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P25346

- GIT1_YEAST

UniProt

P25346 - GIT1_YEAST

Protein

Probable metabolite transport protein GIT1

Gene

GIT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. glycerol-3-phosphate transmembrane transporter activity Source: SGD
    2. glycerophosphodiester transmembrane transporter activity Source: SGD

    GO - Biological processi

    1. glycerol-3-phosphate transport Source: SGD
    2. glycerophosphodiester transport Source: SGD
    3. transmembrane transport Source: SGD

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29392-MONOMER.

    Protein family/group databases

    TCDBi2.A.1.9.7. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable metabolite transport protein GIT1
    Gene namesi
    Name:GIT1
    Ordered Locus Names:YCR098C
    ORF Names:YCR137, YCR98C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCR098c.
    SGDiS000000695. GIT1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: SGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Probable metabolite transport protein GIT1PRO_0000050459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriP25346.

    Interactioni

    Protein-protein interaction databases

    BioGridi31071. 14 interactions.
    DIPiDIP-4626N.
    IntActiP25346. 3 interactions.
    MINTiMINT-546964.
    STRINGi4932.YCR098C.

    Structurei

    3D structure databases

    ProteinModelPortaliP25346.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini66 – 9126ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini113 – 1142CytoplasmicSequence Analysis
    Topological domaini137 – 1382ExtracellularSequence Analysis
    Topological domaini160 – 18425CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini206 – 21611ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini238 – 26831CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini290 – 30617ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini328 – 3358CytoplasmicSequence Analysis
    Topological domaini357 – 3604ExtracellularSequence Analysis
    Topological domaini382 – 39918CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini421 – 43010ExtracellularSequence Analysis
    Topological domaini452 – 51867CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei92 – 11221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei115 – 13622Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei185 – 20521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei217 – 23721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 28921Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei336 – 35621Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei361 – 38121Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei400 – 42021Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei431 – 45121Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00750000118743.
    HOGENOMiHOG000214987.
    OMAiFTPIQNN.
    OrthoDBiEOG7FV40B.

    Family and domain databases

    InterProiIPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25346-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDKDITSVN EKEVNENTNP RIIKYDAERR ATRTETSKKD KWKNIVTIIA    50
    SGFALISDGY VNGSMSMLNK VFVMEYGKKN YSSKVSTRVS NAALVGIIFG 100
    QFFMGIAADY YSRKSCILVA TAILVIGSAL CAASHGTTVP GMFWMLTVMR 150
    GLVGIGVGAE YPTSTLSANE SANEYTTTKR GGILVMVTNL PLAFGGPFAT 200
    IIFLIVYKIC SGTKHLEAIW RTVFAIGCFW PLSVFYFRWK TATTEVYEKG 250
    RIKRNIPYFL ALKFYWKRLL GTCGTWFMYD FVTFPNGIFS STIISSVIKD 300
    QNDLVKVAEW NLLLGVLAVL GVPIGAYLSD RIGRKYTLMF GFSGYIIFGL 350
    IIGCAYDQLK KITPLFIIFY AFMNMLGNAG PGDMLGVISS EASATAVRGV 400
    FYGLSAVTGK IGSVVGVECF QPIRDNLGAR WTFIIAAICG LIGIIITYFF 450
    VPHSLESDLM KQDVEFHNYL VSNGWTGKMG FDETDEESMV RTIEVEENGT 500
    NCSKKNAEII SVRQVDQS 518
    Length:518
    Mass (Da):57,322
    Last modified:May 1, 1992 - v1
    Checksum:iD173B1B0096F4D0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42240.1.
    BK006937 Genomic DNA. Translation: DAA07568.1.
    PIRiS19514.
    RefSeqiNP_010022.1. NM_001178805.1.

    Genome annotation databases

    EnsemblFungiiYCR098C; YCR098C; YCR098C.
    GeneIDi850462.
    KEGGisce:YCR098C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAA42240.1 .
    BK006937 Genomic DNA. Translation: DAA07568.1 .
    PIRi S19514.
    RefSeqi NP_010022.1. NM_001178805.1.

    3D structure databases

    ProteinModelPortali P25346.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31071. 14 interactions.
    DIPi DIP-4626N.
    IntActi P25346. 3 interactions.
    MINTi MINT-546964.
    STRINGi 4932.YCR098C.

    Protein family/group databases

    TCDBi 2.A.1.9.7. the major facilitator superfamily (mfs).

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCR098C ; YCR098C ; YCR098C .
    GeneIDi 850462.
    KEGGi sce:YCR098C.

    Organism-specific databases

    CYGDi YCR098c.
    SGDi S000000695. GIT1.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00750000118743.
    HOGENOMi HOG000214987.
    OMAi FTPIQNN.
    OrthoDBi EOG7FV40B.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29392-MONOMER.

    Miscellaneous databases

    NextBioi 966098.
    PROi P25346.

    Gene expression databases

    Genevestigatori P25346.

    Family and domain databases

    InterProi IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the HMR region on chromosome III of Saccharomyces cerevisiae."
      Sor F., Cheret G., Fabre F., Faye G., Fukuhara H.
      Yeast 8:215-222(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGIT1_YEAST
    AccessioniPrimary (citable) accession number: P25346
    Secondary accession number(s): D6VR99
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3