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P25354 (YCP7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DUP240 protein YCR007C
Gene names
Ordered Locus Names:YCR007C
ORF Names:YCR045, YCR7C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts according to large scale protein interaction studies with MEC3 and ULP1 Potential. Ref.6

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Miscellaneous

Members of the DUP240 multigene family are specific to S.cerevisiae sensu strictu. Cells lacking all 10 DUP240 proteins show no obvious alterations in mating, sporulation and cell growth.

Sequence similarities

Belongs to the DUP/COS family.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239DUP240 protein YCR007C
PRO_0000207531

Regions

Topological domain1 – 5454Cytoplasmic Potential
Transmembrane55 – 7521Helical; Potential
Topological domain76 – 794Extracellular Potential
Transmembrane80 – 10425Helical; Potential
Topological domain105 – 239135Cytoplasmic Potential

Natural variations

Natural variant21Q → K in strain: CLIB 219. Ref.1
Natural variant421M → T in strain: CLIB 219, CLIB 410, CLIB 413, CLIB 630 haplotype Ha1, K1, YIIc12 haplotype Ha2 and CLIB 382. Ref.1
Natural variant2151V → I in strain: CLIB 630. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P25354 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 8A8586E1AA4E4ED7

FASTA23927,564
        10         20         30         40         50         60 
MQPHLDNNSN NDDVKLDTLG EQNVLSSAEN ITLPEDTFKS YMTYLLYEMA HYKPMIFSFL 

        70         80         90        100        110        120 
ALSVSILIVV IFHNVKACDV VFGFSIFVTS ILFLSTLIPF NVYISDEGFR IKLLLEVITH 

       130        140        150        160        170        180 
RPAVKGKEWR AITDNMNQYL LDNGLWSTRY YFYSSERCYK FFRFLVKEKP PGVNVNSSVK 

       190        200        210        220        230 
DATSTQIDAP ANEASNEVIK CFSFSSDPIF EAYFVKAVEV EKQAQQEYWR KQYPDADIP 

« Hide

References

« Hide 'large scale' references
[1]"Differential evolution of the Saccharomyces cerevisiae DUP240 paralogs and implication of recombination in phylogeny."
Leh-Louis V., Wirth B., Despons L., Wain-Hobson S., Potier S., Souciet J.-L.
Nucleic Acids Res. 32:2069-2078(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-2; THR-42 AND ILE-215.
Strain: CLIB 219, CLIB 382, CLIB 388, CLIB 410, CLIB 413, CLIB 556, CLIB 630, CLIB 95, K1, R12, R13, Sigma 1278B, YIIc12 and YIIc17.
[2]"The complete sequence of a 10.8kb fragment to the right of the chromosome III centromere of Saccharomyces cerevisiae."
Biteau N., Fremaux C., Hebrard S., Menara A., Aigle M., Crouzet M.
Yeast 8:61-70(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The complete DNA sequence of yeast chromosome III."
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. expand/collapse author list , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[5]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[6]"A comprehensive two-hybrid analysis to explore the yeast protein interactome."
Ito T., Chiba T., Ozawa R., Yoshida M., Hattori M., Sakaki Y.
Proc. Natl. Acad. Sci. U.S.A. 98:4569-4574(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MEC3 AND ULP1.
[7]"Functional analysis of the Saccharomyces cerevisiae DUP240 multigene family reveals membrane-associated proteins that are not essential for cell viability."
Poirey R., Despons L., Leh V., Lafuente M.-J., Potier S., Souciet J.-L., Jauniaux J.-C.
Microbiology 148:2111-2123(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NULL MUTANT.
[8]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ585549 Genomic DNA. Translation: CAE52069.1.
AJ585550 Genomic DNA. Translation: CAE52070.1.
AJ585551 Genomic DNA. Translation: CAE52071.1.
AJ585552 Genomic DNA. Translation: CAE52072.1.
AJ585553 Genomic DNA. Translation: CAE52073.1.
AJ585554 Genomic DNA. Translation: CAE52074.1.
AJ585555 Genomic DNA. Translation: CAE52075.1.
AJ585556 Genomic DNA. Translation: CAE52076.1.
AJ585557 Genomic DNA. Translation: CAE52077.1.
AJ585558 Genomic DNA. Translation: CAE52078.1.
AJ585559 Genomic DNA. Translation: CAE52079.1.
AJ585560 Genomic DNA. Translation: CAE52080.1.
AJ585561 Genomic DNA. Translation: CAE52081.1.
AJ585562 Genomic DNA. Translation: CAE52082.1.
AJ585563 Genomic DNA. Translation: CAE52083.1.
AJ585564 Genomic DNA. Translation: CAE52084.1.
Z11114 Genomic DNA. Translation: CAA77446.1.
X59720 Genomic DNA. Translation: CAA42324.1.
AY558149 Genomic DNA. Translation: AAS56475.1.
BK006937 Genomic DNA. Translation: DAA07485.1.
PIRS20184.
RefSeqNP_009933.1. NM_001178720.1.

3D structure databases

ProteinModelPortalP25354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid30985. 17 interactions.
DIPDIP-4043N.
IntActP25354. 8 interactions.
MINTMINT-475460.

Proteomic databases

PaxDbP25354.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYCR007C; YCR007C; YCR007C.
GeneID850364.
KEGGsce:YCR007C.

Organism-specific databases

CYGDYCR007c.
SGDS000000600. YCR007C.

Phylogenomic databases

GeneTreeENSGT00390000017646.
HOGENOMHOG000000896.
OrthoDBEOG72JWSS.

Enzyme and pathway databases

BioCycYEAST:G3O-29324-MONOMER.

Gene expression databases

GenevestigatorP25354.

Family and domain databases

InterProIPR001142. DUP.
[Graphical view]
PfamPF00674. DUP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio965844.

Entry information

Entry nameYCP7_YEAST
AccessionPrimary (citable) accession number: P25354
Secondary accession number(s): D6VR16 expand/collapse secondary AC list , Q70DH1, Q70DH4, Q70DH6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: February 19, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome III

Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families