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P25356

- BPH1_YEAST

UniProt

P25356 - BPH1_YEAST

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Protein
Beige protein homolog 1
Gene
BPH1, YCR032W, YCR32W, YCR591, YCR601
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in protein sorting and cell wall formation.1 Publication

GO - Biological processi

  1. fungal-type cell wall organization Source: SGD
  2. intracellular protein transport Source: SGD
  3. response to pH Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29346-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beige protein homolog 1
Gene namesi
Name:BPH1
Ordered Locus Names:YCR032W
ORF Names:YCR32W, YCR591, YCR601
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR032w.
SGDiS000000628. BPH1.

Subcellular locationi

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side 1 Publication

GO - Cellular componenti

  1. cytosol Source: SGD
  2. extrinsic component of membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21672167Beige protein homolog 1
PRO_0000050887Add
BLAST

Proteomic databases

MaxQBiP25356.
PaxDbiP25356.

Expressioni

Gene expression databases

GenevestigatoriP25356.

Interactioni

Protein-protein interaction databases

BioGridi31015. 89 interactions.
MINTiMINT-2787660.

Structurei

3D structure databases

ProteinModelPortaliP25356.
SMRiP25356. Positions 1451-1839.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1545 – 1839295BEACH
Add
BLAST
Repeati1927 – 196539WD 1
Add
BLAST
Repeati1976 – 201540WD 2
Add
BLAST
Repeati2017 – 205438WD 3
Add
BLAST
Repeati2072 – 211140WD 4
Add
BLAST
Repeati2129 – 216739WD 5
Add
BLAST

Sequence similaritiesi

Contains 1 BEACH domain.
Contains 5 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG236271.
GeneTreeiENSGT00670000097722.
HOGENOMiHOG000057139.
OMAiLESRYVS.
OrthoDBiEOG7CK3G4.

Family and domain databases

Gene3Di1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
InterProiIPR000409. BEACH_dom.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25356-1 [UniParc]FASTAAdd to Basket

« Hide

MNSIINAASK VLRLQDDVKK ATIILGDILI LQPINHEVEP DVENLVQHEL     50
TKIIQGYPIQ DNMIINSKKG TVEDDLCELN NYTCFALSKS FDLCHDSRNF 100
NIAQPKRWIQ LLETLTDSVS FAVIVQIILT LSNISLINKQ TLGKLKKLRI 150
RIFEILSNKN DSWKSTLLQK NLIEWYIFML SVDCTPLELQ NLYLHKELKF 200
CNGILNSLTL QVSDPRSQNY LQFENTYKLF QIQKSSRINN SFLFYIEFNS 250
VTSNRIMTIE RHIYLEIKEG QFCISNDNYI IGLFENFEFE AGTLYFIGVL 300
IDHNNRITLY VDGSMINQLT LFENSICQLS TCELGSMICS IKVYRFYLWD 350
GLLTEFAINI LQAIGTNYQY TFSKKKEGPE VLSLCQDFLI AKAHLMARPT 400
TEISSTKYID EIELLEMENI IIDVNPNDIL QDFTESSNFT VKFEESTNSK 450
NIPEVGKCYF YRSSNLVSKF VSIDSIRLAF LNMTESGSID DLFHHVSHLM 500
NLLRNIDILN WFKKDFGFPL FAYTLKQKIT QDLSQPLNIQ FFNLFLEFCG 550
WDFNDISKSI ILDTDAYENI VLNLDLWYMN EDQSSLASGG LEIIRFLFFQ 600
ISSLMEASIY SKFNSNKFND MNILEKLCLS YQAVTKRENQ NSKFNELSSD 650
LISVFVTLLK SNTDKRHLQW FLHLSYYFIK RKDVRSTEII LQAVDQLFSF 700
YLDQGSDENA KILSEIIPLK LILMIMDQIV ENNESNPITC LNILFKVVLT 750
NKPLFKQFYK NDGLKLILTM LCKVGKSYRE EIISLLLTYS IGNYTTANEI 800
FSGAEDMIGG ISNDKITAKE IIYLAVNFIE WHVINSNASD SSSVLDLNNH 850
ILRFVEDLKS LSAVPINESV FDPKKSYVMV SLLDLSIALN ESEDISKFKS 900
SSKVISELIK GNIMCALTKY AAYDFEVYMS TFFCHSTEYK LVYPKTVMNN 950
SSYLELSFIV TLLPEILNDL VDSNNNLNLM MLKHPYTMSN LLYFLRKFRP 1000
DTSQIVMPKD FYFSSYTCLL HCVIQIDKSS FYHFKNVSKS QLLQDFKICI 1050
MNLIYSNTLK QIIWEKEEYE MFSESLMAHQ EVLFAHGACD NETVGLLLIF 1100
FANRLRDCGY NKAVFNCMKV IIKNKERKLK EVACFFDPAN KSEVLEGLSN 1150
ILSCNNSETM NLITEQYPFF FNNTQQVRFI NIVTNILFKN NNFSPISVRQ 1200
IKNQVYEWKN ARSEYVTQNN KKCLILFRKD NTSLDFKIKK SISRYTYNLK 1250
TDREENAVFY RNNLNLLIFH LKHTLEIQSN PNSSCKWSSD FAEDFDGMKR 1300
RLLPAWEPKY EPLINEEDAN QDTITGGNRQ RRESGSILSY EFIEHMETLE 1350
SEPVGDLNEN RKILRLLKDN DSIATIWNCS LIIGLEIKEG ILIHGSNYLY 1400
FVSDYYFSLE DKKILKLSEV SQESRDMTVS LINGPDVKRV STFLKHEVFV 1450
WKLLDITFVT KRPFLLRDVA IELLFKERVS AFFSFYNKRV RDDVLRVLNK 1500
IPKHLPADPI FSSVLQEIND RGNSIVARNG IGKASIASKF TSVFSANNSL 1550
IDGFEISKKW VRGEISNFYY LLSINILAGR SFNDLTQYPV FPWVIADYES 1600
NVLDLENPKT YRDLSKPMGA QSEKRKLQFI ERYEALASLE NADSAPFHYG 1650
THYSSAMIVS SYLIRLKPFV ESFLLLQGGS FGPADRLFSS LERAWSSASS 1700
ENTTDVRELT PEFFFLPEFL INVNSYDFGT DQSGKKVDDV VLPPWANGDP 1750
KVFIQKNREA LESPYVSAHL HEWIDLIFGY KQKGDIAVKS VNVFNRLSYP 1800
GAVNLDNIDD ENERRAITGI IHNFGQTPLQ IFQEPHPEKI ACNVQQLTTE 1850
VWRKVPMKPI FEKTIFNLNE KNRSVDYVIH DPSYFDSLYW RGFAFPNLFF 1900
RTEESLVSLR IVHKNWLKIG LDIFKKTHMA QITSFAYWKL GEFITGDKNG 1950
LIKVWKYRKD KHSVSGNLEN KKTMFGHLCE LKEMRCYHDY NTLLTLDISG 2000
LVYVWDMINF ELVRQITNDA QKVAISQHAG SIMVLTKNNA ISIFNLNGQI 2050
YTSKKFEPAK IVSSIDFFDF TKLDAGYRKH IYWKEMEILL VGFEDGTIEI 2100
YELFLNFHNE WAIKLLKQLC TEKGKAITSI KGQGKTYLSQ KRRKDTAEPH 2150
EIEVIAGTLD GRLAIWY 2167
Length:2,167
Mass (Da):250,872
Last modified:June 27, 2003 - v2
Checksum:iED7D607ADA9982CD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1893 – 18931F → N in AAB21258. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62452 Genomic DNA. Translation: CAA44309.1.
X59720 Genomic DNA. Translation: CAC42982.1.
X59075 Genomic DNA. Translation: CAA41798.1.
S78624 Genomic DNA. Translation: AAB21258.1.
BK006937 Genomic DNA. Translation: DAA07511.1.
PIRiS19444.
RefSeqiNP_009961.2. NM_001178746.1.

Genome annotation databases

EnsemblFungiiYCR032W; YCR032W; YCR032W.
GeneIDi850398.
KEGGisce:YCR032W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62452 Genomic DNA. Translation: CAA44309.1 .
X59720 Genomic DNA. Translation: CAC42982.1 .
X59075 Genomic DNA. Translation: CAA41798.1 .
S78624 Genomic DNA. Translation: AAB21258.1 .
BK006937 Genomic DNA. Translation: DAA07511.1 .
PIRi S19444.
RefSeqi NP_009961.2. NM_001178746.1.

3D structure databases

ProteinModelPortali P25356.
SMRi P25356. Positions 1451-1839.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31015. 89 interactions.
MINTi MINT-2787660.

Proteomic databases

MaxQBi P25356.
PaxDbi P25356.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR032W ; YCR032W ; YCR032W .
GeneIDi 850398.
KEGGi sce:YCR032W.

Organism-specific databases

CYGDi YCR032w.
SGDi S000000628. BPH1.

Phylogenomic databases

eggNOGi NOG236271.
GeneTreei ENSGT00670000097722.
HOGENOMi HOG000057139.
OMAi LESRYVS.
OrthoDBi EOG7CK3G4.

Enzyme and pathway databases

BioCyci YEAST:G3O-29346-MONOMER.

Miscellaneous databases

NextBioi 965929.

Gene expression databases

Genevestigatori P25356.

Family and domain databases

Gene3Di 1.10.1540.10. 1 hit.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
InterProi IPR000409. BEACH_dom.
IPR023362. PH-BEACH_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF02138. Beach. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view ]
SMARTi SM01026. Beach. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEi PS50197. BEACH. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence of 8.8 kb of yeast chromosome III cloned in lambda PM3270 contains an unusual long ORF (YCR601)."
    Rodriguez F., Martegani E., Mauri I., Alberghina L.
    Yeast 7:631-641(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Valles G., Volckaerts G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "The complete sequence of the unit YCR59, situated between CRY1 and MAT, reveals two long open reading frames, which cover 91% of the 10.1 kb segment."
    Jia Y., Slonimski P.P., Herbert C.J.
    Yeast 7:413-424(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 335-2167.
  6. "The complete sequence of a 7.5 kb region of chromosome III from Saccharomyces cerevisiae that lies between CRY1 and MAT."
    Wicksteed B.L., Roberts A.B., Sagliocco F.A., Brown A.J.P.
    Yeast 7:761-772(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1760-2167.
  7. "Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting."
    Shiflett S.L., Vaughn M.B., Huynh D., Kaplan J., McVey Ward D.
    Traffic 5:700-710(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBPH1_YEAST
AccessioniPrimary (citable) accession number: P25356
Secondary accession number(s): D6VR42, Q02396, Q07348
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: June 27, 2003
Last modified: June 11, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi