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P25356

- BPH1_YEAST

UniProt

P25356 - BPH1_YEAST

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Protein

Beige protein homolog 1

Gene

BPH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in protein sorting and cell wall formation.1 Publication

GO - Biological processi

  1. fungal-type cell wall organization Source: SGD
  2. intracellular protein transport Source: SGD
  3. response to pH Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29346-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beige protein homolog 1
Gene namesi
Name:BPH1
Ordered Locus Names:YCR032W
ORF Names:YCR32W, YCR591, YCR601
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR032w.
SGDiS000000628. BPH1.

Subcellular locationi

Cytoplasm 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

GO - Cellular componenti

  1. cytosol Source: SGD
  2. extrinsic component of membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21672167Beige protein homolog 1PRO_0000050887Add
BLAST

Proteomic databases

MaxQBiP25356.
PaxDbiP25356.

Expressioni

Gene expression databases

GenevestigatoriP25356.

Interactioni

Protein-protein interaction databases

BioGridi31015. 89 interactions.
MINTiMINT-2787660.

Structurei

3D structure databases

ProteinModelPortaliP25356.
SMRiP25356. Positions 1451-1839, 1938-2038.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1545 – 1839295BEACHPROSITE-ProRule annotationAdd
BLAST
Repeati1927 – 196539WD 1Add
BLAST
Repeati1976 – 201540WD 2Add
BLAST
Repeati2017 – 205438WD 3Add
BLAST
Repeati2072 – 211140WD 4Add
BLAST
Repeati2129 – 216739WD 5Add
BLAST

Sequence similaritiesi

Contains 1 BEACH domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG236271.
GeneTreeiENSGT00760000119083.
HOGENOMiHOG000057139.
InParanoidiP25356.
OMAiLESRYVS.
OrthoDBiEOG7CK3G4.

Family and domain databases

Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
InterProiIPR000409. BEACH_dom.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25356-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSIINAASK VLRLQDDVKK ATIILGDILI LQPINHEVEP DVENLVQHEL
60 70 80 90 100
TKIIQGYPIQ DNMIINSKKG TVEDDLCELN NYTCFALSKS FDLCHDSRNF
110 120 130 140 150
NIAQPKRWIQ LLETLTDSVS FAVIVQIILT LSNISLINKQ TLGKLKKLRI
160 170 180 190 200
RIFEILSNKN DSWKSTLLQK NLIEWYIFML SVDCTPLELQ NLYLHKELKF
210 220 230 240 250
CNGILNSLTL QVSDPRSQNY LQFENTYKLF QIQKSSRINN SFLFYIEFNS
260 270 280 290 300
VTSNRIMTIE RHIYLEIKEG QFCISNDNYI IGLFENFEFE AGTLYFIGVL
310 320 330 340 350
IDHNNRITLY VDGSMINQLT LFENSICQLS TCELGSMICS IKVYRFYLWD
360 370 380 390 400
GLLTEFAINI LQAIGTNYQY TFSKKKEGPE VLSLCQDFLI AKAHLMARPT
410 420 430 440 450
TEISSTKYID EIELLEMENI IIDVNPNDIL QDFTESSNFT VKFEESTNSK
460 470 480 490 500
NIPEVGKCYF YRSSNLVSKF VSIDSIRLAF LNMTESGSID DLFHHVSHLM
510 520 530 540 550
NLLRNIDILN WFKKDFGFPL FAYTLKQKIT QDLSQPLNIQ FFNLFLEFCG
560 570 580 590 600
WDFNDISKSI ILDTDAYENI VLNLDLWYMN EDQSSLASGG LEIIRFLFFQ
610 620 630 640 650
ISSLMEASIY SKFNSNKFND MNILEKLCLS YQAVTKRENQ NSKFNELSSD
660 670 680 690 700
LISVFVTLLK SNTDKRHLQW FLHLSYYFIK RKDVRSTEII LQAVDQLFSF
710 720 730 740 750
YLDQGSDENA KILSEIIPLK LILMIMDQIV ENNESNPITC LNILFKVVLT
760 770 780 790 800
NKPLFKQFYK NDGLKLILTM LCKVGKSYRE EIISLLLTYS IGNYTTANEI
810 820 830 840 850
FSGAEDMIGG ISNDKITAKE IIYLAVNFIE WHVINSNASD SSSVLDLNNH
860 870 880 890 900
ILRFVEDLKS LSAVPINESV FDPKKSYVMV SLLDLSIALN ESEDISKFKS
910 920 930 940 950
SSKVISELIK GNIMCALTKY AAYDFEVYMS TFFCHSTEYK LVYPKTVMNN
960 970 980 990 1000
SSYLELSFIV TLLPEILNDL VDSNNNLNLM MLKHPYTMSN LLYFLRKFRP
1010 1020 1030 1040 1050
DTSQIVMPKD FYFSSYTCLL HCVIQIDKSS FYHFKNVSKS QLLQDFKICI
1060 1070 1080 1090 1100
MNLIYSNTLK QIIWEKEEYE MFSESLMAHQ EVLFAHGACD NETVGLLLIF
1110 1120 1130 1140 1150
FANRLRDCGY NKAVFNCMKV IIKNKERKLK EVACFFDPAN KSEVLEGLSN
1160 1170 1180 1190 1200
ILSCNNSETM NLITEQYPFF FNNTQQVRFI NIVTNILFKN NNFSPISVRQ
1210 1220 1230 1240 1250
IKNQVYEWKN ARSEYVTQNN KKCLILFRKD NTSLDFKIKK SISRYTYNLK
1260 1270 1280 1290 1300
TDREENAVFY RNNLNLLIFH LKHTLEIQSN PNSSCKWSSD FAEDFDGMKR
1310 1320 1330 1340 1350
RLLPAWEPKY EPLINEEDAN QDTITGGNRQ RRESGSILSY EFIEHMETLE
1360 1370 1380 1390 1400
SEPVGDLNEN RKILRLLKDN DSIATIWNCS LIIGLEIKEG ILIHGSNYLY
1410 1420 1430 1440 1450
FVSDYYFSLE DKKILKLSEV SQESRDMTVS LINGPDVKRV STFLKHEVFV
1460 1470 1480 1490 1500
WKLLDITFVT KRPFLLRDVA IELLFKERVS AFFSFYNKRV RDDVLRVLNK
1510 1520 1530 1540 1550
IPKHLPADPI FSSVLQEIND RGNSIVARNG IGKASIASKF TSVFSANNSL
1560 1570 1580 1590 1600
IDGFEISKKW VRGEISNFYY LLSINILAGR SFNDLTQYPV FPWVIADYES
1610 1620 1630 1640 1650
NVLDLENPKT YRDLSKPMGA QSEKRKLQFI ERYEALASLE NADSAPFHYG
1660 1670 1680 1690 1700
THYSSAMIVS SYLIRLKPFV ESFLLLQGGS FGPADRLFSS LERAWSSASS
1710 1720 1730 1740 1750
ENTTDVRELT PEFFFLPEFL INVNSYDFGT DQSGKKVDDV VLPPWANGDP
1760 1770 1780 1790 1800
KVFIQKNREA LESPYVSAHL HEWIDLIFGY KQKGDIAVKS VNVFNRLSYP
1810 1820 1830 1840 1850
GAVNLDNIDD ENERRAITGI IHNFGQTPLQ IFQEPHPEKI ACNVQQLTTE
1860 1870 1880 1890 1900
VWRKVPMKPI FEKTIFNLNE KNRSVDYVIH DPSYFDSLYW RGFAFPNLFF
1910 1920 1930 1940 1950
RTEESLVSLR IVHKNWLKIG LDIFKKTHMA QITSFAYWKL GEFITGDKNG
1960 1970 1980 1990 2000
LIKVWKYRKD KHSVSGNLEN KKTMFGHLCE LKEMRCYHDY NTLLTLDISG
2010 2020 2030 2040 2050
LVYVWDMINF ELVRQITNDA QKVAISQHAG SIMVLTKNNA ISIFNLNGQI
2060 2070 2080 2090 2100
YTSKKFEPAK IVSSIDFFDF TKLDAGYRKH IYWKEMEILL VGFEDGTIEI
2110 2120 2130 2140 2150
YELFLNFHNE WAIKLLKQLC TEKGKAITSI KGQGKTYLSQ KRRKDTAEPH
2160
EIEVIAGTLD GRLAIWY
Length:2,167
Mass (Da):250,872
Last modified:June 27, 2003 - v2
Checksum:iED7D607ADA9982CD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1893 – 18931F → N in AAB21258. (PubMed:1776366)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62452 Genomic DNA. Translation: CAA44309.1.
X59720 Genomic DNA. Translation: CAC42982.1.
X59075 Genomic DNA. Translation: CAA41798.1.
S78624 Genomic DNA. Translation: AAB21258.1.
BK006937 Genomic DNA. Translation: DAA07511.1.
PIRiS19444.
RefSeqiNP_009961.2. NM_001178746.1.

Genome annotation databases

EnsemblFungiiYCR032W; YCR032W; YCR032W.
GeneIDi850398.
KEGGisce:YCR032W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62452 Genomic DNA. Translation: CAA44309.1 .
X59720 Genomic DNA. Translation: CAC42982.1 .
X59075 Genomic DNA. Translation: CAA41798.1 .
S78624 Genomic DNA. Translation: AAB21258.1 .
BK006937 Genomic DNA. Translation: DAA07511.1 .
PIRi S19444.
RefSeqi NP_009961.2. NM_001178746.1.

3D structure databases

ProteinModelPortali P25356.
SMRi P25356. Positions 1451-1839, 1938-2038.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31015. 89 interactions.
MINTi MINT-2787660.

Proteomic databases

MaxQBi P25356.
PaxDbi P25356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR032W ; YCR032W ; YCR032W .
GeneIDi 850398.
KEGGi sce:YCR032W.

Organism-specific databases

CYGDi YCR032w.
SGDi S000000628. BPH1.

Phylogenomic databases

eggNOGi NOG236271.
GeneTreei ENSGT00760000119083.
HOGENOMi HOG000057139.
InParanoidi P25356.
OMAi LESRYVS.
OrthoDBi EOG7CK3G4.

Enzyme and pathway databases

BioCyci YEAST:G3O-29346-MONOMER.

Miscellaneous databases

NextBioi 965929.

Gene expression databases

Genevestigatori P25356.

Family and domain databases

Gene3Di 1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
InterProi IPR000409. BEACH_dom.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF02138. Beach. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view ]
SMARTi SM01026. Beach. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEi PS50197. BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of 8.8 kb of yeast chromosome III cloned in lambda PM3270 contains an unusual long ORF (YCR601)."
    Rodriguez F., Martegani E., Mauri I., Alberghina L.
    Yeast 7:631-641(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Valles G., Volckaerts G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "The complete sequence of the unit YCR59, situated between CRY1 and MAT, reveals two long open reading frames, which cover 91% of the 10.1 kb segment."
    Jia Y., Slonimski P.P., Herbert C.J.
    Yeast 7:413-424(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 335-2167.
  6. "The complete sequence of a 7.5 kb region of chromosome III from Saccharomyces cerevisiae that lies between CRY1 and MAT."
    Wicksteed B.L., Roberts A.B., Sagliocco F.A., Brown A.J.P.
    Yeast 7:761-772(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1760-2167.
  7. "Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting."
    Shiflett S.L., Vaughn M.B., Huynh D., Kaplan J., McVey Ward D.
    Traffic 5:700-710(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBPH1_YEAST
AccessioniPrimary (citable) accession number: P25356
Secondary accession number(s): D6VR42, Q02396, Q07348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 27, 2003
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3