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Protein

Calcineurin subunit B

Gene

CNB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi34 – 451PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi66 – 772PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi103 – 1143PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi144 – 1554PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: SGD

GO - Biological processi

  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion Source: SGD
  • cellular ion homeostasis Source: SGD
  • fungal-type cell wall organization Source: SGD
  • protein dephosphorylation Source: GOC

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31953-MONOMER.
ReactomeiR-SCE-2871809. FCERI mediated Ca+2 mobilization.
R-SCE-4086398. Ca2+ pathway.
R-SCE-5607763. CLEC7A (Dectin-1) induces NFAT activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B
Alternative name(s):
Calcineurin regulatory subunit
Protein phosphatase 2B regulatory subunit
Gene namesi
Name:CNB1
Synonyms:YCN2, YCNB
Ordered Locus Names:YKL190W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL190W.
SGDiS000001673. CNB1.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000734982 – 175Calcineurin subunit BAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP25296.
PRIDEiP25296.

Interactioni

Subunit structurei

Composed of a catalytic subunit (A) and a regulatory subunit (B).

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33931. 333 interactors.
DIPiDIP-510N.
IntActiP25296. 20 interactors.
MINTiMINT-409037.
STRINGi4932.YKL190W.

Structurei

3D structure databases

ProteinModelPortaliP25296.
SMRiP25296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 56EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini53 – 88EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini90 – 125EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini131 – 166EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00860000133729.
HOGENOMiHOG000233019.
InParanoidiP25296.
KOiK06268.
OMAiVDKTMME.
OrthoDBiEOG092C4XFN.

Family and domain databases

CDDicd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13202. EF-hand_5. 2 hits.
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAPSKIVD GLLEDTNFDR DEIERLRKRF MKLDRDSSGS IDKNEFMSIP
60 70 80 90 100
GVSSNPLAGR IMEVFDADNS GDVDFQEFIT GLSIFSGRGS KDEKLRFAFK
110 120 130 140 150
IYDIDKDGFI SNGELFIVLK IMVGSNLDDE QLQQIVDRTI VENDSDGDGR
160 170
LSFEEFKNAI ETTEVAKSLT LQYDV
Length:175
Mass (Da):19,639
Last modified:January 23, 2007 - v3
Checksum:i6E42DB350DA05BC0
GO

Sequence cautioni

The sequence CAA52248 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26521 Genomic DNA. Translation: CAA81290.1.
D10293 mRNA. Translation: BAA01136.1.
M87508 Genomic DNA. Translation: AAA34505.1.
X69765 Genomic DNA. Translation: CAA49421.1.
X74151 Genomic DNA. Translation: CAA52248.1. Different initiation.
Z28190 Genomic DNA. Translation: CAA82034.1.
Z28189 Genomic DNA. Translation: CAA82033.1.
BK006944 Genomic DNA. Translation: DAA08976.1.
PIRiJH0462.
RefSeqiNP_012731.1. NM_001179756.1.

Genome annotation databases

EnsemblFungiiYKL190W; YKL190W; YKL190W.
GeneIDi853644.
KEGGisce:YKL190W.

Similar proteinsi

Entry informationi

Entry nameiCANB_YEAST
AccessioniPrimary (citable) accession number: P25296
Secondary accession number(s): D6VX10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names