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Protein

Peptidyl-prolyl cis-trans isomerase CPR4

Gene

CPR4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YCR069W-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CPR4 (EC:5.2.1.8)
Short name:
PPIase CPR4
Alternative name(s):
Rotamase
Gene namesi
Name:CPR4
Synonyms:CYP4, SCC3
Ordered Locus Names:YCR069W
ORF Names:YCR69W/YCR70W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR069W
SGDiS000000665 CPR4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei286 – 303HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002549421 – 318Peptidyl-prolyl cis-trans isomerase CPR4Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP25334
PaxDbiP25334
PRIDEiP25334

Interactioni

Protein-protein interaction databases

BioGridi31045, 43 interactors
IntActiP25334, 5 interactors
MINTiP25334
STRINGi4932.YCR069W

Structurei

3D structure databases

ProteinModelPortaliP25334
SMRiP25334
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 225PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST171

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000066609
HOGENOMiHOG000065981
InParanoidiP25334
KOiK01802
OMAiNDIMFND
OrthoDBiEOG092C57CH

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLKSLLLCL YSLVLCQVHA APSSGKQITS KDVDLQKKYE PSPPATHRGI
60 70 80 90 100
ITIEYFDPVS KSMKEADLTF ELYGTVVPKT VNNFAMLAHG VKAVIEGKDP
110 120 130 140 150
NDIHTYSYRK TKINKVYPNK YIQGGVVAPD VGPFTVYGPK FDDENFYLKH
160 170 180 190 200
DRPERLAMAY FGPDSNTSEF IITTKADGNE ELDGKSVVFG QITSGLDQLM
210 220 230 240 250
DAIQYTETDE YGKPQHELRF LYFVLEILKI SNILDLHAAY TEKVEKFRNG
260 270 280 290 300
DVSVGSTLEN IFRNDKAYTP LTTSTGTTAY DLNHPISRAL MCLTVLGLCF
310
IAYKGMHEKP HTVSLRHK
Length:318
Mass (Da):35,780
Last modified:May 1, 1992 - v1
Checksum:iE23AE2763BF5DEE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA Translation: CAA42275.1
AY558152 Genomic DNA Translation: AAS56478.1
BK006937 Genomic DNA Translation: DAA07541.1
PIRiS26658 CSBYC3
RefSeqiNP_009995.1, NM_001178780.1

Genome annotation databases

EnsemblFungiiCAA42275; CAA42275; CAA42275
YCR069W; YCR069W; YCR069W
GeneIDi850433
KEGGisce:YCR069W

Similar proteinsi

Entry informationi

Entry nameiCYPR_YEAST
AccessioniPrimary (citable) accession number: P25334
Secondary accession number(s): D6VR72, P25658
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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