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Protein

Probable DNA-binding protein SNT1

Gene

SNT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi911 – 93424H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

  • histone deacetylation Source: UniProtKB
  • negative regulation of meiotic nuclear division Source: UniProtKB
  • positive regulation of stress-activated MAPK cascade Source: SGD
  • regulation of transcription, DNA-templated Source: SGD
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29347-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA-binding protein SNT1
Alternative name(s):
SANT domain-containing protein 1
Gene namesi
Name:SNT1
Ordered Locus Names:YCR033W
ORF Names:YCR33W, YCR592
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR033W.
SGDiS000000629. SNT1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
  • histone deacetylase complex Source: UniProtKB
  • nucleus Source: SGD
  • Set3 complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12261226Probable DNA-binding protein SNT1PRO_0000197122Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei187 – 1871PhosphoserineCombined sources
Modified residuei395 – 3951PhosphoserineCombined sources
Modified residuei796 – 7961PhosphothreonineCombined sources
Modified residuei1037 – 10371PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25357.
PeptideAtlasiP25357.
PRIDEiP25357.

PTM databases

iPTMnetiP25357.

Interactioni

Subunit structurei

Identified in a Set3C complex with SET3, HST1, HOS2, SIF2, CPR1 and HOS4.1 Publication

Protein-protein interaction databases

BioGridi31016. 325 interactions.
DIPiDIP-2082N.
IntActiP25357. 13 interactions.
MINTiMINT-495459.

Structurei

3D structure databases

ProteinModelPortaliP25357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini668 – 72053SANTPROSITE-ProRule annotationAdd
BLAST
Domaini884 – 93855HTH myb-typePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili539 – 59153Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi28 – 159132Ser-richAdd
BLAST
Compositional biasi594 – 5996Poly-Ser

Sequence similaritiesi

Contains 1 HTH myb-type DNA-binding domain.PROSITE-ProRule annotation
Contains 1 SANT domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00840000129748.
InParanoidiP25357.
OMAiNYYQRNA.
OrthoDBiEOG757D5Q.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25357-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYPPPTRRL GDKKRYHYSN NPNRRHPSAV YSKNSFPKSS NNGFVSSPTA
60 70 80 90 100
DNSTNPSVTP STASVPLPTA APGSTFGIEA PRPSRYDPSS VSRPSSSSYS
110 120 130 140 150
STRKIGSRYN PDVERSSSTT SSTPESMNTS TITHTNTDIG NSRYSRKTMS
160 170 180 190 200
RYNPQSTSST NVTHFPSALS NAPPFYVANG SSRRPRSMDD YSPDVTNKLE
210 220 230 240 250
TNNVSSVNNN SPHSYYSRSN KWRSIGTPSR PPFDNHVGNM TTTSNTNSIH
260 270 280 290 300
QREPFWKANS TTILKSTHSQ SSPSLHTKKF HDANKLDKPE ASVKVETPSK
310 320 330 340 350
DETKAISYHD NNFPPRKSVS KPNAPLEPDN IKVGEEDALG KKEVHKSGRE
360 370 380 390 400
IAKEHPTPVK MKEHDELEAR AKKVSKINID GKQDEIWTTA KTVASAVEVS
410 420 430 440 450
KESQKELTRS VERKESPEIR DYERAYDPKA LKTDVTKLTV DNDNKSYEEP
460 470 480 490 500
LEKVEGCIFP LPKAETRLWE LKNQKRNKII SEQKYLLKKA IRNFSEYPFY
510 520 530 540 550
AQNKLIHQQA TGLILTKIIS KIKKEEHLKK INLKHDYFDL QKKYEKECEI
560 570 580 590 600
LTKLSENLRK EEIENKRKEH ELMEQKRREE GIETEKEKSL RHPSSSSSSR
610 620 630 640 650
RRNRADFVDD AEMENVLLQI DPNYKHYQAA ATIPPLILDP IRKHSYKFCD
660 670 680 690 700
VNNLVTDKKL WASRILKDAS DNFTDHEHSL FLEGYLIHPK KFGKISHYMG
710 720 730 740 750
GLRSPEECVL HYYRTKKTVN YKQLLIDKNK KRKMSAAAKR RKRKERSNDE
760 770 780 790 800
EVEVDESKEE STNTIEKEEK SENNAEENVQ PVLVQGSEVK GDPLGTPEKV
810 820 830 840 850
ENMIEQRGEE FAGELENAER VNDLKRAHDE VGEESNKSSV IETNNGVQIM
860 870 880 890 900
DPKGAVQNGY YPEETKELDF SLENALQRKK HKSAPEHKTS YWSVRESQLF
910 920 930 940 950
PELLKEFGSQ WSLISEKLGT KSTTMVRNYY QRNAARNGWK LLVDETDLKR
960 970 980 990 1000
DGTSSESVQQ SQILIQPERP NINAYSNIPP QQRPALGYFV GQPTHGHNTS
1010 1020 1030 1040 1050
ISSIDGSIRP FGPDFHRDTF SKISAPLTTL PPPRLPSIQF PRSEMAEPTV
1060 1070 1080 1090 1100
TDLRNRPLDH IDTLADAASS VTNNQNFSNE RNAIDIGRKS TTISNLLNNS
1110 1120 1130 1140 1150
DRSMKSSFQS ASRHEAQLED TPSMNNIVVQ EIKPNITTPR SSSISALLNP
1160 1170 1180 1190 1200
VNGNGQSNPD GRPLLPFQHA ISQGTPTFPL PAPRTSPISR APPKFNFSND
1210 1220
PLAALAAVAS APDAMSSFLS KKENNN
Length:1,226
Mass (Da):138,397
Last modified:June 27, 2003 - v2
Checksum:i70AE6622227088EB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti305 – 3051A → T in CAA41799 (PubMed:1872032).Curated
Sequence conflicti375 – 3751S → N in CAA41799 (PubMed:1872032).Curated
Sequence conflicti404 – 4041Q → H in CAA41799 (PubMed:1872032).Curated
Sequence conflicti435 – 4351V → A in CAA41799 (PubMed:1872032).Curated
Sequence conflicti442 – 4421N → D in CAA41799 (PubMed:1872032).Curated
Sequence conflicti482 – 4821E → K in CAA41799 (PubMed:1872032).Curated
Sequence conflicti513 – 5131L → V in AAB21259 (PubMed:1776366).Curated
Sequence conflicti644 – 6441H → Y in CAA41799 (PubMed:1872032).Curated
Sequence conflicti766 – 7661E → D in CAA41799 (PubMed:1872032).Curated
Sequence conflicti806 – 8061Q → K in CAA41799 (PubMed:1872032).Curated
Sequence conflicti831 – 8311V → I in CAA41799 (PubMed:1872032).Curated
Sequence conflicti846 – 8461G → E in CAA41799 (PubMed:1872032).Curated
Sequence conflicti851 – 8511D → A in CAA41799 (PubMed:1872032).Curated
Sequence conflicti855 – 8573AVQ → GVR in CAA41799 (PubMed:1872032).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78624 Genomic DNA. Translation: AAB21259.1.
X59075 Genomic DNA. Translation: CAA41799.1.
X59720 Genomic DNA. Translation: CAC42983.1.
BK006937 Genomic DNA. Translation: DAA07512.1.
PIRiS15053.
RefSeqiNP_009962.2. NM_001178747.1.

Genome annotation databases

EnsemblFungiiCAC42983; CAC42983; CAC42983.
YCR033W; YCR033W; YCR033W.
GeneIDi850399.
KEGGisce:YCR033W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78624 Genomic DNA. Translation: AAB21259.1.
X59075 Genomic DNA. Translation: CAA41799.1.
X59720 Genomic DNA. Translation: CAC42983.1.
BK006937 Genomic DNA. Translation: DAA07512.1.
PIRiS15053.
RefSeqiNP_009962.2. NM_001178747.1.

3D structure databases

ProteinModelPortaliP25357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31016. 325 interactions.
DIPiDIP-2082N.
IntActiP25357. 13 interactions.
MINTiMINT-495459.

PTM databases

iPTMnetiP25357.

Proteomic databases

MaxQBiP25357.
PeptideAtlasiP25357.
PRIDEiP25357.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAC42983; CAC42983; CAC42983.
YCR033W; YCR033W; YCR033W.
GeneIDi850399.
KEGGisce:YCR033W.

Organism-specific databases

EuPathDBiFungiDB:YCR033W.
SGDiS000000629. SNT1.

Phylogenomic databases

GeneTreeiENSGT00840000129748.
InParanoidiP25357.
OMAiNYYQRNA.
OrthoDBiEOG757D5Q.

Enzyme and pathway databases

BioCyciYEAST:G3O-29347-MONOMER.

Miscellaneous databases

PROiP25357.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR017930. Myb_dom.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
[Graphical view]
PfamiPF00249. Myb_DNA-binding. 2 hits.
[Graphical view]
SMARTiSM00717. SANT. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS51294. HTH_MYB. 1 hit.
PS51293. SANT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete sequence of a 7.5 kb region of chromosome III from Saccharomyces cerevisiae that lies between CRY1 and MAT."
    Wicksteed B.L., Roberts A.B., Sagliocco F.A., Brown A.J.P.
    Yeast 7:761-772(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete sequence of the unit YCR59, situated between CRY1 and MAT, reveals two long open reading frames, which cover 91% of the 10.1 kb segment."
    Jia Y., Slonimski P.P., Herbert C.J.
    Yeast 7:413-424(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Valles G., Volckaerts G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  5. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  6. "The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program."
    Pijnappel W.W.M.P., Schaft D., Roguev A., Shevchenko A., Tekotte H., Wilm M., Rigaut G., Seraphin B., Aasland R., Stewart A.F.
    Genes Dev. 15:2991-3004(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH SET3; HST1; HOS2; SIF2; CPR1 AND HOS4.
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187; SER-395; THR-796 AND SER-1037, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-796, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNT1_YEAST
AccessioniPrimary (citable) accession number: P25357
Secondary accession number(s): D6VR43, Q02397, Q8NIL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 27, 2003
Last modified: June 8, 2016
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.