Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P25319

- FRIH1_SCHMA

UniProt

P25319 - FRIH1_SCHMA

Protein

Ferritin-1 heavy chain

Gene

SCM-1

Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi23 – 231Iron 1PROSITE-ProRule annotation
    Metal bindingi58 – 581Iron 1PROSITE-ProRule annotation
    Metal bindingi58 – 581Iron 2PROSITE-ProRule annotation
    Metal bindingi61 – 611Iron 1PROSITE-ProRule annotation
    Metal bindingi103 – 1031Iron 2PROSITE-ProRule annotation
    Metal bindingi137 – 1371Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin-1 heavy chain (EC:1.16.3.1)
    Gene namesi
    Name:SCM-1
    OrganismiSchistosoma mansoni (Blood fluke)
    Taxonomic identifieri6183 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 173173Ferritin-1 heavy chainPRO_0000201082Add
    BLAST

    Interactioni

    Subunit structurei

    Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP25319.
    SMRiP25319. Positions 2-168.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 155150Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000223383.
    KOiK00522.
    OMAiFLETYYL.
    PhylomeDBiP25319.

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P25319-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLCRQNYHE ECEAGVNKQI NMELYASYVY MTMAFHFNRD DVALNGFYKF    50
    FLNESEEERQ HAIKLMTYQN MRGGRIVLQD ISAPPQLSWN SGLHAMQDAL 100
    DLEKKVNQSL MELVAVGERH RDTHFCDFIN NEYLEIQVQS MKKLSDYITN 150
    LIRVGNGLGE YTFDKETLHG ESQ 173
    Length:173
    Mass (Da):20,173
    Last modified:May 1, 1992 - v1
    Checksum:iBDE8C72CCF5B91D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64538 mRNA. Translation: AAA29880.1.
    PIRiB45628.
    UniGeneiSma.8998.

    Genome annotation databases

    KEGGismm:Smp_087760.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M64538 mRNA. Translation: AAA29880.1 .
    PIRi B45628.
    UniGenei Sma.8998.

    3D structure databases

    ProteinModelPortali P25319.
    SMRi P25319. Positions 2-168.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    KEGGi smm:Smp_087760.

    Phylogenomic databases

    HOGENOMi HOG000223383.
    KOi K00522.
    OMAi FLETYYL.
    PhylomeDBi P25319.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR014034. Ferritin_CS.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00204. FERRITIN_2. 1 hit.
    PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Ferritins of Schistosoma mansoni: sequence comparison and expression in female and male worms."
      Dietzel J., Hirzmann J., Preis D., Symmons P., Kunz W.
      Mol. Biochem. Parasitol. 50:245-254(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiFRIH1_SCHMA
    AccessioniPrimary (citable) accession number: P25319
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3