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Protein

Tubulin gamma chain

Gene

tug1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 1487GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic microtubule organization Source: InterPro
  • microtubule nucleation Source: PomBase
  • mitotic cytokinesis, site selection Source: PomBase
  • mitotic spindle midzone assembly Source: PomBase
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma chain
Alternative name(s):
Gamma-tubulin
Gene namesi
Name:tug1
Synonyms:gtb1
ORF Names:SPBC32F12.04
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:SPBC32F12.04.
PomBaseiSPBC32F12.04.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: PomBase
  • equatorial microtubule organizing center Source: PomBase
  • gamma-tubulin complex Source: PomBase
  • interphase microtubule organizing center Source: PomBase
  • microtubule Source: UniProtKB-KW
  • mitotic spindle pole body Source: PomBase
  • nucleus Source: PomBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Tubulin gamma chainPRO_0000048480Add
BLAST

Proteomic databases

MaxQBiP25295.

Interactioni

Protein-protein interaction databases

BioGridi276756. 36 interactions.
IntActiP25295. 4 interactions.
MINTiMINT-4687888.

Structurei

3D structure databases

ProteinModelPortaliP25295.
SMRiP25295. Positions 3-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

HOGENOMiHOG000165714.
InParanoidiP25295.
KOiK10389.
OMAiEHGINKE.
OrthoDBiEOG092C2U1W.
PhylomeDBiP25295.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF7. PTHR11588:SF7. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25295-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGREIITLQA GQCGNQIGSQ FWQQLCLEHG IGPDGTLESF ATEGVDRKDV
60 70 80 90 100
FFYQSDDTRY IPRAILIDLE PRVVNNILSD TYGSLYNPEN ILITKNGGGA
110 120 130 140 150
GNNWANGYSH AERIFEDIMD MIDREADGSD SLEGFSLLHS IAGGTGSGLG
160 170 180 190 200
SFLLERLNDR YPKKIIQTYS VFPNSQSVSD VVVQPYNSLL ALKRLTLNAD
210 220 230 240 250
SVVVLDNAAL AHIAADRLHT QNPTFHQQNQ LVSTVMSAST TTLRYPGYMN
260 270 280 290 300
NDLVSIIASL IPSPRCHFLL TSYTPFTNQQ VEEAKAIRKT TVLDVMRRLL
310 320 330 340 350
LPKNQMVSVN PSKKSCFISI LDIIQGEADP ADVHKSLLRI RERRYASFIP
360 370 380 390 400
WGPASIQVAL SKKSPYIKTN HRVSGLMLAN HTSIASLFKR TLDQYDRLRK
410 420 430 440
RNAFLEQYKK EAIFEDDLNE FDSSRDVVAD LINEYEACED PNYLSL
Length:446
Mass (Da):49,966
Last modified:May 1, 1992 - v1
Checksum:i8A48833EAB3BD469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63447 Genomic DNA. Translation: AAA35305.1.
X62031 Genomic DNA. Translation: CAA43976.1.
CU329671 Genomic DNA. Translation: CAA19365.1.
PIRiB39528. UBZPG.
RefSeqiNP_596147.1. NM_001022066.2.

Genome annotation databases

EnsemblFungiiSPBC32F12.04.1; SPBC32F12.04.1:pep; SPBC32F12.04.
GeneIDi2540223.
KEGGispo:SPBC32F12.04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63447 Genomic DNA. Translation: AAA35305.1.
X62031 Genomic DNA. Translation: CAA43976.1.
CU329671 Genomic DNA. Translation: CAA19365.1.
PIRiB39528. UBZPG.
RefSeqiNP_596147.1. NM_001022066.2.

3D structure databases

ProteinModelPortaliP25295.
SMRiP25295. Positions 3-445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi276756. 36 interactions.
IntActiP25295. 4 interactions.
MINTiMINT-4687888.

Proteomic databases

MaxQBiP25295.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPBC32F12.04.1; SPBC32F12.04.1:pep; SPBC32F12.04.
GeneIDi2540223.
KEGGispo:SPBC32F12.04.

Organism-specific databases

EuPathDBiFungiDB:SPBC32F12.04.
PomBaseiSPBC32F12.04.

Phylogenomic databases

HOGENOMiHOG000165714.
InParanoidiP25295.
KOiK10389.
OMAiEHGINKE.
OrthoDBiEOG092C2U1W.
PhylomeDBiP25295.

Miscellaneous databases

PROiP25295.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PTHR11588:SF7. PTHR11588:SF7. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBG_SCHPO
AccessioniPrimary (citable) accession number: P25295
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 7, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.