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P25320 (FRIH2_SCHMA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin-2 heavy chain

EC=1.16.3.1
Gene names
Name:SCM-2
OrganismSchistosoma mansoni (Blood fluke)
Taxonomic identifier6183 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Protein attributes

Sequence length172 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 172172Ferritin-2 heavy chain
PRO_0000201083

Regions

Domain8 – 157150Ferritin-like diiron

Sites

Metal binding251Iron 1 By similarity
Metal binding601Iron 1 By similarity
Metal binding601Iron 2 By similarity
Metal binding631Iron 1 By similarity
Metal binding1051Iron 2 By similarity
Metal binding1391Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P25320 [UniParc].

Last modified May 1, 1992. Version 1.
Checksum: 1188E8CD20F16B69

FASTA17219,688
        10         20         30         40         50         60 
MSSSRARQSF ATECENAINK QINVELQAAY DYMAFFTYFD RDDVSFPKAA EFFRKASHEE 

        70         80         90        100        110        120 
REHAEKLAKY QNKRVGRVQY SDINGPTKTE FSSLEDAMNT ALGMEKAVSK SLLELHEVAS 

       130        140        150        160        170 
KNNDPALADF IESEFLHEQE DAIKQFADYL TETQRVGKGL GEYLFDKLTL NE 

« Hide

References

[1]"Ferritins of Schistosoma mansoni: sequence comparison and expression in female and male worms."
Dietzel J., Hirzmann J., Preis D., Symmons P., Kunz W.
Mol. Biochem. Parasitol. 50:245-254(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M64539 mRNA. Translation: AAA29881.1.
PIRA45628.

3D structure databases

ProteinModelPortalP25320.
SMRP25320. Positions 4-170.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHOG000223383.

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRIH2_SCHMA
AccessionPrimary (citable) accession number: P25320
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 16, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families