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Protein

Probable metabolite transport protein GIT1

Gene

GIT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • glycerol-3-phosphate transmembrane transporter activity Source: SGD
  • glycerophosphodiester transmembrane transporter activity Source: SGD

GO - Biological processi

  • glycerol-3-phosphate transport Source: SGD
  • glycerophosphodiester transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29392-MONOMER.

Protein family/group databases

TCDBi2.A.1.9.7. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable metabolite transport protein GIT1
Gene namesi
Name:GIT1
Ordered Locus Names:YCR098C
ORF Names:YCR137, YCR98C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome III

Organism-specific databases

CYGDiYCR098c.
EuPathDBiFungiDB:YCR098C.
SGDiS000000695. GIT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini66 – 9126ExtracellularSequence AnalysisAdd
BLAST
Transmembranei92 – 11221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini113 – 1142CytoplasmicSequence Analysis
Transmembranei115 – 13622Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini137 – 1382ExtracellularSequence Analysis
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 18425CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini206 – 21611ExtracellularSequence AnalysisAdd
BLAST
Transmembranei217 – 23721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini238 – 26831CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini290 – 30617ExtracellularSequence AnalysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini328 – 3358CytoplasmicSequence Analysis
Transmembranei336 – 35621Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini357 – 3604ExtracellularSequence Analysis
Transmembranei361 – 38121Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini382 – 39918CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei400 – 42021Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini421 – 43010ExtracellularSequence Analysis
Transmembranei431 – 45121Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini452 – 51867CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Probable metabolite transport protein GIT1PRO_0000050459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi31071. 15 interactions.
DIPiDIP-4626N.
IntActiP25346. 3 interactions.
MINTiMINT-546964.
STRINGi4932.YCR098C.

Structurei

3D structure databases

ProteinModelPortaliP25346.
SMRiP25346. Positions 87-112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00750000118743.
HOGENOMiHOG000214987.
InParanoidiP25346.
OMAiFTPIQNN.
OrthoDBiEOG7FV40B.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDKDITSVN EKEVNENTNP RIIKYDAERR ATRTETSKKD KWKNIVTIIA
60 70 80 90 100
SGFALISDGY VNGSMSMLNK VFVMEYGKKN YSSKVSTRVS NAALVGIIFG
110 120 130 140 150
QFFMGIAADY YSRKSCILVA TAILVIGSAL CAASHGTTVP GMFWMLTVMR
160 170 180 190 200
GLVGIGVGAE YPTSTLSANE SANEYTTTKR GGILVMVTNL PLAFGGPFAT
210 220 230 240 250
IIFLIVYKIC SGTKHLEAIW RTVFAIGCFW PLSVFYFRWK TATTEVYEKG
260 270 280 290 300
RIKRNIPYFL ALKFYWKRLL GTCGTWFMYD FVTFPNGIFS STIISSVIKD
310 320 330 340 350
QNDLVKVAEW NLLLGVLAVL GVPIGAYLSD RIGRKYTLMF GFSGYIIFGL
360 370 380 390 400
IIGCAYDQLK KITPLFIIFY AFMNMLGNAG PGDMLGVISS EASATAVRGV
410 420 430 440 450
FYGLSAVTGK IGSVVGVECF QPIRDNLGAR WTFIIAAICG LIGIIITYFF
460 470 480 490 500
VPHSLESDLM KQDVEFHNYL VSNGWTGKMG FDETDEESMV RTIEVEENGT
510
NCSKKNAEII SVRQVDQS
Length:518
Mass (Da):57,322
Last modified:May 1, 1992 - v1
Checksum:iD173B1B0096F4D0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42240.1.
BK006937 Genomic DNA. Translation: DAA07568.1.
PIRiS19514.
RefSeqiNP_010022.1. NM_001178805.1.

Genome annotation databases

EnsemblFungiiYCR098C; YCR098C; YCR098C.
GeneIDi850462.
KEGGisce:YCR098C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42240.1.
BK006937 Genomic DNA. Translation: DAA07568.1.
PIRiS19514.
RefSeqiNP_010022.1. NM_001178805.1.

3D structure databases

ProteinModelPortaliP25346.
SMRiP25346. Positions 87-112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31071. 15 interactions.
DIPiDIP-4626N.
IntActiP25346. 3 interactions.
MINTiMINT-546964.
STRINGi4932.YCR098C.

Protein family/group databases

TCDBi2.A.1.9.7. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYCR098C; YCR098C; YCR098C.
GeneIDi850462.
KEGGisce:YCR098C.

Organism-specific databases

CYGDiYCR098c.
EuPathDBiFungiDB:YCR098C.
SGDiS000000695. GIT1.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00750000118743.
HOGENOMiHOG000214987.
InParanoidiP25346.
OMAiFTPIQNN.
OrthoDBiEOG7FV40B.

Enzyme and pathway databases

BioCyciYEAST:G3O-29392-MONOMER.

Miscellaneous databases

NextBioi966098.
PROiP25346.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the HMR region on chromosome III of Saccharomyces cerevisiae."
    Sor F., Cheret G., Fabre F., Faye G., Fukuhara H.
    Yeast 8:215-222(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGIT1_YEAST
AccessioniPrimary (citable) accession number: P25346
Secondary accession number(s): D6VR99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 24, 2015
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.