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Protein

Modification methylase HgiGI

Gene

hgiGIM

Organism
Herpetosiphon aurantiacus (Herpetosiphon giganteus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GRCGYC, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the HgiEI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3420 M.HgiGI

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase HgiGI (EC:2.1.1.37)
Short name:
M.HgiGI
Alternative name(s):
Cytosine-specific methyltransferase HgiGI
Gene namesi
Name:hgiGIM
OrganismiHerpetosiphon aurantiacus (Herpetosiphon giganteus)
Taxonomic identifieri65 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878911 – ›126Modification methylase HgiGIAdd BLAST›126

Structurei

3D structure databases

ProteinModelPortaliP25267
SMRiP25267
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 126SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST126

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Fragment.

P25267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIDLFAGC GGMSLGFMQA GFEIVAAVDN WRPAITTYQQ NFIHPIHELD
60 70 80 90 100
LAEVDEAISL IKTYSPELII GGPPCQDFSS AGKRDEGLGR ANLTLDFVKI
110 120
VLAIQPAWVI MENVERARLS KIHQQA
Length:126
Mass (Da):13,871
Last modified:May 1, 1992 - v1
Checksum:iFF3695B03BC02399
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1261

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55143 Genomic DNA Translation: CAA38947.1
PIRiS21955

Entry informationi

Entry nameiMTG1_HERAU
AccessioniPrimary (citable) accession number: P25267
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health