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P25356

- BPH1_YEAST

UniProt

P25356 - BPH1_YEAST

Protein

Beige protein homolog 1

Gene

BPH1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (27 Jun 2003)
      Previous versions | rss
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    Functioni

    May be involved in protein sorting and cell wall formation.1 Publication

    GO - Biological processi

    1. fungal-type cell wall organization Source: SGD
    2. intracellular protein transport Source: SGD
    3. response to pH Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29346-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beige protein homolog 1
    Gene namesi
    Name:BPH1
    Ordered Locus Names:YCR032W
    ORF Names:YCR32W, YCR591, YCR601
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR032w.
    SGDiS000000628. BPH1.

    Subcellular locationi

    Cytoplasm 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. extrinsic component of membrane Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21672167Beige protein homolog 1PRO_0000050887Add
    BLAST

    Proteomic databases

    MaxQBiP25356.
    PaxDbiP25356.

    Expressioni

    Gene expression databases

    GenevestigatoriP25356.

    Interactioni

    Protein-protein interaction databases

    BioGridi31015. 89 interactions.
    MINTiMINT-2787660.

    Structurei

    3D structure databases

    ProteinModelPortaliP25356.
    SMRiP25356. Positions 1451-1839.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1545 – 1839295BEACHPROSITE-ProRule annotationAdd
    BLAST
    Repeati1927 – 196539WD 1Add
    BLAST
    Repeati1976 – 201540WD 2Add
    BLAST
    Repeati2017 – 205438WD 3Add
    BLAST
    Repeati2072 – 211140WD 4Add
    BLAST
    Repeati2129 – 216739WD 5Add
    BLAST

    Sequence similaritiesi

    Contains 1 BEACH domain.PROSITE-ProRule annotation
    Contains 5 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG236271.
    GeneTreeiENSGT00670000097722.
    HOGENOMiHOG000057139.
    OMAiLESRYVS.
    OrthoDBiEOG7CK3G4.

    Family and domain databases

    Gene3Di1.10.1540.10. 1 hit.
    2.130.10.10. 1 hit.
    2.30.29.40. 1 hit.
    InterProiIPR000409. BEACH_dom.
    IPR023362. PH-BEACH_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF02138. Beach. 1 hit.
    PF14844. PH_BEACH. 1 hit.
    [Graphical view]
    SMARTiSM01026. Beach. 1 hit.
    SM00320. WD40. 3 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.
    SSF81837. SSF81837. 1 hit.
    PROSITEiPS50197. BEACH. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25356-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSIINAASK VLRLQDDVKK ATIILGDILI LQPINHEVEP DVENLVQHEL     50
    TKIIQGYPIQ DNMIINSKKG TVEDDLCELN NYTCFALSKS FDLCHDSRNF 100
    NIAQPKRWIQ LLETLTDSVS FAVIVQIILT LSNISLINKQ TLGKLKKLRI 150
    RIFEILSNKN DSWKSTLLQK NLIEWYIFML SVDCTPLELQ NLYLHKELKF 200
    CNGILNSLTL QVSDPRSQNY LQFENTYKLF QIQKSSRINN SFLFYIEFNS 250
    VTSNRIMTIE RHIYLEIKEG QFCISNDNYI IGLFENFEFE AGTLYFIGVL 300
    IDHNNRITLY VDGSMINQLT LFENSICQLS TCELGSMICS IKVYRFYLWD 350
    GLLTEFAINI LQAIGTNYQY TFSKKKEGPE VLSLCQDFLI AKAHLMARPT 400
    TEISSTKYID EIELLEMENI IIDVNPNDIL QDFTESSNFT VKFEESTNSK 450
    NIPEVGKCYF YRSSNLVSKF VSIDSIRLAF LNMTESGSID DLFHHVSHLM 500
    NLLRNIDILN WFKKDFGFPL FAYTLKQKIT QDLSQPLNIQ FFNLFLEFCG 550
    WDFNDISKSI ILDTDAYENI VLNLDLWYMN EDQSSLASGG LEIIRFLFFQ 600
    ISSLMEASIY SKFNSNKFND MNILEKLCLS YQAVTKRENQ NSKFNELSSD 650
    LISVFVTLLK SNTDKRHLQW FLHLSYYFIK RKDVRSTEII LQAVDQLFSF 700
    YLDQGSDENA KILSEIIPLK LILMIMDQIV ENNESNPITC LNILFKVVLT 750
    NKPLFKQFYK NDGLKLILTM LCKVGKSYRE EIISLLLTYS IGNYTTANEI 800
    FSGAEDMIGG ISNDKITAKE IIYLAVNFIE WHVINSNASD SSSVLDLNNH 850
    ILRFVEDLKS LSAVPINESV FDPKKSYVMV SLLDLSIALN ESEDISKFKS 900
    SSKVISELIK GNIMCALTKY AAYDFEVYMS TFFCHSTEYK LVYPKTVMNN 950
    SSYLELSFIV TLLPEILNDL VDSNNNLNLM MLKHPYTMSN LLYFLRKFRP 1000
    DTSQIVMPKD FYFSSYTCLL HCVIQIDKSS FYHFKNVSKS QLLQDFKICI 1050
    MNLIYSNTLK QIIWEKEEYE MFSESLMAHQ EVLFAHGACD NETVGLLLIF 1100
    FANRLRDCGY NKAVFNCMKV IIKNKERKLK EVACFFDPAN KSEVLEGLSN 1150
    ILSCNNSETM NLITEQYPFF FNNTQQVRFI NIVTNILFKN NNFSPISVRQ 1200
    IKNQVYEWKN ARSEYVTQNN KKCLILFRKD NTSLDFKIKK SISRYTYNLK 1250
    TDREENAVFY RNNLNLLIFH LKHTLEIQSN PNSSCKWSSD FAEDFDGMKR 1300
    RLLPAWEPKY EPLINEEDAN QDTITGGNRQ RRESGSILSY EFIEHMETLE 1350
    SEPVGDLNEN RKILRLLKDN DSIATIWNCS LIIGLEIKEG ILIHGSNYLY 1400
    FVSDYYFSLE DKKILKLSEV SQESRDMTVS LINGPDVKRV STFLKHEVFV 1450
    WKLLDITFVT KRPFLLRDVA IELLFKERVS AFFSFYNKRV RDDVLRVLNK 1500
    IPKHLPADPI FSSVLQEIND RGNSIVARNG IGKASIASKF TSVFSANNSL 1550
    IDGFEISKKW VRGEISNFYY LLSINILAGR SFNDLTQYPV FPWVIADYES 1600
    NVLDLENPKT YRDLSKPMGA QSEKRKLQFI ERYEALASLE NADSAPFHYG 1650
    THYSSAMIVS SYLIRLKPFV ESFLLLQGGS FGPADRLFSS LERAWSSASS 1700
    ENTTDVRELT PEFFFLPEFL INVNSYDFGT DQSGKKVDDV VLPPWANGDP 1750
    KVFIQKNREA LESPYVSAHL HEWIDLIFGY KQKGDIAVKS VNVFNRLSYP 1800
    GAVNLDNIDD ENERRAITGI IHNFGQTPLQ IFQEPHPEKI ACNVQQLTTE 1850
    VWRKVPMKPI FEKTIFNLNE KNRSVDYVIH DPSYFDSLYW RGFAFPNLFF 1900
    RTEESLVSLR IVHKNWLKIG LDIFKKTHMA QITSFAYWKL GEFITGDKNG 1950
    LIKVWKYRKD KHSVSGNLEN KKTMFGHLCE LKEMRCYHDY NTLLTLDISG 2000
    LVYVWDMINF ELVRQITNDA QKVAISQHAG SIMVLTKNNA ISIFNLNGQI 2050
    YTSKKFEPAK IVSSIDFFDF TKLDAGYRKH IYWKEMEILL VGFEDGTIEI 2100
    YELFLNFHNE WAIKLLKQLC TEKGKAITSI KGQGKTYLSQ KRRKDTAEPH 2150
    EIEVIAGTLD GRLAIWY 2167
    Length:2,167
    Mass (Da):250,872
    Last modified:June 27, 2003 - v2
    Checksum:iED7D607ADA9982CD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1893 – 18931F → N in AAB21258. (PubMed:1776366)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62452 Genomic DNA. Translation: CAA44309.1.
    X59720 Genomic DNA. Translation: CAC42982.1.
    X59075 Genomic DNA. Translation: CAA41798.1.
    S78624 Genomic DNA. Translation: AAB21258.1.
    BK006937 Genomic DNA. Translation: DAA07511.1.
    PIRiS19444.
    RefSeqiNP_009961.2. NM_001178746.1.

    Genome annotation databases

    EnsemblFungiiYCR032W; YCR032W; YCR032W.
    GeneIDi850398.
    KEGGisce:YCR032W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62452 Genomic DNA. Translation: CAA44309.1 .
    X59720 Genomic DNA. Translation: CAC42982.1 .
    X59075 Genomic DNA. Translation: CAA41798.1 .
    S78624 Genomic DNA. Translation: AAB21258.1 .
    BK006937 Genomic DNA. Translation: DAA07511.1 .
    PIRi S19444.
    RefSeqi NP_009961.2. NM_001178746.1.

    3D structure databases

    ProteinModelPortali P25356.
    SMRi P25356. Positions 1451-1839.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31015. 89 interactions.
    MINTi MINT-2787660.

    Proteomic databases

    MaxQBi P25356.
    PaxDbi P25356.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR032W ; YCR032W ; YCR032W .
    GeneIDi 850398.
    KEGGi sce:YCR032W.

    Organism-specific databases

    CYGDi YCR032w.
    SGDi S000000628. BPH1.

    Phylogenomic databases

    eggNOGi NOG236271.
    GeneTreei ENSGT00670000097722.
    HOGENOMi HOG000057139.
    OMAi LESRYVS.
    OrthoDBi EOG7CK3G4.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29346-MONOMER.

    Miscellaneous databases

    NextBioi 965929.

    Gene expression databases

    Genevestigatori P25356.

    Family and domain databases

    Gene3Di 1.10.1540.10. 1 hit.
    2.130.10.10. 1 hit.
    2.30.29.40. 1 hit.
    InterProi IPR000409. BEACH_dom.
    IPR023362. PH-BEACH_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF02138. Beach. 1 hit.
    PF14844. PH_BEACH. 1 hit.
    [Graphical view ]
    SMARTi SM01026. Beach. 1 hit.
    SM00320. WD40. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    SSF81837. SSF81837. 1 hit.
    PROSITEi PS50197. BEACH. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence of 8.8 kb of yeast chromosome III cloned in lambda PM3270 contains an unusual long ORF (YCR601)."
      Rodriguez F., Martegani E., Mauri I., Alberghina L.
      Yeast 7:631-641(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Valles G., Volckaerts G.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "The complete sequence of the unit YCR59, situated between CRY1 and MAT, reveals two long open reading frames, which cover 91% of the 10.1 kb segment."
      Jia Y., Slonimski P.P., Herbert C.J.
      Yeast 7:413-424(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 335-2167.
    6. "The complete sequence of a 7.5 kb region of chromosome III from Saccharomyces cerevisiae that lies between CRY1 and MAT."
      Wicksteed B.L., Roberts A.B., Sagliocco F.A., Brown A.J.P.
      Yeast 7:761-772(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1760-2167.
    7. "Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting."
      Shiflett S.L., Vaughn M.B., Huynh D., Kaplan J., McVey Ward D.
      Traffic 5:700-710(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
      Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
      Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBPH1_YEAST
    AccessioniPrimary (citable) accession number: P25356
    Secondary accession number(s): D6VR42, Q02396, Q07348
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: June 27, 2003
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3