SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P25390

- SSK22_YEAST

UniProt

P25390 - SSK22_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Serine/threonine-protein kinase SSK22

Gene
SSK22, YCR073C, YCR73C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the PBS2 MAP kinase kinase by phosphorylation.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1063 – 10631ATP By similarity
Active sitei1158 – 11581Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1040 – 10489ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase kinase kinase activity Source: SGD
  3. protein binding Source: IntAct

GO - Biological processi

  1. activation of MAPKK activity Source: GOC
  2. MAPK cascade involved in osmosensory signaling pathway Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSK22 (EC:2.7.11.1)
Alternative name(s):
MAP kinase kinase kinase SSK22
Suppressor of sensor kinase 22
Gene namesi
Name:SSK22
Ordered Locus Names:YCR073C
ORF Names:YCR73C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR073c.
SGDiS000000669. SSK22.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13311331Serine/threonine-protein kinase SSK22PRO_0000086681Add
BLAST

Proteomic databases

PaxDbiP25390.
PRIDEiP25390.

Expressioni

Gene expression databases

GenevestigatoriP25390.

Interactioni

Subunit structurei

Interacts with by SSK1.

Binary interactionsi

WithEntry#Exp.IntActNotes
SSK1Q070844EBI-18129,EBI-18184

Protein-protein interaction databases

BioGridi31048. 55 interactions.
DIPiDIP-5989N.
IntActiP25390. 10 interactions.
MINTiMINT-592715.
STRINGi4932.YCR073C.

Structurei

3D structure databases

ProteinModelPortaliP25390.
SMRiP25390. Positions 973-1310.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1034 – 1310277Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00590000083157.
HOGENOMiHOG000207441.
KOiK11230.
OMAiHANINGA.
OrthoDBiEOG7ZPNTB.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR017240. MAPKKK_SSK22.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037579. MAPKKK_SSK22. 1 hit.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25390-1 [UniParc]FASTAAdd to Basket

« Hide

MMMDILNTQQ QKAAEGGRVL APHTISSKLV KRLSSHSSHK LSRSDLKALG     50
GSETISDGPS QLTFKDRYVF NESLYLKKLK KTALDDYYTR GIKLTNRYEE 100
DDGDDEIIRL SNGDRIDEDL HSGVKFFSTT PYCRKMRSDS DELAWNEIAT 150
ERFKWQSMLA RVLKGDIVKG EKTRIANQVK KPGLNKELSD EIWLELKAWL 200
NGRTMQEMEQ SLTYLRDSSD SVFEEIMKFQ IPQGKILSLD ALEAILQDLM 250
NRYHSVVSYW PNLKKMYKDK PITNTAEFTA RIDVMNSWLN FKTNLTLRRQ 300
ELDDWINRFS PISSSDNCQE DFDGVPQWNC KMKILAEQLM KEKNIESIFQ 350
KKIFYPLSPW MFKLKLHFIV YRETLTKMNI KYPYERLRSL LAFPVYLIKE 400
VILTRLSYAR KLKNPTMMMI DQMIDDFNAF IRLSVQLKYT LTKYCSNLPF 450
DVDFDPTFEN TVIEAIRYLF FLLNLKLIDS SKQNFKAPDL LLKYWDHLKN 500
TGHYINGAET VIPNEFLKLT LRLVHKLQFY LLKQQNFPPT FANASEAEKW 550
LSSIFENLGA MKRKLNRFSN ILVKAFQNSA VYQINHNAQL VKKLKDAHYF 600
LVYSGNTFES SGVYMFAAPE LLGCDNDTIL RILRNKSIGC DLVPKLDIGN 650
NLNVYDITTK ETDLNILVSK GEDSKGIPYY RVVANSSSDL DRHAHQSKKK 700
NFSTDPFDQH LDEKNNEVFE LEVALSSLGA LVVLYPGEPV VWDGPVYKLP 750
GNNLFASNEM DLGKIGNPNT LILLNQGSNY ALTYQIDKFN QTVGDSVSFI 800
EKRCSLNSIE SSLQKINKAY YKLTYTVLNN YKGILGSFMK QCPGNELLNS 850
IFMFGRDFGR SFLKYNAFSS KRKYVIIFLM VKLGMNWLKF LVEECDPTDQ 900
RTFRWCVLAM DFAMQMTSGY NILALNVKQF QELKERVSVC MSLLISHFDV 950
MGARATEAEN GMQQARLNID TEENIDEEAT LEINSRLRLE AIKTLEKTMK 1000
RNPRQMGKVL DATDQGNKYL LSLASSLSNV SMRWQKRSFI GGGTFGQVYS 1050
AINLENGEIL AVKEIKIHDT TTMKKIFPLI KEEMTVLEML NHPNIVQYYG 1100
VEVHRDKVNI FMEYCEGGSL ASLLDHGRIE DEMVTQVYTF ELLEGLAYLH 1150
QSGVVHRDIK PENILLDFNG IIKYVDFGTA RTVVGSRTRT VRNAAVQDFG 1200
VETKSLNEMM GTPMYMAPET ISGSAVKGKL GADDVWALGC VVLEMATGRR 1250
PWSNLDNEWA IMYHVAAGRI PQLPNRDEMT AAGRAFLERC LVQDPTMRAT 1300
AVELLIDPWM IQIREIAFGN SEKDQVPILS S 1331
Length:1,331
Mass (Da):152,718
Last modified:March 15, 2004 - v2
Checksum:i2C3CE7C4FF4463B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42271.2.
BK006937 Genomic DNA. Translation: DAA07544.1.
PIRiS19488.
RefSeqiNP_009998.2. NM_001178783.1.

Genome annotation databases

EnsemblFungiiYCR073C; YCR073C; YCR073C.
GeneIDi850436.
KEGGisce:YCR073C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42271.2 .
BK006937 Genomic DNA. Translation: DAA07544.1 .
PIRi S19488.
RefSeqi NP_009998.2. NM_001178783.1.

3D structure databases

ProteinModelPortali P25390.
SMRi P25390. Positions 973-1310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31048. 55 interactions.
DIPi DIP-5989N.
IntActi P25390. 10 interactions.
MINTi MINT-592715.
STRINGi 4932.YCR073C.

Proteomic databases

PaxDbi P25390.
PRIDEi P25390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR073C ; YCR073C ; YCR073C .
GeneIDi 850436.
KEGGi sce:YCR073C.

Organism-specific databases

CYGDi YCR073c.
SGDi S000000669. SSK22.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00590000083157.
HOGENOMi HOG000207441.
KOi K11230.
OMAi HANINGA.
OrthoDBi EOG7ZPNTB.

Enzyme and pathway databases

BioCyci YEAST:G3O-29373-MONOMER.

Miscellaneous databases

NextBioi 966030.

Gene expression databases

Genevestigatori P25390.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR017240. MAPKKK_SSK22.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF037579. MAPKKK_SSK22. 1 hit.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Valles G., Volckaerts G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO C-TERMINUS.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor."
    Maeda T., Takekawa M., Saito H.
    Science 269:554-558(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSSK22_YEAST
AccessioniPrimary (citable) accession number: P25390
Secondary accession number(s): D6VR75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 15, 2004
Last modified: June 11, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 56 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi