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Protein

Copper transport protein 86

Gene

CTR86

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential protein which may be involved in threonine biosynthesis.

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Enzyme and pathway databases

BioCyciYEAST:G3O-29362-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper transport protein 86
Gene namesi
Name:CTR86
Ordered Locus Names:YCR054C
ORF Names:YCR54C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR054c.
SGDiS000000650. CTR86.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Copper transport protein 86PRO_0000202572Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei433 – 4331Phosphothreonine1 Publication
Modified residuei559 – 5591Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP25355.
PaxDbiP25355.

Expressioni

Gene expression databases

GenevestigatoriP25355.

Interactioni

Protein-protein interaction databases

BioGridi31034. 3 interactions.
DIPiDIP-2728N.
IntActiP25355. 8 interactions.
MINTiMINT-1625390.
STRINGi4932.YCR054C.

Structurei

3D structure databases

ProteinModelPortaliP25355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CTR86 family.Curated

Phylogenomic databases

eggNOGiNOG330117.
GeneTreeiENSGT00390000010377.
HOGENOMiHOG000000904.
InParanoidiP25355.
OMAiPFIKERS.
OrthoDBiEOG7GN2WV.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019156. Ataxin-10_domain.
[Graphical view]
PfamiPF09759. Atx10homo_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.

Sequencei

Sequence statusi: Complete.

P25355-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPMNNFLDEF NLFDSIITMM KNDPCCVEDY EPIVENLNRI FQRTFNDEEH
60 70 80 90 100
RKSMANSQLF WERLRDTLEA MLLPASLNEN SSIPYTRTVR GLILMMRNLA
110 120 130 140 150
AENQEIPQKL LLQNLVIRGF LHATSEYVVD TPLIKHLYIA CLTCLFNIQQ
160 170 180 190 200
NYSTVDMTTF PALLQFLQYP YGIKLEDGEE EEHFWLPYLF LFKTYLNNDE
210 220 230 240 250
FSNEFFRDND TPQKDYYCVR DRIFFDIVTA KFIQDQENSF LIEKGRNYLD
260 270 280 290 300
DSKLEITSID LSVLECISKS LTTASFGKYL NGLEERQPGK FTTLLQILQL
310 320 330 340 350
VVTSKEDWNT YELTAIMSWC YPILQRLACK DIPAFFNKSC NDYAPSVAIQ
360 370 380 390 400
LHSTLLSCLD IISDLCKFNH VRKFLISYDS VKILVSLLDT FQKNLLRINF
410 420 430 440 450
LKGNGDTVNE IKITDHEGNK IEDRLLIFNR VNTNESFIRA DNFPHCKLVI
460 470 480 490 500
IEILASLVYA HPEIQDQIRE LGGLALILSN CVIDDNDPFI KERSIVCLKF
510 520 530 540 550
LLKNNAKNQE YVKKMEAQDV VQDDALSKAG FEISVEKGGK VRLVSKEEDP
560
GNENSEIISI DED
Length:563
Mass (Da):65,206
Last modified:May 1, 1992 - v1
Checksum:i38DE4EBFA781D629
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42285.1.
BK006937 Genomic DNA. Translation: DAA07531.1.
PIRiS22837.
RefSeqiNP_009983.1. NM_001178768.1.

Genome annotation databases

EnsemblFungiiYCR054C; YCR054C; YCR054C.
GeneIDi850421.
KEGGisce:YCR054C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42285.1.
BK006937 Genomic DNA. Translation: DAA07531.1.
PIRiS22837.
RefSeqiNP_009983.1. NM_001178768.1.

3D structure databases

ProteinModelPortaliP25355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31034. 3 interactions.
DIPiDIP-2728N.
IntActiP25355. 8 interactions.
MINTiMINT-1625390.
STRINGi4932.YCR054C.

Proteomic databases

MaxQBiP25355.
PaxDbiP25355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYCR054C; YCR054C; YCR054C.
GeneIDi850421.
KEGGisce:YCR054C.

Organism-specific databases

CYGDiYCR054c.
SGDiS000000650. CTR86.

Phylogenomic databases

eggNOGiNOG330117.
GeneTreeiENSGT00390000010377.
HOGENOMiHOG000000904.
InParanoidiP25355.
OMAiPFIKERS.
OrthoDBiEOG7GN2WV.

Enzyme and pathway databases

BioCyciYEAST:G3O-29362-MONOMER.

Miscellaneous databases

NextBioi965989.
PROiP25355.

Gene expression databases

GenevestigatoriP25355.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR019156. Ataxin-10_domain.
[Graphical view]
PfamiPF09759. Atx10homo_assoc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the THR4 region on chromosome III of the yeast Saccharomyces cerevisiae."
    Mannhaupt G., van der Linden C.G., Vetter I., Maurer K., Pilz U., Planta R.J., Feldmann H.
    Yeast 6:353-361(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-433 AND SER-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-559, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCTR86_YEAST
AccessioniPrimary (citable) accession number: P25355
Secondary accession number(s): D6VR62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: January 7, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8970 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.