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P25356 (BPH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beige protein homolog 1
Gene names
Name:BPH1
Ordered Locus Names:YCR032W
ORF Names:YCR32W, YCR591, YCR601
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length2167 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in protein sorting and cell wall formation. Ref.7

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side Ref.7.

Sequence similarities

Contains 1 BEACH domain.

Contains 5 WD repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21672167Beige protein homolog 1
PRO_0000050887

Regions

Domain1545 – 1839295BEACH
Repeat1927 – 196539WD 1
Repeat1976 – 201540WD 2
Repeat2017 – 205438WD 3
Repeat2072 – 211140WD 4
Repeat2129 – 216739WD 5

Experimental info

Sequence conflict18931F → N in AAB21258. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P25356 [UniParc].

Last modified June 27, 2003. Version 2.
Checksum: ED7D607ADA9982CD

FASTA2,167250,872
        10         20         30         40         50         60 
MNSIINAASK VLRLQDDVKK ATIILGDILI LQPINHEVEP DVENLVQHEL TKIIQGYPIQ 

        70         80         90        100        110        120 
DNMIINSKKG TVEDDLCELN NYTCFALSKS FDLCHDSRNF NIAQPKRWIQ LLETLTDSVS 

       130        140        150        160        170        180 
FAVIVQIILT LSNISLINKQ TLGKLKKLRI RIFEILSNKN DSWKSTLLQK NLIEWYIFML 

       190        200        210        220        230        240 
SVDCTPLELQ NLYLHKELKF CNGILNSLTL QVSDPRSQNY LQFENTYKLF QIQKSSRINN 

       250        260        270        280        290        300 
SFLFYIEFNS VTSNRIMTIE RHIYLEIKEG QFCISNDNYI IGLFENFEFE AGTLYFIGVL 

       310        320        330        340        350        360 
IDHNNRITLY VDGSMINQLT LFENSICQLS TCELGSMICS IKVYRFYLWD GLLTEFAINI 

       370        380        390        400        410        420 
LQAIGTNYQY TFSKKKEGPE VLSLCQDFLI AKAHLMARPT TEISSTKYID EIELLEMENI 

       430        440        450        460        470        480 
IIDVNPNDIL QDFTESSNFT VKFEESTNSK NIPEVGKCYF YRSSNLVSKF VSIDSIRLAF 

       490        500        510        520        530        540 
LNMTESGSID DLFHHVSHLM NLLRNIDILN WFKKDFGFPL FAYTLKQKIT QDLSQPLNIQ 

       550        560        570        580        590        600 
FFNLFLEFCG WDFNDISKSI ILDTDAYENI VLNLDLWYMN EDQSSLASGG LEIIRFLFFQ 

       610        620        630        640        650        660 
ISSLMEASIY SKFNSNKFND MNILEKLCLS YQAVTKRENQ NSKFNELSSD LISVFVTLLK 

       670        680        690        700        710        720 
SNTDKRHLQW FLHLSYYFIK RKDVRSTEII LQAVDQLFSF YLDQGSDENA KILSEIIPLK 

       730        740        750        760        770        780 
LILMIMDQIV ENNESNPITC LNILFKVVLT NKPLFKQFYK NDGLKLILTM LCKVGKSYRE 

       790        800        810        820        830        840 
EIISLLLTYS IGNYTTANEI FSGAEDMIGG ISNDKITAKE IIYLAVNFIE WHVINSNASD 

       850        860        870        880        890        900 
SSSVLDLNNH ILRFVEDLKS LSAVPINESV FDPKKSYVMV SLLDLSIALN ESEDISKFKS 

       910        920        930        940        950        960 
SSKVISELIK GNIMCALTKY AAYDFEVYMS TFFCHSTEYK LVYPKTVMNN SSYLELSFIV 

       970        980        990       1000       1010       1020 
TLLPEILNDL VDSNNNLNLM MLKHPYTMSN LLYFLRKFRP DTSQIVMPKD FYFSSYTCLL 

      1030       1040       1050       1060       1070       1080 
HCVIQIDKSS FYHFKNVSKS QLLQDFKICI MNLIYSNTLK QIIWEKEEYE MFSESLMAHQ 

      1090       1100       1110       1120       1130       1140 
EVLFAHGACD NETVGLLLIF FANRLRDCGY NKAVFNCMKV IIKNKERKLK EVACFFDPAN 

      1150       1160       1170       1180       1190       1200 
KSEVLEGLSN ILSCNNSETM NLITEQYPFF FNNTQQVRFI NIVTNILFKN NNFSPISVRQ 

      1210       1220       1230       1240       1250       1260 
IKNQVYEWKN ARSEYVTQNN KKCLILFRKD NTSLDFKIKK SISRYTYNLK TDREENAVFY 

      1270       1280       1290       1300       1310       1320 
RNNLNLLIFH LKHTLEIQSN PNSSCKWSSD FAEDFDGMKR RLLPAWEPKY EPLINEEDAN 

      1330       1340       1350       1360       1370       1380 
QDTITGGNRQ RRESGSILSY EFIEHMETLE SEPVGDLNEN RKILRLLKDN DSIATIWNCS 

      1390       1400       1410       1420       1430       1440 
LIIGLEIKEG ILIHGSNYLY FVSDYYFSLE DKKILKLSEV SQESRDMTVS LINGPDVKRV 

      1450       1460       1470       1480       1490       1500 
STFLKHEVFV WKLLDITFVT KRPFLLRDVA IELLFKERVS AFFSFYNKRV RDDVLRVLNK 

      1510       1520       1530       1540       1550       1560 
IPKHLPADPI FSSVLQEIND RGNSIVARNG IGKASIASKF TSVFSANNSL IDGFEISKKW 

      1570       1580       1590       1600       1610       1620 
VRGEISNFYY LLSINILAGR SFNDLTQYPV FPWVIADYES NVLDLENPKT YRDLSKPMGA 

      1630       1640       1650       1660       1670       1680 
QSEKRKLQFI ERYEALASLE NADSAPFHYG THYSSAMIVS SYLIRLKPFV ESFLLLQGGS 

      1690       1700       1710       1720       1730       1740 
FGPADRLFSS LERAWSSASS ENTTDVRELT PEFFFLPEFL INVNSYDFGT DQSGKKVDDV 

      1750       1760       1770       1780       1790       1800 
VLPPWANGDP KVFIQKNREA LESPYVSAHL HEWIDLIFGY KQKGDIAVKS VNVFNRLSYP 

      1810       1820       1830       1840       1850       1860 
GAVNLDNIDD ENERRAITGI IHNFGQTPLQ IFQEPHPEKI ACNVQQLTTE VWRKVPMKPI 

      1870       1880       1890       1900       1910       1920 
FEKTIFNLNE KNRSVDYVIH DPSYFDSLYW RGFAFPNLFF RTEESLVSLR IVHKNWLKIG 

      1930       1940       1950       1960       1970       1980 
LDIFKKTHMA QITSFAYWKL GEFITGDKNG LIKVWKYRKD KHSVSGNLEN KKTMFGHLCE 

      1990       2000       2010       2020       2030       2040 
LKEMRCYHDY NTLLTLDISG LVYVWDMINF ELVRQITNDA QKVAISQHAG SIMVLTKNNA 

      2050       2060       2070       2080       2090       2100 
ISIFNLNGQI YTSKKFEPAK IVSSIDFFDF TKLDAGYRKH IYWKEMEILL VGFEDGTIEI 

      2110       2120       2130       2140       2150       2160 
YELFLNFHNE WAIKLLKQLC TEKGKAITSI KGQGKTYLSQ KRRKDTAEPH EIEVIAGTLD 


GRLAIWY 

« Hide

References

« Hide 'large scale' references
[1]"The sequence of 8.8 kb of yeast chromosome III cloned in lambda PM3270 contains an unusual long ORF (YCR601)."
Rodriguez F., Martegani E., Mauri I., Alberghina L.
Yeast 7:631-641(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"The complete DNA sequence of yeast chromosome III."
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. expand/collapse author list , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Valles G., Volckaerts G.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[4]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"The complete sequence of the unit YCR59, situated between CRY1 and MAT, reveals two long open reading frames, which cover 91% of the 10.1 kb segment."
Jia Y., Slonimski P.P., Herbert C.J.
Yeast 7:413-424(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 335-2167.
[6]"The complete sequence of a 7.5 kb region of chromosome III from Saccharomyces cerevisiae that lies between CRY1 and MAT."
Wicksteed B.L., Roberts A.B., Sagliocco F.A., Brown A.J.P.
Yeast 7:761-772(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1760-2167.
[7]"Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting."
Shiflett S.L., Vaughn M.B., Huynh D., Kaplan J., McVey Ward D.
Traffic 5:700-710(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[8]"Sites of ubiquitin attachment in Saccharomyces cerevisiae."
Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X62452 Genomic DNA. Translation: CAA44309.1.
X59720 Genomic DNA. Translation: CAC42982.1.
X59075 Genomic DNA. Translation: CAA41798.1.
S78624 Genomic DNA. Translation: AAB21258.1.
BK006937 Genomic DNA. Translation: DAA07511.1.
PIRS19444.
RefSeqNP_009961.2. NM_001178746.1.

3D structure databases

ProteinModelPortalP25356.
SMRP25356. Positions 1451-1839.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31015. 89 interactions.
MINTMINT-2787660.

Proteomic databases

MaxQBP25356.
PaxDbP25356.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYCR032W; YCR032W; YCR032W.
GeneID850398.
KEGGsce:YCR032W.

Organism-specific databases

CYGDYCR032w.
SGDS000000628. BPH1.

Phylogenomic databases

eggNOGNOG236271.
GeneTreeENSGT00670000097722.
HOGENOMHOG000057139.
OMALESRYVS.
OrthoDBEOG7CK3G4.

Enzyme and pathway databases

BioCycYEAST:G3O-29346-MONOMER.

Gene expression databases

GenevestigatorP25356.

Family and domain databases

Gene3D1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
InterProIPR000409. BEACH_dom.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF02138. Beach. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTSM01026. Beach. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEPS50197. BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio965929.

Entry information

Entry nameBPH1_YEAST
AccessionPrimary (citable) accession number: P25356
Secondary accession number(s): D6VR42, Q02396, Q07348
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 27, 2003
Last modified: June 11, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome III

Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families