UniProtKB - P25285 (GCST_BOVIN)
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Protein
Aminomethyltransferase, mitochondrial
Gene
AMT
Organism
Bos taurus (Bovine)
Status
Functioni
The glycine cleavage system catalyzes the degradation of glycine.By similarity
Catalytic activityi
[Protein]-S8-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 226 | SubstrateBy similarity | 1 | |
Binding sitei | 255 | SubstrateBy similarity | 1 | |
Binding sitei | 393 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- aminomethyltransferase activity Source: UniProtKB
- lipoic acid binding Source: AgBase
- transaminase activity Source: UniProtKB-KW
GO - Biological processi
- glycine catabolic process Source: AgBase
- glycine decarboxylation via glycine cleavage system Source: UniProtKB
Keywordsi
Molecular function | Aminotransferase, Transferase |
Enzyme and pathway databases
Reactomei | R-BTA-6783984. Glycine degradation. |
Names & Taxonomyi
Protein namesi | Recommended name: Aminomethyltransferase, mitochondrialCurated (EC:2.1.2.10By similarity)Alternative name(s): Glycine cleavage system T protein1 Publication Short name: GCVT |
Gene namesi | Name:AMTBy similarity |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 22 | Mitochondrion1 PublicationAdd BLAST | 22 | |
ChainiPRO_0000010753 | 23 – 397 | Aminomethyltransferase, mitochondrialAdd BLAST | 375 |
Proteomic databases
PaxDbi | P25285. |
PRIDEi | P25285. |
Interactioni
Subunit structurei
The glycine cleavage system is composed of four proteins: P, T, L and H.By similarity
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000002992. |
Structurei
3D structure databases
ProteinModelPortali | P25285. |
SMRi | P25285. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the GcvT family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2770. Eukaryota. COG0404. LUCA. |
GeneTreei | ENSGT00530000063120. |
HOGENOMi | HOG000239380. |
HOVERGENi | HBG005822. |
InParanoidi | P25285. |
KOi | K00605. |
OMAi | MPVQYPA. |
OrthoDBi | EOG091G07Z1. |
TreeFami | TF313026. |
Family and domain databases
Gene3Di | 3.30.1360.120. 2 hits. |
InterProi | View protein in InterPro IPR006223. GCS_T. IPR028896. GCST/YgfZ/DmdA. IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR029043. GcvT/YgfZ_C. IPR027266. TrmE/GcvT_dom1. |
Pfami | View protein in Pfam PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. |
PIRSFi | PIRSF006487. GcvT. 1 hit. |
SUPFAMi | SSF101790. SSF101790. 1 hit. |
TIGRFAMsi | TIGR00528. gcvT. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P25285-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSRLSSRLQ ALASAPCRSL SCAQDVLHRT PLYDFHLAHG GKMVAFAGWS
60 70 80 90 100
LPVQYRDSHV NSHLHTRQHC SLFDVSHMLQ TKIFGCDRVK LMESLVVGDI
110 120 130 140 150
AELKPNQGTL SLFTNEAGGI LDDLIVTSAS EGHLYVVSNA GCREKDLTLM
160 170 180 190 200
QDKVRELQNK GSDVALEVMD NALLALQGPT AAQVLQAGVA DDLRKLPFMT
210 220 230 240 250
SAVMEVFGVS GCRVTRCGYT GEDGVEISVP AAEAVHLAAA LLKNPEVKLA
260 270 280 290 300
GLAARDSLRL EAGLCLYGND IDEHTTPVEG SLSWTLGKRR RAAMDFPGAS
310 320 330 340 350
VIVPQLKSKA QRRRVGLMCD GAPVRAQSPI LSPEGTVIGA VTSGCPSPCL
360 370 380 390
KKNVAMGYVP YEYSRPGTPL LVEVRRKQQP AVVSKMPFVS TNYYILK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M59799 mRNA. Translation: AAA30786.1. |
PIRi | A23707. |
RefSeqi | NP_803451.1. NM_177485.2. |
UniGenei | Bt.7177. |
Genome annotation databases
Ensembli | ENSBTAT00000002992; ENSBTAP00000002992; ENSBTAG00000002321. |
GeneIDi | 280719. |
KEGGi | bta:280719. |
Similar proteinsi
Entry informationi
Entry namei | GCST_BOVIN | |
Accessioni | P25285Primary (citable) accession number: P25285 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | March 28, 2018 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |