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Protein

Gap junction beta-3 protein

Gene

Gjb3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

  • cell communication Source: InterPro
  • cellular response to retinoic acid Source: RGD
  • in utero embryonic development Source: RGD
  • placenta development Source: Ensembl
  • skin development Source: RGD
  • spermatogenesis Source: RGD

Enzyme and pathway databases

ReactomeiR-RNO-190861 Gap junction assembly

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-3 protein
Alternative name(s):
Connexin-31
Short name:
Cx31
Gene namesi
Name:Gjb3
Synonyms:Cxn-31
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi2695 Gjb3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 40HelicalSequence analysisAdd BLAST20
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 98HelicalSequence analysisAdd BLAST23
Topological domaini99 – 126CytoplasmicSequence analysisAdd BLAST28
Transmembranei127 – 149HelicalSequence analysisAdd BLAST23
Topological domaini150 – 188ExtracellularSequence analysisAdd BLAST39
Transmembranei189 – 211HelicalSequence analysisAdd BLAST23
Topological domaini212 – 270CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578641 – 270Gap junction beta-3 proteinAdd BLAST270

Proteomic databases

PaxDbiP25305
PRIDEiP25305

PTM databases

iPTMnetiP25305
PhosphoSitePlusiP25305

Expressioni

Gene expression databases

BgeeiENSRNOG00000014372
GenevisibleiP25305 RN

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019266

Structurei

3D structure databases

SMRiP25305
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE21 Eukaryota
ENOG410Y9C2 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiP25305
KOiK07622
OMAiHTLWHGF
OrthoDBiEOG091G0FKH
PhylomeDBiP25305
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR002269 Connexin31
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PTHR11984:SF65 PTHR11984:SF65, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
PR01140 CONNEXINB3
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

P25305-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWKKLQDLL SGVNQYSTAF GRIWLSVVFV FRVLVYVVAA ERVWGDEQKD
60 70 80 90 100
FDCNTRQPGC TNVCYDNFFP ISNIRLWALQ LIFVTCPSML VILHVAYREE
110 120 130 140 150
RERKHRQKHG EHCAKLYSHP GKKHGGLWWT YLFSLIFKLI IELVFLYVLH
160 170 180 190 200
TLWHGFTMPR LVQCASVVPC PNTVDCYIAR PTEKKVFTYF MVGASAVCII
210 220 230 240 250
LTICEICYLI FHRIMRGLSK DKSTKSISSP KSSSRASTCR CHHKLLESGD
260 270
LEAVPADDKL QASAPSLTPI
Length:270
Mass (Da):30,969
Last modified:May 1, 1992 - v1
Checksum:i3D0C506FCE179C44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M59936 Genomic DNA Translation: AAA40997.1
PIRiA38737
RefSeqiNP_062113.1, NM_019240.1
XP_006238907.1, XM_006238845.3
UniGeneiRn.162823

Genome annotation databases

EnsembliENSRNOT00000019266; ENSRNOP00000019266; ENSRNOG00000014372
GeneIDi29585
KEGGirno:29585
UCSCiRGD:2695 rat

Similar proteinsi

Entry informationi

Entry nameiCXB3_RAT
AccessioniPrimary (citable) accession number: P25305
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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