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P25385

- BOS1_YEAST

UniProt

P25385 - BOS1_YEAST

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Protein

Protein transport protein BOS1

Gene

BOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.1 Publication

GO - Molecular functioni

  1. SNAP receptor activity Source: SGD

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: SGD
  2. protein transport Source: UniProtKB-KW
  3. vesicle fusion Source: SGD
  4. vesicle fusion with Golgi apparatus Source: SGD
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32229-MONOMER.
ReactomeiREACT_188969. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein BOS1
Alternative name(s):
Bet one suppressor 1
Gene namesi
Name:BOS1
Ordered Locus Names:YLR078C
ORF Names:L9449.9
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR078c.
SGDiS000004068. BOS1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: SGD
  2. ER to Golgi transport vesicle membrane Source: SGD
  3. Golgi apparatus Source: UniProtKB-KW
  4. integral component of membrane Source: SGD
  5. SNARE complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 244244Protein transport protein BOS1PRO_0000207557Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP25385.
PaxDbiP25385.
PeptideAtlasiP25385.

Expressioni

Gene expression databases

GenevestigatoriP25385.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of SED5, BOS1, BET1 and SEC22 or YKT6. Interacts with YIF1 and YIP1.2 Publications

Protein-protein interaction databases

BioGridi31351. 146 interactions.
DIPiDIP-2020N.
IntActiP25385. 10 interactions.
MINTiMINT-391154.
STRINGi4932.YLR078C.

Structurei

3D structure databases

ProteinModelPortaliP25385.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 222222CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini241 – 2444VesicularSequence Analysis

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei223 – 24018Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the BOS1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG246137.
HOGENOMiHOG000217458.
InParanoidiP25385.
KOiK08496.
OMAiTSETIMN.
OrthoDBiEOG7X0VV3.

Sequencei

Sequence statusi: Complete.

P25385 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNALYNHAVK QKNQLQQELA RFEKNSVTAP ISLQGSISAT LVSLEKTVKQ
60 70 80 90 100
YAEHLNRYKE DTNAEEIDPK FANRLATLTQ DLHDFTAKFK DLKQSYNENN
110 120 130 140 150
SRTQLFGSGA SHVMDSDNPF STSETIMNKR NVGGASANGK EGSSNGGGLP
160 170 180 190 200
LYQGLQKEQS VFERGNAQLD YILEMGQQSF ENIVEQNKIL SKVQDRMSNG
210 220 230 240
LRTLGVSEQT ITSINKRVFK DKLVFWIALI LLIIGIYYVL KWLR
Length:244
Mass (Da):27,500
Last modified:May 1, 1992 - v1
Checksum:iE2F13D444ADC0D93
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57792 Genomic DNA. Translation: CAA40933.1.
Z73250 Genomic DNA. Translation: CAA97636.1.
U53880 Genomic DNA. Translation: AAB67582.1.
BK006945 Genomic DNA. Translation: DAA09394.1.
PIRiA39206.
RefSeqiNP_013179.1. NM_001181965.1.

Genome annotation databases

EnsemblFungiiYLR078C; YLR078C; YLR078C.
GeneIDi850767.
KEGGisce:YLR078C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X57792 Genomic DNA. Translation: CAA40933.1 .
Z73250 Genomic DNA. Translation: CAA97636.1 .
U53880 Genomic DNA. Translation: AAB67582.1 .
BK006945 Genomic DNA. Translation: DAA09394.1 .
PIRi A39206.
RefSeqi NP_013179.1. NM_001181965.1.

3D structure databases

ProteinModelPortali P25385.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31351. 146 interactions.
DIPi DIP-2020N.
IntActi P25385. 10 interactions.
MINTi MINT-391154.
STRINGi 4932.YLR078C.

Proteomic databases

MaxQBi P25385.
PaxDbi P25385.
PeptideAtlasi P25385.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR078C ; YLR078C ; YLR078C .
GeneIDi 850767.
KEGGi sce:YLR078C.

Organism-specific databases

CYGDi YLR078c.
SGDi S000004068. BOS1.

Phylogenomic databases

eggNOGi NOG246137.
HOGENOMi HOG000217458.
InParanoidi P25385.
KOi K08496.
OMAi TSETIMN.
OrthoDBi EOG7X0VV3.

Enzyme and pathway databases

BioCyci YEAST:G3O-32229-MONOMER.
Reactomei REACT_188969. XBP1(S) activates chaperone genes.

Miscellaneous databases

NextBioi 966927.
PROi P25385.

Gene expression databases

Genevestigatori P25385.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The BOS1 gene encodes an essential 27-kD putative membrane protein that is required for vesicular transport from the ER to the Golgi complex in yeast."
    Shim J., Newman A.P., Ferro-Novick S.
    J. Cell Biol. 113:55-64(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Topological restriction of SNARE-dependent membrane fusion."
    Parlati F., McNew J.A., Fukuda R., Miller R., Sollner T.H., Rothman J.E.
    Nature 407:194-198(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH BET1; SEC22 AND SED5.
  5. "The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles."
    Barrowman J., Wang W., Zhang Y., Ferro-Novick S.
    J. Biol. Chem. 278:19878-19884(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH YIF1 AND YIP1.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBOS1_YEAST
AccessioniPrimary (citable) accession number: P25385
Secondary accession number(s): D6VY78
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3