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P25371

- ADP1_YEAST

UniProt

P25371 - ADP1_YEAST

Protein

Probable ATP-dependent permease

Gene

ADP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (15 Mar 2004)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi423 – 4308ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: SGD
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29328-MONOMER.
    ReactomeiREACT_189191. Iron uptake and transport.
    REACT_221494. Abacavir transmembrane transport.

    Protein family/group databases

    TCDBi3.A.1.204.9. the atp-binding cassette (abc) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ATP-dependent permease
    Gene namesi
    Name:ADP1
    Ordered Locus Names:YCR011C
    ORF Names:YCR105, YCR11C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR011c.
    SGDiS000000604. ADP1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 10491024Probable ATP-dependent permeasePRO_0000000257Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi165 – 1651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi221 – 2211N-linked (GlcNAc...)Sequence Analysis
    Modified residuei659 – 6591Phosphoserine2 Publications
    Modified residuei702 – 7021Phosphoserine2 Publications
    Glycosylationi935 – 9351N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP25371.
    PaxDbiP25371.
    PeptideAtlasiP25371.

    Expressioni

    Gene expression databases

    GenevestigatoriP25371.

    Interactioni

    Protein-protein interaction databases

    BioGridi30990. 35 interactions.
    DIPiDIP-1775N.
    IntActiP25371. 5 interactions.
    MINTiMINT-389954.
    STRINGi4932.YCR011C.

    Structurei

    3D structure databases

    ProteinModelPortaliP25371.
    SMRiP25371. Positions 49-137, 372-639.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 324299LumenalSequence AnalysisAdd
    BLAST
    Topological domaini346 – 463118CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini482 – 793312LumenalSequence AnalysisAdd
    BLAST
    Topological domaini815 – 82814CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini850 – 87728LumenalSequence AnalysisAdd
    BLAST
    Topological domaini899 – 90911CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini931 – 9377LumenalSequence Analysis
    Topological domaini959 – 100042CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1022 – 10243LumenalSequence Analysis
    Topological domaini1046 – 10494CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei325 – 34521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei464 – 48118HelicalSequence AnalysisAdd
    BLAST
    Transmembranei794 – 81421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei829 – 84921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei878 – 89821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei910 – 93021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei938 – 95821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1001 – 102121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1025 – 104521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini384 – 631248ABC transporterPROSITE-ProRule annotationAdd
    BLAST
    Domaini793 – 1044252ABC transmembrane type-2Add
    BLAST

    Sequence similaritiesi

    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0842.
    GeneTreeiENSGT00740000114855.
    HOGENOMiHOG000214640.
    OMAiLMMALIS.
    OrthoDBiEOG7XDBQ6.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR013032. EGF-like_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01061. ABC2_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25371-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSHRRYLYY SILSFLLLSC SVVLAKQDKT PFFEGTSSKN SRLTAQDKGN     50
    DTCPPCFNCM LPIFECKQFS ECNSYTGRCE CIEGFAGDDC SLPLCGGLSP 100
    DESGNKDRPI RAQNDTCHCD NGWGGINCDV CQEDFVCDAF MPDPSIKGTC 150
    YKNGMIVDKV FSGCNVTNEK ILQILNGKIP QITFACDKPN QECNFQFWID 200
    QLESFYCGLS DCAFEYDLEQ NTSHYKCNDV QCKCVPDTVL CGAKGSIDIS 250
    DFLTETIKGP GDFSCDLETR QCKFSEPSMN DLILTVFGDP YITLKCESGE 300
    CVHYSEIPGY KSPSKDPTVS WQGKLVLALT AVMVLALFTF ATFYISKSPL 350
    FRNGLGSSKS PIRLPDEDAV NNFLQNEDDT LATLSFENIT YSVPSINSDG 400
    VEETVLNEIS GIVKPGQILA IMGGSGAGKT TLLDILAMKR KTGHVSGSIK 450
    VNGISMDRKS FSKIIGFVDQ DDFLLPTLTV FETVLNSALL RLPKALSFEA 500
    KKARVYKVLE ELRIIDIKDR IIGNEFDRGI SGGEKRRVSI ACELVTSPLV 550
    LFLDEPTSGL DASNANNVIE CLVRLSSDYN RTLVLSIHQP RSNIFYLFDK 600
    LVLLSKGEMV YSGNAKKVSE FLRNEGYICP DNYNIADYLI DITFEAGPQG 650
    KRRRIRNISD LEAGTDTNDI DNTIHQTTFT SSDGTTQREW AHLAAHRDEI 700
    RSLLRDEEDV EGTDGRRGAT EIDLNTKLLH DKYKDSVYYA ELSQEIEEVL 750
    SEGDEESNVL NGDLPTGQQS AGFLQQLSIL NSRSFKNMYR NPKLLLGNYL 800
    LTILLSLFLG TLYYNVSNDI SGFQNRMGLF FFILTYFGFV TFTGLSSFAL 850
    ERIIFIKERS NNYYSPLAYY ISKIMSEVVP LRVVPPILLS LIVYPMTGLN 900
    MKDNAFFKCI GILILFNLGI SLEILTIGII FEDLNNSIIL SVLVLLGSLL 950
    FSGLFINTKN ITNVAFKYLK NFSVFYYAYE SLLINEVKTL MLKERKYGLN 1000
    IEVPGATILS TFGFVVQNLV FDIKILALFN VVFLIMGYLA LKWIVVEQK 1049
    Length:1,049
    Mass (Da):117,231
    Last modified:March 15, 2004 - v2
    Checksum:iA3E9CE54BC28407B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti29 – 291K → E no nucleotide entry (PubMed:1789009)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42328.2.
    AY693056 Genomic DNA. Translation: AAT93075.1.
    BK006937 Genomic DNA. Translation: DAA07489.1.
    PIRiS19421.
    RefSeqiNP_009937.2. NM_001178724.1.

    Genome annotation databases

    EnsemblFungiiYCR011C; YCR011C; YCR011C.
    GeneIDi850369.
    KEGGisce:YCR011C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42328.2 .
    AY693056 Genomic DNA. Translation: AAT93075.1 .
    BK006937 Genomic DNA. Translation: DAA07489.1 .
    PIRi S19421.
    RefSeqi NP_009937.2. NM_001178724.1.

    3D structure databases

    ProteinModelPortali P25371.
    SMRi P25371. Positions 49-137, 372-639.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 30990. 35 interactions.
    DIPi DIP-1775N.
    IntActi P25371. 5 interactions.
    MINTi MINT-389954.
    STRINGi 4932.YCR011C.

    Protein family/group databases

    TCDBi 3.A.1.204.9. the atp-binding cassette (abc) superfamily.

    Proteomic databases

    MaxQBi P25371.
    PaxDbi P25371.
    PeptideAtlasi P25371.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR011C ; YCR011C ; YCR011C .
    GeneIDi 850369.
    KEGGi sce:YCR011C.

    Organism-specific databases

    CYGDi YCR011c.
    SGDi S000000604. ADP1.

    Phylogenomic databases

    eggNOGi COG0842.
    GeneTreei ENSGT00740000114855.
    HOGENOMi HOG000214640.
    OMAi LMMALIS.
    OrthoDBi EOG7XDBQ6.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29328-MONOMER.
    Reactomei REACT_189191. Iron uptake and transport.
    REACT_221494. Abacavir transmembrane transport.

    Miscellaneous databases

    NextBioi 965858.

    Gene expression databases

    Genevestigatori P25371.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR013525. ABC_2_trans.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR013032. EGF-like_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01061. ABC2_membrane. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The product of the YCR105 gene located on the chromosome III from Saccharomyces cerevisiae presents homologies to ATP-dependent permeases."
      Purnelle B., Skala J., Goffeau A.
      Yeast 7:867-872(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete sequence of a 10.8 kb segment distal of SUF2 on the right arm of chromosome III from Saccharomyces cerevisiae reveals seven open reading frames including the RVS161, ADP1 and PGK genes."
      Skala J., Purnelle B., Goffeau A.
      Yeast 8:409-417(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Valles G., Volckaerts G.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 29.
    5. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    6. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    7. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    10. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-659 AND SER-702, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-659 AND SER-702, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiADP1_YEAST
    AccessioniPrimary (citable) accession number: P25371
    Secondary accession number(s): D6VR20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: March 15, 2004
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 339 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3