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Protein

Allantoicase

Gene

DAL2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Utilization of purines as secondary nitrogen sources, when primary sources are limiting.

Catalytic activityi

Allantoate + H2O = (S)-ureidoglycolate + urea.

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes (S)-ureidoglycolate from allantoate (aminidohydrolase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Allantoicase (DAL2)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-ureidoglycolate from allantoate (aminidohydrolase route), the pathway (S)-allantoin degradation and in Nitrogen metabolism.

GO - Molecular functioni

  • allantoicase activity Source: SGD

GO - Biological processi

  • allantoin catabolic process Source: SGD
  • purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Enzyme and pathway databases

BioCyciMetaCyc:YIR029W-MONOMER.
YEAST:YIR029W-MONOMER.
UniPathwayiUPA00395; UER00654.

Names & Taxonomyi

Protein namesi
Recommended name:
Allantoicase (EC:3.5.3.4)
Alternative name(s):
Allantoate amidinohydrolase
Gene namesi
Name:DAL2
Synonyms:ALC1
Ordered Locus Names:YIR029W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IX

Organism-specific databases

EuPathDBiFungiDB:YIR029W.
SGDiS000001468. DAL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343AllantoicasePRO_0000205914Add
BLAST

Proteomic databases

MaxQBiP25335.

Expressioni

Inductioni

Repressed by nitrogen.

Interactioni

Protein-protein interaction databases

BioGridi35020. 20 interactions.
IntActiP25335. 1 interaction.
MINTiMINT-1761898.

Structurei

Secondary structure

1
343
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 43Combined sources
Helixi6 – 83Combined sources
Helixi9 – 168Combined sources
Turni17 – 204Combined sources
Helixi28 – 303Combined sources
Beta strandi33 – 386Combined sources
Beta strandi41 – 433Combined sources
Helixi45 – 495Combined sources
Beta strandi69 – 724Combined sources
Beta strandi78 – 803Combined sources
Beta strandi82 – 876Combined sources
Beta strandi89 – 913Combined sources
Beta strandi93 – 1019Combined sources
Beta strandi106 – 1094Combined sources
Beta strandi111 – 1188Combined sources
Beta strandi135 – 1428Combined sources
Beta strandi148 – 1525Combined sources
Beta strandi162 – 17110Combined sources
Beta strandi174 – 18411Combined sources
Helixi201 – 2033Combined sources
Beta strandi206 – 2116Combined sources
Beta strandi214 – 2163Combined sources
Helixi218 – 2225Combined sources
Beta strandi224 – 2263Combined sources
Helixi230 – 2323Combined sources
Beta strandi233 – 2353Combined sources
Beta strandi246 – 2516Combined sources
Beta strandi257 – 2659Combined sources
Beta strandi270 – 2723Combined sources
Beta strandi275 – 2828Combined sources
Beta strandi297 – 3059Combined sources
Beta strandi311 – 3199Combined sources
Beta strandi323 – 3319Combined sources
Beta strandi337 – 3437Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1O59X-ray2.40A1-343[»]
1SG3X-ray2.60A/B1-343[»]
ProteinModelPortaliP25335.
SMRiP25335. Positions 1-343.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25335.

Family & Domainsi

Sequence similaritiesi

Belongs to the allantoicase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000001793.
HOGENOMiHOG000256158.
InParanoidiP25335.
KOiK01477.
OMAiKWKPLLP.
OrthoDBiEOG092C2P52.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
InterProiIPR005164. Allantoicase.
IPR015908. Allantoicase_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PANTHERiPTHR12045. PTHR12045. 1 hit.
PfamiPF03561. Allantoicase. 2 hits.
[Graphical view]
PIRSFiPIRSF016516. Allantoicase. 1 hit.
SUPFAMiSSF49785. SSF49785. 2 hits.
TIGRFAMsiTIGR02961. allantoicase. 1 hit.

Sequencei

Sequence statusi: Complete.

P25335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFSLADEA EFKSIIISKN KAVDVIGSKL GGQVVSFSDE WFASAENLIQ
60 70 80 90 100
PTAPIRDPTR FVHSGAWYDG WETRRHNEME YDWVIIKMGV AAAHIIGGEI
110 120 130 140 150
DTAFFNGNHA PFVSIEALYD EGEEGNIVED DSRWVEIVEK FECGPSQRHL
160 170 180 190 200
FVRGNGLTKE RFTHIKLKMY PDGGIARFRL YGRVVPPELK TKDHIIDLAY
210 220 230 240 250
VCNGAVALKY SDQHFGSVDN LLLPGRGHDM SDGWETKRSR QPGHTDWAVI
260 270 280 290 300
QLGRESSFIE KIIVDTAHFR GNFPQFITVE GCLKESESSE NTGEGTWVEL
310 320 330 340
VGKSKTGPDK EHVYEIRKSI RVSHVKLTII PDGGVKRIRV WGY
Length:343
Mass (Da):38,714
Last modified:May 1, 1992 - v1
Checksum:i0F9CB0FBA5EB76F1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 931A → S in CAA42994 (PubMed:1839481).Curated
Sequence conflicti134 – 1352WV → SL in CAA42994 (PubMed:1839481).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64720 Genomic DNA. Translation: AAA34554.1.
X60460 Genomic DNA. Translation: CAA42994.1.
Z38061 Genomic DNA. Translation: CAA86189.1.
BK006942 Genomic DNA. Translation: DAA08576.1.
PIRiJH0442.
RefSeqiNP_012295.1. NM_001179551.1.

Genome annotation databases

EnsemblFungiiYIR029W; YIR029W; YIR029W.
GeneIDi854847.
KEGGisce:YIR029W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64720 Genomic DNA. Translation: AAA34554.1.
X60460 Genomic DNA. Translation: CAA42994.1.
Z38061 Genomic DNA. Translation: CAA86189.1.
BK006942 Genomic DNA. Translation: DAA08576.1.
PIRiJH0442.
RefSeqiNP_012295.1. NM_001179551.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1O59X-ray2.40A1-343[»]
1SG3X-ray2.60A/B1-343[»]
ProteinModelPortaliP25335.
SMRiP25335. Positions 1-343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35020. 20 interactions.
IntActiP25335. 1 interaction.
MINTiMINT-1761898.

Proteomic databases

MaxQBiP25335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYIR029W; YIR029W; YIR029W.
GeneIDi854847.
KEGGisce:YIR029W.

Organism-specific databases

EuPathDBiFungiDB:YIR029W.
SGDiS000001468. DAL2.

Phylogenomic databases

GeneTreeiENSGT00390000001793.
HOGENOMiHOG000256158.
InParanoidiP25335.
KOiK01477.
OMAiKWKPLLP.
OrthoDBiEOG092C2P52.

Enzyme and pathway databases

UniPathwayiUPA00395; UER00654.
BioCyciMetaCyc:YIR029W-MONOMER.
YEAST:YIR029W-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP25335.
PROiP25335.

Family and domain databases

Gene3Di2.60.120.260. 2 hits.
InterProiIPR005164. Allantoicase.
IPR015908. Allantoicase_dom.
IPR008979. Galactose-bd-like.
[Graphical view]
PANTHERiPTHR12045. PTHR12045. 1 hit.
PfamiPF03561. Allantoicase. 2 hits.
[Graphical view]
PIRSFiPIRSF016516. Allantoicase. 1 hit.
SUPFAMiSSF49785. SSF49785. 2 hits.
TIGRFAMsiTIGR02961. allantoicase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALLC_YEAST
AccessioniPrimary (citable) accession number: P25335
Secondary accession number(s): D6VVW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 7, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.