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Protein

Gap junction beta-3 protein

Gene

Gjb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • cell communication Source: InterPro
  • in utero embryonic development Source: RGD
  • placenta development Source: Ensembl
  • sensory perception of sound Source: RGD
  • skin development Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-3 protein
Alternative name(s):
Connexin-31
Short name:
Cx31
Gene namesi
Name:Gjb3
Synonyms:Cxn-31
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2695. Gjb3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 126CytoplasmicSequence analysisAdd BLAST28
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Topological domaini150 – 188ExtracellularSequence analysisAdd BLAST39
Transmembranei189 – 211HelicalSequence analysisAdd BLAST23
Topological domaini212 – 270CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578641 – 270Gap junction beta-3 proteinAdd BLAST270

Proteomic databases

PaxDbiP25305.
PRIDEiP25305.

PTM databases

iPTMnetiP25305.
PhosphoSitePlusiP25305.

Expressioni

Gene expression databases

BgeeiENSRNOG00000014372.
GenevisibleiP25305. RN.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019266.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE21. Eukaryota.
ENOG410Y9C2. LUCA.
GeneTreeiENSGT00860000133694.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP25305.
KOiK07622.
OMAiHTLWHGF.
OrthoDBiEOG091G0FKH.
PhylomeDBiP25305.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002269. Connexin31.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF65. PTHR11984:SF65. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01140. CONNEXINB3.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWKKLQDLL SGVNQYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD
60 70 80 90 100
FDCNTRQPGC TNVCYDNFFP ISNIRLWALQ LIFVTCPSML VILHVAYREE
110 120 130 140 150
RERKHRQKHG EHCAKLYSHP GKKHGGLWWT YLFSLIFKLI IELVFLYVLH
160 170 180 190 200
TLWHGFTMPR LVQCASVVPC PNTVDCYIAR PTEKKVFTYF MVGASAVCII
210 220 230 240 250
LTICEICYLI FHRIMRGLSK DKSTKSISSP KSSSRASTCR CHHKLLESGD
260 270
LEAVPADDKL QASAPSLTPI
Length:270
Mass (Da):30,969
Last modified:May 1, 1992 - v1
Checksum:i3D0C506FCE179C44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59936 Genomic DNA. Translation: AAA40997.1.
PIRiA38737.
RefSeqiNP_062113.1. NM_019240.1.
XP_006238907.1. XM_006238845.3.
UniGeneiRn.162823.

Genome annotation databases

EnsembliENSRNOT00000019266; ENSRNOP00000019266; ENSRNOG00000014372.
GeneIDi29585.
KEGGirno:29585.
UCSCiRGD:2695. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59936 Genomic DNA. Translation: AAA40997.1.
PIRiA38737.
RefSeqiNP_062113.1. NM_019240.1.
XP_006238907.1. XM_006238845.3.
UniGeneiRn.162823.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019266.

PTM databases

iPTMnetiP25305.
PhosphoSitePlusiP25305.

Proteomic databases

PaxDbiP25305.
PRIDEiP25305.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000019266; ENSRNOP00000019266; ENSRNOG00000014372.
GeneIDi29585.
KEGGirno:29585.
UCSCiRGD:2695. rat.

Organism-specific databases

CTDi2707.
RGDi2695. Gjb3.

Phylogenomic databases

eggNOGiENOG410IE21. Eukaryota.
ENOG410Y9C2. LUCA.
GeneTreeiENSGT00860000133694.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiP25305.
KOiK07622.
OMAiHTLWHGF.
OrthoDBiEOG091G0FKH.
PhylomeDBiP25305.
TreeFamiTF329606.

Miscellaneous databases

PROiP25305.

Gene expression databases

BgeeiENSRNOG00000014372.
GenevisibleiP25305. RN.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002269. Connexin31.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PTHR11984:SF65. PTHR11984:SF65. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01140. CONNEXINB3.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXB3_RAT
AccessioniPrimary (citable) accession number: P25305
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.