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P25266

- MTE1_HERAU

UniProt

P25266 - MTE1_HERAU

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Protein
Modification methylase HgiEI
Gene
hgiEIM
Organism
Herpetosiphon aurantiacus (Herpetosiphon giganteus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GGWCC, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the HgiEI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei75 – 751 By similarity

GO - Molecular functioni

  1. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  2. DNA binding Source: InterPro

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3419. M.HgiEI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase HgiEI (EC:2.1.1.37)
Short name:
M.HgiEI
Alternative name(s):
Cytosine-specific methyltransferase HgiEI
Gene namesi
Name:hgiEIM
OrganismiHerpetosiphon aurantiacus (Herpetosiphon giganteus)
Taxonomic identifieri65 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Modification methylase HgiEI
PRO_0000087890Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP25266.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 431428SAM-dependent MTase C5-type
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF00145. DNA_methylase. 1 hit.
[Graphical view]
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P25266-1 [UniParc]FASTAAdd to Basket

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MQQFRFIDLF AGIGGFRLGL EAVGGVCVAS AEIDQQAIKV YWQNWPTDGV    50
DHNLGDITQI QQLPAHDVLV GGVPCQPWSI AGKNQAFDDP RGQLWADVIR 100
LVQINQPKAF IFENVKGLVD PRNRLCLEII LDSFKDLGYS VFYKLLNSFD 150
FGVAQNRDRV FIVGIQQKLD LNGFSFPEYA ESDQRLYHIL DNLEAPETKL 200
ESIPIQRNLF GERIEVGYNK LTPRGAFNDF FILNDIRNGP TSIHSWEIYP 250
TTEREKHICM IIMRNRRNSR YGNCDGNPMS YSDIAELVVD LAENELQILV 300
KKRILRQYPD GKYEFFNRRL SGGIDGTYRI FMPNARFFGT LTARGMHDEI 350
AEINVSGANA AEYKYNFIQQ VLIPKRYRPI TVSEAARLQG FPSTFKFHSN 400
QSANFRLIGN SVAPPVIVAL GKRLQCVKLF EQELCEV 437
Length:437
Mass (Da):49,817
Last modified:May 1, 1992 - v1
Checksum:iAC27AF38B5BC973F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55142 Genomic DNA. Translation: CAA38944.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X55142 Genomic DNA. Translation: CAA38944.1 .

3D structure databases

ProteinModelPortali P25266.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3419. M.HgiEI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF00145. DNA_methylase. 1 hit.
[Graphical view ]
PRINTSi PR00105. C5METTRFRASE.
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Erdmann D., Kroeger M.
    Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: HPG24.
  2. "Organization and gene expression within restriction-modification systems of Herpetosiphon giganteus."
    Kroeger M., Blum E., Deppe E., Duesterhoeft A., Erdmann D., Kilz S., Meyer-Rogge S., Moestl D.
    Gene 157:43-47(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiMTE1_HERAU
AccessioniPrimary (citable) accession number: P25266
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: September 3, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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