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Protein

Thioredoxin-3, mitochondrial

Gene

TRX3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei49Deprotonates C-terminal active site CysBy similarity1
Active sitei55NucleophileBy similarity1
Sitei56Contributes to redox potential valueBy similarity1
Sitei57Contributes to redox potential valueBy similarity1
Active sitei58NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: GO_Central
  • cellular response to oxidative stress Source: SGD
  • glycerol ether metabolic process Source: InterPro
  • protein folding Source: GO_Central
  • sulfate assimilation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29379-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-3, mitochondrial
Gene namesi
Name:TRX3
Ordered Locus Names:YCR083W
ORF Names:YCR83W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR083W.
SGDiS000000679. TRX3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionSequence analysisAdd BLAST21
ChainiPRO_000003415522 – 127Thioredoxin-3, mitochondrialAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 58Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP25372.
PRIDEiP25372.

Interactioni

Protein-protein interaction databases

BioGridi31056. 32 interactors.
IntActiP25372. 3 interactors.
MINTiMINT-4478665.

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 26Combined sources3
Helixi33 – 42Combined sources10
Beta strandi44 – 51Combined sources8
Helixi56 – 60Combined sources5
Helixi62 – 71Combined sources10
Beta strandi75 – 81Combined sources7
Turni82 – 84Combined sources3
Helixi86 – 91Combined sources6
Beta strandi96 – 104Combined sources9
Beta strandi107 – 115Combined sources9
Helixi117 – 125Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OE0X-ray2.00A/B22-127[»]
2OE1X-ray2.10A/B22-127[»]
2OE3X-ray1.80A/B22-127[»]
ProteinModelPortaliP25372.
SMRiP25372.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25372.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 127ThioredoxinPROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Belongs to the thioredoxin family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Transit peptide

Phylogenomic databases

GeneTreeiENSGT00530000063008.
HOGENOMiHOG000292977.
InParanoidiP25372.
KOiK03671.
OMAiNGEKTGH.
OrthoDBiEOG092C4AE3.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFYKPVMRM AVRPLKSIRF QSSYTSITKL TNLTEFRNLI KQNDKLVIDF
60 70 80 90 100
YATWCGPCKM MQPHLTKLIQ AYPDVRFVKC DVDESPDIAK ECEVTAMPTF
110 120
VLGKDGQLIG KIIGANPTAL EKGIKDL
Length:127
Mass (Da):14,432
Last modified:May 1, 1992 - v1
Checksum:iB55D434B6E5DB28A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42258.1.
BK006937 Genomic DNA. Translation: DAA07553.1.
PIRiS19498.
RefSeqiNP_010006.1. NM_001178789.1.

Genome annotation databases

EnsemblFungiiCAA42258; CAA42258; CAA42258.
YCR083W; YCR083W; YCR083W.
GeneIDi850444.
KEGGisce:YCR083W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42258.1.
BK006937 Genomic DNA. Translation: DAA07553.1.
PIRiS19498.
RefSeqiNP_010006.1. NM_001178789.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OE0X-ray2.00A/B22-127[»]
2OE1X-ray2.10A/B22-127[»]
2OE3X-ray1.80A/B22-127[»]
ProteinModelPortaliP25372.
SMRiP25372.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31056. 32 interactors.
IntActiP25372. 3 interactors.
MINTiMINT-4478665.

Proteomic databases

MaxQBiP25372.
PRIDEiP25372.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42258; CAA42258; CAA42258.
YCR083W; YCR083W; YCR083W.
GeneIDi850444.
KEGGisce:YCR083W.

Organism-specific databases

EuPathDBiFungiDB:YCR083W.
SGDiS000000679. TRX3.

Phylogenomic databases

GeneTreeiENSGT00530000063008.
HOGENOMiHOG000292977.
InParanoidiP25372.
KOiK03671.
OMAiNGEKTGH.
OrthoDBiEOG092C4AE3.

Enzyme and pathway databases

BioCyciYEAST:G3O-29379-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP25372.
PROiP25372.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRX3_YEAST
AccessioniPrimary (citable) accession number: P25372
Secondary accession number(s): D6VR84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Yeast has two cytoplasmic thioredoxins, TRX1 and TRX2, and one mitochondrial, TRX3.
Present with 1010 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.