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Protein

Ferritin-1 heavy chain

Gene

SCM-1

Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23Iron 1PROSITE-ProRule annotation1
Metal bindingi58Iron 1PROSITE-ProRule annotation1
Metal bindingi58Iron 2PROSITE-ProRule annotation1
Metal bindingi61Iron 1PROSITE-ProRule annotation1
Metal bindingi103Iron 2PROSITE-ProRule annotation1
Metal bindingi137Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-1 heavy chain (EC:1.16.3.1)
Gene namesi
Name:SCM-1
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002010821 – 173Ferritin-1 heavy chainAdd BLAST173

Interactioni

Subunit structurei

Oligomer of 24 subunits. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP25319.
SMRiP25319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 155Ferritin-like diironPROSITE-ProRule annotationAdd BLAST150

Sequence similaritiesi

Belongs to the ferritin family.Curated

Phylogenomic databases

eggNOGiKOG2332. Eukaryota.
COG1528. LUCA.
HOGENOMiHOG000223383.
OMAiNFHEECE.
OrthoDBiEOG091G0J20.
PhylomeDBiP25319.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiView protein in InterPro
IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiView protein in Pfam
PF00210. Ferritin. 1 hit.
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiView protein in PROSITE
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

P25319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLCRQNYHE ECEAGVNKQI NMELYASYVY MTMAFHFNRD DVALNGFYKF
60 70 80 90 100
FLNESEEERQ HAIKLMTYQN MRGGRIVLQD ISAPPQLSWN SGLHAMQDAL
110 120 130 140 150
DLEKKVNQSL MELVAVGERH RDTHFCDFIN NEYLEIQVQS MKKLSDYITN
160 170
LIRVGNGLGE YTFDKETLHG ESQ
Length:173
Mass (Da):20,173
Last modified:May 1, 1992 - v1
Checksum:iBDE8C72CCF5B91D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64538 mRNA. Translation: AAA29880.1.
PIRiB45628.
RefSeqiXP_018645099.1. XM_018791779.1.
UniGeneiSma.8998.

Genome annotation databases

EnsemblMetazoaiSmp_087760.1; Smp_087760.1:pep; Smp_087760.
GeneDBiSmp_087760.1:pep.
GeneIDi8355419.

Similar proteinsi

Entry informationi

Entry nameiFRIH1_SCHMA
AccessioniPrimary (citable) accession number: P25319
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 27, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families