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Protein

Catabolic L-serine/threonine dehydratase

Gene

CHA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 36600 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

L-serine = pyruvate + NH3.
L-threonine = 2-oxobutanoate + NH3.

Cofactori

GO - Molecular functioni

  • L-serine ammonia-lyase activity Source: SGD
  • L-threonine ammonia-lyase activity Source: SGD
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  • L-serine catabolic process Source: SGD
  • threonine catabolic process Source: SGD

Keywordsi

Molecular functionLyase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciYEAST:YCL064C-MONOMER
ReactomeiR-SCE-8849175 Threonine catabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Catabolic L-serine/threonine dehydratase
Including the following 2 domains:
L-serine dehydratase (EC:4.3.1.17)
Alternative name(s):
L-serine deaminase
L-threonine dehydratase (EC:4.3.1.19)
Alternative name(s):
L-threonine deaminase
Gene namesi
Name:CHA1
Ordered Locus Names:YCL064C
ORF Names:YCL64C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL064C
SGDiS000000569 CHA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001855982 – 360Catabolic L-serine/threonine dehydrataseAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei37N6-(pyridoxal phosphate)lysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP25379
PaxDbiP25379
PRIDEiP25379

PTM databases

iPTMnetiP25379

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
RCK1P386222EBI-3804607,EBI-14880

Protein-protein interaction databases

BioGridi30924, 50 interactors
DIPiDIP-7970N
IntActiP25379, 31 interactors
MINTiP25379
STRINGi4932.YCL064C

Structurei

3D structure databases

ProteinModelPortaliP25379
SMRiP25379
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00550000074775
HOGENOMiHOG000046976
InParanoidiP25379
KOiK17989
OMAiDAKLPWI
OrthoDBiEOG092C371W

Family and domain databases

InterProiView protein in InterPro
IPR001926 PLP-dep
IPR000634 Ser/Thr_deHydtase_PyrdxlP-BS
IPR036052 Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291 PALP, 1 hit
SUPFAMiSSF53686 SSF53686, 1 hit
PROSITEiView protein in PROSITE
PS00165 DEHYDRATASE_SER_THR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIVYNKTPL LRQFFPGKAS AQFFLKYECL QPSGSFKSRG IGNLIMKSAI
60 70 80 90 100
RIQKDGKRSP QVFASSGGNA GFAAATACQR LSLPCTVVVP TATKKRMVDK
110 120 130 140 150
IRNTGAQVIV SGAYWKEADT FLKTNVMNKI DSQVIEPIYV HPFDNPDIWE
160 170 180 190 200
GHSSMIDEIV QDLKSQHISV NKVKGIVCSV GGGGLYNGII QGLERYGLAD
210 220 230 240 250
RIPIVGVETN GCHVFNTSLK IGQPVQFKKI TSIATSLGTA VISNQTFEYA
260 270 280 290 300
RKYNTRSVVI EDKDVIETCL KYTHQFNMVI EPACGAALHL GYNTKILENA
310 320 330 340 350
LGSKLAADDI VIIIACGGSS NTIKDLEEAL DSMRKKDTPV IEVADNFIFP
360
EKNIVNLKSA
Length:360
Mass (Da):39,301
Last modified:March 15, 2004 - v2
Checksum:iFC905FF3D111187D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34G → A in AAA35040 (PubMed:1628804).Curated1
Sequence conflicti268T → P in AAA35040 (PubMed:1628804).Curated1
Sequence conflicti317 – 318GG → AS in AAA35040 (PubMed:1628804).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85194 Genomic DNA Translation: AAA35040.1
X59720 Genomic DNA Translation: CAA42403.2
BK006937 Genomic DNA Translation: DAA07423.1
PIRiS19395 DWBYLH
RefSeqiNP_001018030.1, NM_001178706.1

Genome annotation databases

EnsemblFungiiCAA42403; CAA42403; CAA42403
YCL064C; YCL064C; YCL064C
GeneIDi850295
KEGGisce:YCL064C

Similar proteinsi

Entry informationi

Entry nameiSTDH_YEAST
AccessioniPrimary (citable) accession number: P25379
Secondary accession number(s): D6VQV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 15, 2004
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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