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Protein

Tubulin gamma chain

Gene

tug1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi142 – 148GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic microtubule organization Source: PomBase
  • microtubule nucleation Source: PomBase
  • mitotic cytokinesis, site selection Source: PomBase
  • mitotic spindle midzone assembly Source: PomBase
  • mitotic spindle organization Source: PomBase

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma chain
Alternative name(s):
Gamma-tubulin
Gene namesi
Name:tug1
Synonyms:gtb1
ORF Names:SPBC32F12.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC32F12.04
PomBaseiSPBC32F12.04

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484801 – 446Tubulin gamma chainAdd BLAST446

Proteomic databases

MaxQBiP25295
PaxDbiP25295
PRIDEiP25295

Interactioni

Protein-protein interaction databases

BioGridi276756, 36 interactors
IntActiP25295, 4 interactors
MINTiP25295
STRINGi4896.SPBC32F12.04.1

Structurei

3D structure databases

ProteinModelPortaliP25295
SMRiP25295
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

HOGENOMiHOG000165714
InParanoidiP25295
KOiK10389
OMAiEGFMLMH
OrthoDBiEOG092C2U1W
PhylomeDBiP25295

Family and domain databases

CDDicd02188 gamma_tubulin, 1 hit
Gene3Di1.10.287.600, 1 hit
3.30.1330.20, 1 hit
3.40.50.1440, 1 hit
InterProiView protein in InterPro
IPR002454 Gamma_tubulin
IPR008280 Tub_FtsZ_C
IPR000217 Tubulin
IPR018316 Tubulin/FtsZ_2-layer-sand-dom
IPR037103 Tubulin/FtsZ_C_sf
IPR036525 Tubulin/FtsZ_GTPase_sf
IPR023123 Tubulin_C
IPR017975 Tubulin_CS
IPR003008 Tubulin_FtsZ_GTPase
PANTHERiPTHR11588 PTHR11588, 1 hit
PfamiView protein in Pfam
PF00091 Tubulin, 1 hit
PF03953 Tubulin_C, 1 hit
PRINTSiPR01164 GAMMATUBULIN
PR01161 TUBULIN
SMARTiView protein in SMART
SM00864 Tubulin, 1 hit
SM00865 Tubulin_C, 1 hit
SUPFAMiSSF52490 SSF52490, 1 hit
SSF55307 SSF55307, 1 hit
PROSITEiView protein in PROSITE
PS00227 TUBULIN, 1 hit

Sequencei

Sequence statusi: Complete.

P25295-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGREIITLQA GQCGNQIGSQ FWQQLCLEHG IGPDGTLESF ATEGVDRKDV
60 70 80 90 100
FFYQSDDTRY IPRAILIDLE PRVVNNILSD TYGSLYNPEN ILITKNGGGA
110 120 130 140 150
GNNWANGYSH AERIFEDIMD MIDREADGSD SLEGFSLLHS IAGGTGSGLG
160 170 180 190 200
SFLLERLNDR YPKKIIQTYS VFPNSQSVSD VVVQPYNSLL ALKRLTLNAD
210 220 230 240 250
SVVVLDNAAL AHIAADRLHT QNPTFHQQNQ LVSTVMSAST TTLRYPGYMN
260 270 280 290 300
NDLVSIIASL IPSPRCHFLL TSYTPFTNQQ VEEAKAIRKT TVLDVMRRLL
310 320 330 340 350
LPKNQMVSVN PSKKSCFISI LDIIQGEADP ADVHKSLLRI RERRYASFIP
360 370 380 390 400
WGPASIQVAL SKKSPYIKTN HRVSGLMLAN HTSIASLFKR TLDQYDRLRK
410 420 430 440
RNAFLEQYKK EAIFEDDLNE FDSSRDVVAD LINEYEACED PNYLSL
Length:446
Mass (Da):49,966
Last modified:May 1, 1992 - v1
Checksum:i8A48833EAB3BD469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63447 Genomic DNA Translation: AAA35305.1
X62031 Genomic DNA Translation: CAA43976.1
CU329671 Genomic DNA Translation: CAA19365.1
PIRiB39528 UBZPG
RefSeqiNP_596147.1, NM_001022066.2

Genome annotation databases

EnsemblFungiiSPBC32F12.04.1; SPBC32F12.04.1:pep; SPBC32F12.04
GeneIDi2540223
KEGGispo:SPBC32F12.04

Similar proteinsi

Entry informationi

Entry nameiTBG_SCHPO
AccessioniPrimary (citable) accession number: P25295
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: May 23, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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