Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P25377

- ADH7_YEAST

UniProt

P25377 - ADH7_YEAST

Protein

NADP-dependent alcohol dehydrogenase 7

Gene

ADH7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    NADP-dependent alcohol dehydrogenase with a broad substrate specificity.

    Catalytic activityi

    An alcohol + NADP+ = an aldehyde + NADPH.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi46 – 461Zinc 1; catalyticBy similarity
    Metal bindingi68 – 681Zinc 1; catalyticBy similarity
    Metal bindingi100 – 1001Zinc 2By similarity
    Metal bindingi103 – 1031Zinc 2By similarity
    Metal bindingi106 – 1061Zinc 2By similarity
    Metal bindingi114 – 1141Zinc 2By similarity
    Metal bindingi164 – 1641Zinc 1; catalyticBy similarity
    Binding sitei216 – 2161NADBy similarity
    Binding sitei349 – 3491NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi188 – 1936NADBy similarity
    Nucleotide bindingi276 – 2783NADBy similarity

    GO - Molecular functioni

    1. alcohol dehydrogenase (NADP+) activity Source: SGD
    2. cofactor binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. alcohol metabolic process Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NADP, Zinc

    Enzyme and pathway databases

    BioCyciYEAST:YCR105W-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADP-dependent alcohol dehydrogenase 7 (EC:1.1.1.2)
    Alternative name(s):
    NADP-dependent alcohol dehydrogenase VII
    Short name:
    ADHVII
    Gene namesi
    Name:ADH7
    Ordered Locus Names:YCR105W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR105w.
    SGDiS000000702. ADH7.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361NADP-dependent alcohol dehydrogenase 7PRO_0000160735Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei316 – 3161Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP25377.

    Expressioni

    Gene expression databases

    GenevestigatoriP25377.

    Interactioni

    Subunit structurei

    Homodimer.1 Publication

    Protein-protein interaction databases

    BioGridi31077. 14 interactions.
    DIPiDIP-7661N.
    MINTiMINT-2789097.
    STRINGi4932.YCR105W.

    Structurei

    3D structure databases

    ProteinModelPortaliP25377.
    SMRiP25377. Positions 1-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1064.
    GeneTreeiENSGT00750000118226.
    HOGENOMiHOG000294667.
    KOiK00002.
    OrthoDBiEOG757D7B.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25377-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLYPEKFQGI GISNAKDWKH PKLVSFDPKP FGDHDVDVEI EACGICGSDF    50
    HIAVGNWGPV PENQILGHEI IGRVVKVGSK CHTGVKIGDR VGVGAQALAC 100
    FECERCKSDN EQYCTNDHVL TMWTPYKDGY ISQGGFASHV RLHEHFAIQI 150
    PENIPSPLAA PLLCGGITVF SPLLRNGCGP GKRVGIVGIG GIGHMGILLA 200
    KAMGAEVYAF SRGHSKREDS MKLGADHYIA MLEDKGWTEQ YSNALDLLVV 250
    CSSSLSKVNF DSIVKIMKIG GSIVSIAAPE VNEKLVLKPL GLMGVSISSS 300
    AIGSRKEIEQ LLKLVSEKNV KIWVEKLPIS EEGVSHAFTR MESGDVKYRF 350
    TLVDYDKKFH K 361
    Length:361
    Mass (Da):39,348
    Last modified:May 1, 1992 - v1
    Checksum:iBFB0E6C5F93D3F07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42237.1.
    BK006937 Genomic DNA. Translation: DAA07574.1.
    PIRiS19417.
    RefSeqiNP_010030.1. NM_001178812.1.

    Genome annotation databases

    EnsemblFungiiYCR105W; YCR105W; YCR105W.
    GeneIDi850469.
    KEGGisce:YCR105W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42237.1 .
    BK006937 Genomic DNA. Translation: DAA07574.1 .
    PIRi S19417.
    RefSeqi NP_010030.1. NM_001178812.1.

    3D structure databases

    ProteinModelPortali P25377.
    SMRi P25377. Positions 1-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31077. 14 interactions.
    DIPi DIP-7661N.
    MINTi MINT-2789097.
    STRINGi 4932.YCR105W.

    Proteomic databases

    PaxDbi P25377.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR105W ; YCR105W ; YCR105W .
    GeneIDi 850469.
    KEGGi sce:YCR105W.

    Organism-specific databases

    CYGDi YCR105w.
    SGDi S000000702. ADH7.

    Phylogenomic databases

    eggNOGi COG1064.
    GeneTreei ENSGT00750000118226.
    HOGENOMi HOG000294667.
    KOi K00002.
    OrthoDBi EOG757D7B.

    Enzyme and pathway databases

    BioCyci YEAST:YCR105W-MONOMER.

    Miscellaneous databases

    NextBioi 966116.

    Gene expression databases

    Genevestigatori P25377.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Characterization of a Saccharomyces cerevisiae NADP(H)-dependent alcohol dehydrogenase (ADHVII), a member of the cinnamyl alcohol dehydrogenase family."
      Larroy C., Pares X., Biosca J.A.
      Eur. J. Biochem. 269:5738-5745(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, SUBUNIT.
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry."
      Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.
      Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-316, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiADH7_YEAST
    AccessioniPrimary (citable) accession number: P25377
    Secondary accession number(s): D6VRA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 2870 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3