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Protein

Probable ATP-dependent permease

Gene

ADP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi423 – 430ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: SGD
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29328-MONOMER.
ReactomeiR-SCE-1369062. ABC transporters in lipid homeostasis.
R-SCE-194223. HDL-mediated lipid transport.
R-SCE-917937. Iron uptake and transport.

Protein family/group databases

TCDBi3.A.1.204.9. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent permease
Gene namesi
Name:ADP1
Ordered Locus Names:YCR011C
ORF Names:YCR105, YCR11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR011C.
SGDiS000000604. ADP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 324LumenalSequence analysisAdd BLAST299
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 463CytoplasmicSequence analysisAdd BLAST118
Transmembranei464 – 481HelicalSequence analysisAdd BLAST18
Topological domaini482 – 793LumenalSequence analysisAdd BLAST312
Transmembranei794 – 814HelicalSequence analysisAdd BLAST21
Topological domaini815 – 828CytoplasmicSequence analysisAdd BLAST14
Transmembranei829 – 849HelicalSequence analysisAdd BLAST21
Topological domaini850 – 877LumenalSequence analysisAdd BLAST28
Transmembranei878 – 898HelicalSequence analysisAdd BLAST21
Topological domaini899 – 909CytoplasmicSequence analysisAdd BLAST11
Transmembranei910 – 930HelicalSequence analysisAdd BLAST21
Topological domaini931 – 937LumenalSequence analysis7
Transmembranei938 – 958HelicalSequence analysisAdd BLAST21
Topological domaini959 – 1000CytoplasmicSequence analysisAdd BLAST42
Transmembranei1001 – 1021HelicalSequence analysisAdd BLAST21
Topological domaini1022 – 1024LumenalSequence analysis3
Transmembranei1025 – 1045HelicalSequence analysisAdd BLAST21
Topological domaini1046 – 1049CytoplasmicSequence analysis4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000025726 – 1049Probable ATP-dependent permeaseAdd BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi114N-linked (GlcNAc...)Sequence analysis1
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Glycosylationi221N-linked (GlcNAc...)Sequence analysis1
Modified residuei659PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Glycosylationi935N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP25371.
PRIDEiP25371.

PTM databases

iPTMnetiP25371.

Interactioni

Protein-protein interaction databases

BioGridi30990. 35 interactors.
DIPiDIP-1775N.
IntActiP25371. 5 interactors.
MINTiMINT-389954.

Structurei

3D structure databases

ProteinModelPortaliP25371.
SMRiP25371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini384 – 631ABC transporterPROSITE-ProRule annotationAdd BLAST248
Domaini793 – 1044ABC transmembrane type-2Add BLAST252

Sequence similaritiesi

Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00740000114855.
HOGENOMiHOG000214640.
InParanoidiP25371.
OMAiREWAHLA.
OrthoDBiEOG092C0EF9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013032. EGF-like_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSHRRYLYY SILSFLLLSC SVVLAKQDKT PFFEGTSSKN SRLTAQDKGN
60 70 80 90 100
DTCPPCFNCM LPIFECKQFS ECNSYTGRCE CIEGFAGDDC SLPLCGGLSP
110 120 130 140 150
DESGNKDRPI RAQNDTCHCD NGWGGINCDV CQEDFVCDAF MPDPSIKGTC
160 170 180 190 200
YKNGMIVDKV FSGCNVTNEK ILQILNGKIP QITFACDKPN QECNFQFWID
210 220 230 240 250
QLESFYCGLS DCAFEYDLEQ NTSHYKCNDV QCKCVPDTVL CGAKGSIDIS
260 270 280 290 300
DFLTETIKGP GDFSCDLETR QCKFSEPSMN DLILTVFGDP YITLKCESGE
310 320 330 340 350
CVHYSEIPGY KSPSKDPTVS WQGKLVLALT AVMVLALFTF ATFYISKSPL
360 370 380 390 400
FRNGLGSSKS PIRLPDEDAV NNFLQNEDDT LATLSFENIT YSVPSINSDG
410 420 430 440 450
VEETVLNEIS GIVKPGQILA IMGGSGAGKT TLLDILAMKR KTGHVSGSIK
460 470 480 490 500
VNGISMDRKS FSKIIGFVDQ DDFLLPTLTV FETVLNSALL RLPKALSFEA
510 520 530 540 550
KKARVYKVLE ELRIIDIKDR IIGNEFDRGI SGGEKRRVSI ACELVTSPLV
560 570 580 590 600
LFLDEPTSGL DASNANNVIE CLVRLSSDYN RTLVLSIHQP RSNIFYLFDK
610 620 630 640 650
LVLLSKGEMV YSGNAKKVSE FLRNEGYICP DNYNIADYLI DITFEAGPQG
660 670 680 690 700
KRRRIRNISD LEAGTDTNDI DNTIHQTTFT SSDGTTQREW AHLAAHRDEI
710 720 730 740 750
RSLLRDEEDV EGTDGRRGAT EIDLNTKLLH DKYKDSVYYA ELSQEIEEVL
760 770 780 790 800
SEGDEESNVL NGDLPTGQQS AGFLQQLSIL NSRSFKNMYR NPKLLLGNYL
810 820 830 840 850
LTILLSLFLG TLYYNVSNDI SGFQNRMGLF FFILTYFGFV TFTGLSSFAL
860 870 880 890 900
ERIIFIKERS NNYYSPLAYY ISKIMSEVVP LRVVPPILLS LIVYPMTGLN
910 920 930 940 950
MKDNAFFKCI GILILFNLGI SLEILTIGII FEDLNNSIIL SVLVLLGSLL
960 970 980 990 1000
FSGLFINTKN ITNVAFKYLK NFSVFYYAYE SLLINEVKTL MLKERKYGLN
1010 1020 1030 1040
IEVPGATILS TFGFVVQNLV FDIKILALFN VVFLIMGYLA LKWIVVEQK
Length:1,049
Mass (Da):117,231
Last modified:March 15, 2004 - v2
Checksum:iA3E9CE54BC28407B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29K → E no nucleotide entry (PubMed:1789009).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42328.2.
AY693056 Genomic DNA. Translation: AAT93075.1.
BK006937 Genomic DNA. Translation: DAA07489.1.
PIRiS19421.
RefSeqiNP_009937.2. NM_001178724.1.

Genome annotation databases

EnsemblFungiiCAA42328; CAA42328; CAA42328.
YCR011C; YCR011C; YCR011C.
GeneIDi850369.
KEGGisce:YCR011C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42328.2.
AY693056 Genomic DNA. Translation: AAT93075.1.
BK006937 Genomic DNA. Translation: DAA07489.1.
PIRiS19421.
RefSeqiNP_009937.2. NM_001178724.1.

3D structure databases

ProteinModelPortaliP25371.
SMRiP25371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30990. 35 interactors.
DIPiDIP-1775N.
IntActiP25371. 5 interactors.
MINTiMINT-389954.

Protein family/group databases

TCDBi3.A.1.204.9. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP25371.

Proteomic databases

MaxQBiP25371.
PRIDEiP25371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42328; CAA42328; CAA42328.
YCR011C; YCR011C; YCR011C.
GeneIDi850369.
KEGGisce:YCR011C.

Organism-specific databases

EuPathDBiFungiDB:YCR011C.
SGDiS000000604. ADP1.

Phylogenomic databases

GeneTreeiENSGT00740000114855.
HOGENOMiHOG000214640.
InParanoidiP25371.
OMAiREWAHLA.
OrthoDBiEOG092C0EF9.

Enzyme and pathway databases

BioCyciYEAST:G3O-29328-MONOMER.
ReactomeiR-SCE-1369062. ABC transporters in lipid homeostasis.
R-SCE-194223. HDL-mediated lipid transport.
R-SCE-917937. Iron uptake and transport.

Miscellaneous databases

PROiP25371.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013032. EGF-like_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADP1_YEAST
AccessioniPrimary (citable) accession number: P25371
Secondary accession number(s): D6VR20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 15, 2004
Last modified: November 30, 2016
This is version 165 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.