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P25346

- GIT1_YEAST

UniProt

P25346 - GIT1_YEAST

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Protein
Probable metabolite transport protein GIT1
Gene
GIT1, YCR098C, YCR137, YCR98C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. glycerol-3-phosphate transmembrane transporter activity Source: SGD
  2. glycerophosphodiester transmembrane transporter activity Source: SGD

GO - Biological processi

  1. glycerol-3-phosphate transport Source: SGD
  2. glycerophosphodiester transport Source: SGD
  3. transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29392-MONOMER.

Protein family/group databases

TCDBi2.A.1.9.7. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Probable metabolite transport protein GIT1
Gene namesi
Name:GIT1
Ordered Locus Names:YCR098C
ORF Names:YCR137, YCR98C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCR098c.
SGDiS000000695. GIT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei45 – 6521Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini66 – 9126Extracellular Reviewed prediction
Add
BLAST
Transmembranei92 – 11221Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini113 – 1142Cytoplasmic Reviewed prediction
Transmembranei115 – 13622Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini137 – 1382Extracellular Reviewed prediction
Transmembranei139 – 15921Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini160 – 18425Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei185 – 20521Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini206 – 21611Extracellular Reviewed prediction
Add
BLAST
Transmembranei217 – 23721Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini238 – 26831Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei269 – 28921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini290 – 30617Extracellular Reviewed prediction
Add
BLAST
Transmembranei307 – 32721Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini328 – 3358Cytoplasmic Reviewed prediction
Transmembranei336 – 35621Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini357 – 3604Extracellular Reviewed prediction
Transmembranei361 – 38121Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini382 – 39918Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei400 – 42021Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini421 – 43010Extracellular Reviewed prediction
Transmembranei431 – 45121Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini452 – 51867Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Probable metabolite transport protein GIT1
PRO_0000050459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Gene expression databases

GenevestigatoriP25346.

Interactioni

Protein-protein interaction databases

BioGridi31071. 14 interactions.
DIPiDIP-4626N.
IntActiP25346. 3 interactions.
MINTiMINT-546964.
STRINGi4932.YCR098C.

Structurei

3D structure databases

ProteinModelPortaliP25346.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00750000118743.
HOGENOMiHOG000214987.
OMAiFTPIQNN.
OrthoDBiEOG7FV40B.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25346-1 [UniParc]FASTAAdd to Basket

« Hide

MEDKDITSVN EKEVNENTNP RIIKYDAERR ATRTETSKKD KWKNIVTIIA    50
SGFALISDGY VNGSMSMLNK VFVMEYGKKN YSSKVSTRVS NAALVGIIFG 100
QFFMGIAADY YSRKSCILVA TAILVIGSAL CAASHGTTVP GMFWMLTVMR 150
GLVGIGVGAE YPTSTLSANE SANEYTTTKR GGILVMVTNL PLAFGGPFAT 200
IIFLIVYKIC SGTKHLEAIW RTVFAIGCFW PLSVFYFRWK TATTEVYEKG 250
RIKRNIPYFL ALKFYWKRLL GTCGTWFMYD FVTFPNGIFS STIISSVIKD 300
QNDLVKVAEW NLLLGVLAVL GVPIGAYLSD RIGRKYTLMF GFSGYIIFGL 350
IIGCAYDQLK KITPLFIIFY AFMNMLGNAG PGDMLGVISS EASATAVRGV 400
FYGLSAVTGK IGSVVGVECF QPIRDNLGAR WTFIIAAICG LIGIIITYFF 450
VPHSLESDLM KQDVEFHNYL VSNGWTGKMG FDETDEESMV RTIEVEENGT 500
NCSKKNAEII SVRQVDQS 518
Length:518
Mass (Da):57,322
Last modified:May 1, 1992 - v1
Checksum:iD173B1B0096F4D0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42240.1.
BK006937 Genomic DNA. Translation: DAA07568.1.
PIRiS19514.
RefSeqiNP_010022.1. NM_001178805.1.

Genome annotation databases

EnsemblFungiiYCR098C; YCR098C; YCR098C.
GeneIDi850462.
KEGGisce:YCR098C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAA42240.1 .
BK006937 Genomic DNA. Translation: DAA07568.1 .
PIRi S19514.
RefSeqi NP_010022.1. NM_001178805.1.

3D structure databases

ProteinModelPortali P25346.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31071. 14 interactions.
DIPi DIP-4626N.
IntActi P25346. 3 interactions.
MINTi MINT-546964.
STRINGi 4932.YCR098C.

Protein family/group databases

TCDBi 2.A.1.9.7. the major facilitator superfamily (mfs).

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCR098C ; YCR098C ; YCR098C .
GeneIDi 850462.
KEGGi sce:YCR098C.

Organism-specific databases

CYGDi YCR098c.
SGDi S000000695. GIT1.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00750000118743.
HOGENOMi HOG000214987.
OMAi FTPIQNN.
OrthoDBi EOG7FV40B.

Enzyme and pathway databases

BioCyci YEAST:G3O-29392-MONOMER.

Miscellaneous databases

NextBioi 966098.
PROi P25346.

Gene expression databases

Genevestigatori P25346.

Family and domain databases

InterProi IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
IPR005828. Sub_transporter.
IPR005829. Sugar_transporter_CS.
[Graphical view ]
Pfami PF00083. Sugar_tr. 1 hit.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 1 hit.
PROSITEi PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of the HMR region on chromosome III of Saccharomyces cerevisiae."
    Sor F., Cheret G., Fabre F., Faye G., Fukuhara H.
    Yeast 8:215-222(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGIT1_YEAST
AccessioniPrimary (citable) accession number: P25346
Secondary accession number(s): D6VR99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: June 11, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

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