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P25354

- YCP7_YEAST

UniProt

P25354 - YCP7_YEAST

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Protein
DUP240 protein YCR007C
Gene
YCR007C, YCR045, YCR7C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciYEAST:G3O-29324-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DUP240 protein YCR007C
Gene namesi
Ordered Locus Names:YCR007C
ORF Names:YCR045, YCR7C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR007c.
SGDiS000000600. YCR007C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5454Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei55 – 7521Helical; Reviewed prediction
Add
BLAST
Topological domaini76 – 794Extracellular Reviewed prediction
Transmembranei80 – 10425Helical; Reviewed prediction
Add
BLAST
Topological domaini105 – 239135Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239DUP240 protein YCR007C
PRO_0000207531Add
BLAST

Proteomic databases

MaxQBiP25354.
PaxDbiP25354.

Expressioni

Gene expression databases

GenevestigatoriP25354.

Interactioni

Subunit structurei

Interacts according to large scale protein interaction studies with MEC3 and ULP1 Reviewed prediction.1 Publication

Protein-protein interaction databases

BioGridi30985. 18 interactions.
DIPiDIP-4043N.
IntActiP25354. 8 interactions.
MINTiMINT-475460.

Structurei

3D structure databases

ProteinModelPortaliP25354.

Family & Domainsi

Sequence similaritiesi

Belongs to the DUP/COS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000017646.
HOGENOMiHOG000000896.
OrthoDBiEOG72JWSS.

Family and domain databases

InterProiIPR001142. DUP.
[Graphical view]
PfamiPF00674. DUP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25354-1 [UniParc]FASTAAdd to Basket

« Hide

MQPHLDNNSN NDDVKLDTLG EQNVLSSAEN ITLPEDTFKS YMTYLLYEMA    50
HYKPMIFSFL ALSVSILIVV IFHNVKACDV VFGFSIFVTS ILFLSTLIPF 100
NVYISDEGFR IKLLLEVITH RPAVKGKEWR AITDNMNQYL LDNGLWSTRY 150
YFYSSERCYK FFRFLVKEKP PGVNVNSSVK DATSTQIDAP ANEASNEVIK 200
CFSFSSDPIF EAYFVKAVEV EKQAQQEYWR KQYPDADIP 239
Length:239
Mass (Da):27,564
Last modified:May 1, 1992 - v1
Checksum:i8A8586E1AA4E4ED7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21Q → K in strain: CLIB 219. 1 Publication
Natural varianti42 – 421M → T in strain: CLIB 219, CLIB 410, CLIB 413, CLIB 630 haplotype Ha1, K1, YIIc12 haplotype Ha2 and CLIB 382. 1 Publication
Natural varianti215 – 2151V → I in strain: CLIB 630. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ585549 Genomic DNA. Translation: CAE52069.1.
AJ585550 Genomic DNA. Translation: CAE52070.1.
AJ585551 Genomic DNA. Translation: CAE52071.1.
AJ585552 Genomic DNA. Translation: CAE52072.1.
AJ585553 Genomic DNA. Translation: CAE52073.1.
AJ585554 Genomic DNA. Translation: CAE52074.1.
AJ585555 Genomic DNA. Translation: CAE52075.1.
AJ585556 Genomic DNA. Translation: CAE52076.1.
AJ585557 Genomic DNA. Translation: CAE52077.1.
AJ585558 Genomic DNA. Translation: CAE52078.1.
AJ585559 Genomic DNA. Translation: CAE52079.1.
AJ585560 Genomic DNA. Translation: CAE52080.1.
AJ585561 Genomic DNA. Translation: CAE52081.1.
AJ585562 Genomic DNA. Translation: CAE52082.1.
AJ585563 Genomic DNA. Translation: CAE52083.1.
AJ585564 Genomic DNA. Translation: CAE52084.1.
Z11114 Genomic DNA. Translation: CAA77446.1.
X59720 Genomic DNA. Translation: CAA42324.1.
AY558149 Genomic DNA. Translation: AAS56475.1.
BK006937 Genomic DNA. Translation: DAA07485.1.
PIRiS20184.
RefSeqiNP_009933.1. NM_001178720.1.

Genome annotation databases

EnsemblFungiiYCR007C; YCR007C; YCR007C.
GeneIDi850364.
KEGGisce:YCR007C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ585549 Genomic DNA. Translation: CAE52069.1 .
AJ585550 Genomic DNA. Translation: CAE52070.1 .
AJ585551 Genomic DNA. Translation: CAE52071.1 .
AJ585552 Genomic DNA. Translation: CAE52072.1 .
AJ585553 Genomic DNA. Translation: CAE52073.1 .
AJ585554 Genomic DNA. Translation: CAE52074.1 .
AJ585555 Genomic DNA. Translation: CAE52075.1 .
AJ585556 Genomic DNA. Translation: CAE52076.1 .
AJ585557 Genomic DNA. Translation: CAE52077.1 .
AJ585558 Genomic DNA. Translation: CAE52078.1 .
AJ585559 Genomic DNA. Translation: CAE52079.1 .
AJ585560 Genomic DNA. Translation: CAE52080.1 .
AJ585561 Genomic DNA. Translation: CAE52081.1 .
AJ585562 Genomic DNA. Translation: CAE52082.1 .
AJ585563 Genomic DNA. Translation: CAE52083.1 .
AJ585564 Genomic DNA. Translation: CAE52084.1 .
Z11114 Genomic DNA. Translation: CAA77446.1 .
X59720 Genomic DNA. Translation: CAA42324.1 .
AY558149 Genomic DNA. Translation: AAS56475.1 .
BK006937 Genomic DNA. Translation: DAA07485.1 .
PIRi S20184.
RefSeqi NP_009933.1. NM_001178720.1.

3D structure databases

ProteinModelPortali P25354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 30985. 18 interactions.
DIPi DIP-4043N.
IntActi P25354. 8 interactions.
MINTi MINT-475460.

Proteomic databases

MaxQBi P25354.
PaxDbi P25354.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR007C ; YCR007C ; YCR007C .
GeneIDi 850364.
KEGGi sce:YCR007C.

Organism-specific databases

CYGDi YCR007c.
SGDi S000000600. YCR007C.

Phylogenomic databases

GeneTreei ENSGT00390000017646.
HOGENOMi HOG000000896.
OrthoDBi EOG72JWSS.

Enzyme and pathway databases

BioCyci YEAST:G3O-29324-MONOMER.

Miscellaneous databases

NextBioi 965844.

Gene expression databases

Genevestigatori P25354.

Family and domain databases

InterProi IPR001142. DUP.
[Graphical view ]
Pfami PF00674. DUP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny."
    Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S., Souciet J.-L.
    Nucleic Acids Res. 32:2069-2078(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-2; THR-42 AND ILE-215.
    Strain: CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, CLIB 95, K1, R12, R13, Sigma 1278B, YIIc12 and YIIc17.
  2. "The complete sequence of a 10.8kb fragment to the right of the chromosome III centromere of Saccharomyces cerevisiae."
    Biteau N., Fremaux C., Hebrard S., Menara A., Aigle M., Crouzet M.
    Yeast 8:61-70(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  6. "A comprehensive two-hybrid analysis to explore the yeast protein interactome."
    Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., Sakaki Y.
    Proc. Natl. Acad. Sci. U.S.A. 98:4569-4574(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MEC3 AND ULP1.
  7. "Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability."
    Poirey R., Despons L., Leh V., Lafuente M.-J., Potier S., Souciet J.-L., Jauniaux J.-C.
    Microbiology 148:2111-2123(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiYCP7_YEAST
AccessioniPrimary (citable) accession number: P25354
Secondary accession number(s): D6VR16
, Q70DH1, Q70DH4, Q70DH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi