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Protein

Peptidyl-prolyl cis-trans isomerase CPR4

Gene

CPR4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: SGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciYEAST:YCR069W-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CPR4 (EC:5.2.1.8)
Short name:
PPIase CPR4
Alternative name(s):
Rotamase
Gene namesi
Name:CPR4
Synonyms:CYP4, SCC3
Ordered Locus Names:YCR069W
ORF Names:YCR69W/YCR70W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR069W.
SGDiS000000665. CPR4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei286 – 303HelicalSequence analysisAdd BLAST18

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002549421 – 318Peptidyl-prolyl cis-trans isomerase CPR4Add BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP25334.
PRIDEiP25334.

Interactioni

Protein-protein interaction databases

BioGridi31045. 5 interactors.
IntActiP25334. 5 interactors.
MINTiMINT-4478613.

Structurei

3D structure databases

ProteinModelPortaliP25334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini55 – 225PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST171

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000066609.
HOGENOMiHOG000065981.
InParanoidiP25334.
KOiK01802.
OMAiYTETDEY.
OrthoDBiEOG092C57CH.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLKSLLLCL YSLVLCQVHA APSSGKQITS KDVDLQKKYE PSPPATHRGI
60 70 80 90 100
ITIEYFDPVS KSMKEADLTF ELYGTVVPKT VNNFAMLAHG VKAVIEGKDP
110 120 130 140 150
NDIHTYSYRK TKINKVYPNK YIQGGVVAPD VGPFTVYGPK FDDENFYLKH
160 170 180 190 200
DRPERLAMAY FGPDSNTSEF IITTKADGNE ELDGKSVVFG QITSGLDQLM
210 220 230 240 250
DAIQYTETDE YGKPQHELRF LYFVLEILKI SNILDLHAAY TEKVEKFRNG
260 270 280 290 300
DVSVGSTLEN IFRNDKAYTP LTTSTGTTAY DLNHPISRAL MCLTVLGLCF
310
IAYKGMHEKP HTVSLRHK
Length:318
Mass (Da):35,780
Last modified:May 1, 1992 - v1
Checksum:iE23AE2763BF5DEE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42275.1.
AY558152 Genomic DNA. Translation: AAS56478.1.
BK006937 Genomic DNA. Translation: DAA07541.1.
PIRiS26658. CSBYC3.
RefSeqiNP_009995.1. NM_001178780.1.

Genome annotation databases

EnsemblFungiiCAA42275; CAA42275; CAA42275.
YCR069W; YCR069W; YCR069W.
GeneIDi850433.
KEGGisce:YCR069W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAA42275.1.
AY558152 Genomic DNA. Translation: AAS56478.1.
BK006937 Genomic DNA. Translation: DAA07541.1.
PIRiS26658. CSBYC3.
RefSeqiNP_009995.1. NM_001178780.1.

3D structure databases

ProteinModelPortaliP25334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31045. 5 interactors.
IntActiP25334. 5 interactors.
MINTiMINT-4478613.

Proteomic databases

MaxQBiP25334.
PRIDEiP25334.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAA42275; CAA42275; CAA42275.
YCR069W; YCR069W; YCR069W.
GeneIDi850433.
KEGGisce:YCR069W.

Organism-specific databases

EuPathDBiFungiDB:YCR069W.
SGDiS000000665. CPR4.

Phylogenomic databases

GeneTreeiENSGT00530000066609.
HOGENOMiHOG000065981.
InParanoidiP25334.
KOiK01802.
OMAiYTETDEY.
OrthoDBiEOG092C57CH.

Enzyme and pathway databases

BioCyciYEAST:YCR069W-MONOMER.

Miscellaneous databases

PROiP25334.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYPR_YEAST
AccessioniPrimary (citable) accession number: P25334
Secondary accession number(s): D6VR72, P25658
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 2, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.