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Protein

Modification methylase HgiDII

Gene

hgiDIIM

Organism
Herpetosiphon aurantiacus (Herpetosiphon giganteus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GTCGAC, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the HgiDII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3418 M.HgiDII

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase HgiDII (EC:2.1.1.37)
Short name:
M.HgiDII
Alternative name(s):
Cytosine-specific methyltransferase HgiDII
Gene namesi
Name:hgiDIIM
OrganismiHerpetosiphon aurantiacus (Herpetosiphon giganteus)
Taxonomic identifieri65 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878891 – 354Modification methylase HgiDIIAdd BLAST354

Structurei

3D structure databases

ProteinModelPortaliP25265
SMRiP25265
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 344SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST342

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105NI8 Bacteria
COG0270 LUCA

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR031303 C5_meth_CS
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS00095 C5_MTASE_2, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P25265-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGAVIDLFC GVGGLTHGLI LEGFGVLAGI DNDPSCKYAY EQNNRTRFIE
60 70 80 90 100
KSISEVDGRE LNALYPNNQH KILVGCAPCQ DFSQYTKKSR TGTKWQLLTE
110 120 130 140 150
FSRLIREIEP DIISMENVPE VRTFNRGEVF NNFIQSLEQL GYHVSHSVVH
160 170 180 190 200
CPDYGIPQQR DRLVLFAAKQ GVIKIIPPTH TPENYRTVRD VIGSLATNYS
210 220 230 240 250
GGHWEGDSMH AASRLEDINL RRIQHSVPGG TWADWPEELI AECHKKESGE
260 270 280 290 300
SYGSVYGRME WDKVAPTITT QCNGYGNGRF GHPEQDRAIS LREAALLQTF
310 320 330 340 350
PRSYQFAPEG QLKFKTVSRQ IGNAVPVALG RVIAKSIKRF LEGLHERQRV

RIII
Length:354
Mass (Da):39,853
Last modified:May 1, 1992 - v1
Checksum:iBDA017785D5ADC75
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55141 Genomic DNA Translation: CAA38941.1
PIRiS21949 JT0594

Similar proteinsi

Entry informationi

Entry nameiMTD2_HERAU
AccessioniPrimary (citable) accession number: P25265
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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