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Protein

NADP-dependent alcohol dehydrogenase 7

Gene

ADH7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NADP-dependent alcohol dehydrogenase with a broad substrate specificity.

Miscellaneous

Present with 2870 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi68Zinc 1; catalyticBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi164Zinc 1; catalyticBy similarity1
Binding sitei216NADBy similarity1
Binding sitei349NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi188 – 193NADBy similarity6
Nucleotide bindingi276 – 278NADBy similarity3

GO - Molecular functioni

  • alcohol dehydrogenase (NADP+) activity Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • alcohol metabolic process Source: SGD

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NADP, Zinc

Enzyme and pathway databases

BioCyciYEAST:YCR105W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-dependent alcohol dehydrogenase 7 (EC:1.1.1.2)
Alternative name(s):
NADP-dependent alcohol dehydrogenase VII
Short name:
ADHVII
Gene namesi
Name:ADH7
Ordered Locus Names:YCR105W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR105W
SGDiS000000702 ADH7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607351 – 361NADP-dependent alcohol dehydrogenase 7Add BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei132PhosphoserineBy similarity1
Modified residuei316PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP25377
PRIDEiP25377

PTM databases

iPTMnetiP25377

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PRS5Q122652EBI-2347652,EBI-9886

Protein-protein interaction databases

BioGridi31077, 30 interactors
DIPiDIP-7661N
IntActiP25377, 1 interactor
MINTiP25377
STRINGi4932.YCR105W

Structurei

3D structure databases

ProteinModelPortaliP25377
SMRiP25377
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00840000131639
HOGENOMiHOG000294667
InParanoidiP25377
KOiK00002
OMAiYRFSIDM
OrthoDBiEOG092C34I7

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR029752 D-isomer_DH_CS1
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P25377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYPEKFQGI GISNAKDWKH PKLVSFDPKP FGDHDVDVEI EACGICGSDF
60 70 80 90 100
HIAVGNWGPV PENQILGHEI IGRVVKVGSK CHTGVKIGDR VGVGAQALAC
110 120 130 140 150
FECERCKSDN EQYCTNDHVL TMWTPYKDGY ISQGGFASHV RLHEHFAIQI
160 170 180 190 200
PENIPSPLAA PLLCGGITVF SPLLRNGCGP GKRVGIVGIG GIGHMGILLA
210 220 230 240 250
KAMGAEVYAF SRGHSKREDS MKLGADHYIA MLEDKGWTEQ YSNALDLLVV
260 270 280 290 300
CSSSLSKVNF DSIVKIMKIG GSIVSIAAPE VNEKLVLKPL GLMGVSISSS
310 320 330 340 350
AIGSRKEIEQ LLKLVSEKNV KIWVEKLPIS EEGVSHAFTR MESGDVKYRF
360
TLVDYDKKFH K
Length:361
Mass (Da):39,348
Last modified:May 1, 1992 - v1
Checksum:iBFB0E6C5F93D3F07
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42237.1
BK006937 Genomic DNA Translation: DAA07574.1
PIRiS19417
RefSeqiNP_010030.1, NM_001178812.1

Genome annotation databases

EnsemblFungiiCAA42237; CAA42237; CAA42237
YCR105W; YCR105W; YCR105W
GeneIDi850469
KEGGisce:YCR105W

Similar proteinsi

Entry informationi

Entry nameiADH7_YEAST
AccessioniPrimary (citable) accession number: P25377
Secondary accession number(s): D6VRA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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