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Protein

Zinc-alpha-2-glycoprotein

Gene

AZGP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • glycoprotein binding Source: UniProtKB
  • protein transmembrane transporter activity Source: UniProtKB
  • ribonuclease activity Source: UniProtKB

GO - Biological processi

  • antigen processing and presentation Source: GO_Central
  • cell adhesion Source: UniProtKB
  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • retina homeostasis Source: UniProtKB
  • transmembrane transport Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160862-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-alpha-2-glycoprotein
Short name:
Zn-alpha-2-GP
Short name:
Zn-alpha-2-glycoprotein
Gene namesi
Name:AZGP1
Synonyms:ZAG, ZNGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:910. AZGP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi563.
OpenTargetsiENSG00000160862.
PharmGKBiPA25203.

Polymorphism and mutation databases

BioMutaiAZGP1.
DMDMi292495049.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000001901221 – 298Zinc-alpha-2-glycoproteinAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acid1 Publication1
Glycosylationi109N-linked (GlcNAc...) (complex)5 Publications1
Glycosylationi112N-linked (GlcNAc...)5 Publications1
Disulfide bondi123 ↔ 186
Glycosylationi128N-linked (GlcNAc...) (complex)9 Publications1
Disulfide bondi225 ↔ 280
Glycosylationi259N-linked (GlcNAc...)3 Publications1

Post-translational modificationi

N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.11 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP25311.
MaxQBiP25311.
PaxDbiP25311.
PeptideAtlasiP25311.
PRIDEiP25311.

2D gel databases

REPRODUCTION-2DPAGEIPI00166729.
SWISS-2DPAGEP25311.

PTM databases

iPTMnetiP25311.
PhosphoSitePlusiP25311.
UniCarbKBiP25311.

Expressioni

Tissue specificityi

Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.

Gene expression databases

BgeeiENSG00000160862.
CleanExiHS_AZGP1.
ExpressionAtlasiP25311. baseline and differential.
GenevisibleiP25311. HS.

Organism-specific databases

HPAiCAB016087.
CAB032276.
HPA012582.

Interactioni

Subunit structurei

Interacts with PIP.1 Publication

Protein-protein interaction databases

BioGridi107040. 19 interactors.
IntActiP25311. 14 interactors.
STRINGi9606.ENSP00000292401.

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 39Combined sources13
Beta strandi42 – 44Combined sources3
Beta strandi46 – 53Combined sources8
Beta strandi56 – 62Combined sources7
Turni63 – 65Combined sources3
Helixi72 – 76Combined sources5
Beta strandi79 – 81Combined sources3
Helixi83 – 107Combined sources25
Beta strandi116 – 126Combined sources11
Beta strandi129 – 139Combined sources11
Beta strandi142 – 148Combined sources7
Turni149 – 152Combined sources4
Beta strandi153 – 156Combined sources4
Helixi159 – 168Combined sources10
Helixi173 – 183Combined sources11
Helixi185 – 196Combined sources12
Helixi198 – 201Combined sources4
Beta strandi208 – 215Combined sources8
Beta strandi217 – 219Combined sources3
Beta strandi221 – 233Combined sources13
Beta strandi235 – 241Combined sources7
Beta strandi244 – 246Combined sources3
Beta strandi249 – 256Combined sources8
Turni257 – 260Combined sources4
Beta strandi261 – 270Combined sources10
Beta strandi278 – 284Combined sources7
Beta strandi291 – 294Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T7VX-ray1.95A21-298[»]
1T7WX-ray2.70A21-298[»]
1T7XX-ray3.10A21-298[»]
1T7YX-ray2.80A21-298[»]
1T7ZX-ray3.00A21-298[»]
1T80X-ray2.10A21-298[»]
1ZAGX-ray2.80A/B/C/D25-298[»]
3ES6X-ray3.23A21-298[»]
ProteinModelPortaliP25311.
SMRiP25311.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25311.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 292Ig-like C1-typeAdd BLAST86

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9FR. Eukaryota.
ENOG4111CJX. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP25311.
OMAiIFMVTLK.
OrthoDBiEOG091G0K1X.
PhylomeDBiP25311.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRMVPVLLS LLLLLGPAVP QENQDGRYSL TYIYTGLSKH VEDVPAFQAL
60 70 80 90 100
GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET
110 120 130 140 150
LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE
160 170 180 190 200
IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI
210 220 230 240 250
LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL
260 270 280 290
RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS
Length:298
Mass (Da):34,259
Last modified:March 23, 2010 - v2
Checksum:i006A153A8E32A0B1
GO

Sequence cautioni

The sequence AAA61311 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA03123 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA14417 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA42438 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2V → S in CAA42438 (PubMed:1915885).Curated1
Sequence conflicti5V → L in CAA42438 (PubMed:1915885).Curated1
Sequence conflicti33I → V in AAH05306 (PubMed:15489334).Curated1
Sequence conflicti85Q → E AA sequence (PubMed:3422450).Curated1
Sequence conflicti96 – 97Missing AA sequence (PubMed:3422450).Curated2
Sequence conflicti244E → Q AA sequence (PubMed:3422450).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59766 mRNA. Translation: CAA42438.1. Different initiation.
D14034 Genomic DNA. Translation: BAA03123.1. Different initiation.
X69953 Genomic DNA. Translation: CAA49574.1.
AC004522 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23862.1.
CH471091 Genomic DNA. Translation: EAW76621.1.
CH471091 Genomic DNA. Translation: EAW76622.1.
BC005306 mRNA. Translation: AAH05306.1.
BC033830 mRNA. Translation: AAH33830.1.
D90427 mRNA. Translation: BAA14417.1. Different initiation.
M76707 mRNA. Translation: AAA61311.1. Different initiation.
CCDSiCCDS5680.1.
PIRiA54175.
RefSeqiNP_001176.1. NM_001185.3.
UniGeneiHs.546239.

Genome annotation databases

EnsembliENST00000292401; ENSP00000292401; ENSG00000160862.
GeneIDi563.
KEGGihsa:563.
UCSCiuc003ush.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59766 mRNA. Translation: CAA42438.1. Different initiation.
D14034 Genomic DNA. Translation: BAA03123.1. Different initiation.
X69953 Genomic DNA. Translation: CAA49574.1.
AC004522 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23862.1.
CH471091 Genomic DNA. Translation: EAW76621.1.
CH471091 Genomic DNA. Translation: EAW76622.1.
BC005306 mRNA. Translation: AAH05306.1.
BC033830 mRNA. Translation: AAH33830.1.
D90427 mRNA. Translation: BAA14417.1. Different initiation.
M76707 mRNA. Translation: AAA61311.1. Different initiation.
CCDSiCCDS5680.1.
PIRiA54175.
RefSeqiNP_001176.1. NM_001185.3.
UniGeneiHs.546239.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T7VX-ray1.95A21-298[»]
1T7WX-ray2.70A21-298[»]
1T7XX-ray3.10A21-298[»]
1T7YX-ray2.80A21-298[»]
1T7ZX-ray3.00A21-298[»]
1T80X-ray2.10A21-298[»]
1ZAGX-ray2.80A/B/C/D25-298[»]
3ES6X-ray3.23A21-298[»]
ProteinModelPortaliP25311.
SMRiP25311.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107040. 19 interactors.
IntActiP25311. 14 interactors.
STRINGi9606.ENSP00000292401.

PTM databases

iPTMnetiP25311.
PhosphoSitePlusiP25311.
UniCarbKBiP25311.

Polymorphism and mutation databases

BioMutaiAZGP1.
DMDMi292495049.

2D gel databases

REPRODUCTION-2DPAGEIPI00166729.
SWISS-2DPAGEP25311.

Proteomic databases

EPDiP25311.
MaxQBiP25311.
PaxDbiP25311.
PeptideAtlasiP25311.
PRIDEiP25311.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292401; ENSP00000292401; ENSG00000160862.
GeneIDi563.
KEGGihsa:563.
UCSCiuc003ush.4. human.

Organism-specific databases

CTDi563.
DisGeNETi563.
GeneCardsiAZGP1.
HGNCiHGNC:910. AZGP1.
HPAiCAB016087.
CAB032276.
HPA012582.
MIMi194460. gene.
neXtProtiNX_P25311.
OpenTargetsiENSG00000160862.
PharmGKBiPA25203.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9FR. Eukaryota.
ENOG4111CJX. LUCA.
GeneTreeiENSGT00760000118960.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiP25311.
OMAiIFMVTLK.
OrthoDBiEOG091G0K1X.
PhylomeDBiP25311.
TreeFamiTF336617.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160862-MONOMER.
ReactomeiR-HSA-5223345. Miscellaneous transport and binding events.

Miscellaneous databases

ChiTaRSiAZGP1. human.
EvolutionaryTraceiP25311.
GeneWikiiAZGP1.
GenomeRNAii563.
PROiP25311.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160862.
CleanExiHS_AZGP1.
ExpressionAtlasiP25311. baseline and differential.
GenevisibleiP25311. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZA2G_HUMAN
AccessioniPrimary (citable) accession number: P25311
Secondary accession number(s): D6W5T8
, O60386, Q5XKQ4, Q8N4N0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 23, 2010
Last modified: November 30, 2016
This is version 176 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.