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Protein

Protein transport protein BOS1

Gene

BOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.1 Publication

GO - Molecular functioni

  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: SGD
  • Golgi to vacuole transport Source: GO_Central
  • intra-Golgi vesicle-mediated transport Source: GO_Central
  • protein targeting to vacuole Source: GO_Central
  • retrograde transport, endosome to Golgi Source: GO_Central
  • vesicle fusion Source: SGD
  • vesicle fusion with Golgi apparatus Source: SGD

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32229-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein BOS1
Alternative name(s):
Bet one suppressor 1
Gene namesi
Name:BOS1
Ordered Locus Names:YLR078C
ORF Names:L9449.9
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR078C
SGDiS000004068 BOS1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 222CytoplasmicSequence analysisAdd BLAST222
Transmembranei223 – 240Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST18
Topological domaini241 – 244VesicularSequence analysis4

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075571 – 244Protein transport protein BOS1Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP25385
PaxDbiP25385
PRIDEiP25385

PTM databases

iPTMnetiP25385

Interactioni

Subunit structurei

Component of a SNARE complex consisting of SED5, BOS1, BET1 and SEC22 or YKT6. Interacts with YIF1 and YIP1.2 Publications

GO - Molecular functioni

  • SNAP receptor activity Source: SGD
  • SNARE binding Source: GO_Central

Protein-protein interaction databases

BioGridi31351, 684 interactors
ComplexPortaliCPX-1854 Golgi t-SNARE complex, BOS1 variant
DIPiDIP-2020N
IntActiP25385, 10 interactors
MINTiP25385
STRINGi4932.YLR078C

Structurei

3D structure databases

ProteinModelPortaliP25385
SMRiP25385
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BOS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000217458
InParanoidiP25385
KOiK08496
OMAiIGWIERR
OrthoDBiEOG092C4KNX

Family and domain databases

InterProiView protein in InterPro
IPR027027 GOSR2/Membrin/Bos1
PIRSFiPIRSF028865 Membrin-2, 1 hit

Sequencei

Sequence statusi: Complete.

P25385-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNALYNHAVK QKNQLQQELA RFEKNSVTAP ISLQGSISAT LVSLEKTVKQ
60 70 80 90 100
YAEHLNRYKE DTNAEEIDPK FANRLATLTQ DLHDFTAKFK DLKQSYNENN
110 120 130 140 150
SRTQLFGSGA SHVMDSDNPF STSETIMNKR NVGGASANGK EGSSNGGGLP
160 170 180 190 200
LYQGLQKEQS VFERGNAQLD YILEMGQQSF ENIVEQNKIL SKVQDRMSNG
210 220 230 240
LRTLGVSEQT ITSINKRVFK DKLVFWIALI LLIIGIYYVL KWLR
Length:244
Mass (Da):27,500
Last modified:May 1, 1992 - v1
Checksum:iE2F13D444ADC0D93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57792 Genomic DNA Translation: CAA40933.1
Z73250 Genomic DNA Translation: CAA97636.1
U53880 Genomic DNA Translation: AAB67582.1
BK006945 Genomic DNA Translation: DAA09394.1
PIRiA39206
RefSeqiNP_013179.1, NM_001181965.1

Genome annotation databases

EnsemblFungiiYLR078C; YLR078C; YLR078C
GeneIDi850767
KEGGisce:YLR078C

Similar proteinsi

Entry informationi

Entry nameiBOS1_YEAST
AccessioniPrimary (citable) accession number: P25385
Secondary accession number(s): D6VY78
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 20, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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