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P25385

- BOS1_YEAST

UniProt

P25385 - BOS1_YEAST

Protein

Protein transport protein BOS1

Gene

BOS1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.1 Publication

    GO - Molecular functioni

    1. SNAP receptor activity Source: SGD

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: SGD
    2. protein transport Source: UniProtKB-KW
    3. vesicle fusion Source: SGD
    4. vesicle fusion with Golgi apparatus Source: SGD

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32229-MONOMER.
    ReactomeiREACT_188969. XBP1(S) activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein transport protein BOS1
    Alternative name(s):
    Bet one suppressor 1
    Gene namesi
    Name:BOS1
    Ordered Locus Names:YLR078C
    ORF Names:L9449.9
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR078c.
    SGDiS000004068. BOS1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: SGD
    2. ER to Golgi transport vesicle membrane Source: SGD
    3. Golgi membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: SGD
    5. SNARE complex Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 244244Protein transport protein BOS1PRO_0000207557Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP25385.
    PaxDbiP25385.
    PeptideAtlasiP25385.

    Expressioni

    Gene expression databases

    GenevestigatoriP25385.

    Interactioni

    Subunit structurei

    Component of a SNARE complex consisting of SED5, BOS1, BET1 and SEC22 or YKT6. Interacts with YIF1 and YIP1.2 Publications

    Protein-protein interaction databases

    BioGridi31351. 146 interactions.
    DIPiDIP-2020N.
    IntActiP25385. 10 interactions.
    MINTiMINT-391154.
    STRINGi4932.YLR078C.

    Structurei

    3D structure databases

    ProteinModelPortaliP25385.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 222222CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini241 – 2444VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei223 – 24018Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BOS1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG246137.
    HOGENOMiHOG000217458.
    KOiK08496.
    OMAiTSETIMN.
    OrthoDBiEOG7X0VV3.

    Sequencei

    Sequence statusi: Complete.

    P25385-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNALYNHAVK QKNQLQQELA RFEKNSVTAP ISLQGSISAT LVSLEKTVKQ    50
    YAEHLNRYKE DTNAEEIDPK FANRLATLTQ DLHDFTAKFK DLKQSYNENN 100
    SRTQLFGSGA SHVMDSDNPF STSETIMNKR NVGGASANGK EGSSNGGGLP 150
    LYQGLQKEQS VFERGNAQLD YILEMGQQSF ENIVEQNKIL SKVQDRMSNG 200
    LRTLGVSEQT ITSINKRVFK DKLVFWIALI LLIIGIYYVL KWLR 244
    Length:244
    Mass (Da):27,500
    Last modified:May 1, 1992 - v1
    Checksum:iE2F13D444ADC0D93
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57792 Genomic DNA. Translation: CAA40933.1.
    Z73250 Genomic DNA. Translation: CAA97636.1.
    U53880 Genomic DNA. Translation: AAB67582.1.
    BK006945 Genomic DNA. Translation: DAA09394.1.
    PIRiA39206.
    RefSeqiNP_013179.1. NM_001181965.1.

    Genome annotation databases

    EnsemblFungiiYLR078C; YLR078C; YLR078C.
    GeneIDi850767.
    KEGGisce:YLR078C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X57792 Genomic DNA. Translation: CAA40933.1 .
    Z73250 Genomic DNA. Translation: CAA97636.1 .
    U53880 Genomic DNA. Translation: AAB67582.1 .
    BK006945 Genomic DNA. Translation: DAA09394.1 .
    PIRi A39206.
    RefSeqi NP_013179.1. NM_001181965.1.

    3D structure databases

    ProteinModelPortali P25385.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31351. 146 interactions.
    DIPi DIP-2020N.
    IntActi P25385. 10 interactions.
    MINTi MINT-391154.
    STRINGi 4932.YLR078C.

    Proteomic databases

    MaxQBi P25385.
    PaxDbi P25385.
    PeptideAtlasi P25385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR078C ; YLR078C ; YLR078C .
    GeneIDi 850767.
    KEGGi sce:YLR078C.

    Organism-specific databases

    CYGDi YLR078c.
    SGDi S000004068. BOS1.

    Phylogenomic databases

    eggNOGi NOG246137.
    HOGENOMi HOG000217458.
    KOi K08496.
    OMAi TSETIMN.
    OrthoDBi EOG7X0VV3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32229-MONOMER.
    Reactomei REACT_188969. XBP1(S) activates chaperone genes.

    Miscellaneous databases

    NextBioi 966927.
    PROi P25385.

    Gene expression databases

    Genevestigatori P25385.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The BOS1 gene encodes an essential 27-kD putative membrane protein that is required for vesicular transport from the ER to the Golgi complex in yeast."
      Shim J., Newman A.P., Ferro-Novick S.
      J. Cell Biol. 113:55-64(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Topological restriction of SNARE-dependent membrane fusion."
      Parlati F., McNew J.A., Fukuda R., Miller R., Sollner T.H., Rothman J.E.
      Nature 407:194-198(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH BET1; SEC22 AND SED5.
    5. "The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles."
      Barrowman J., Wang W., Zhang Y., Ferro-Novick S.
      J. Biol. Chem. 278:19878-19884(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH YIF1 AND YIP1.
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBOS1_YEAST
    AccessioniPrimary (citable) accession number: P25385
    Secondary accession number(s): D6VY78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3