Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P25371

- ADP1_YEAST

UniProt

P25371 - ADP1_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable ATP-dependent permease

Gene

ADP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi423 – 4308ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: SGD
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29328-MONOMER.
ReactomeiREACT_189191. Iron uptake and transport.
REACT_221494. Abacavir transmembrane transport.

Protein family/group databases

TCDBi3.A.1.204.9. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent permease
Gene namesi
Name:ADP1
Ordered Locus Names:YCR011C
ORF Names:YCR105, YCR11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR011c.
SGDiS000000604. ADP1.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 324299LumenalSequence AnalysisAdd
BLAST
Transmembranei325 – 34521HelicalSequence AnalysisAdd
BLAST
Topological domaini346 – 463118CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei464 – 48118HelicalSequence AnalysisAdd
BLAST
Topological domaini482 – 793312LumenalSequence AnalysisAdd
BLAST
Transmembranei794 – 81421HelicalSequence AnalysisAdd
BLAST
Topological domaini815 – 82814CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei829 – 84921HelicalSequence AnalysisAdd
BLAST
Topological domaini850 – 87728LumenalSequence AnalysisAdd
BLAST
Transmembranei878 – 89821HelicalSequence AnalysisAdd
BLAST
Topological domaini899 – 90911CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei910 – 93021HelicalSequence AnalysisAdd
BLAST
Topological domaini931 – 9377LumenalSequence Analysis
Transmembranei938 – 95821HelicalSequence AnalysisAdd
BLAST
Topological domaini959 – 100042CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1001 – 102121HelicalSequence AnalysisAdd
BLAST
Topological domaini1022 – 10243LumenalSequence Analysis
Transmembranei1025 – 104521HelicalSequence AnalysisAdd
BLAST
Topological domaini1046 – 10494CytoplasmicSequence Analysis

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 10491024Probable ATP-dependent permeasePRO_0000000257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
Modified residuei659 – 6591Phosphoserine2 Publications
Modified residuei702 – 7021Phosphoserine2 Publications
Glycosylationi935 – 9351N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP25371.
PaxDbiP25371.
PeptideAtlasiP25371.

Expressioni

Gene expression databases

GenevestigatoriP25371.

Interactioni

Protein-protein interaction databases

BioGridi30990. 35 interactions.
DIPiDIP-1775N.
IntActiP25371. 5 interactions.
MINTiMINT-389954.
STRINGi4932.YCR011C.

Structurei

3D structure databases

ProteinModelPortaliP25371.
SMRiP25371. Positions 351-639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini384 – 631248ABC transporterPROSITE-ProRule annotationAdd
BLAST
Domaini793 – 1044252ABC transmembrane type-2Add
BLAST

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0842.
GeneTreeiENSGT00740000114855.
HOGENOMiHOG000214640.
InParanoidiP25371.
OMAiLMMALIS.
OrthoDBiEOG7XDBQ6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013032. EGF-like_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25371-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSHRRYLYY SILSFLLLSC SVVLAKQDKT PFFEGTSSKN SRLTAQDKGN
60 70 80 90 100
DTCPPCFNCM LPIFECKQFS ECNSYTGRCE CIEGFAGDDC SLPLCGGLSP
110 120 130 140 150
DESGNKDRPI RAQNDTCHCD NGWGGINCDV CQEDFVCDAF MPDPSIKGTC
160 170 180 190 200
YKNGMIVDKV FSGCNVTNEK ILQILNGKIP QITFACDKPN QECNFQFWID
210 220 230 240 250
QLESFYCGLS DCAFEYDLEQ NTSHYKCNDV QCKCVPDTVL CGAKGSIDIS
260 270 280 290 300
DFLTETIKGP GDFSCDLETR QCKFSEPSMN DLILTVFGDP YITLKCESGE
310 320 330 340 350
CVHYSEIPGY KSPSKDPTVS WQGKLVLALT AVMVLALFTF ATFYISKSPL
360 370 380 390 400
FRNGLGSSKS PIRLPDEDAV NNFLQNEDDT LATLSFENIT YSVPSINSDG
410 420 430 440 450
VEETVLNEIS GIVKPGQILA IMGGSGAGKT TLLDILAMKR KTGHVSGSIK
460 470 480 490 500
VNGISMDRKS FSKIIGFVDQ DDFLLPTLTV FETVLNSALL RLPKALSFEA
510 520 530 540 550
KKARVYKVLE ELRIIDIKDR IIGNEFDRGI SGGEKRRVSI ACELVTSPLV
560 570 580 590 600
LFLDEPTSGL DASNANNVIE CLVRLSSDYN RTLVLSIHQP RSNIFYLFDK
610 620 630 640 650
LVLLSKGEMV YSGNAKKVSE FLRNEGYICP DNYNIADYLI DITFEAGPQG
660 670 680 690 700
KRRRIRNISD LEAGTDTNDI DNTIHQTTFT SSDGTTQREW AHLAAHRDEI
710 720 730 740 750
RSLLRDEEDV EGTDGRRGAT EIDLNTKLLH DKYKDSVYYA ELSQEIEEVL
760 770 780 790 800
SEGDEESNVL NGDLPTGQQS AGFLQQLSIL NSRSFKNMYR NPKLLLGNYL
810 820 830 840 850
LTILLSLFLG TLYYNVSNDI SGFQNRMGLF FFILTYFGFV TFTGLSSFAL
860 870 880 890 900
ERIIFIKERS NNYYSPLAYY ISKIMSEVVP LRVVPPILLS LIVYPMTGLN
910 920 930 940 950
MKDNAFFKCI GILILFNLGI SLEILTIGII FEDLNNSIIL SVLVLLGSLL
960 970 980 990 1000
FSGLFINTKN ITNVAFKYLK NFSVFYYAYE SLLINEVKTL MLKERKYGLN
1010 1020 1030 1040
IEVPGATILS TFGFVVQNLV FDIKILALFN VVFLIMGYLA LKWIVVEQK
Length:1,049
Mass (Da):117,231
Last modified:March 15, 2004 - v2
Checksum:iA3E9CE54BC28407B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti29 – 291K → E no nucleotide entry (PubMed:1789009)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42328.2.
AY693056 Genomic DNA. Translation: AAT93075.1.
BK006937 Genomic DNA. Translation: DAA07489.1.
PIRiS19421.
RefSeqiNP_009937.2. NM_001178724.1.

Genome annotation databases

EnsemblFungiiYCR011C; YCR011C; YCR011C.
GeneIDi850369.
KEGGisce:YCR011C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42328.2 .
AY693056 Genomic DNA. Translation: AAT93075.1 .
BK006937 Genomic DNA. Translation: DAA07489.1 .
PIRi S19421.
RefSeqi NP_009937.2. NM_001178724.1.

3D structure databases

ProteinModelPortali P25371.
SMRi P25371. Positions 351-639.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 30990. 35 interactions.
DIPi DIP-1775N.
IntActi P25371. 5 interactions.
MINTi MINT-389954.
STRINGi 4932.YCR011C.

Protein family/group databases

TCDBi 3.A.1.204.9. the atp-binding cassette (abc) superfamily.

Proteomic databases

MaxQBi P25371.
PaxDbi P25371.
PeptideAtlasi P25371.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR011C ; YCR011C ; YCR011C .
GeneIDi 850369.
KEGGi sce:YCR011C.

Organism-specific databases

CYGDi YCR011c.
SGDi S000000604. ADP1.

Phylogenomic databases

eggNOGi COG0842.
GeneTreei ENSGT00740000114855.
HOGENOMi HOG000214640.
InParanoidi P25371.
OMAi LMMALIS.
OrthoDBi EOG7XDBQ6.

Enzyme and pathway databases

BioCyci YEAST:G3O-29328-MONOMER.
Reactomei REACT_189191. Iron uptake and transport.
REACT_221494. Abacavir transmembrane transport.

Miscellaneous databases

NextBioi 965858.

Gene expression databases

Genevestigatori P25371.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013032. EGF-like_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The product of the YCR105 gene located on the chromosome III from Saccharomyces cerevisiae presents homologies to ATP-dependent permeases."
    Purnelle B., Skala J., Goffeau A.
    Yeast 7:867-872(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete sequence of a 10.8 kb segment distal of SUF2 on the right arm of chromosome III from Saccharomyces cerevisiae reveals seven open reading frames including the RVS161, ADP1 and PGK genes."
    Skala J., Purnelle B., Goffeau A.
    Yeast 8:409-417(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Valles G., Volckaerts G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 29.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-659 AND SER-702, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-659 AND SER-702, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiADP1_YEAST
AccessioniPrimary (citable) accession number: P25371
Secondary accession number(s): D6VR20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 15, 2004
Last modified: November 26, 2014
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3