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Protein

Asparagine--tRNA ligase, mitochondrial

Gene

SLM5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

GO - Molecular functioni

GO - Biological processi

  • asparaginyl-tRNA aminoacylation Source: UniProtKB
  • mitochondrial asparaginyl-tRNA aminoacylation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29339-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine--tRNA ligase, mitochondrial (EC:6.1.1.22)
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name:
AsnRS
Gene namesi
Name:SLM5
Ordered Locus Names:YCR024C
ORF Names:YCR242, YCR24C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR024C.
SGDiS000000618. SLM5.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000035801? – 492Asparagine--tRNA ligase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP25345.
PRIDEiP25345.

Interactioni

Protein-protein interaction databases

BioGridi31006. 22 interactors.
DIPiDIP-2597N.
IntActiP25345. 4 interactors.
MINTiMINT-426906.

Structurei

3D structure databases

ProteinModelPortaliP25345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00550000074970.
HOGENOMiHOG000226033.
InParanoidiP25345.
KOiK01893.
OMAiPEDMEFF.
OrthoDBiEOG092C1DI9.

Family and domain databases

InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF6. PTHR22594:SF6. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHAFTFLKG GRFYSSLTVK SLYEQVHHTS HDPISINGWI KSIRLLKRIA
60 70 80 90 100
FLDLQDGTSV NPLRIVIPLT NTDEVQFLKI LKTGQTLSIS NATWQSTPNR
110 120 130 140 150
KQPFELQIKN PVKSIKLVGP VSENYPLQKK YQTLRYLRSL PTLKYRTAYL
160 170 180 190 200
SAILRLRSFV EFQFMLYFQK NHFTKVSPPI LTSNDCEGAG ELFQVSTNTS
210 220 230 240 250
PTASSYFGKP TYLTVSTQLH LEILALSLSR CWTLSPCFRA EKSDTPRHLS
260 270 280 290 300
EFWMLEVEMC FVNSVNELTS FVETTIKHII KACIDNQQEL LPKQFISSQE
310 320 330 340 350
NNASSELSIN QETQQIKTRW EDLINEKWHN ITYTNAIEIL KKRHNEVSHF
360 370 380 390 400
KYEPKWGQPL QTEHEKFLAG EYFKSPVFVT DYPRLCKPFY MKQNSTPDDT
410 420 430 440 450
VGCFDLLVPG MGEIIGGSLR EDDYDKLCRE MKARGMNRSG ELDWYVSLRK
460 470 480 490
EGSAPHGGFG LGFERFISYL YGNHNIKDAI PFYRTSAESI DF
Length:492
Mass (Da):56,785
Last modified:May 1, 1992 - v1
Checksum:iE20C6F921C9BAA9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42316.1.
BK006937 Genomic DNA. Translation: DAA07502.1.
PIRiS19435.
RefSeqiNP_009953.1. NM_001178738.1.

Genome annotation databases

EnsemblFungiiCAA42316; CAA42316; CAA42316.
YCR024C; YCR024C; YCR024C.
GeneIDi850388.
KEGGisce:YCR024C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42316.1.
BK006937 Genomic DNA. Translation: DAA07502.1.
PIRiS19435.
RefSeqiNP_009953.1. NM_001178738.1.

3D structure databases

ProteinModelPortaliP25345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31006. 22 interactors.
DIPiDIP-2597N.
IntActiP25345. 4 interactors.
MINTiMINT-426906.

Proteomic databases

MaxQBiP25345.
PRIDEiP25345.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42316; CAA42316; CAA42316.
YCR024C; YCR024C; YCR024C.
GeneIDi850388.
KEGGisce:YCR024C.

Organism-specific databases

EuPathDBiFungiDB:YCR024C.
SGDiS000000618. SLM5.

Phylogenomic databases

GeneTreeiENSGT00550000074970.
HOGENOMiHOG000226033.
InParanoidiP25345.
KOiK01893.
OMAiPEDMEFF.
OrthoDBiEOG092C1DI9.

Enzyme and pathway databases

BioCyciYEAST:G3O-29339-MONOMER.

Miscellaneous databases

PROiP25345.

Family and domain databases

InterProiIPR004364. aa-tRNA-synt_II.
IPR018150. aa-tRNA-synt_II-like.
IPR006195. aa-tRNA-synth_II.
IPR004522. Asn-tRNA-ligase.
IPR002312. Asp/Asn-tRNA-synth_IIb.
IPR012340. NA-bd_OB-fold.
IPR004365. NA-bd_OB_tRNA.
[Graphical view]
PANTHERiPTHR22594. PTHR22594. 1 hit.
PTHR22594:SF6. PTHR22594:SF6. 1 hit.
PfamiPF00152. tRNA-synt_2. 1 hit.
PF01336. tRNA_anti-codon. 1 hit.
[Graphical view]
PRINTSiPR01042. TRNASYNTHASP.
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00457. asnS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYNM_YEAST
AccessioniPrimary (citable) accession number: P25345
Secondary accession number(s): D6VR33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 784 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.