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Protein

Uncharacterized membrane protein YCR023C

Gene

YCR023C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29338-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized membrane protein YCR023C
Gene namesi
Ordered Locus Names:YCR023C
ORF Names:YCR23C, YCR241
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR023C.
SGDiS000000617. YCR023C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8989ExtracellularSequence analysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence analysisAdd
BLAST
Topological domaini111 – 15242CytoplasmicSequence analysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence analysisAdd
BLAST
Topological domaini174 – 19926ExtracellularSequence analysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence analysisAdd
BLAST
Topological domaini221 – 353133CytoplasmicSequence analysisAdd
BLAST
Transmembranei354 – 37219HelicalSequence analysisAdd
BLAST
Topological domaini373 – 41341ExtracellularSequence analysisAdd
BLAST
Transmembranei414 – 43421HelicalSequence analysisAdd
BLAST
Topological domaini435 – 4428CytoplasmicSequence analysis
Transmembranei443 – 46321HelicalSequence analysisAdd
BLAST
Topological domaini464 – 54279ExtracellularSequence analysisAdd
BLAST
Transmembranei543 – 56321HelicalSequence analysisAdd
BLAST
Topological domaini564 – 61148CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 611611Uncharacterized membrane protein YCR023CPRO_0000173425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei313 – 3131PhosphoserineCombined sources
Modified residuei603 – 6031PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

PTM databases

iPTMnetiP25351.

Interactioni

Protein-protein interaction databases

BioGridi31005. 8 interactions.
DIPiDIP-1960N.

Structurei

3D structure databases

ProteinModelPortaliP25351.
SMRiP25351. Positions 148-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000246660.
InParanoidiP25351.
OMAiHECNASE.
OrthoDBiEOG7FR7RN.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25351-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARQKLTFKE QMDGFPWVQL VVVSLVRFSE PIAFSSLFPY VYFMVRDFNI
60 70 80 90 100
APNDAQVSKY SGYLSSSFAL CQVISAYHWG RFSEKHGRKI TLTCGLIGTS
110 120 130 140 150
VSLLILGFSR NFYQALVARS LMGLLNGNVG VIRTIIGEIA TERKHQALAF
160 170 180 190 200
STMPLLFQFG AVVGPMIGGF LVFRDGTMNE VPLWFPHFAK RIIRSYPYAL
210 220 230 240 250
PNVVVCMFLM FGLTNATLFL EETHPAFKDR RDYGLEVGDF IKKNIFGIQP
260 270 280 290 300
KRRPWQKRIQ DDSENIHHRN ENVNSIRGQD SEEDENSPLV NTTNDDDTES
310 320 330 340 350
IQSIDPILTR RQSVGLIRTY SLHEPTDAVH ANIDTAPDGC KESSIFHHVF
360 370 380 390 400
HTKVFYPISV NFIMALHLIV YNEFLPVFLA YDLAVDPENP KKLASKFPWK
410 420 430 440 450
ISGGIGYEPE QTGTLLSTTG IFGCFVVIFI FPIVDRNFDC LTIFRTLVKL
460 470 480 490 500
YPIMYVMVPY VVFLQNERIP SWYTVVYLYI ITGIKTFCGA LTSPQIMLLI
510 520 530 540 550
HNSSPLSCRS VINGATISIS ASARFIGPLV WGYIMSWSQQ NDVAWVSWWS
560 570 580 590 600
LSLFCMVALY QSYKIAPIDD NENELHGQGS EDAYNSQSQS SDLRMAHRSS
610
LSSLSNQRCT T
Length:611
Mass (Da):69,218
Last modified:May 16, 2003 - v2
Checksum:i1BD182315B11E7B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAC42975.1.
BK006937 Genomic DNA. Translation: DAA07501.1.
PIRiS19434.
RefSeqiNP_009952.2. NM_001178737.1.

Genome annotation databases

EnsemblFungiiCAC42975; CAC42975; CAC42975.
YCR023C; YCR023C; YCR023C.
GeneIDi850387.
KEGGisce:YCR023C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAC42975.1.
BK006937 Genomic DNA. Translation: DAA07501.1.
PIRiS19434.
RefSeqiNP_009952.2. NM_001178737.1.

3D structure databases

ProteinModelPortaliP25351.
SMRiP25351. Positions 148-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31005. 8 interactions.
DIPiDIP-1960N.

PTM databases

iPTMnetiP25351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAC42975; CAC42975; CAC42975.
YCR023C; YCR023C; YCR023C.
GeneIDi850387.
KEGGisce:YCR023C.

Organism-specific databases

EuPathDBiFungiDB:YCR023C.
SGDiS000000617. YCR023C.

Phylogenomic databases

HOGENOMiHOG000246660.
InParanoidiP25351.
OMAiHECNASE.
OrthoDBiEOG7FR7RN.

Enzyme and pathway databases

BioCyciYEAST:G3O-29338-MONOMER.

Miscellaneous databases

PROiP25351.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete sequence of K3B, a 7.9 kb fragment between PGK1 and CRY1 on chromosome III, reveals the presence of seven open reading frames."
    Bolle P.-A., Gilliquet V., Berben G., Dumont J., Hilger F.
    Yeast 8:205-213(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Valles G., Volckaerts G.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  6. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-313, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-603, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiYCR3_YEAST
AccessioniPrimary (citable) accession number: P25351
Secondary accession number(s): D6VR32, Q8NKJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 16, 2003
Last modified: July 6, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.