Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P25310

- LYSM1_STRGL

UniProt

P25310 - LYSM1_STRGL

Protein

Lysozyme M1

Gene

acm

Organism
Streptomyces globisporus
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 May 1992)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei86 – 861PROSITE-ProRule annotation
    Active sitei177 – 1771PROSITE-ProRule annotation

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cell wall macromolecule catabolic process Source: InterPro
    3. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH25. Glycoside Hydrolase Family 25.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme M1 (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase M1
    Gene namesi
    Name:acm
    OrganismiStreptomyces globisporus
    Taxonomic identifieri1908 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei? – 771 PublicationPRO_0000018517
    Signal peptidei1 – ?Sequence Analysis
    Chaini78 – 294217Lysozyme M1PRO_0000018518Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi185 ↔ 2241 Publication

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP25310.

    Structurei

    Secondary structure

    1
    294
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi81 – 877
    Helixi89 – 913
    Helixi96 – 1016
    Beta strandi106 – 1138
    Turni114 – 1163
    Helixi122 – 13110
    Beta strandi135 – 1417
    Turni144 – 1463
    Helixi149 – 15810
    Beta strandi166 – 1694
    Beta strandi173 – 1753
    Beta strandi180 – 1823
    Turni184 – 1874
    Helixi190 – 20819
    Beta strandi213 – 2164
    Helixi218 – 2258
    Turni230 – 2345
    Beta strandi237 – 2404
    Beta strandi253 – 2553
    Beta strandi257 – 26711
    Beta strandi270 – 28112
    Helixi283 – 2919

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1JFXX-ray1.65A78-294[»]
    ProteinModelPortaliP25310.
    SMRiP25310. Positions 78-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP25310.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 25 family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    InterProiIPR002053. Glyco_hydro_25.
    IPR008270. Glyco_hydro_25_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR018077. Glyco_hydro_fam25_subgr.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF01183. Glyco_hydro_25. 1 hit.
    [Graphical view]
    SMARTiSM00641. Glyco_25. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00953. GLYCOSYL_HYDROL_F25. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P25310-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAYSSLARR GRRPAVVLLG GLVSASLALT LAPTAAAAPL APPPGKDVGP    50
    GEAYMGVGTR IEQGLGAGPD ERTIGPADTS GVQGIDVSHW QGSINWSSVK 100
    SAGMSFAYIK ATEGTNYKDD RFSANYTNAY NAGIIRGAYH FARPNASSGT 150
    AQADYFASNG GGWSRDNRTL PGVLDIEHNP SGAMCYGLST TQMRTWINDF 200
    HARYKARTTR DVVIYTTASW WNTCTGSWNG MAAKSPFWVA HWGVSAPTVP 250
    SGFPTWTFWQ YSATGRVGGV SGDVDRNKFN GSAARLLALA NNTA 294
    Length:294
    Mass (Da):31,169
    Last modified:May 1, 1992 - v1
    Checksum:iD96EFE914FA04997
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30645 Genomic DNA. Translation: AAA26687.1.
    PIRiJQ0529. MUSMM1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M30645 Genomic DNA. Translation: AAA26687.1 .
    PIRi JQ0529. MUSMM1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1JFX X-ray 1.65 A 78-294 [» ]
    ProteinModelPortali P25310.
    SMRi P25310. Positions 78-294.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH25. Glycoside Hydrolase Family 25.

    Proteomic databases

    PRIDEi P25310.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P25310.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    InterProi IPR002053. Glyco_hydro_25.
    IPR008270. Glyco_hydro_25_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR018077. Glyco_hydro_fam25_subgr.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF01183. Glyco_hydro_25. 1 hit.
    [Graphical view ]
    SMARTi SM00641. Glyco_25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00953. GLYCOSYL_HYDROL_F25. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and nucleotide sequence of the N-acetylmuramidase M1-encoding gene from Streptomyces globisporus."
      Lichenstein H.S., Hastings A.E., Langley K.E., Mendiaz E.A., Rohde M.F., Elmore R., Zukowski M.M.
      Gene 88:81-86(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 78-117, DISULFIDE BOND.
      Strain: ATCC 21553 / DSM 40991 / FERM P-596.

    Entry informationi

    Entry nameiLYSM1_STRGL
    AccessioniPrimary (citable) accession number: P25310
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 1992
    Last sequence update: May 1, 1992
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3