Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Asparagine--tRNA ligase, mitochondrial

Gene

SLM5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Present with 784 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn).

GO - Molecular functioni

  • asparagine-tRNA ligase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • nucleic acid binding Source: InterPro

GO - Biological processi

  • asparaginyl-tRNA aminoacylation Source: SGD
  • mitochondrial asparaginyl-tRNA aminoacylation Source: SGD

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29339-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Asparagine--tRNA ligase, mitochondrial (EC:6.1.1.22)
Alternative name(s):
Asparaginyl-tRNA synthetase
Short name:
AsnRS
Gene namesi
Name:SLM5
Ordered Locus Names:YCR024C
ORF Names:YCR242, YCR24C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR024C
SGDiS000000618 SLM5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000035801? – 492Asparagine--tRNA ligase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

MaxQBiP25345
PaxDbiP25345
PRIDEiP25345

Interactioni

Protein-protein interaction databases

BioGridi31006, 154 interactors
DIPiDIP-2597N
IntActiP25345, 4 interactors
MINTiP25345
STRINGi4932.YCR024C

Structurei

3D structure databases

ProteinModelPortaliP25345
SMRiP25345
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00550000074970
HOGENOMiHOG000226033
InParanoidiP25345
KOiK01893
OMAiWWYLDTR
OrthoDBiEOG092C1DI9

Family and domain databases

InterProiView protein in InterPro
IPR004364 aa-tRNA-synt_II
IPR006195 aa-tRNA-synth_II
IPR004522 Asn-tRNA-ligase
IPR002312 Asp/Asn-tRNA-synth_IIb
IPR012340 NA-bd_OB-fold
IPR004365 NA-bd_OB_tRNA
PfamiView protein in Pfam
PF00152 tRNA-synt_2, 1 hit
PF01336 tRNA_anti-codon, 1 hit
PRINTSiPR01042 TRNASYNTHASP
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00457 asnS, 1 hit
PROSITEiView protein in PROSITE
PS50862 AA_TRNA_LIGASE_II, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHAFTFLKG GRFYSSLTVK SLYEQVHHTS HDPISINGWI KSIRLLKRIA
60 70 80 90 100
FLDLQDGTSV NPLRIVIPLT NTDEVQFLKI LKTGQTLSIS NATWQSTPNR
110 120 130 140 150
KQPFELQIKN PVKSIKLVGP VSENYPLQKK YQTLRYLRSL PTLKYRTAYL
160 170 180 190 200
SAILRLRSFV EFQFMLYFQK NHFTKVSPPI LTSNDCEGAG ELFQVSTNTS
210 220 230 240 250
PTASSYFGKP TYLTVSTQLH LEILALSLSR CWTLSPCFRA EKSDTPRHLS
260 270 280 290 300
EFWMLEVEMC FVNSVNELTS FVETTIKHII KACIDNQQEL LPKQFISSQE
310 320 330 340 350
NNASSELSIN QETQQIKTRW EDLINEKWHN ITYTNAIEIL KKRHNEVSHF
360 370 380 390 400
KYEPKWGQPL QTEHEKFLAG EYFKSPVFVT DYPRLCKPFY MKQNSTPDDT
410 420 430 440 450
VGCFDLLVPG MGEIIGGSLR EDDYDKLCRE MKARGMNRSG ELDWYVSLRK
460 470 480 490
EGSAPHGGFG LGFERFISYL YGNHNIKDAI PFYRTSAESI DF
Length:492
Mass (Da):56,785
Last modified:May 1, 1992 - v1
Checksum:iE20C6F921C9BAA9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42316.1
BK006937 Genomic DNA Translation: DAA07502.1
PIRiS19435
RefSeqiNP_009953.1, NM_001178738.1

Genome annotation databases

EnsemblFungiiCAA42316; CAA42316; CAA42316
YCR024C; YCR024C; YCR024C
GeneIDi850388
KEGGisce:YCR024C

Similar proteinsi

Entry informationi

Entry nameiSYNM_YEAST
AccessioniPrimary (citable) accession number: P25345
Secondary accession number(s): D6VR33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health