Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc-alpha-2-glycoprotein

Gene

AZGP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers. May bind polyunsaturated fatty acids.

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

GO - Molecular functioni

  • protein transmembrane transporter activity Source: UniProtKB
  • ribonuclease activity Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • detection of chemical stimulus involved in sensory perception of bitter taste Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • retina homeostasis Source: UniProtKB
  • transmembrane transport Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc-alpha-2-glycoprotein
Short name:
Zn-alpha-2-GP
Short name:
Zn-alpha-2-glycoprotein
Gene namesi
Name:AZGP1
Synonyms:ZAG, ZNGP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000160862.12
HGNCiHGNC:910 AZGP1
MIMi194460 gene
neXtProtiNX_P25311

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi563
OpenTargetsiENSG00000160862
PharmGKBiPA25203

Chemistry databases

DrugBankiDB03721 N-acetyl-alpha-neuraminic acid

Polymorphism and mutation databases

BioMutaiAZGP1
DMDMi292495049

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 202 PublicationsAdd BLAST20
ChainiPRO_000001901221 – 298Zinc-alpha-2-glycoproteinAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acid1 Publication1
Glycosylationi109N-linked (GlcNAc...) (complex) asparagine5 Publications1
Glycosylationi112N-linked (GlcNAc...) asparagine5 Publications1
Disulfide bondi123 ↔ 186
Glycosylationi128N-linked (GlcNAc...) (complex) asparagine9 Publications1
Disulfide bondi225 ↔ 280
Glycosylationi259N-linked (GlcNAc...) asparagine3 Publications1

Post-translational modificationi

N-glycosylated. N-glycan at Asn-128: Hex5HexNAc4.11 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP25311
MaxQBiP25311
PaxDbiP25311
PeptideAtlasiP25311
PRIDEiP25311

2D gel databases

REPRODUCTION-2DPAGEiIPI00166729
SWISS-2DPAGEiP25311

PTM databases

CarbonylDBiP25311
GlyConnecti692
iPTMnetiP25311
PhosphoSitePlusiP25311
UniCarbKBiP25311

Expressioni

Tissue specificityi

Blood plasma, seminal plasma, urine, saliva, sweat, epithelial cells of various human glands, liver.

Gene expression databases

BgeeiENSG00000160862
CleanExiHS_AZGP1
ExpressionAtlasiP25311 baseline and differential
GenevisibleiP25311 HS

Organism-specific databases

HPAiCAB016087
CAB032276
HPA012582

Interactioni

Subunit structurei

Interacts with PIP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN2Q9UHD94EBI-2513837,EBI-947187

Protein-protein interaction databases

BioGridi10704027 interactors.
CORUMiP25311
IntActiP25311 14 interactors.
MINTiP25311
STRINGi9606.ENSP00000292401

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 39Combined sources13
Beta strandi42 – 44Combined sources3
Beta strandi46 – 53Combined sources8
Beta strandi56 – 62Combined sources7
Turni63 – 65Combined sources3
Helixi72 – 76Combined sources5
Beta strandi79 – 81Combined sources3
Helixi83 – 107Combined sources25
Beta strandi116 – 126Combined sources11
Beta strandi129 – 139Combined sources11
Beta strandi142 – 148Combined sources7
Turni149 – 152Combined sources4
Beta strandi153 – 156Combined sources4
Helixi159 – 168Combined sources10
Helixi173 – 183Combined sources11
Helixi185 – 196Combined sources12
Helixi198 – 201Combined sources4
Beta strandi208 – 215Combined sources8
Beta strandi217 – 219Combined sources3
Beta strandi221 – 233Combined sources13
Beta strandi235 – 241Combined sources7
Beta strandi244 – 246Combined sources3
Beta strandi249 – 256Combined sources8
Turni257 – 260Combined sources4
Beta strandi261 – 270Combined sources10
Beta strandi278 – 284Combined sources7
Beta strandi291 – 294Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1T7VX-ray1.95A21-298[»]
1T7WX-ray2.70A21-298[»]
1T7XX-ray3.10A21-298[»]
1T7YX-ray2.80A21-298[»]
1T7ZX-ray3.00A21-298[»]
1T80X-ray2.10A21-298[»]
1ZAGX-ray2.80A/B/C/D25-298[»]
3ES6X-ray3.23A21-298[»]
ProteinModelPortaliP25311
SMRiP25311
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP25311

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 292Ig-like C1-typeAdd BLAST86

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9FR Eukaryota
ENOG4111CJX LUCA
GeneTreeiENSGT00740000114936
HOGENOMiHOG000296917
HOVERGENiHBG016709
InParanoidiP25311
OMAiTYQSWVV
OrthoDBiEOG091G0K1X
PhylomeDBiP25311
TreeFamiTF336617

Family and domain databases

Gene3Di2.60.40.101 hit
3.30.500.101 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
IPR001039 MHC_I_a_a1/a2
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00129 MHC_I, 1 hit
PRINTSiPR01638 MHCCLASSI
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25311-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRMVPVLLS LLLLLGPAVP QENQDGRYSL TYIYTGLSKH VEDVPAFQAL
60 70 80 90 100
GSLNDLQFFR YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET
110 120 130 140 150
LKDIVEYYND SNGSHVLQGR FGCEIENNRS SGAFWKYYYD GKDYIEFNKE
160 170 180 190 200
IPAWVPFDPA AQITKQKWEA EPVYVQRAKA YLEEECPATL RKYLKYSKNI
210 220 230 240 250
LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT RAGEVQEPEL
260 270 280 290
RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS
Length:298
Mass (Da):34,259
Last modified:March 23, 2010 - v2
Checksum:i006A153A8E32A0B1
GO

Sequence cautioni

The sequence AAA61311 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA03123 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA14417 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA42438 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2V → S in CAA42438 (PubMed:1915885).Curated1
Sequence conflicti5V → L in CAA42438 (PubMed:1915885).Curated1
Sequence conflicti33I → V in AAH05306 (PubMed:15489334).Curated1
Sequence conflicti85Q → E AA sequence (PubMed:3422450).Curated1
Sequence conflicti96 – 97Missing AA sequence (PubMed:3422450).Curated2
Sequence conflicti244E → Q AA sequence (PubMed:3422450).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59766 mRNA Translation: CAA42438.1 Different initiation.
D14034 Genomic DNA Translation: BAA03123.1 Different initiation.
X69953 Genomic DNA Translation: CAA49574.1
AC004522 Genomic DNA No translation available.
CH236956 Genomic DNA Translation: EAL23862.1
CH471091 Genomic DNA Translation: EAW76621.1
CH471091 Genomic DNA Translation: EAW76622.1
BC005306 mRNA Translation: AAH05306.1
BC033830 mRNA Translation: AAH33830.1
D90427 mRNA Translation: BAA14417.1 Different initiation.
M76707 mRNA Translation: AAA61311.1 Different initiation.
CCDSiCCDS5680.1
PIRiA54175
RefSeqiNP_001176.1, NM_001185.3
UniGeneiHs.546239

Genome annotation databases

EnsembliENST00000292401; ENSP00000292401; ENSG00000160862
GeneIDi563
KEGGihsa:563
UCSCiuc003ush.4 human

Similar proteinsi

Entry informationi

Entry nameiZA2G_HUMAN
AccessioniPrimary (citable) accession number: P25311
Secondary accession number(s): D6W5T8
, O60386, Q5XKQ4, Q8N4N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: March 23, 2010
Last modified: April 25, 2018
This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome