P25356 (BPH1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beige protein homolog 1

Gene names

Name:	BPH1
Ordered Locus Names:	YCR032W
ORF Names:	YCR32W, YCR591, YCR601

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	2167 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Function	May be involved in protein sorting and cell wall formation. Ref.7
Subcellular location	Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side Ref.7.
Sequence similarities	Contains 1 BEACH domain. Contains 5 WD repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fungal-type cell wall organization Inferred from mutant phenotype Ref.7. Source: SGD intracellular protein transport Inferred from mutant phenotype Ref.7. Source: SGD response to pH Inferred from mutant phenotype PubMed 9509574. Source: SGD
Cellular_component	cytosol Inferred from direct assay Ref.7. Source: SGD extrinsic to membrane Inferred from direct assay Ref.7. Source: SGD mitochondrion Inferred from direct assay PubMed 14576278PubMed 16823961. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2167	2167	Beige protein homolog 1		PRO_0000050887
Regions
	Domain	1545 – 1839	295	BEACH
	Repeat	1927 – 1965	39	WD 1
	Repeat	1976 – 2015	40	WD 2
	Repeat	2017 – 2054	38	WD 3
	Repeat	2072 – 2111	40	WD 4
	Repeat	2129 – 2167	39	WD 5
Experimental info
	Sequence conflict	1893	1	F → N in AAB21258. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	P25356 [UniParc]. Last modified June 27, 2003. Version 2. Checksum: ED7D607ADA9982CD	FASTA	2,167	250,872
	10 20 30 40 50 60 MNSIINAASK VLRLQDDVKK ATIILGDILI LQPINHEVEP DVENLVQHEL TKIIQGYPIQ 70 80 90 100 110 120 DNMIINSKKG TVEDDLCELN NYTCFALSKS FDLCHDSRNF NIAQPKRWIQ LLETLTDSVS 130 140 150 160 170 180 FAVIVQIILT LSNISLINKQ TLGKLKKLRI RIFEILSNKN DSWKSTLLQK NLIEWYIFML 190 200 210 220 230 240 SVDCTPLELQ NLYLHKELKF CNGILNSLTL QVSDPRSQNY LQFENTYKLF QIQKSSRINN 250 260 270 280 290 300 SFLFYIEFNS VTSNRIMTIE RHIYLEIKEG QFCISNDNYI IGLFENFEFE AGTLYFIGVL 310 320 330 340 350 360 IDHNNRITLY VDGSMINQLT LFENSICQLS TCELGSMICS IKVYRFYLWD GLLTEFAINI 370 380 390 400 410 420 LQAIGTNYQY TFSKKKEGPE VLSLCQDFLI AKAHLMARPT TEISSTKYID EIELLEMENI 430 440 450 460 470 480 IIDVNPNDIL QDFTESSNFT VKFEESTNSK NIPEVGKCYF YRSSNLVSKF VSIDSIRLAF 490 500 510 520 530 540 LNMTESGSID DLFHHVSHLM NLLRNIDILN WFKKDFGFPL FAYTLKQKIT QDLSQPLNIQ 550 560 570 580 590 600 FFNLFLEFCG WDFNDISKSI ILDTDAYENI VLNLDLWYMN EDQSSLASGG LEIIRFLFFQ 610 620 630 640 650 660 ISSLMEASIY SKFNSNKFND MNILEKLCLS YQAVTKRENQ NSKFNELSSD LISVFVTLLK 670 680 690 700 710 720 SNTDKRHLQW FLHLSYYFIK RKDVRSTEII LQAVDQLFSF YLDQGSDENA KILSEIIPLK 730 740 750 760 770 780 LILMIMDQIV ENNESNPITC LNILFKVVLT NKPLFKQFYK NDGLKLILTM LCKVGKSYRE 790 800 810 820 830 840 EIISLLLTYS IGNYTTANEI FSGAEDMIGG ISNDKITAKE IIYLAVNFIE WHVINSNASD 850 860 870 880 890 900 SSSVLDLNNH ILRFVEDLKS LSAVPINESV FDPKKSYVMV SLLDLSIALN ESEDISKFKS 910 920 930 940 950 960 SSKVISELIK GNIMCALTKY AAYDFEVYMS TFFCHSTEYK LVYPKTVMNN SSYLELSFIV 970 980 990 1000 1010 1020 TLLPEILNDL VDSNNNLNLM MLKHPYTMSN LLYFLRKFRP DTSQIVMPKD FYFSSYTCLL 1030 1040 1050 1060 1070 1080 HCVIQIDKSS FYHFKNVSKS QLLQDFKICI MNLIYSNTLK QIIWEKEEYE MFSESLMAHQ 1090 1100 1110 1120 1130 1140 EVLFAHGACD NETVGLLLIF FANRLRDCGY NKAVFNCMKV IIKNKERKLK EVACFFDPAN 1150 1160 1170 1180 1190 1200 KSEVLEGLSN ILSCNNSETM NLITEQYPFF FNNTQQVRFI NIVTNILFKN NNFSPISVRQ 1210 1220 1230 1240 1250 1260 IKNQVYEWKN ARSEYVTQNN KKCLILFRKD NTSLDFKIKK SISRYTYNLK TDREENAVFY 1270 1280 1290 1300 1310 1320 RNNLNLLIFH LKHTLEIQSN PNSSCKWSSD FAEDFDGMKR RLLPAWEPKY EPLINEEDAN 1330 1340 1350 1360 1370 1380 QDTITGGNRQ RRESGSILSY EFIEHMETLE SEPVGDLNEN RKILRLLKDN DSIATIWNCS 1390 1400 1410 1420 1430 1440 LIIGLEIKEG ILIHGSNYLY FVSDYYFSLE DKKILKLSEV SQESRDMTVS LINGPDVKRV 1450 1460 1470 1480 1490 1500 STFLKHEVFV WKLLDITFVT KRPFLLRDVA IELLFKERVS AFFSFYNKRV RDDVLRVLNK 1510 1520 1530 1540 1550 1560 IPKHLPADPI FSSVLQEIND RGNSIVARNG IGKASIASKF TSVFSANNSL IDGFEISKKW 1570 1580 1590 1600 1610 1620 VRGEISNFYY LLSINILAGR SFNDLTQYPV FPWVIADYES NVLDLENPKT YRDLSKPMGA 1630 1640 1650 1660 1670 1680 QSEKRKLQFI ERYEALASLE NADSAPFHYG THYSSAMIVS SYLIRLKPFV ESFLLLQGGS 1690 1700 1710 1720 1730 1740 FGPADRLFSS LERAWSSASS ENTTDVRELT PEFFFLPEFL INVNSYDFGT DQSGKKVDDV 1750 1760 1770 1780 1790 1800 VLPPWANGDP KVFIQKNREA LESPYVSAHL HEWIDLIFGY KQKGDIAVKS VNVFNRLSYP 1810 1820 1830 1840 1850 1860 GAVNLDNIDD ENERRAITGI IHNFGQTPLQ IFQEPHPEKI ACNVQQLTTE VWRKVPMKPI 1870 1880 1890 1900 1910 1920 FEKTIFNLNE KNRSVDYVIH DPSYFDSLYW RGFAFPNLFF RTEESLVSLR IVHKNWLKIG 1930 1940 1950 1960 1970 1980 LDIFKKTHMA QITSFAYWKL GEFITGDKNG LIKVWKYRKD KHSVSGNLEN KKTMFGHLCE 1990 2000 2010 2020 2030 2040 LKEMRCYHDY NTLLTLDISG LVYVWDMINF ELVRQITNDA QKVAISQHAG SIMVLTKNNA 2050 2060 2070 2080 2090 2100 ISIFNLNGQI YTSKKFEPAK IVSSIDFFDF TKLDAGYRKH IYWKEMEILL VGFEDGTIEI 2110 2120 2130 2140 2150 2160 YELFLNFHNE WAIKLLKQLC TEKGKAITSI KGQGKTYLSQ KRRKDTAEPH EIEVIAGTLD GRLAIWY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The sequence of 8.8 kb of yeast chromosome III cloned in lambda PM3270 contains an unusual long ORF (YCR601)." Rodriguez F., Martegani E., Mauri I., Alberghina L. Yeast 7:631-641(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"The complete DNA sequence of yeast chromosome III." Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G. Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[3]	Valles G., Volckaerts G. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[4]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[5]	"The complete sequence of the unit YCR59, situated between CRY1 and MAT, reveals two long open reading frames, which cover 91% of the 10.1 kb segment." Jia Y., Slonimski P.P., Herbert C.J. Yeast 7:413-424(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 335-2167.
[6]	"The complete sequence of a 7.5 kb region of chromosome III from Saccharomyces cerevisiae that lies between CRY1 and MAT." Wicksteed B.L., Roberts A.B., Sagliocco F.A., Brown A.J.P. Yeast 7:761-772(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1760-2167.
[7]	"Bph1p, the Saccharomyces cerevisiae homologue of CHS1/beige, functions in cell wall formation and protein sorting." Shiflett S.L., Vaughn M.B., Huynh D., Kaplan J., McVey Ward D. Traffic 5:700-710(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X62452 Genomic DNA. Translation: CAA44309.1. X59720 Genomic DNA. Translation: CAC42982.1. X59075 Genomic DNA. Translation: CAA41798.1. S78624 Genomic DNA. Translation: AAB21258.1. BK006937 Genomic DNA. Translation: DAA07511.1.
PIR	S19444.
RefSeq	NP_009961.2. NM_001178746.1.
3D structure databases
ProteinModelPortal	P25356.
SMR	P25356. Positions 1451-1839, 1938-2038.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-2787660.
Proteomic databases
PaxDb	P25356.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YCR032W; YCR032W; YCR032W.
GeneID	850398.
KEGG	sce:YCR032W.
Organism-specific databases
CYGD	YCR032w.
SGD	S000000628. BPH1.
Phylogenomic databases
eggNOG	NOG236271.
GeneTree	ENSGT00670000097747.
HOGENOM	HOG000057139.
OMA	TGIIHNF.
OrthoDB	EOG4BS0TQ.
Enzyme and pathway databases
BioCyc	YEAST:G3O-29346-MONOMER.
Gene expression databases
Genevestigator	P25356.
GermOnline	YCR032W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.10.1540.10. 1 hit. 2.130.10.10. 1 hit. 2.30.29.40. 1 hit.
InterPro	IPR000409. BEACH_dom. IPR023362. PH-BEACH_dom. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF02138. Beach. 1 hit. [Graphical view]
SMART	SM01026. Beach. 1 hit. SM00320. WD40. 3 hits. [Graphical view]
SUPFAM	SSF81837. Beige_BEACH. 1 hit. SSF50978. WD40_like. 1 hit.
PROSITE	PS50197. BEACH. 1 hit. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	965929.

Entry information

Entry name

BPH1_YEAST

Accession

Primary (citable) accession number: P25356
Secondary accession number(s): D6VR42, Q02396, Q07348

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 1992
Last sequence update:	June 27, 2003
Last modified:	May 29, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program