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Protein

Sporulation-specific protein 22

Gene

SPS22

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Redundant with SPS2 for the organization of the beta-glucan layer of the spore wall.1 Publication

GO - Biological processi

  • ascospore wall assembly Source: SGD
  • fungal-type cell wall organization Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sporulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29303-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sporulation-specific protein 22
Gene namesi
Name:SPS22
Ordered Locus Names:YCL048W
ORF Names:YCL48W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL048W.
SGDiS000000553. SPS22.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 440415Sporulation-specific protein 22PRO_0000202550Add
BLAST
Propeptidei441 – 46323Removed in mature formSequence analysisPRO_0000277472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence analysis
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence analysis
Glycosylationi327 – 3271N-linked (GlcNAc...)Sequence analysis
Lipidationi440 – 4401GPI-anchor amidated asparagineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

PTM databases

iPTMnetiP25380.

Interactioni

Protein-protein interaction databases

BioGridi30937. 23 interactions.
DIPiDIP-7724N.
IntActiP25380. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP25380.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati127 – 14721LRR 1Add
BLAST
Repeati185 – 20622LRR 2Add
BLAST
Repeati207 – 23327LRR 3Add
BLAST
Repeati251 – 27525LRR 4Add
BLAST
Repeati302 – 32524LRR 5Add
BLAST

Sequence similaritiesi

Belongs to the SPS2 family.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00530000065410.
HOGENOMiHOG000057088.
InParanoidiP25380.
OMAiECINANN.
OrthoDBiEOG75XGWQ.

Family and domain databases

Gene3Di3.80.20.20. 1 hit.
InterProiIPR032675. L_dom-like.
IPR000494. Rcpt_L-dom.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRITRKSCL FAIIFASLFV THALGAAIDP PRRPHNVKPF HNGNLELQRR
60 70 80 90 100
ANEPFFEIDV KSLNTNSPIS ELCKKDLHVI ESSHDLFHLQ NQCEFILGSL
110 120 130 140 150
KVTNYDSNIL DLNSLRAIGG DLIIQDSPEL IRIQAGNLNK IEGLFQLQGL
160 170 180 190 200
TSLVSVEIPT LKFCQSLEWK VVPILNYVSM DSQNIEIIKD IVISDTSLAN
210 220 230 240 250
IENFNKVQEI DTFNINNNRF LETIHSNVKT IRGQFSVHAN AKELELEMPH
260 270 280 290 300
LREVENITIR DTSLVYLPQL TKVKSSLEFI ENYFYELNLN NLQKIGGTLG
310 320 330 340 350
IINNVNLIKV NLENLTDIQG GLMIADNESL EDITFLPNLK QIGGAIFFEG
360 370 380 390 400
SFKDIMFDSL KLVKGSAFIK SSSNVLDCNK WTNPSNGRSI IRGGKFTCIS
410 420 430 440 450
GKKENTLNVK QDGTIIEKGY KDLTQEGEDS KKRVISKYAN SANPSMQLDP
460
LLFGTCLVAM LLF
Length:463
Mass (Da):52,008
Last modified:May 1, 1992 - v1
Checksum:iDC84F0F4C16B1B59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42368.1.
BK006937 Genomic DNA. Translation: DAA07438.1.
PIRiS19377.
RefSeqiNP_009882.1. NM_001178693.1.

Genome annotation databases

EnsemblFungiiCAA42368; CAA42368; CAA42368.
YCL048W; YCL048W; YCL048W.
GeneIDi850309.
KEGGisce:YCL048W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42368.1.
BK006937 Genomic DNA. Translation: DAA07438.1.
PIRiS19377.
RefSeqiNP_009882.1. NM_001178693.1.

3D structure databases

ProteinModelPortaliP25380.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30937. 23 interactions.
DIPiDIP-7724N.
IntActiP25380. 3 interactions.

PTM databases

iPTMnetiP25380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42368; CAA42368; CAA42368.
YCL048W; YCL048W; YCL048W.
GeneIDi850309.
KEGGisce:YCL048W.

Organism-specific databases

EuPathDBiFungiDB:YCL048W.
SGDiS000000553. SPS22.

Phylogenomic databases

GeneTreeiENSGT00530000065410.
HOGENOMiHOG000057088.
InParanoidiP25380.
OMAiECINANN.
OrthoDBiEOG75XGWQ.

Enzyme and pathway databases

BioCyciYEAST:G3O-29303-MONOMER.

Miscellaneous databases

NextBioi965703.
PROiP25380.

Family and domain databases

Gene3Di3.80.20.20. 1 hit.
InterProiIPR032675. L_dom-like.
IPR000494. Rcpt_L-dom.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Morphogenetic pathway of spore wall assembly in Saccharomyces cerevisiae."
    Coluccio A., Bogengruber E., Conrad M.N., Dresser M.E., Briza P., Neiman A.M.
    Eukaryot. Cell 3:1464-1475(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiSPS22_YEAST
AccessioniPrimary (citable) accession number: P25380
Secondary accession number(s): D6VQW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.