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Protein

Glycerophosphoinositol transporter 1

Gene

GIT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Glycerophosphodiester transporter that mediates uptake of both glycerophosphoinositol (GroPIns) and glycerophosphocholine (GroPCho) as sources of the nutrients inositol and phosphate (PubMed:9691030, PubMed:12912892, PubMed:16141200).3 Publications

GO - Molecular functioni

  • glycerol-3-phosphate transmembrane transporter activity Source: SGD
  • glycerophosphodiester transmembrane transporter activity Source: SGD

GO - Biological processi

  • glycerol-3-phosphate transport Source: SGD
  • glycerophosphodiester transmembrane transport Source: SGD
  • transmembrane transport Source: SGD

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciYEAST:G3O-29392-MONOMER.

Protein family/group databases

TCDBi2.A.1.9.7. the major facilitator superfamily (mfs).

Chemistry databases

SwissLipidsiSLP:000000076.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerophosphoinositol transporter 11 Publication
Gene namesi
Name:GIT11 Publication
Ordered Locus Names:YCR098C
ORF Names:YCR137, YCR98C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR098C.
SGDiS000000695. GIT1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 91ExtracellularSequence analysisAdd BLAST26
Transmembranei92 – 112Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini113 – 114CytoplasmicSequence analysis2
Transmembranei115 – 136Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini137 – 138ExtracellularSequence analysis2
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 184CytoplasmicSequence analysisAdd BLAST25
Transmembranei185 – 205Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini206 – 216ExtracellularSequence analysisAdd BLAST11
Transmembranei217 – 237Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini238 – 268CytoplasmicSequence analysisAdd BLAST31
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 306ExtracellularSequence analysisAdd BLAST17
Transmembranei307 – 327Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini328 – 335CytoplasmicSequence analysis8
Transmembranei336 – 356Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini357 – 360ExtracellularSequence analysis4
Transmembranei361 – 381Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini382 – 399CytoplasmicSequence analysisAdd BLAST18
Transmembranei400 – 420Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini421 – 430ExtracellularSequence analysis10
Transmembranei431 – 451Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini452 – 518CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Impairs the uptake of glycerophosphoinositol (GroPIns) (PubMed:9691030). Impairs also the uptake of glycerophosphocholine (GroPCho) (PubMed:9691030).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504591 – 518Glycerophosphoinositol transporter 1Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP25346.
TopDownProteomicsiP25346.

PTM databases

iPTMnetiP25346.

Expressioni

Inductioni

Both inositol and phosphate regulate GIT1 transcription and expression is positively regulated by the transcription factor PHO4 (PubMed:12912892).1 Publication

Interactioni

Protein-protein interaction databases

BioGridi31071. 28 interactors.
DIPiDIP-4626N.
IntActiP25346. 3 interactors.
MINTiMINT-546964.
STRINGi4932.YCR098C.

Structurei

3D structure databases

ProteinModelPortaliP25346.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000214987.
InParanoidiP25346.
OMAiIMVTNFV.
OrthoDBiEOG092C241Y.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR036259. MFS_trans_sf.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 1 hit.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P25346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDKDITSVN EKEVNENTNP RIIKYDAERR ATRTETSKKD KWKNIVTIIA
60 70 80 90 100
SGFALISDGY VNGSMSMLNK VFVMEYGKKN YSSKVSTRVS NAALVGIIFG
110 120 130 140 150
QFFMGIAADY YSRKSCILVA TAILVIGSAL CAASHGTTVP GMFWMLTVMR
160 170 180 190 200
GLVGIGVGAE YPTSTLSANE SANEYTTTKR GGILVMVTNL PLAFGGPFAT
210 220 230 240 250
IIFLIVYKIC SGTKHLEAIW RTVFAIGCFW PLSVFYFRWK TATTEVYEKG
260 270 280 290 300
RIKRNIPYFL ALKFYWKRLL GTCGTWFMYD FVTFPNGIFS STIISSVIKD
310 320 330 340 350
QNDLVKVAEW NLLLGVLAVL GVPIGAYLSD RIGRKYTLMF GFSGYIIFGL
360 370 380 390 400
IIGCAYDQLK KITPLFIIFY AFMNMLGNAG PGDMLGVISS EASATAVRGV
410 420 430 440 450
FYGLSAVTGK IGSVVGVECF QPIRDNLGAR WTFIIAAICG LIGIIITYFF
460 470 480 490 500
VPHSLESDLM KQDVEFHNYL VSNGWTGKMG FDETDEESMV RTIEVEENGT
510
NCSKKNAEII SVRQVDQS
Length:518
Mass (Da):57,322
Last modified:May 1, 1992 - v1
Checksum:iD173B1B0096F4D0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42240.1.
BK006937 Genomic DNA. Translation: DAA07568.1.
PIRiS19514.
RefSeqiNP_010022.1. NM_001178805.1.

Genome annotation databases

EnsemblFungiiYCR098C; YCR098C; YCR098C.
GeneIDi850462.
KEGGisce:YCR098C.

Similar proteinsi

Entry informationi

Entry nameiGIT1_YEAST
AccessioniPrimary (citable) accession number: P25346
Secondary accession number(s): D6VR99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 22, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names