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Protein

Calcineurin subunit B

Gene

CNB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.

Miscellaneous

This protein has four functional calcium-binding sites.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi34 – 451PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi66 – 772PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi103 – 1143PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi144 – 1554PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: SGD

GO - Biological processi

  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion Source: SGD
  • cellular ion homeostasis Source: SGD
  • fungal-type cell wall organization Source: SGD
  • protein dephosphorylation Source: GOC

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31953-MONOMER
ReactomeiR-SCE-2871809 FCERI mediated Ca+2 mobilization
R-SCE-4086398 Ca2+ pathway
R-SCE-5607763 CLEC7A (Dectin-1) induces NFAT activation

Names & Taxonomyi

Protein namesi
Recommended name:
Calcineurin subunit B
Alternative name(s):
Calcineurin regulatory subunit
Protein phosphatase 2B regulatory subunit
Gene namesi
Name:CNB1
Synonyms:YCN2, YCNB
Ordered Locus Names:YKL190W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL190W
SGDiS000001673 CNB1

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000734982 – 175Calcineurin subunit BAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiP25296
PaxDbiP25296
PRIDEiP25296

PTM databases

iPTMnetiP25296

Interactioni

Subunit structurei

Composed of a catalytic subunit (A) and a regulatory subunit (B).

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33931, 344 interactors
DIPiDIP-510N
IntActiP25296, 19 interactors
MINTiP25296
STRINGi4932.YKL190W

Structurei

3D structure databases

ProteinModelPortaliP25296
SMRiP25296
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 56EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini53 – 88EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini90 – 125EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini131 – 166EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00860000133729
HOGENOMiHOG000233019
InParanoidiP25296
KOiK06268
OMAiVDKTMME
OrthoDBiEOG092C4XFN

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13202 EF-hand_5, 2 hits
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P25296-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAAPSKIVD GLLEDTNFDR DEIERLRKRF MKLDRDSSGS IDKNEFMSIP
60 70 80 90 100
GVSSNPLAGR IMEVFDADNS GDVDFQEFIT GLSIFSGRGS KDEKLRFAFK
110 120 130 140 150
IYDIDKDGFI SNGELFIVLK IMVGSNLDDE QLQQIVDRTI VENDSDGDGR
160 170
LSFEEFKNAI ETTEVAKSLT LQYDV
Length:175
Mass (Da):19,639
Last modified:January 23, 2007 - v3
Checksum:i6E42DB350DA05BC0
GO

Sequence cautioni

The sequence CAA52248 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26521 Genomic DNA Translation: CAA81290.1
D10293 mRNA Translation: BAA01136.1
M87508 Genomic DNA Translation: AAA34505.1
X69765 Genomic DNA Translation: CAA49421.1
X74151 Genomic DNA Translation: CAA52248.1 Different initiation.
Z28190 Genomic DNA Translation: CAA82034.1
Z28189 Genomic DNA Translation: CAA82033.1
BK006944 Genomic DNA Translation: DAA08976.1
PIRiJH0462
RefSeqiNP_012731.1, NM_001179756.1

Genome annotation databases

EnsemblFungiiYKL190W; YKL190W; YKL190W
GeneIDi853644
KEGGisce:YKL190W

Similar proteinsi

Entry informationi

Entry nameiCANB_YEAST
AccessioniPrimary (citable) accession number: P25296
Secondary accession number(s): D6VX10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health