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Protein

Allantoicase

Gene

DAL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Utilization of purines as secondary nitrogen sources, when primary sources are limiting.

Catalytic activityi

Allantoate + H2O = (S)-ureidoglycolate + urea.

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes (S)-ureidoglycolate from allantoate (aminidohydrolase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Allantoicase (DAL2)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-ureidoglycolate from allantoate (aminidohydrolase route), the pathway (S)-allantoin degradation and in Nitrogen metabolism.

GO - Molecular functioni

  • allantoicase activity Source: SGD

GO - Biological processi

  • allantoin catabolic process Source: SGD
  • purine nucleobase metabolic process Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processPurine metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YIR029W-MONOMER
YEAST:YIR029W-MONOMER
UniPathwayiUPA00395; UER00654

Names & Taxonomyi

Protein namesi
Recommended name:
Allantoicase (EC:3.5.3.4)
Alternative name(s):
Allantoate amidinohydrolase
Gene namesi
Name:DAL2
Synonyms:ALC1
Ordered Locus Names:YIR029W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR029W
SGDiS000001468 DAL2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002059141 – 343AllantoicaseAdd BLAST343

Proteomic databases

MaxQBiP25335
PaxDbiP25335
PRIDEiP25335

Expressioni

Inductioni

Repressed by nitrogen.

Interactioni

Protein-protein interaction databases

BioGridi35020, 93 interactors
IntActiP25335, 1 interactor
STRINGi4932.YIR029W

Structurei

Secondary structure

1343
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Helixi6 – 8Combined sources3
Helixi9 – 16Combined sources8
Turni17 – 20Combined sources4
Helixi28 – 30Combined sources3
Beta strandi33 – 38Combined sources6
Beta strandi41 – 43Combined sources3
Helixi45 – 49Combined sources5
Beta strandi69 – 72Combined sources4
Beta strandi78 – 80Combined sources3
Beta strandi82 – 87Combined sources6
Beta strandi89 – 91Combined sources3
Beta strandi93 – 101Combined sources9
Beta strandi106 – 109Combined sources4
Beta strandi111 – 118Combined sources8
Beta strandi135 – 142Combined sources8
Beta strandi148 – 152Combined sources5
Beta strandi162 – 171Combined sources10
Beta strandi174 – 184Combined sources11
Helixi201 – 203Combined sources3
Beta strandi206 – 211Combined sources6
Beta strandi214 – 216Combined sources3
Helixi218 – 222Combined sources5
Beta strandi224 – 226Combined sources3
Helixi230 – 232Combined sources3
Beta strandi233 – 235Combined sources3
Beta strandi246 – 251Combined sources6
Beta strandi257 – 265Combined sources9
Beta strandi270 – 272Combined sources3
Beta strandi275 – 282Combined sources8
Beta strandi297 – 305Combined sources9
Beta strandi311 – 319Combined sources9
Beta strandi323 – 331Combined sources9
Beta strandi337 – 343Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1O59X-ray2.40A1-343[»]
1SG3X-ray2.60A/B1-343[»]
ProteinModelPortaliP25335
SMRiP25335
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25335

Family & Domainsi

Sequence similaritiesi

Belongs to the allantoicase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000001793
HOGENOMiHOG000256158
InParanoidiP25335
KOiK01477
OMAiHPGVITQ
OrthoDBiEOG092C2P52

Family and domain databases

Gene3Di2.60.120.260, 2 hits
HAMAPiMF_00813 Allantoicase, 1 hit
InterProiView protein in InterPro
IPR005164 Allantoicase
IPR015908 Allantoicase_dom
IPR008979 Galactose-bd-like_sf
PANTHERiPTHR12045 PTHR12045, 1 hit
PfamiView protein in Pfam
PF03561 Allantoicase, 2 hits
PIRSFiPIRSF016516 Allantoicase, 1 hit
SUPFAMiSSF49785 SSF49785, 2 hits
TIGRFAMsiTIGR02961 allantoicase, 1 hit

Sequencei

Sequence statusi: Complete.

P25335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFSLADEA EFKSIIISKN KAVDVIGSKL GGQVVSFSDE WFASAENLIQ
60 70 80 90 100
PTAPIRDPTR FVHSGAWYDG WETRRHNEME YDWVIIKMGV AAAHIIGGEI
110 120 130 140 150
DTAFFNGNHA PFVSIEALYD EGEEGNIVED DSRWVEIVEK FECGPSQRHL
160 170 180 190 200
FVRGNGLTKE RFTHIKLKMY PDGGIARFRL YGRVVPPELK TKDHIIDLAY
210 220 230 240 250
VCNGAVALKY SDQHFGSVDN LLLPGRGHDM SDGWETKRSR QPGHTDWAVI
260 270 280 290 300
QLGRESSFIE KIIVDTAHFR GNFPQFITVE GCLKESESSE NTGEGTWVEL
310 320 330 340
VGKSKTGPDK EHVYEIRKSI RVSHVKLTII PDGGVKRIRV WGY
Length:343
Mass (Da):38,714
Last modified:May 1, 1992 - v1
Checksum:i0F9CB0FBA5EB76F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93A → S in CAA42994 (PubMed:1839481).Curated1
Sequence conflicti134 – 135WV → SL in CAA42994 (PubMed:1839481).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64720 Genomic DNA Translation: AAA34554.1
X60460 Genomic DNA Translation: CAA42994.1
Z38061 Genomic DNA Translation: CAA86189.1
BK006942 Genomic DNA Translation: DAA08576.1
PIRiJH0442
RefSeqiNP_012295.1, NM_001179551.1

Genome annotation databases

EnsemblFungiiYIR029W; YIR029W; YIR029W
GeneIDi854847
KEGGisce:YIR029W

Similar proteinsi

Entry informationi

Entry nameiALLC_YEAST
AccessioniPrimary (citable) accession number: P25335
Secondary accession number(s): D6VVW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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