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P25354

- YCP7_YEAST

UniProt

P25354 - YCP7_YEAST

Protein

DUP240 protein YCR007C

Gene

YCR007C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29324-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DUP240 protein YCR007C
    Gene namesi
    Ordered Locus Names:YCR007C
    ORF Names:YCR045, YCR7C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR007c.
    SGDiS000000600. YCR007C.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239DUP240 protein YCR007CPRO_0000207531Add
    BLAST

    Proteomic databases

    MaxQBiP25354.
    PaxDbiP25354.

    Expressioni

    Gene expression databases

    GenevestigatoriP25354.

    Interactioni

    Subunit structurei

    Interacts according to large scale protein interaction studies with MEC3 and ULP1.Curated

    Protein-protein interaction databases

    BioGridi30985. 18 interactions.
    DIPiDIP-4043N.
    IntActiP25354. 8 interactions.
    MINTiMINT-475460.

    Structurei

    3D structure databases

    ProteinModelPortaliP25354.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5454CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini76 – 794ExtracellularSequence Analysis
    Topological domaini105 – 239135CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10425HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DUP/COS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00390000017646.
    HOGENOMiHOG000000896.
    OrthoDBiEOG72JWSS.

    Family and domain databases

    InterProiIPR001142. DUP.
    [Graphical view]
    PfamiPF00674. DUP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25354-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPHLDNNSN NDDVKLDTLG EQNVLSSAEN ITLPEDTFKS YMTYLLYEMA    50
    HYKPMIFSFL ALSVSILIVV IFHNVKACDV VFGFSIFVTS ILFLSTLIPF 100
    NVYISDEGFR IKLLLEVITH RPAVKGKEWR AITDNMNQYL LDNGLWSTRY 150
    YFYSSERCYK FFRFLVKEKP PGVNVNSSVK DATSTQIDAP ANEASNEVIK 200
    CFSFSSDPIF EAYFVKAVEV EKQAQQEYWR KQYPDADIP 239
    Length:239
    Mass (Da):27,564
    Last modified:May 1, 1992 - v1
    Checksum:i8A8586E1AA4E4ED7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21Q → K in strain: CLIB 219. 1 Publication
    Natural varianti42 – 421M → T in strain: CLIB 219, CLIB 410, CLIB 413, CLIB 630 haplotype Ha1, K1, YIIc12 haplotype Ha2 and CLIB 382. 1 Publication
    Natural varianti215 – 2151V → I in strain: CLIB 630. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ585549 Genomic DNA. Translation: CAE52069.1.
    AJ585550 Genomic DNA. Translation: CAE52070.1.
    AJ585551 Genomic DNA. Translation: CAE52071.1.
    AJ585552 Genomic DNA. Translation: CAE52072.1.
    AJ585553 Genomic DNA. Translation: CAE52073.1.
    AJ585554 Genomic DNA. Translation: CAE52074.1.
    AJ585555 Genomic DNA. Translation: CAE52075.1.
    AJ585556 Genomic DNA. Translation: CAE52076.1.
    AJ585557 Genomic DNA. Translation: CAE52077.1.
    AJ585558 Genomic DNA. Translation: CAE52078.1.
    AJ585559 Genomic DNA. Translation: CAE52079.1.
    AJ585560 Genomic DNA. Translation: CAE52080.1.
    AJ585561 Genomic DNA. Translation: CAE52081.1.
    AJ585562 Genomic DNA. Translation: CAE52082.1.
    AJ585563 Genomic DNA. Translation: CAE52083.1.
    AJ585564 Genomic DNA. Translation: CAE52084.1.
    Z11114 Genomic DNA. Translation: CAA77446.1.
    X59720 Genomic DNA. Translation: CAA42324.1.
    AY558149 Genomic DNA. Translation: AAS56475.1.
    BK006937 Genomic DNA. Translation: DAA07485.1.
    PIRiS20184.
    RefSeqiNP_009933.1. NM_001178720.1.

    Genome annotation databases

    EnsemblFungiiYCR007C; YCR007C; YCR007C.
    GeneIDi850364.
    KEGGisce:YCR007C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ585549 Genomic DNA. Translation: CAE52069.1 .
    AJ585550 Genomic DNA. Translation: CAE52070.1 .
    AJ585551 Genomic DNA. Translation: CAE52071.1 .
    AJ585552 Genomic DNA. Translation: CAE52072.1 .
    AJ585553 Genomic DNA. Translation: CAE52073.1 .
    AJ585554 Genomic DNA. Translation: CAE52074.1 .
    AJ585555 Genomic DNA. Translation: CAE52075.1 .
    AJ585556 Genomic DNA. Translation: CAE52076.1 .
    AJ585557 Genomic DNA. Translation: CAE52077.1 .
    AJ585558 Genomic DNA. Translation: CAE52078.1 .
    AJ585559 Genomic DNA. Translation: CAE52079.1 .
    AJ585560 Genomic DNA. Translation: CAE52080.1 .
    AJ585561 Genomic DNA. Translation: CAE52081.1 .
    AJ585562 Genomic DNA. Translation: CAE52082.1 .
    AJ585563 Genomic DNA. Translation: CAE52083.1 .
    AJ585564 Genomic DNA. Translation: CAE52084.1 .
    Z11114 Genomic DNA. Translation: CAA77446.1 .
    X59720 Genomic DNA. Translation: CAA42324.1 .
    AY558149 Genomic DNA. Translation: AAS56475.1 .
    BK006937 Genomic DNA. Translation: DAA07485.1 .
    PIRi S20184.
    RefSeqi NP_009933.1. NM_001178720.1.

    3D structure databases

    ProteinModelPortali P25354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 30985. 18 interactions.
    DIPi DIP-4043N.
    IntActi P25354. 8 interactions.
    MINTi MINT-475460.

    Proteomic databases

    MaxQBi P25354.
    PaxDbi P25354.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR007C ; YCR007C ; YCR007C .
    GeneIDi 850364.
    KEGGi sce:YCR007C.

    Organism-specific databases

    CYGDi YCR007c.
    SGDi S000000600. YCR007C.

    Phylogenomic databases

    GeneTreei ENSGT00390000017646.
    HOGENOMi HOG000000896.
    OrthoDBi EOG72JWSS.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29324-MONOMER.

    Miscellaneous databases

    NextBioi 965844.

    Gene expression databases

    Genevestigatori P25354.

    Family and domain databases

    InterProi IPR001142. DUP.
    [Graphical view ]
    Pfami PF00674. DUP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny."
      Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S., Souciet J.-L.
      Nucleic Acids Res. 32:2069-2078(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-2; THR-42 AND ILE-215.
      Strain: CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, CLIB 95, K1, R12, R13, Sigma 1278B, YIIc12 and YIIc17.
    2. "The complete sequence of a 10.8kb fragment to the right of the chromosome III centromere of Saccharomyces cerevisiae."
      Biteau N., Fremaux C., Hebrard S., Menara A., Aigle M., Crouzet M.
      Yeast 8:61-70(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    6. "A comprehensive two-hybrid analysis to explore the yeast protein interactome."
      Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., Sakaki Y.
      Proc. Natl. Acad. Sci. U.S.A. 98:4569-4574(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MEC3 AND ULP1.
    7. "Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability."
      Poirey R., Despons L., Leh V., Lafuente M.-J., Potier S., Souciet J.-L., Jauniaux J.-C.
      Microbiology 148:2111-2123(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    8. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.

    Entry informationi

    Entry nameiYCP7_YEAST
    AccessioniPrimary (citable) accession number: P25354
    Secondary accession number(s): D6VR16
    , Q70DH1, Q70DH4, Q70DH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3