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Protein

Modification methylase HgiCII

Gene

hgiCIIM

Organism
Herpetosiphon aurantiacus (Herpetosiphon giganteus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GGWCC, causes specific methylation on C-? on both strands and protects the DNA from cleavage by the HgiCII endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei75PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Protein family/group databases

REBASEi3416. M.HgiCII.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase HgiCII (EC:2.1.1.37)
Short name:
M.HgiCII
Alternative name(s):
Cytosine-specific methyltransferase HgiCII
Gene namesi
Name:hgiCIIM
OrganismiHerpetosiphon aurantiacus (Herpetosiphon giganteus)
Taxonomic identifieri65 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaHerpetosiphonalesHerpetosiphonaceaeHerpetosiphon

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878871 – 437Modification methylase HgiCIIAdd BLAST437

Structurei

3D structure databases

ProteinModelPortaliP25264.
SMRiP25264.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 431SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST428

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR029063. SAM-dependent_MTases.
PRINTSiPR00105. C5METTRFRASE.
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiView protein in PROSITE
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.

Sequencei

Sequence statusi: Complete.

P25264-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQFRFIDLF AGIGGFRLGL EAVGGICVGS AEIDQQAIKV YRQNWPTDRS
60 70 80 90 100
EHNLGDITTL QQLPAHDLVV GGVPCQPWSI AGKNQAFDDP RGQLWADVIR
110 120 130 140 150
LVRINQPKAF IFENVKGLID PRNRLCLESI LDSFKAEGYN VYYKLLNSFD
160 170 180 190 200
YGVAQNRDRV FIIGIQQKLG VPDFSFPEYS ESEQRLYDIL DNLQTPSIIP
210 220 230 240 250
ESLPIQRNLF GERIEVGFNK LTPRGAFNDF FILNDIRNGP TSIHSWEIYA
260 270 280 290 300
TTEREKQICT TIMRNRGNPR YGDCDGNPMS YQDIADLVVD LAESELQVLI
310 320 330 340 350
QKRILRQYED GKYEFFNRRL SGGIDGTYRI FLPHARFFGR LTARGMHDEI
360 370 380 390 400
AEISVSGATA EAYKQNFIQQ ILIPKRHRPI TVNEAARIQG FPATFKFHSN
410 420 430
QSANFRLIGN SVAPPVIMAL GKALPNDHLF EPELCEV
Length:437
Mass (Da):49,622
Last modified:May 1, 1992 - v1
Checksum:i721217050B382081
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55139 Genomic DNA. Translation: CAA38935.1.
PIRiJC1165.

Similar proteinsi

Entry informationi

Entry nameiMTC2_HERAU
AccessioniPrimary (citable) accession number: P25264
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: May 1, 1992
Last modified: October 25, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families