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Protein

LAS seventeen-binding protein 5

Gene

LSB5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking, together with YSC84.1 Publication

GO - Biological processi

  • actin cortical patch localization Source: SGD
  • actin cytoskeleton organization Source: SGD
  • actin filament organization Source: SGD
  • endocytosis Source: SGD

Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

BioCyciYEAST:G3O-29294-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
LAS seventeen-binding protein 5
Short name:
LAS17-binding protein 5
Gene namesi
Name:LSB5
Ordered Locus Names:YCL034W
ORF Names:YCL186, YCL34W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCL034W.
SGDiS000000539. LSB5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000845021 – 354LAS seventeen-binding protein 5Add BLAST354

Proteomic databases

MaxQBiP25369.
PRIDEiP25369.

PTM databases

iPTMnetiP25369.

Interactioni

Subunit structurei

Interacts with SLA1 and LAS17.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi30949. 43 interactors.
DIPiDIP-6258N.
IntActiP25369. 14 interactors.
MINTiMINT-375039.
STRINGi4932.YCL034W.

Structurei

3D structure databases

ProteinModelPortaliP25369.
SMRiP25369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 161VHSAdd BLAST147

Sequence similaritiesi

Belongs to the LSB5 family.Curated

Phylogenomic databases

HOGENOMiHOG000057096.
InParanoidiP25369.
KOiK20524.
OMAiPADESIF.
OrthoDBiEOG092C30PV.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiView protein in InterPro
IPR008942. ENTH_VHS.
SUPFAMiSSF48464. SSF48464. 1 hit.

Sequencei

Sequence statusi: Complete.

P25369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLSDHPHT AITETIFRIV SSRDYTLEVE LAPLIQLIKA DHNDYNYTVN
60 70 80 90 100
QEEAARALRK KIKYGNRLQQ SRTLDLLDLF ISQGVKFTVM YNDDKLLQRL
110 120 130 140 150
RGMATNSENS GSGEKYEPRI IKKCAAYAIS WLNYITQNNL ENARAYSGLY
160 170 180 190 200
QLGQTVKQRY SKSSRSRRSG GGSGGRSNFM DDSADDTLYQ SNSLTSADRL
210 220 230 240 250
YRIPQINMNK EAPRIRLIIS DALASAVSLQ NSLIGLPKGK FSTDDEEATS
260 270 280 290 300
KFIQARAIRR KVLRYLQLVT EGEFLGSLIH ANDELVAALT AYDDRSAQDD
310 320 330 340 350
SSDESDHGSY DDGIYDENEQ DNSRYIDSES SEEESLSSYQ PSTISNPFGD

HNKI
Length:354
Mass (Da):39,872
Last modified:June 27, 2003 - v3
Checksum:i35772B575D40BEB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAC42957.1.
BK006937 Genomic DNA. Translation: DAA07450.1.
PIRiS74282.
RefSeqiNP_009896.2. NM_001178679.1.

Genome annotation databases

EnsemblFungiiCAC42957; CAC42957; CAC42957.
YCL034W; YCL034W; YCL034W.
GeneIDi850323.
KEGGisce:YCL034W.

Similar proteinsi

Entry informationi

Entry nameiLSB5_YEAST
AccessioniPrimary (citable) accession number: P25369
Secondary accession number(s): D6VQY1, P87004, Q8NIM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 27, 2003
Last modified: September 27, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names