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Protein

Probable serine/threonine-protein kinase KCC4

Gene

KCC4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of bud growth during cell cycle and in septin organization. Plays a role in cell wall synthesis.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei50ATPPROSITE-ProRule annotation1
Active sitei152Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 35ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • phosphatidic acid binding Source: UniProtKB
  • phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
  • phosphatidylserine binding Source: UniProtKB
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • budding cell bud growth Source: SGD
  • intracellular signal transduction Source: GO_Central
  • morphogenesis checkpoint Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of cell shape Source: UniProtKB-KW
  • septin ring assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29286-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase KCC4 (EC:2.7.11.1)
Gene namesi
Name:KCC4
Ordered Locus Names:YCL024W
ORF Names:YCL24W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL024W.
SGDiS000000529. KCC4.

Subcellular locationi

GO - Cellular componenti

  • cellular bud neck Source: SGD
  • cellular bud neck septin collar Source: SGD
  • incipient cellular bud site Source: SGD
  • nucleus Source: GO_Central
  • plasma membrane Source: UniProtKB
  • septin ring Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000861091 – 1037Probable serine/threonine-protein kinase KCC4Add BLAST1037

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei396PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1
Modified residuei777PhosphoserineCombined sources1
Modified residuei822PhosphoserineCombined sources1
Modified residuei825PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25389.
PRIDEiP25389.

PTM databases

iPTMnetiP25389.

Interactioni

Subunit structurei

Interacts with septin proteins, primarily with CDC11. Interacts with SWE1 and NAP1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
NAP1P252936EBI-9607,EBI-11850

Protein-protein interaction databases

BioGridi30960. 83 interactors.
DIPiDIP-1779N.
IntActiP25389. 14 interactors.
MINTiMINT-397998.

Structurei

Secondary structure

11037
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi921 – 924Combined sources4
Helixi925 – 927Combined sources3
Beta strandi930 – 933Combined sources4
Beta strandi938 – 942Combined sources5
Helixi944 – 956Combined sources13
Helixi959 – 961Combined sources3
Beta strandi963 – 969Combined sources7
Turni970 – 973Combined sources4
Beta strandi974 – 979Combined sources6
Beta strandi984 – 986Combined sources3
Beta strandi990 – 998Combined sources9
Beta strandi1004 – 1013Combined sources10
Helixi1015 – 1031Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OSMX-ray1.70A917-1037[»]
3OSTX-ray1.69A917-1037[»]
ProteinModelPortaliP25389.
SMRiP25389.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25389.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 285Protein kinasePROSITE-ProRule annotationAdd BLAST265

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi388 – 499Ser-richAdd BLAST112

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00860000133738.
HOGENOMiHOG000057100.
InParanoidiP25389.
KOiK18639.
OMAiVANTETH.
OrthoDBiEOG092C0QJU.

Family and domain databases

InterProiIPR031850. Fungal_KA1_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF16797. Fungal_KA1. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25389-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVANTETHS AAKPSSTIGP WKLGETLGFG STGKVQLAQH ERTGHRTAVK
60 70 80 90 100
VISKSIFNNN GNHSNDDSVL PYNIEREIVI MKLLSHPNVL SLYDVWETNN
110 120 130 140 150
NLYLILEYAE KGELFNLLVD HGPLPEREAI NCFRQIIIGI SYCHALGIVH
160 170 180 190 200
RDLKPENLLL DSFYNIKIAD FGMAALQTDA DLLETSCGSP HYAAPEIVSG
210 220 230 240 250
LPYEGFASDV WSCGVILFAL LTGRLPFDEE NGNVRDLLLK VQKGQFEMPN
260 270 280 290 300
DTEISRDAQD LIGKILVVDP RQRIKIRDIL SHPLLKKYQT IKDSKSIKDL
310 320 330 340 350
PRENTYLYPL ADSNNHTSAS IDDSILQNLV VLWHGRHADD IVSKLKENGT
360 370 380 390 400
NKEKILYALL YRFKLDSVRG SNKKNRNKIK KTKKNKRSST LSSSSSLLLN
410 420 430 440 450
NRSIQSTPRR RTSKRHSREF SSSRKRSSFL LSSNPTDSSP IPLRSSKRIT
460 470 480 490 500
HINVASANTQ ATPSGVPNPH KRNSKKRSSK RLSYMPNTKR SSLTSKSLSN
510 520 530 540 550
FTNLIDDDDW EYIEKDAKRT SSNFATLIDE IFEPEKFELA KREKAELQRK
560 570 580 590 600
VQEAKRQSVN AQKINEDEFG SEVSDGMKEL KKINDKVSSP LINYEFSQQE
610 620 630 640 650
LLQDIDTLLT NRYQLSSYTR PISRLDPGLT PVTETLPNNL KEKTALLQDT
660 670 680 690 700
EKKIIETIRR SKFLGSLLNV RGGLSPGKSE LAPIEESPIV STTPLIYNDR
710 720 730 740 750
MEPRRISDVE VPHFTRKSKH FTTANNRRSV LSLYAKDSIK DLNEFLIKED
760 770 780 790 800
PDLPPQGSTD NESRSEDPEI AESITDSRNI QYDEDDSKDG DNVNNDNILS
810 820 830 840 850
DFPQGVGISQ EYDMKDKNPN QSPISKSAEP TLVVKLPSLS SFQGKNASGL
860 870 880 890 900
GLYQREPSKV TLPSLTSNNS SVGENIEDGA EKGTESEKIA ASLSDDDLKE
910 920 930 940 950
DNDKKDNDTV NAPTTVKKPP NSVLLKKFSK GKILELEIHA KIPEKRLYEG
960 970 980 990 1000
LHKLLEGWKQ YGLKNLVFNI TNMIITGKLV NDSILFLRST LFEIMVLPNG
1010 1020 1030
DGRSLIKFNK KTGSTKTLTK LATEIQIILQ KEGVLDK
Length:1,037
Mass (Da):116,475
Last modified:June 27, 2003 - v3
Checksum:i2F5FF36DA8C5B1A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAC42961.1.
BK006937 Genomic DNA. Translation: DAA07461.1.
PIRiS74283.
RefSeqiNP_009907.2. NM_001178670.1.

Genome annotation databases

EnsemblFungiiCAC42961; CAC42961; CAC42961.
YCL024W; YCL024W; YCL024W.
GeneIDi850334.
KEGGisce:YCL024W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAC42961.1.
BK006937 Genomic DNA. Translation: DAA07461.1.
PIRiS74283.
RefSeqiNP_009907.2. NM_001178670.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3OSMX-ray1.70A917-1037[»]
3OSTX-ray1.69A917-1037[»]
ProteinModelPortaliP25389.
SMRiP25389.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30960. 83 interactors.
DIPiDIP-1779N.
IntActiP25389. 14 interactors.
MINTiMINT-397998.

PTM databases

iPTMnetiP25389.

Proteomic databases

MaxQBiP25389.
PRIDEiP25389.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAC42961; CAC42961; CAC42961.
YCL024W; YCL024W; YCL024W.
GeneIDi850334.
KEGGisce:YCL024W.

Organism-specific databases

EuPathDBiFungiDB:YCL024W.
SGDiS000000529. KCC4.

Phylogenomic databases

GeneTreeiENSGT00860000133738.
HOGENOMiHOG000057100.
InParanoidiP25389.
KOiK18639.
OMAiVANTETH.
OrthoDBiEOG092C0QJU.

Enzyme and pathway databases

BioCyciYEAST:G3O-29286-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP25389.
PROiP25389.

Family and domain databases

InterProiIPR031850. Fungal_KA1_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF16797. Fungal_KA1. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCC4_YEAST
AccessioniPrimary (citable) accession number: P25389
Secondary accession number(s): D6VQZ2, P87005, Q8NKJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 27, 2003
Last modified: November 30, 2016
This is version 162 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 538 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.