ADP1

Functionⁱ

Miscellaneous

Present with 339 molecules/cell in log phase SD medium.1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	423 – 430	ATPPROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATPase activity, coupled to transmembrane movement of substances
Source: SGD
Inferred from sequence or structural similarityⁱ
- 9020838
ATP binding Source: UniProtKB-KW

Complete GO annotation...

GO - Biological processⁱ

transmembrane transport
Source: SGD
Inferred from sequence or structural similarityⁱ
- 9020838

Complete GO annotation...

Keywordsⁱ

Biological process	Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29328-MONOMER.
Reactomeⁱ	R-SCE-1369062. ABC transporters in lipid homeostasis. R-SCE-8964058. HDL remodeling. R-SCE-917937. Iron uptake and transport.

Protein family/group databases

TCDBⁱ	3.A.1.204.9. the atp-binding cassette (abc) superfamily.

TCDBⁱ

3.A.1.204.9. the atp-binding cassette (abc) superfamily.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable ATP-dependent permease
Gene namesⁱ	Name:ADP1 Ordered Locus Names:YCR011C ORF Names:YCR105, YCR11C
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome III

Organism-specific databases

EuPathDBⁱ	FungiDB:YCR011C.
Saccharomyces Genome Database More...SGDⁱ	S000000604. ADP1.

Subcellular locationⁱ

Endoplasmic reticulum membrane
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "Global analysis of protein localization in budding yeast."
  Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
  Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
; Multi-pass membrane protein
1 Publication
Manual assertion based on experiment inⁱ
- Ref.7
  "Global analysis of protein localization in budding yeast."
  Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
  Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 324	LumenalSequence analysisAdd BLAST	299
Transmembraneⁱ	325 – 345	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	346 – 463	CytoplasmicSequence analysisAdd BLAST	118
Transmembraneⁱ	464 – 481	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	482 – 793	LumenalSequence analysisAdd BLAST	312
Transmembraneⁱ	794 – 814	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	815 – 828	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	829 – 849	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	850 – 877	LumenalSequence analysisAdd BLAST	28
Transmembraneⁱ	878 – 898	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	899 – 909	CytoplasmicSequence analysisAdd BLAST	11
Transmembraneⁱ	910 – 930	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	931 – 937	LumenalSequence analysis	7
Transmembraneⁱ	938 – 958	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	959 – 1000	CytoplasmicSequence analysisAdd BLAST	42
Transmembraneⁱ	1001 – 1021	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1022 – 1024	LumenalSequence analysis	3
Transmembraneⁱ	1025 – 1045	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1046 – 1049	CytoplasmicSequence analysis	4

GO - Cellular componentⁱ

endoplasmic reticulum membrane Source: UniProtKB-SubCell
integral component of membrane Source: GO_Central
plasma membrane Source: GO_Central

Complete GO annotation...

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000000257	26 – 1049	Probable ATP-dependent permeaseAdd BLAST		1024

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	50	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	114	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	165	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	221	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	659	PhosphoserineCombined sources	1
Modified residueⁱ	702	PhosphoserineCombined sources	1
Glycosylationⁱ	935	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P25371.
PRIDEⁱ	P25371.

PTM databases

iPTMnetⁱ	P25371.

iPTMnetⁱ

P25371.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	30990. 48 interactors.
Database of interacting proteins More...DIPⁱ	DIP-1775N.
IntActⁱ	P25371. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-389954.
STRINGⁱ	4932.YCR011C.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P25371.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	384 – 631	ABC transporterPROSITE-ProRule annotationAdd BLAST		248
Domainⁱ	793 – 1044	ABC transmembrane type-2Add BLAST		252

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. [View classification]Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00740000114855.
HOGENOMⁱ	HOG000214640.
InParanoidⁱ	P25371.
OMAⁱ	LMLTHYA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0EF9.

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593. AAA+_ATPase. IPR013525. ABC_2_trans. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR013032. EGF-like_CS. IPR027417. P-loop_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01061. ABC2_membrane. 1 hit. PF00005. ABC_tran. 1 hit.
SMARTⁱ	View protein in SMART SM00382. AAA. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P25371-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGSHRRYLYY SILSFLLLSC SVVLAKQDKT PFFEGTSSKN SRLTAQDKGN 
        60         70         80         90        100
DTCPPCFNCM LPIFECKQFS ECNSYTGRCE CIEGFAGDDC SLPLCGGLSP 
       110        120        130        140        150
DESGNKDRPI RAQNDTCHCD NGWGGINCDV CQEDFVCDAF MPDPSIKGTC 
       160        170        180        190        200
YKNGMIVDKV FSGCNVTNEK ILQILNGKIP QITFACDKPN QECNFQFWID 
       210        220        230        240        250
QLESFYCGLS DCAFEYDLEQ NTSHYKCNDV QCKCVPDTVL CGAKGSIDIS 
       260        270        280        290        300
DFLTETIKGP GDFSCDLETR QCKFSEPSMN DLILTVFGDP YITLKCESGE 
       310        320        330        340        350
CVHYSEIPGY KSPSKDPTVS WQGKLVLALT AVMVLALFTF ATFYISKSPL 
       360        370        380        390        400
FRNGLGSSKS PIRLPDEDAV NNFLQNEDDT LATLSFENIT YSVPSINSDG 
       410        420        430        440        450
VEETVLNEIS GIVKPGQILA IMGGSGAGKT TLLDILAMKR KTGHVSGSIK 
       460        470        480        490        500
VNGISMDRKS FSKIIGFVDQ DDFLLPTLTV FETVLNSALL RLPKALSFEA 
       510        520        530        540        550
KKARVYKVLE ELRIIDIKDR IIGNEFDRGI SGGEKRRVSI ACELVTSPLV 
       560        570        580        590        600
LFLDEPTSGL DASNANNVIE CLVRLSSDYN RTLVLSIHQP RSNIFYLFDK 
       610        620        630        640        650
LVLLSKGEMV YSGNAKKVSE FLRNEGYICP DNYNIADYLI DITFEAGPQG 
       660        670        680        690        700
KRRRIRNISD LEAGTDTNDI DNTIHQTTFT SSDGTTQREW AHLAAHRDEI 
       710        720        730        740        750
RSLLRDEEDV EGTDGRRGAT EIDLNTKLLH DKYKDSVYYA ELSQEIEEVL 
       760        770        780        790        800
SEGDEESNVL NGDLPTGQQS AGFLQQLSIL NSRSFKNMYR NPKLLLGNYL 
       810        820        830        840        850
LTILLSLFLG TLYYNVSNDI SGFQNRMGLF FFILTYFGFV TFTGLSSFAL 
       860        870        880        890        900
ERIIFIKERS NNYYSPLAYY ISKIMSEVVP LRVVPPILLS LIVYPMTGLN 
       910        920        930        940        950
MKDNAFFKCI GILILFNLGI SLEILTIGII FEDLNNSIIL SVLVLLGSLL 
       960        970        980        990       1000
FSGLFINTKN ITNVAFKYLK NFSVFYYAYE SLLINEVKTL MLKERKYGLN 
      1010       1020       1030       1040 
IEVPGATILS TFGFVVQNLV FDIKILALFN VVFLIMGYLA LKWIVVEQK

Length:1,049

Mass (Da):117,231

Last modified:March 15, 2004 - v2

Checksum:ⁱA3E9CE54BC28407B

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	29	K → E no nucleotide entry (PubMed:1789009).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X59720 Genomic DNA. Translation: CAA42328.2. AY693056 Genomic DNA. Translation: AAT93075.1. BK006937 Genomic DNA. Translation: DAA07489.1.
PIRⁱ	S19421.
NCBI Reference Sequences More...RefSeqⁱ	NP_009937.2. NM_001178724.1.

Genome annotation databases

EnsemblFungiⁱ	CAA42328; CAA42328; CAA42328. YCR011C; YCR011C; YCR011C.
GeneIDⁱ	850369.
KEGGⁱ	sce:YCR011C.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X59720 Genomic DNA. Translation: CAA42328.2. AY693056 Genomic DNA. Translation: AAT93075.1. BK006937 Genomic DNA. Translation: DAA07489.1.
PIRⁱ	S19421.
NCBI Reference Sequences More...RefSeqⁱ	NP_009937.2. NM_001178724.1.

3D structure databases

ProteinModelPortalⁱ	P25371.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	30990. 48 interactors.
Database of interacting proteins More...DIPⁱ	DIP-1775N.
IntActⁱ	P25371. 5 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-389954.
STRINGⁱ	4932.YCR011C.

Protein family/group databases

TCDBⁱ	3.A.1.204.9. the atp-binding cassette (abc) superfamily.

TCDBⁱ

3.A.1.204.9. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetⁱ	P25371.

iPTMnetⁱ

P25371.

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P25371.
PRIDEⁱ	P25371.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	CAA42328; CAA42328; CAA42328. YCR011C; YCR011C; YCR011C.
GeneIDⁱ	850369.
KEGGⁱ	sce:YCR011C.

Organism-specific databases

EuPathDBⁱ	FungiDB:YCR011C.
Saccharomyces Genome Database More...SGDⁱ	S000000604. ADP1.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00740000114855.
HOGENOMⁱ	HOG000214640.
InParanoidⁱ	P25371.
OMAⁱ	LMLTHYA.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0EF9.

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-29328-MONOMER.
Reactomeⁱ	R-SCE-1369062. ABC transporters in lipid homeostasis. R-SCE-8964058. HDL remodeling. R-SCE-917937. Iron uptake and transport.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P25371.

PROⁱ

PR:P25371.

Family and domain databases

InterProⁱ	View protein in InterPro IPR003593. AAA+_ATPase. IPR013525. ABC_2_trans. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR013032. EGF-like_CS. IPR027417. P-loop_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01061. ABC2_membrane. 1 hit. PF00005. ABC_tran. 1 hit.
SMARTⁱ	View protein in SMART SM00382. AAA. 1 hit.
SUPFAMⁱ	SSF52540. SSF52540. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADP1_YEAST
Accessionⁱ	P25371Primary (citable) accession number: P25371 Secondary accession number(s): D6VR20
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
	Last sequence update:	March 15, 2004
	Last modified:	July 5, 2017
	This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome III
Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P25371 (ADP1_YEAST)

Your basket is currently empty.

Probable ATP-dependent permease

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ