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Protein

Probable glutathione S-transferase parA

Gene

PARA

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141GlutathioneBy similarity
Binding sitei41 – 411GlutathioneBy similarity
Binding sitei55 – 551Glutathione; via amide nitrogen and carbonyl oxygenBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. auxin-activated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Auxin signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione S-transferase parA (EC:2.5.1.18)
Alternative name(s):
Auxin-regulated protein parA
STR246C protein
Gene namesi
Name:PARA
Synonyms:PAR
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Probable glutathione S-transferase parAPRO_0000185863Add
BLAST

Expressioni

Inductioni

By auxin.

Structurei

3D structure databases

ProteinModelPortaliP25317.
SMRiP25317. Positions 2-219.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 8380GST N-terminalAdd
BLAST
Domaini89 – 209121GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 682Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. HSP26 family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESNNVVLLD FWPSSFGMRL RIALALKGIK YEAKEENLSD KSPLLLEMNP
60 70 80 90 100
VHKKIPILIH NSKAICESLN ILEYIDEVWH DKCPLLPSDP YERSQARFWA
110 120 130 140 150
DYIDKKIYST GRRVWSGKGE DQEEAKKEFI EILKTLEGEL GNKTYFGGDN
160 170 180 190 200
LGFVDVALVP FTSWFYSYET CANFSIEAEC PKLVVWAKTC MESESVSKSL
210 220
PHPHKIYGFV LELKHKLGLA
Length:220
Mass (Da):25,225
Last modified:April 30, 1992 - v1
Checksum:i2433BEA9D71D2AC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90215 Genomic DNA. Translation: BAA14243.1.
M29274 mRNA. Translation: AAA67894.1.
X80829 Genomic DNA. Translation: CAA56790.1.
X80828 mRNA. Translation: CAA56789.1.
PIRiA36225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90215 Genomic DNA. Translation: BAA14243.1.
M29274 mRNA. Translation: AAA67894.1.
X80829 Genomic DNA. Translation: CAA56790.1.
X80828 mRNA. Translation: CAA56789.1.
PIRiA36225.

3D structure databases

ProteinModelPortaliP25317.
SMRiP25317. Positions 2-219.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of an auxin-regulated gene cDNA expressed during the transition from G0 to S phase in tobacco mesophyll protoplasts."
    Takahashi Y., Kuroda H., Tanaka T., Machida Y., Takebe I., Nagata T.
    Proc. Natl. Acad. Sci. U.S.A. 86:9279-9283(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leaf mesophyll.
  2. "Structural organization of str 246C and str 246N, plant defense-related genes from Nicotiana tabacum."
    Froissard D., Gough C., Czernic P., Schneider M., Toppan A., Roby D., Marco Y.
    Plant Mol. Biol. 26:515-521(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: cv. NK 326.
  3. "Location of the cis-acting auxin-responsive region in the promoter of the par gene from tobacco mesophyll protoplasts."
    Takahashi Y., Niwa Y., Machida Y., Nagata T.
    Proc. Natl. Acad. Sci. U.S.A. 87:8013-8016(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-106.

Entry informationi

Entry nameiGSTXA_TOBAC
AccessioniPrimary (citable) accession number: P25317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 1992
Last sequence update: April 30, 1992
Last modified: September 30, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.