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Protein

Serine/threonine-protein kinase HAL4/SAT4

Gene

SAT4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes K+ uptake, by the potassium transporter TRK1-TRK2, which leads to the subsequent cellular resistance to toxic cations such as Na+, Li+ and Ca2+.1 Publication

Miscellaneous

Present with 1030 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei353ATPPROSITE-ProRule annotation1
Active sitei449Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi322 – 330ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein kinase activity Source: SGD
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • cellular cation homeostasis Source: SGD
  • cellular protein localization Source: SGD
  • G1/S transition of mitotic cell cycle Source: SGD
  • intracellular signal transduction Source: GO_Central
  • protein dephosphorylation Source: SGD
  • protein lipoylation Source: SGD
  • regulation of iron-sulfur cluster assembly Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29325-MONOMER
BRENDAi2.7.11.1 984

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase HAL4/SAT4 (EC:2.7.11.1)
Alternative name(s):
Halotolerance protein 4
Gene namesi
Name:SAT4
Synonyms:HAL4
Ordered Locus Names:YCR008W
ORF Names:YCR046, YCR101, YCR8W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome III

Organism-specific databases

EuPathDBiFungiDB:YCR008W
SGDiS000000601 SAT4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000859871 – 603Serine/threonine-protein kinase HAL4/SAT4Add BLAST603

Proteomic databases

MaxQBiP25333
PaxDbiP25333
PRIDEiP25333

PTM databases

iPTMnetiP25333

Interactioni

Protein-protein interaction databases

BioGridi30987218 interactors.
DIPiDIP-4495N
IntActiP25333 32 interactors.
MINTiP25333
STRINGi4932.YCR008W

Structurei

3D structure databases

ProteinModelPortaliP25333
SMRiP25333
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini316 – 590Protein kinasePROSITE-ProRule annotationAdd BLAST275

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi99 – 111Ser-richAdd BLAST13

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00550000075309
HOGENOMiHOG000172097
InParanoidiP25333
KOiK08286
OMAiEEATPGC
OrthoDBiEOG092C35VZ

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P25333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGMNDNNAA IPQQTPRKHA LSSKVMQLFR SGSRSSRQGK ASSNIQPPSN
60 70 80 90 100
INTNVPSASK SAKFGLHTPT TATPRVVSNP SNTAGVSKPG MYMPEYYQSA
110 120 130 140 150
SPSHSSSSAS LNNHIDINTS KSSSAASLTS SVSALSLSPT SAINISSKSL
160 170 180 190 200
SPKFSHHSNS NTAITPAPTP TASNINNVNK ITNTSAPICG RFLVHKDGTH
210 220 230 240 250
EHHLKNAKRQ EKLSTMIKNM VGASKLRGEA KSAVPDIIMD PKTTLKSNKN
260 270 280 290 300
PPTLFAGFMK QVVDMDDKYP EGAPTSGALN CPERDIYRSD QKDSKNNTHN
310 320 330 340 350
ITTTKKDRQC FAEKYGRCQE VLGKGAFGVV RICQKKNVSS QDGNKSEKLY
360 370 380 390 400
AVKEFKRRTS ESAEKYSKRL TSEFCISSSL HHTNIVTTLD LFQDAKGEYC
410 420 430 440 450
EVMEYCAGGD LFTLVVAAGK LEYMEADCFF KQLIRGVVYM HEMGVCHRDL
460 470 480 490 500
KPENLLLTHD GVLKITDFGN SECFKMAWEK NIHLSGGVCG SSPYIAPEEY
510 520 530 540 550
IKEEFDPRPV DIWACGVIYM AMRTGRQLWS SAEKDDPFYM NYLKGRKEKG
560 570 580 590 600
GYEPIESLKR ARCRNVIYSM LDPVPYRRIN GKQILNSEWG REIKCCHNGR

ALK
Length:603
Mass (Da):66,666
Last modified:May 1, 1992 - v1
Checksum:i9DD31B74C05EE212
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S76380 Genomic DNA Translation: AAB20894.1
X59720 Genomic DNA Translation: CAA42325.1
Z11114 Genomic DNA Translation: CAA77445.1
BK006937 Genomic DNA Translation: DAA07486.1
PIRiS17470 OKBY8W
RefSeqiNP_009934.1, NM_001178721.1

Genome annotation databases

EnsemblFungiiCAA42325; CAA42325; CAA42325
YCR008W; YCR008W; YCR008W
GeneIDi850366
KEGGisce:YCR008W

Similar proteinsi

Entry informationi

Entry nameiHAL4_YEAST
AccessioniPrimary (citable) accession number: P25333
Secondary accession number(s): D6VR17
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome