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P25346 (GIT1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable metabolite transport protein GIT1
Gene names
Name:GIT1
Ordered Locus Names:YCR098C
ORF Names:YCR137, YCR98C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length518 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 518518Probable metabolite transport protein GIT1
PRO_0000050459

Regions

Topological domain1 – 4444Cytoplasmic Potential
Transmembrane45 – 6521Helical; Name=1; Potential
Topological domain66 – 9126Extracellular Potential
Transmembrane92 – 11221Helical; Name=2; Potential
Topological domain113 – 1142Cytoplasmic Potential
Transmembrane115 – 13622Helical; Name=3; Potential
Topological domain137 – 1382Extracellular Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 18425Cytoplasmic Potential
Transmembrane185 – 20521Helical; Name=5; Potential
Topological domain206 – 21611Extracellular Potential
Transmembrane217 – 23721Helical; Name=6; Potential
Topological domain238 – 26831Cytoplasmic Potential
Transmembrane269 – 28921Helical; Name=7; Potential
Topological domain290 – 30617Extracellular Potential
Transmembrane307 – 32721Helical; Name=8; Potential
Topological domain328 – 3358Cytoplasmic Potential
Transmembrane336 – 35621Helical; Name=9; Potential
Topological domain357 – 3604Extracellular Potential
Transmembrane361 – 38121Helical; Name=10; Potential
Topological domain382 – 39918Cytoplasmic Potential
Transmembrane400 – 42021Helical; Name=11; Potential
Topological domain421 – 43010Extracellular Potential
Transmembrane431 – 45121Helical; Name=12; Potential
Topological domain452 – 51867Cytoplasmic Potential

Amino acid modifications

Glycosylation801N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P25346 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: D173B1B0096F4D0D

FASTA51857,322
        10         20         30         40         50         60 
MEDKDITSVN EKEVNENTNP RIIKYDAERR ATRTETSKKD KWKNIVTIIA SGFALISDGY 

        70         80         90        100        110        120 
VNGSMSMLNK VFVMEYGKKN YSSKVSTRVS NAALVGIIFG QFFMGIAADY YSRKSCILVA 

       130        140        150        160        170        180 
TAILVIGSAL CAASHGTTVP GMFWMLTVMR GLVGIGVGAE YPTSTLSANE SANEYTTTKR 

       190        200        210        220        230        240 
GGILVMVTNL PLAFGGPFAT IIFLIVYKIC SGTKHLEAIW RTVFAIGCFW PLSVFYFRWK 

       250        260        270        280        290        300 
TATTEVYEKG RIKRNIPYFL ALKFYWKRLL GTCGTWFMYD FVTFPNGIFS STIISSVIKD 

       310        320        330        340        350        360 
QNDLVKVAEW NLLLGVLAVL GVPIGAYLSD RIGRKYTLMF GFSGYIIFGL IIGCAYDQLK 

       370        380        390        400        410        420 
KITPLFIIFY AFMNMLGNAG PGDMLGVISS EASATAVRGV FYGLSAVTGK IGSVVGVECF 

       430        440        450        460        470        480 
QPIRDNLGAR WTFIIAAICG LIGIIITYFF VPHSLESDLM KQDVEFHNYL VSNGWTGKMG 

       490        500        510 
FDETDEESMV RTIEVEENGT NCSKKNAEII SVRQVDQS

« Hide

References

« Hide 'large scale' references
[1]"Sequence of the HMR region on chromosome III of Saccharomyces cerevisiae."
Sor F., Cheret G., Fabre F., Faye G., Fukuhara H.
Yeast 8:215-222(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The complete DNA sequence of yeast chromosome III."
Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M. expand/collapse author list , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X59720 Genomic DNA. Translation: CAA42240.1.
BK006937 Genomic DNA. Translation: DAA07568.1.
PIRS19514.
RefSeqNP_010022.1. NM_001178805.1.

3D structure databases

ProteinModelPortalP25346.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4626N.
MINTMINT-546964.
STRING4932.YCR098C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYCR098C; YCR098C; YCR098C.
GeneID850462.
KEGGsce:YCR098C.

Organism-specific databases

CYGDYCR098c.
SGDS000000695. GIT1.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00620000089137.
HOGENOMHOG000214987.
OMAAMNSIGM.
OrthoDBEOG473T0T.

Enzyme and pathway databases

BioCycYEAST:G3O-29392-MONOMER.

Gene expression databases

GenevestigatorP25346.
GermOnlineYCR098C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
PROSITEPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio966098.

Entry information

Entry nameGIT1_YEAST
AccessionPrimary (citable) accession number: P25346
Secondary accession number(s): D6VR99
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 29, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome III

Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents