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UniProtKB - P25371 (ADP1_YEAST)

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Protein

Probable ATP-dependent permease

Gene

ADP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi423 – 430ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: SGD
  • ATP binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  • transmembrane transport Source: SGD
Complete GO annotation...

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29328-MONOMER.
ReactomeiR-SCE-1369062. ABC transporters in lipid homeostasis.
R-SCE-8964058. HDL remodeling.
R-SCE-917937. Iron uptake and transport.

Protein family/group databases

TCDBi3.A.1.204.9. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent permease
Gene namesi
Name:ADP1
Ordered Locus Names:YCR011C
ORF Names:YCR105, YCR11C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR011C.
SGDiS000000604. ADP1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 324LumenalSequence analysisAdd BLAST299
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Topological domaini346 – 463CytoplasmicSequence analysisAdd BLAST118
Transmembranei464 – 481HelicalSequence analysisAdd BLAST18
Topological domaini482 – 793LumenalSequence analysisAdd BLAST312
Transmembranei794 – 814HelicalSequence analysisAdd BLAST21
Topological domaini815 – 828CytoplasmicSequence analysisAdd BLAST14
Transmembranei829 – 849HelicalSequence analysisAdd BLAST21
Topological domaini850 – 877LumenalSequence analysisAdd BLAST28
Transmembranei878 – 898HelicalSequence analysisAdd BLAST21
Topological domaini899 – 909CytoplasmicSequence analysisAdd BLAST11
Transmembranei910 – 930HelicalSequence analysisAdd BLAST21
Topological domaini931 – 937LumenalSequence analysis7
Transmembranei938 – 958HelicalSequence analysisAdd BLAST21
Topological domaini959 – 1000CytoplasmicSequence analysisAdd BLAST42
Transmembranei1001 – 1021HelicalSequence analysisAdd BLAST21
Topological domaini1022 – 1024LumenalSequence analysis3
Transmembranei1025 – 1045HelicalSequence analysisAdd BLAST21
Topological domaini1046 – 1049CytoplasmicSequence analysis4

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000025726 – 1049Probable ATP-dependent permeaseAdd BLAST1024

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi114N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi221N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei659PhosphoserineCombined sources1
Modified residuei702PhosphoserineCombined sources1
Glycosylationi935N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP25371.
PRIDEiP25371.

PTM databases

iPTMnetiP25371.

Interactioni

Protein-protein interaction databases

BioGridi30990. 48 interactors.
DIPiDIP-1775N.
IntActiP25371. 5 interactors.
MINTiMINT-389954.

Structurei

3D structure databases

ProteinModelPortaliP25371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini384 – 631ABC transporterPROSITE-ProRule annotationAdd BLAST248
Domaini793 – 1044ABC transmembrane type-2Add BLAST252

Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. [View classification]Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00740000114855.
HOGENOMiHOG000214640.
InParanoidiP25371.
OMAiLMLTHYA.
OrthoDBiEOG092C0EF9.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013032. EGF-like_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25371-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSHRRYLYY SILSFLLLSC SVVLAKQDKT PFFEGTSSKN SRLTAQDKGN 
        60         70         80         90        100
DTCPPCFNCM LPIFECKQFS ECNSYTGRCE CIEGFAGDDC SLPLCGGLSP 
       110        120        130        140        150
DESGNKDRPI RAQNDTCHCD NGWGGINCDV CQEDFVCDAF MPDPSIKGTC 
       160        170        180        190        200
YKNGMIVDKV FSGCNVTNEK ILQILNGKIP QITFACDKPN QECNFQFWID 
       210        220        230        240        250
QLESFYCGLS DCAFEYDLEQ NTSHYKCNDV QCKCVPDTVL CGAKGSIDIS 
       260        270        280        290        300
DFLTETIKGP GDFSCDLETR QCKFSEPSMN DLILTVFGDP YITLKCESGE 
       310        320        330        340        350
CVHYSEIPGY KSPSKDPTVS WQGKLVLALT AVMVLALFTF ATFYISKSPL 
       360        370        380        390        400
FRNGLGSSKS PIRLPDEDAV NNFLQNEDDT LATLSFENIT YSVPSINSDG 
       410        420        430        440        450
VEETVLNEIS GIVKPGQILA IMGGSGAGKT TLLDILAMKR KTGHVSGSIK 
       460        470        480        490        500
VNGISMDRKS FSKIIGFVDQ DDFLLPTLTV FETVLNSALL RLPKALSFEA 
       510        520        530        540        550
KKARVYKVLE ELRIIDIKDR IIGNEFDRGI SGGEKRRVSI ACELVTSPLV 
       560        570        580        590        600
LFLDEPTSGL DASNANNVIE CLVRLSSDYN RTLVLSIHQP RSNIFYLFDK 
       610        620        630        640        650
LVLLSKGEMV YSGNAKKVSE FLRNEGYICP DNYNIADYLI DITFEAGPQG 
       660        670        680        690        700
KRRRIRNISD LEAGTDTNDI DNTIHQTTFT SSDGTTQREW AHLAAHRDEI 
       710        720        730        740        750
RSLLRDEEDV EGTDGRRGAT EIDLNTKLLH DKYKDSVYYA ELSQEIEEVL 
       760        770        780        790        800
SEGDEESNVL NGDLPTGQQS AGFLQQLSIL NSRSFKNMYR NPKLLLGNYL 
       810        820        830        840        850
LTILLSLFLG TLYYNVSNDI SGFQNRMGLF FFILTYFGFV TFTGLSSFAL 
       860        870        880        890        900
ERIIFIKERS NNYYSPLAYY ISKIMSEVVP LRVVPPILLS LIVYPMTGLN 
       910        920        930        940        950
MKDNAFFKCI GILILFNLGI SLEILTIGII FEDLNNSIIL SVLVLLGSLL 
       960        970        980        990       1000
FSGLFINTKN ITNVAFKYLK NFSVFYYAYE SLLINEVKTL MLKERKYGLN 
      1010       1020       1030       1040 
IEVPGATILS TFGFVVQNLV FDIKILALFN VVFLIMGYLA LKWIVVEQK
Length:1,049
Mass (Da):117,231
Last modified:March 15, 2004 - v2
Checksum:iA3E9CE54BC28407B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29K → E no nucleotide entry (PubMed:1789009).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42328.2.
AY693056 Genomic DNA. Translation: AAT93075.1.
BK006937 Genomic DNA. Translation: DAA07489.1.
PIRiS19421.
RefSeqiNP_009937.2. NM_001178724.1.

Genome annotation databases

EnsemblFungiiCAA42328; CAA42328; CAA42328.
YCR011C; YCR011C; YCR011C.
GeneIDi850369.
KEGGisce:YCR011C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42328.2.
AY693056 Genomic DNA. Translation: AAT93075.1.
BK006937 Genomic DNA. Translation: DAA07489.1.
PIRiS19421.
RefSeqiNP_009937.2. NM_001178724.1.

3D structure databases

ProteinModelPortaliP25371.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30990. 48 interactors.
DIPiDIP-1775N.
IntActiP25371. 5 interactors.
MINTiMINT-389954.

Protein family/group databases

TCDBi3.A.1.204.9. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP25371.

Proteomic databases

MaxQBiP25371.
PRIDEiP25371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42328; CAA42328; CAA42328.
YCR011C; YCR011C; YCR011C.
GeneIDi850369.
KEGGisce:YCR011C.

Organism-specific databases

EuPathDBiFungiDB:YCR011C.
SGDiS000000604. ADP1.

Phylogenomic databases

GeneTreeiENSGT00740000114855.
HOGENOMiHOG000214640.
InParanoidiP25371.
OMAiLMLTHYA.
OrthoDBiEOG092C0EF9.

Enzyme and pathway databases

BioCyciYEAST:G3O-29328-MONOMER.
ReactomeiR-SCE-1369062. ABC transporters in lipid homeostasis.
R-SCE-8964058. HDL remodeling.
R-SCE-917937. Iron uptake and transport.

Miscellaneous databases

PROiPR:P25371.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR013032. EGF-like_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADP1_YEAST
AccessioniPrimary (citable) accession number: P25371
Secondary accession number(s): D6VR20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 15, 2004
Last modified: June 7, 2017
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.