KEGGisce:YCR073C.

Organism-specific databases

EuPathDBiFungiDB:YCR073C.
SGDiS000000669. SSK22.

Phylogenomic databases

GeneTreeiENSGT00590000083157.
HOGENOMiHOG000207441.
InParanoidiP25390.
KOiK11230.
OMAiWNEIATE.
OrthoDBiEOG092C05H5.

Enzyme and pathway databases

BioCyciYEAST:G3O-29373-MONOMER.

Miscellaneous databases

PROiP25390.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR017240. MAPKKK_Ssk2/Ssk22.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037579. MAPKKK_SSK22. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSSK22_YEAST
AccessioniPrimary (citable) accession number: P25390
Secondary accession number(s): D6VR75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 15, 2004
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 56 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.