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P25319

- FRIH1_SCHMA

UniProt

P25319 - FRIH1_SCHMA

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Protein

Ferritin-1 heavy chain

Gene

SCM-1

Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi23 – 231Iron 1PROSITE-ProRule annotation
Metal bindingi58 – 581Iron 1PROSITE-ProRule annotation
Metal bindingi58 – 581Iron 2PROSITE-ProRule annotation
Metal bindingi61 – 611Iron 1PROSITE-ProRule annotation
Metal bindingi103 – 1031Iron 2PROSITE-ProRule annotation
Metal bindingi137 – 1371Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-1 heavy chain (EC:1.16.3.1)
Gene namesi
Name:SCM-1
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Ferritin-1 heavy chainPRO_0000201082Add
BLAST

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP25319.
SMRiP25319. Positions 2-168.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 155150Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000223383.
KOiK00522.
OMAiFLETYYL.
PhylomeDBiP25319.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25319-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLCRQNYHE ECEAGVNKQI NMELYASYVY MTMAFHFNRD DVALNGFYKF
60 70 80 90 100
FLNESEEERQ HAIKLMTYQN MRGGRIVLQD ISAPPQLSWN SGLHAMQDAL
110 120 130 140 150
DLEKKVNQSL MELVAVGERH RDTHFCDFIN NEYLEIQVQS MKKLSDYITN
160 170
LIRVGNGLGE YTFDKETLHG ESQ
Length:173
Mass (Da):20,173
Last modified:May 1, 1992 - v1
Checksum:iBDE8C72CCF5B91D0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64538 mRNA. Translation: AAA29880.1.
PIRiB45628.

Genome annotation databases

KEGGismm:Smp_087760.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M64538 mRNA. Translation: AAA29880.1 .
PIRi B45628.

3D structure databases

ProteinModelPortali P25319.
SMRi P25319. Positions 2-168.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

KEGGi smm:Smp_087760.

Phylogenomic databases

HOGENOMi HOG000223383.
KOi K00522.
OMAi FLETYYL.
PhylomeDBi P25319.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Ferritins of Schistosoma mansoni: sequence comparison and expression in female and male worms."
    Dietzel J., Hirzmann J., Preis D., Symmons P., Kunz W.
    Mol. Biochem. Parasitol. 50:245-254(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFRIH1_SCHMA
AccessioniPrimary (citable) accession number: P25319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3